Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma

Current Opinion in Pharmacology

Volumn 16, Issue 1, 2014, Pages 142-147

  Walker, Julia K L ^a   Defea, Katherine A ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; CHEMOKINE RECEPTOR CCR4; G PROTEIN COUPLED RECEPTOR; PROSTAGLANDIN E2; PROTEINASE ACTIVATED RECEPTOR 2; RETINA S ANTIGEN;

ARTICLE; ASTHMA; HUMAN; INFLAMMATION; LIGAND BINDING; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION; ANIMAL; METABOLISM;

ANIMALS; ARRESTINS; ASTHMA; HUMANS; RECEPTOR, PAR-2; RECEPTORS, ADRENERGIC, BETA-2;

EID: 84902009097     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.03.007     Document Type: Review

References (52)

1. J.K.L. Walker, M. Kraft, and J.T. Fisher Assessment of murine lung mechanics outcome measures: alignment with those made in asthmatics Front Physiol 2013 3
2. (NAEPP) NAEaPP Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma - summary report 2007 J Allergy Clin Immunol 120 2007 S94 S138
3. J.K.L. Walker, R.B. Penn, N.A. Hanania, B.F. Dickey, and R.A. Bond New perspectives regarding β2-adrenoceptor ligands in the treatment of asthma Br J Pharmacol 163 2011 18 28
4. H.L. Nichols, M. Saffeddine, B.S. Theriot, A. Hegde, D. Polley, T. El-Mays, H. Vliagoftis, M.D. Hollenberg, E.H. Wilson, and J.K.L. Walker et al. β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway Proc Natl Acad Sci U S A 109 2012 16660 16665
5. R.J. Lefkowitz, and E.J. Whalen [beta]-Arrestins: traffic cops of cell signaling Curr Opin Cell Biol 16 2004 162 168 (Pubitemid 38757292)
6. R.J. Lefkowitz, K. Rajagopal, and E.J. Whalen New roles for β-arrestins in cell signaling: not just for seven-transmembrane receptors Mol Cell 24 2006 643 652 (Pubitemid 44839219)
7. M. Zoudilova, P. Kumar, L. Ge, P. Wang, G.M. Bokoch, and K.A. DeFea Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2 J Biol Chem 282 2007 20634 20646 (Pubitemid 47100047)
8. S. Ahn, S.K. Shenoy, H. Wei, and R.J. Lefkowitz Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor J Biol Chem 279 2004 35518 35525 (Pubitemid 39100552)
9. D.A. Deshpande, B.S. Theriot, R.B. Penn, and J.K. Walker Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle FASEB J 22 2008 2134 2141 (Pubitemid 351948632)
10. R. Lin, S. Degan, B.S. Theriot, B.M. Fischer, R.T. Strachan, J. Liang, R.A. Pierce, M.E. Sunday, P.W. Noble, and M. Kraft et al. Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β2-adrenoceptors and exacerbates lung inflammation in mice Br J Pharmacol 165 2012 2365 2377
11. Z. Callaerts-Vegh, K.L.J. Evans, N. Dudekula, D. Cuba, B.J. Knoll, P.F.K. Callaerts, H. Giles, F.R. Shardonofsky, and R.A. Bond Effects of acute and chronic administration of β-adrenoceptor ligands on airway function in a murine model of asthma Proc Natl Acad Sci U S A 101 2004 4948 4953 (Pubitemid 38469183)
12. J.K. Walker, A.M. Fong, B.L. Lawson, J.D. Savov, D.D. Patel, D.A. Schwartz, and R.J. Lefkowitz Beta-arrestin-2 regulates the development of allergic asthma J Clin Invest 112 2003 566 574 (Pubitemid 38056341)
13. S.K. Shenoy, and R.J. Lefkowitz Seven-transmembrane receptor signaling through beta-arrestin Sci STKE 2005 2005 cm10
14. P. Wang, Y. Jiang, Y. Wang, J.Y. Shyy, and K.A. DeFea Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated- receptor-2 BMC Biochem 11 2010 36
15. P. Wang, P. Kumar, C. Wang, and K.A. Defea Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins Biochem J 408 2007 221 230 (Pubitemid 350206345)
