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Volumn 6, Issue 11, 2011, Pages

Budesonide and formoterol reduce early innate anti-viral immune responses In Vitro

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; BUDESONIDE; CORTICOSTEROID; FLUTICASONE; FORMOTEROL; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMIQUIMOD; INTERLEUKIN 6; PROTEIN A; SALMETEROL; VIRUS ANTIBODY; AMINOQUINOLINE DERIVATIVE; BRONCHODILATING AGENT; CXCL10 PROTEIN, HUMAN; ETHANOLAMINE DERIVATIVE; IMMUNOLOGICAL ADJUVANT; TLR7 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 7;

EID: 81355136055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027898     Document Type: Article
Times cited : (47)

References (48)
  • 1
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: executive summary of the GINA Dissemination Committee report
    • Masoli M, Fabian D, Holt S, Beasley R, (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59: 469-478.
    • (2004) Allergy , vol.59 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 2
    • 0035141851 scopus 로고    scopus 로고
    • The health economics of asthma and rhinitis. I. Assessing the economic impact
    • Weiss KB, Sullivan SD, (2001) The health economics of asthma and rhinitis. I. Assessing the economic impact. J Allergy Clin Immunol 107: 3-8.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 3-8
    • Weiss, K.B.1    Sullivan, S.D.2
  • 3
    • 26944489955 scopus 로고    scopus 로고
    • Exacerbations: the asthma paradox
    • Holgate ST, (2005) Exacerbations: the asthma paradox. Am J Respir Crit Care Med 172: 941-943.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 941-943
    • Holgate, S.T.1
  • 4
    • 79952015893 scopus 로고    scopus 로고
    • Viruses and bacteria in acute asthma exacerbations - A GA2LEN-DARE* systematic review
    • Papadopoulos N, Christodoulou I, Rohde G, Agache I, Almqvist C, et al. (2011) Viruses and bacteria in acute asthma exacerbations - A GA2LEN-DARE* systematic review. Allergy 66: 458-468.
    • (2011) Allergy , vol.66 , pp. 458-468
    • Papadopoulos, N.1    Christodoulou, I.2    Rohde, G.3    Agache, I.4    Almqvist, C.5
  • 5
    • 0027525233 scopus 로고
    • Respiratory viruses and exacerbations of asthma in adults
    • Nicholson KG, Kent J, Ireland DC, (1993) Respiratory viruses and exacerbations of asthma in adults. BMJ 307: 982-986.
    • (1993) BMJ , vol.307 , pp. 982-986
    • Nicholson, K.G.1    Kent, J.2    Ireland, D.C.3
  • 6
    • 0024557812 scopus 로고
    • Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions
    • Lemanske RF Jr, Dick EC, Swenson CA, Vrtis RF, Busse WW, (1989) Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest 83: 1-10.
    • (1989) J Clin Invest , vol.83 , pp. 1-10
    • Lemanske Jr., R.F.1    Dick, E.C.2    Swenson, C.A.3    Vrtis, R.F.4    Busse, W.W.5
  • 7
    • 34247500952 scopus 로고    scopus 로고
    • Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
    • Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, et al. (2007) Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 119: 1105-1110.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1105-1110
    • Kusel, M.M.1    de Klerk, N.H.2    Kebadze, T.3    Vohma, V.4    Holt, P.G.5
  • 8
    • 0028990124 scopus 로고
    • Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
    • Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, et al. (1995) Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 310: 1225-1229.
    • (1995) BMJ , vol.310 , pp. 1225-1229
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3    Smith, S.4    Lampe, F.5
  • 9
    • 70349254245 scopus 로고    scopus 로고
    • Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children
    • Cates CJ, Lasserson TJ, (2009) Combination formoterol and budesonide as maintenance and reliever therapy versus inhaled steroid maintenance for chronic asthma in adults and children. Cochrane Database Syst Rev pp. CD007313.
