Fenoterol inhibits LPS-induced AMPK activation and inflammatory cytokine production through β-arrestin-2 in THP-1 cell line

Biochemical and Biophysical Research Communications

Volumn 462, Issue 2, 2015, Pages 119-123

  Wang, Wei ^a   Zhang, Yuan ^a   Xu, Ming ^a   Zhang, You Yi ^a   He, Bei ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

AMPK; Fenoterol; Lipopolysaccharide; THP 1 cell line; arrestin 2; 2 adrenergic receptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; FENOTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AUTACOID; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN; CYTOKINE; PRKAA1 PROTEIN, HUMAN; RETINA S ANTIGEN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; AMP-ACTIVATED PROTEIN KINASES; ARRESTINS; CELL LINE; CYTOKINES; ENZYME ACTIVATION; FENOTEROL; GENE KNOCKDOWN TECHNIQUES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; NF-KAPPA B; RNA, SMALL INTERFERING;

EID: 84929841468     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.097     Document Type: Article

References (38)

1. R. Karima, S. Matsumoto, H. Higashi, and K. Matsushima The molecular pathogenesis of endotoxic shock and organ failure Mol. Med. Today 5 1999 123 132
2. R. Risitano, M. Curro, S. Cirmi, N. Ferlazzo, P. Campiglia, et al. Flavonoid fraction of bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-kB inhibition in THP-1 monocytes PLoS One 9 2014 e107431
3. S.M. Miggin, and L.A. O'Neill New insights into the regulation of TLR signaling J. Leukoc. Biol. 80 2006 220 226
4. M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
5. C. Page, and M. Cazzola Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease Eur. Respir. J. 44 2014 475 482
6. N.C. Barnes, Y.S. Qiu, I.D. Pavord, D. Parker, P.A. Davis, et al. Anti-inflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease Am. J. Respir. Crit. Care. Med. 173 2006 736 743
7. 2-agonist therapy in lung disease Am. J. Respir. Crit. Care. Med. 187 2013 690 696
8. K.C. Verhoeckx, R.P. Doornbos, J. van der Greef, R.F. Witkamp, and R.J. Rodenburg Inhibitory effects of the beta-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo J. Vet. Pharmacol. Ther. 28 2005 531 537
9. N. Szabo-Fresnais, F. Lefebvre, A. Germain, R. Fischmeister, and M. Pomérance A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic and IL-1 beta receptors and induction of cellular hypertrophy by IL-6 trans-signalling Cell. Signal 22 2010 1143 1152
10. J.M. Davies, M.L. Carroll, H. Li, A.M. Poh, D. Kirkegard, et al. Budesonide and formoterol reduce early innate anti-viral immune responses in vitro PLoS One 6 2011 e27898
11. W. Wang, M. Xu, Y. Zhang, and B. He Fenoterol, a beta(2)-adrenoceptor agonist, inhibits LPS-induced membrane-bound CD14, TLR4/CD14 complex, and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line Acta Pharmacol. Sin. 30 2009 1522 1528
12. N. Jessen, E.I. Sundelin, and A.B. Møller AMP kinase in exercise adaptation of skeletal muscle Drug Discov. Today 19 2014 999 1002
13. K. Burkewitz, Y. Zhang, and W.B. Mair AMPK at the Nexus of energetics and aging Cell. Metab. 20 2014 10 25
14. Y. Zhao, Y. Tan, S. Xi, Y. Li, C. Li, et al. A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated interleukin-6 generation Diabetes 62 2013 2545 2558
15. D. Sag, D. Carling, R.D. Stout, and J. Suttles Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype J. Immunol. 181 2008 8633 8641
16. D.P. Cioca, Y. Aoki, and K. Kiyosawa RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines Cancer Gene Ther. 10 2003 125 133
17. F. Yin, Y. Wang, J. Du, C. Li, Z. Lu, et al. Noncanonical cAMP pathway and p38 MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts J. Mol. Cell. Cardiol. 40 2006 384 393
18. D. Grahame Hardie AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease J. Intern. Med. 276 2014 543 559
19. S. Giri, N. Nath, B. Smith, B. Viollet, A.K. Singh, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase J. Neurosci. 24 2004 479 487
20. Y. Hattori, Y. Nakano, S. Hattori, A. Tomizawa, K. Inukai, et al. High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells FEBS Lett. 582 2008 1719 1724
21. D. Lu, C. Tang, Y. Chen, and I. Wei Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia J. Cell. Biochem. 110 2010 697 705
22. J. Du, N. Xu, Y. Song, M. Xu, Z. Lu, et al. AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK Biochem. Biophys. Res. Commun. 337 2005 1139 1144
23. C. Tang, Y. Chiu, T. Tan, R. Yang, and W. Fu Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway J. Immunol. 179 2007 5483 5492
24. Peter J. Barnes, and Michael Karin Nuclear factor-κB-a pivotal transcription factor in chronic inflammatory diseases N. Engl. J. Med. 336 1997 1066 1071
25. A.K. Lee, S.H. Sung, Y.C. Kim, and S.G. Kim Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation Br. J. Pharmacol. 139 2003 11 20
26. J. Hu, G. Wang, X. Liu, L. Zhou, M. Jiang, et al. Polo-Like kinase 1 (PLK1) is involved in toll-like receptor (TLR)-Mediated TNF-α production in monocytic THP-1 cells PLOS One 8 2013 e78832
27. J. Hisatsune, M. Nakayama, H. Isomoto, H. Kurazono, N. Mukaida, et al. Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation J. Immunol. 180 2008 5017 5027
28. Y. Zhang, J. Qiu, X. Wang, Y. Zhang, and M. Xia AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300 Arterioscler. Thromb. Vasc. Biol. 31 2011 2897 2908
29. E.N. McNamee, E.W. Griffin, K.M. Ryan, K.J. Ryan, S. Heffernan, et al. Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex Neuropharmacology 59 2010 37 48
30. N. Morioka, H. Tanabe, A. Inoue, T. Dohi, and Y. Nakata Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia Neurochem. Int. 55 2009 226 234
31. J. Szelenyi, Z. Selmeczy, A. Brozik, D. Medgyesi, and M. Magocsi Dual beta-adrenergic modulation in the immune system: stimulus-dependent effect of isoproterenol on MAPK activation and inflammatory mediator production in macrophages Neurochem. Int. 49 2006 94 103
32. K. Bshesh, B. Zhao, D. Spight, I. Biaggioni, I. Feokistov, et al. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells J. Leukoc. Biol. 72 2002 1027 1036
33. P. Farmer, and J. Pugin beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway Am. J. Physiol. Lung Cell. Mol. Physiol. 279 2000 L675 L682
34. K.S. Tan, A.G. Nackley, and K. Satterfield Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms Cell. Signal 19 2007 251 260
35. J.K. Walker, and K.A. DeFea Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma Curr. Opin. Pharmacol. 16 2014 142 147
36. H. Gao, Y. Sun, and Y. Wu Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways Mol. Cell. 14 2004 303 317
37. Y. Wang, Y. Tang, and L. Teng Association of beta-arrestin and TRAF6 negatively regulates toll-like receptor-interleukin 1 receptor signaling Nat. Immunol. 7 2006 139 147
38. P. Wang, Y. Jiang, Y. Wang, J.Y. Shyy, and K.A. DeFea Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2 BMC Biochem. 11 2010 36