16. S.M. DeWire, S. Ahn, R.J. Lefkowitz, and S.K. Shenoy Beta-arrestins and cell signaling Annu Rev Physiol 69 2007 483 510
17. K. Defea Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction Br J Pharmacol 153 Suppl. 1 2008 S298 S309
18. L.M. Luttrell, and D. Gesty-Palmer Beyond desensitization: physiological relevance of arrestin-dependent signaling Pharmacol Rev 62 2010 305 330
19. J.W. Hollingsworth, B.S. Theriot, Z. Li, B.L. Lawson, M. Sunday, D.A. Schwartz, and J.K. Walker Both hematopoietic-derived and non-hematopoietic- derived {beta}-arrestin-2 regulates murine allergic airway disease Am J Respir Cell Mol Biol 43 2010 269 275
20. A.M. Lands, A. Arnold, J.P. McAuliff, F.P. Luduena, and T.G. Brown Jr. Differentiation of receptor systems activated by sympathomimetc amines Nature 214 1967 597 598
21. R. Penn, R. Bond, and J.L. Walker GPCRs and arrestins in airways: implications for asthma V.V. Gurevich, Arrestins - Pharmacology and Therapeutic Potential Handbook of Experimental Pharmacology vol 219 2014 Springer Berlin, Heidelberg 387 403
22. C. Billington, and R. Penn Signaling and regulation of G protein-coupled receptors in airway smooth muscle Respir Res 4 2003 2
23. S.K. Shenoy, M.T. Drake, C.D. Nelson, D.A. Houtz, K. Xiao, S. Madabushi, E. Reiter, R.T. Premont, O. Lichtarge, and R.J. Lefkowitz beta-arrestin- dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor J Biol Chem 281 2006 1261 1273
24. H. Fan β-Arrestins 1 and 2 are critical regulators of inflammation Innate Immun 2013 10.1177/1753425913501098
25. A. Vroon, C.J. Heijnen, and A. Kavelaars GRKs and arrestins: regulators of migration and inflammation J Leukoc Biol 80 2006 1214 1221 (Pubitemid 44904958)
26. L.P. Nguyen, R. Lin, S. Parra, O. Omoluabi, N.A. Hanania, M.J. Tuvim, B.J. Knoll, B.F. Dickey, and R.A. Bond β2-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model Proc Natl Acad Sci U S A 106 2009 2435 2440
27. V.J. Thanawala, G.S. Forkuo, N. Al-Sawalha, Z. Azzegagh, L.P. Nguyen, J.L. Eriksen, M.J. Tuvim, T.W. Lowder, B.F. Dickey, and B.J. Knoll et al. β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model Am J Respir Cell Mol Biol 48 2013 220 229
28. L.P. Nguyen, O. Omoluabi, S. Parra, J.M. Frieske, C. Clement, Z. Ammar-Aouchiche, S.B. Ho, C. Ehre, M. Kesimer, and B.J. Knoll et al. Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model Am J Respir Cell Mol Biol 38 2008 256 262 (Pubitemid 351567693)
29. N.A. Hanania, S. Singh, R. El-Wali, M. Flashner, A.E. Franklin, W.J. Garner, B.F. Dickey, S. Parra, S. Ruoss, and F. Shardonofsky et al. The safety and effects of the β-blocker, nadolol, in mild asthma: an open-label pilot study Pulm Pharmacol Therapeut 21 2008 134 141
30. E. Riesenfeld, M. Sullivan, J. Thompson-Figueroa, H. Haverkamp, L. Lundblad, J. Bates, and C. Irvin Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways disease Respir Res 11 2010 22
31. B.F. Dickey, J.K. Walker, N.A. Hanania, and R.A. Bond Beta-adrenoceptor inverse agonists in asthma Curr Opin Pharmacol 10 2010 254 259
32. T.M. Cocks, and J.D. Moffatt Protease-activated receptor-2 (PAR2) in the airways Pulm Pharmacol Ther 14 2001 183 191 (Pubitemid 32619923)
33. R. Ramachandran, F. Noorbakhsh, K. Defea, and M.D. Hollenberg Targeting proteinase-activated receptors: therapeutic potential and challenges Nat Rev Drug Discov 11 2012 69 86
34. J.J. McGuire, M. Saifeddine, C.R. Triggle, K. Sun, and M.D. Hollenberg 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist J Pharmacol Exp Ther 309 2004 1124 1131 (Pubitemid 38669700)