    • (2009) Cochrane Database Syst Rev
    • Cates, C.J.1    Lasserson, T.J.2
  • 10
    • 34548130729 scopus 로고    scopus 로고
    • Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    • Buhl R, Vogelmeier C, (2007) Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma. Curr Med Res Opin 23: 1867-1878.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1867-1878
    • Buhl, R.1    Vogelmeier, C.2
  • 11
    • 77956026534 scopus 로고    scopus 로고
    • Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal
    • Chapman KR, Barnes NC, Greening AP, Jones PW, Pedersen S, (2010) Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax 65: 747-752.
    • (2010) Thorax , vol.65 , pp. 747-752
    • Chapman, K.R.1    Barnes, N.C.2    Greening, A.P.3    Jones, P.W.4    Pedersen, S.5
  • 13
    • 0036225349 scopus 로고    scopus 로고
    • Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects
    • Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL, (2002) Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects. Clin Exp Allergy 32: 537-542.
    • (2002) Clin Exp Allergy , vol.32 , pp. 537-542
    • Papadopoulos, N.G.1    Stanciu, L.A.2    Papi, A.3    Holgate, S.T.4    Johnston, S.L.5
  • 14
    • 77954939630 scopus 로고    scopus 로고
    • Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge
    • Kohlmeier JE, Cookenham T, Roberts AD, Miller SC, Woodland DL, (2010) Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity 33: 96-105.
    • (2010) Immunity , vol.33 , pp. 96-105
    • Kohlmeier, J.E.1    Cookenham, T.2    Roberts, A.D.3    Miller, S.C.4    Woodland, D.L.5
  • 15
    • 0842304593 scopus 로고    scopus 로고
    • Host defense function of the airway epithelium in health and disease: clinical background
    • Message SD, Johnston SL, (2004) Host defense function of the airway epithelium in health and disease: clinical background. J Leukoc Biol 75: 5-17.
    • (2004) J Leukoc Biol , vol.75 , pp. 5-17
    • Message, S.D.1    Johnston, S.L.2
  • 17
    • 79955763980 scopus 로고    scopus 로고
    • Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis
    • Holt PG, Sly PD, (2011) Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis. Chest 139: 1165-1171.
    • (2011) Chest , vol.139 , pp. 1165-1171
    • Holt, P.G.1    Sly, P.D.2
  • 18
    • 70149089062 scopus 로고    scopus 로고
    • Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children
    • Subrata LS, Bizzintino J, Mamessier E, Bosco A, McKenna KL, et al. (2009) Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children. J Immunol 183: 2793-2800.
    • (2009) J Immunol , vol.183 , pp. 2793-2800
    • Subrata, L.S.1    Bizzintino, J.2    Mamessier, E.3    Bosco, A.4    McKenna, K.L.5
  • 19
    • 0036118734 scopus 로고    scopus 로고
    • Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release
    • Bufe A, Gehlhar K, Grage-Griebenow E, Ernst M, (2002) Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release. Int Arch Allergy Immunol 127: 82-88.
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 82-88
    • Bufe, A.1    Gehlhar, K.2    Grage-Griebenow, E.3    Ernst, M.4
  • 21
  • 22
    • 0034006651 scopus 로고    scopus 로고
    • Rhinovirus-induced PBMC responses and outcome of experimental infection in allergic subjects
    • Parry DE, Busse WW, Sukow KA, Dick CR, Swenson C, et al. (2000) Rhinovirus-induced PBMC responses and outcome of experimental infection in allergic subjects. J Allergy Clin Immunol 105: 692-698.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 692-698
    • Parry, D.E.1    Busse, W.W.2    Sukow, K.A.3    Dick, C.R.4    Swenson, C.5
  • 23
    • 51649109114 scopus 로고    scopus 로고
    • Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
    • Message SD, Laza-Stanca V, Mallia P, Parker HL, Zhu J, et al. (2008) Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A 105: 13562-13567.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13562-13567
    • Message, S.D.1    Laza-Stanca, V.2    Mallia, P.3    Parker, H.L.4    Zhu, J.5
  • 25
    • 70350330313 scopus 로고    scopus 로고
    • Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus
    • Skevaki CL, Christodoulou I, Spyridaki IS, Tiniakou I, Georgiou V, et al. (2009) Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus. Clin Exp Allergy 39: 1700-1710.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1700-1710
    • Skevaki, C.L.1    Christodoulou, I.2    Spyridaki, I.S.3    Tiniakou, I.4    Georgiou, V.5
  • 26
    • 34447530935 scopus 로고    scopus 로고
    • Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements
    • Edwards MR, Haas J, Panettieri RA Jr, Johnson M, Johnston SL, (2007) Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem 282: 15366-15375.
