Hispolon induces apoptosis through JNK1/2-mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 42, 2013, Pages 10063-10073

  Hsiao, Pei Ching ^a,b   Hsieh, Yi Hsien ^a   Chow, Jyh Ming ^c   Yang, Shun Fa ^a,b   Hsiao, Michael ^d   Hua, Kuo Tai ^e   Lin, Chien Huang ^f   Chen, Hui Yu ^a   Chien, Ming Hsien ^f,g  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d GENOMICS RESEARCH CENTER   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

acute myeloid leukemia; apoptosis; caspase; hispolon; JNK1 2; xenograft tumor

Indexed keywords

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CHEMICAL ACTIVATION; DISEASES; MAMMALS;

ACUTE MYELOID LEUKEMIA; ANTIOXIDANT AND ANTICANCER ACTIVITIES; CASPASES; HISPOLON; JNK1/2; MOLECULAR MECHANISM; PHELLINUS IGNIARIUS; SUSTAINED ACTIVATION;

TUMORS;

BASIDIOMYCOTA; MUS; PHELLINUS IGNIARIUS;

CASPASE 3; CASPASE 8; CASPASE 9; CATECHOL DERIVATIVE; HISPOLON; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE 1;

ACUTE GRANULOCYTIC LEUKEMIA; AGARICALES; ANIMAL; APOPTOSIS; ARTICLE; CANCER TRANSPLANTATION; CELL PROLIFERATION; CELL STRAIN HL 60; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; SCID MOUSE;

AGARICALES; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CATECHOLS; CELL PROLIFERATION; DOWN-REGULATION; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84886469849     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf402956m     Document Type: Article

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