The MAPK pathway as an apoptosis enhancer in melanoma

Oncotarget

Volumn 5, Issue 13, 2014, Pages 5040-5053

  Haydn, Johannes M ^a   Hufnagel, Anita ^a   Grimm, Johannes ^a   Maurus, Katja ^a   Schartl, Manfred ^a,b   Meierjohann, Svenja ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Chemotherapy resistance; Crosstalk; Melanoma; PI3K; RAS

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; B RAF KINASE; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PICTILISIB; PROTEIN; PUMA PROTEIN; RAS PROTEIN; SPRED1 PROTEIN; SPRED2 PROTEIN; SPROUTY PROTEIN; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 2-(1H-INDAZOL-4-YL)-6-(4-METHANESULFONYLPIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YLTHIENO(3,2-D)PYRIMIDINE; 2-(2-CHLORO-4-IODOPHENYLAMINO)-N-CYCLOPROPYLMETHOXY-3,4-DIFLUOROBENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; BRAF PROTEIN, HUMAN; ENZYME INHIBITOR; INDAZOLE DERIVATIVE; MAPK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRILE; PROTEIN KINASE B; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SPRED1 PROTEIN, HUMAN; SPRED2 PROTEIN, HUMAN; SULFONAMIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BBC3 GENE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; FEEDBACK SYSTEM; GENE SILENCING; GENOTOXICITY; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; MELANOMA; MELANOMA CELL LINE; PROTEIN PROTEIN INTERACTION; SPRED1 GENE; SPRED2 GENE; SPRY2 GENE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MISSENSE MUTATION; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; BLOTTING, WESTERN; BUTADIENES; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MELANOMA; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTATION, MISSENSE; NITRILES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SULFONAMIDES;

EID: 84905003322     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2079     Document Type: Article

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