    • (2007) J Biol Chem , vol.282 , pp. 15366-15375
    • Edwards, M.R.1    Haas, J.2    Panettieri Jr., R.A.3    Johnson, M.4    Johnston, S.L.5
  • 27
    • 37349117437 scopus 로고    scopus 로고
    • Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells
    • Kaur M, Chivers JE, Giembycz MA, Newton R, (2008) Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol 73: 203-214.
    • (2008) Mol Pharmacol , vol.73 , pp. 203-214
    • Kaur, M.1    Chivers, J.E.2    Giembycz, M.A.3    Newton, R.4
  • 28
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-lambda production in asthma exacerbations
    • Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, et al. (2006) Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 12: 1023-1026.
    • (2006) Nat Med , vol.12 , pp. 1023-1026
    • Contoli, M.1    Message, S.D.2    Laza-Stanca, V.3    Edwards, M.R.4    Wark, P.A.5
  • 29
    • 0035097113 scopus 로고    scopus 로고
    • Nitric oxide inhibits rhinovirus-induced granulocyte macrophage colony-stimulating factor production in bronchial epithelial cells
    • Sanders SP, Kim J, Connolly KR, Porter JD, Siekierski ES, et al. (2001) Nitric oxide inhibits rhinovirus-induced granulocyte macrophage colony-stimulating factor production in bronchial epithelial cells. Am J Respir Cell Mol Biol 24: 317-325.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 317-325
    • Sanders, S.P.1    Kim, J.2    Connolly, K.R.3    Porter, J.D.4    Siekierski, E.S.5
  • 30
    • 0029159796 scopus 로고
    • Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure
    • Subauste MC, Jacoby DB, Richards SM, Proud D, (1995) Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 96: 549-557.
    • (1995) J Clin Invest , vol.96 , pp. 549-557
    • Subauste, M.C.1    Jacoby, D.B.2    Richards, S.M.3    Proud, D.4
  • 32
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 33
    • 36049038984 scopus 로고    scopus 로고
    • Budesonide/formoterol: a review of its use as maintenance and reliever inhalation therapy in asthma
    • McCormack PL, Lyseng-Williamson KA, (2007) Budesonide/formoterol: a review of its use as maintenance and reliever inhalation therapy in asthma. Drugs 67: 2407-2431.
    • (2007) Drugs , vol.67 , pp. 2407-2431
    • McCormack, P.L.1    Lyseng-Williamson, K.A.2
  • 34
    • 33646452550 scopus 로고    scopus 로고
    • Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells
    • Edwards MR, Johnson MW, Johnston SL, (2006) Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 34: 616-624.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 616-624
    • Edwards, M.R.1    Johnson, M.W.2    Johnston, S.L.3
  • 35
    • 0033899452 scopus 로고    scopus 로고
    • Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells
    • Pang L, Knox AJ, (2000) Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol 23: 79-85.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 79-85
    • Pang, L.1    Knox, A.J.2
  • 36
    • 0037180086 scopus 로고    scopus 로고
    • Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling
    • Roth M, Johnson PR, Rudiger JJ, King GG, Ge Q, et al. (2002) Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 360: 1293-1299.
    • (2002) Lancet , vol.360 , pp. 1293-1299
    • Roth, M.1    Johnson, P.R.2    Rudiger, J.J.3    King, G.G.4    Ge, Q.5
  • 37
  • 38
    • 49649109576 scopus 로고    scopus 로고
    • Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells
    • Hung CH, Chu YT, Hua YM, Hsu SH, Lin CS, et al. (2008) Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells. Eur Respir J 31: 1313-1321.