35. S. Boitano, A.N. Flynn, S.M. Schulz, J. Hoffman, T.J. Price, and J. Vagner Potent agonists of the protease activated receptor 2 (PAR2) J Med Chem 54 2011 1308 1313
36. A.N. Flynn, J. Hoffman, D.V. Tillu, C.L. Sherwood, Z. Zhang, R. Patek, M.N. Asiedu, J. Vagner, T.J. Price, and S. Boitano Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering FASEB J 27 2013 1498 1510
37. T.M. Cocks, B. Fong, J.M. Chow, G.P. Anderson, A.G. Frauman, R.G. Goldie, P.J. Henry, M.J. Carr, J.R. Hamilton, and J.D. Moffatt A protective role for protease-activated receptors in the airways Nature 398 1999 156 160
38. J.D. Moffatt, K.L. Jeffrey, and T.M. Cocks Protease-activated receptor-2 activating peptide sligrl inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice Am J Respir Cell Mol Biol 26 2002 680 684 (Pubitemid 34557368)
39. R. Gatti, E. Andre, S. Amadesi, T.Q. Dinh, A. Fischer, N.W. Bunnett, S. Harrison, P. Geppetti, and M. Trevisani Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs J Appl Physiol 101 2006 506 511 (Pubitemid 44162360)
40. F. Schmidlin, S. Amadesi, K. Dabbagh, D.E. Lewis, P. Knott, N.W. Bunnett, P.R. Gater, P. Geppetti, C. Bertrand, and M.E. Stevens Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway J Immunol 169 2002 5315 5321 (Pubitemid 35217205)
41. F. Schmidlin, S. Amadesi, R. Vidil, M. Trevisani, N. Martinet, G. Caughey, M. Tognetto, G. Cavallesco, C. Mapp, and P. Geppetti et al. Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle Am J Respir Crit Care Med 164 2001 1276 1281 (Pubitemid 33052263)
42. T. Takizawa, M. Tamiya, T. Hara, J. Matsumoto, N. Saito, T. Kanke, J. Kawagoe, and Y. Hattori Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice J Pharmacol Sci 98 2005 99 102 (Pubitemid 40806134)
43. C. Ebeling, T. Lam, J.R. Gordon, M.D. Hollenberg, and H. Vliagoftis Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway J Immunol 179 2007 2910 2917
44. C. Ebeling, P. Forsythe, J. Ng, J.R. Gordon, M. Hollenberg, and H. Vliagoftis Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways J Allergy Clin Immunol 115 2005 623 630 (Pubitemid 40341720)
45. L. Ge, Y. Ly, M. Hollenberg, and K. DeFea A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis J Biol Chem 278 2003 34418 34426 (Pubitemid 37553288)
46. P. Wang, and K.A. DeFea Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase Biochemistry 45 2006 9374 9385 (Pubitemid 44223242)
47. K.A. DeFea Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization Annu Rev Physiol 69 2007 535 560
48. M. Nagataki, K. Moriyuki, F. Sekiguchi, and A. Kawabata Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells Cell Biochem Funct 26 2008 279 282 (Pubitemid 351373978)
49. V. Shpacovitch, M. Feld, N.W. Bunnett, and M. Steinhoff Protease-activated receptors: novel PARtners in innate immunity Trends Immunol 28 2007 541 550
50. N.W. Bunnett Protease-activated receptors: how proteases signal to cells to cause inflammation and pain Semin Thromb Hemost 32 Suppl 1 2006 39 48
51. A. Kawabata, S. Kubo, T. Ishiki, N. Kawao, F. Sekiguchi, R. Kuroda, M.D. Hollenberg, T. Kanke, and N. Saito Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity J Pharmacol Exp Ther 311 2004 402 410 (Pubitemid 39287822)
52. J.W. Wisler, S.M. DeWire, E.J. Whalen, J.D. Violin, M.T. Drake, S. Ahn, S.K. Shenoy, and R.J. Lefkowitz A unique mechanism of β-blocker action: carvedilol stimulates β-arrestin signaling Proc Natl Acad Sci U S A 104 2007 16657 16662 (Pubitemid 350211072)