    • (2008) Eur Respir J , vol.31 , pp. 1313-1321
    • Hung, C.H.1    Chu, Y.T.2    Hua, Y.M.3    Hsu, S.H.4    Lin, C.S.5
  • 39
    • 38749140983 scopus 로고    scopus 로고
    • Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract
    • van Elden LJ, Sachs AP, van Loon AM, Haarman M, van de Vijver DA, et al. (2008) Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract. J Clin Virol 41: 116-121.
    • (2008) J Clin Virol , vol.41 , pp. 116-121
    • van Elden, L.J.1    Sachs, A.P.2    van Loon, A.M.3    Haarman, M.4    van de Vijver, D.A.5
  • 40
    • 0037045846 scopus 로고    scopus 로고
    • Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
    • Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, et al. (2002) Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 359: 831-834.
    • (2002) Lancet , vol.359 , pp. 831-834
    • Corne, J.M.1    Marshall, C.2    Smith, S.3    Schreiber, J.4    Sanderson, G.5
  • 41
    • 0035891605 scopus 로고    scopus 로고
    • Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection
    • Grunberg K, Sharon RF, Sont JK, In 't Veen JC, Van Schadewijk WA, et al. (2001) Rhinovirus-induced airway inflammation in asthma: effect of treatment with inhaled corticosteroids before and during experimental infection. Am J Respir Crit Care Med 164: 1816-1822.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1816-1822
    • Grunberg, K.1    Sharon, R.F.2    Sont, J.K.3    In 't Veen, J.C.4    Van Schadewijk, W.A.5
  • 42
    • 34548263714 scopus 로고    scopus 로고
    • IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
    • Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, et al. (2007) IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol 120: 586-593.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 586-593
    • Wark, P.A.1    Bucchieri, F.2    Johnston, S.L.3    Gibson, P.G.4    Hamilton, L.5
  • 43
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, et al. (2005) Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 201: 937-947.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3    Powell, R.4    Puddicombe, S.5
  • 44
    • 61349118001 scopus 로고    scopus 로고
    • Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    • Wark PA, Grissell T, Davies B, See H, Gibson PG, (2009) Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains. Respirology 14: 180-186.
    • (2009) Respirology , vol.14 , pp. 180-186
    • Wark, P.A.1    Grissell, T.2    Davies, B.3    See, H.4    Gibson, P.G.5
  • 45
    • 0036924110 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod
    • Gibson SJ, Lindh JM, Riter TR, Gleason RM, Rogers LM, et al. (2002) Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod. Cell Immunol 218: 74-86.
    • (2002) Cell Immunol , vol.218 , pp. 74-86
    • Gibson, S.J.1    Lindh, J.M.2    Riter, T.R.3    Gleason, R.M.4    Rogers, L.M.5
  • 46
    • 70449707289 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing
    • Upham JW, Zhang G, Rate A, Yerkovich ST, Kusel M, et al. (2009) Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. J Allergy Clin Immunol 124: 707-713 e702.
    • (2009) J Allergy Clin Immunol , vol.124
    • Upham, J.W.1    Zhang, G.2    Rate, A.3    Yerkovich, S.T.4    Kusel, M.5
  • 47
    • 0344393717 scopus 로고    scopus 로고
    • Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma
    • Simon HU, Seelbach H, Ehmann R, Schmitz M, (2003) Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma. Allergy 58: 1250-1255.
    • (2003) Allergy , vol.58 , pp. 1250-1255
    • Simon, H.U.1    Seelbach, H.2    Ehmann, R.3    Schmitz, M.4
  • 48
    • 79955634439 scopus 로고    scopus 로고
    • Exogenous IFN-beta has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus
    • Cakebread JA, Xu Y, Grainge C, Kehagia V, Howarth PH, et al. (2011) Exogenous IFN-beta has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. J Allergy Clin Immunol 127: 1148-1154.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1148-1154
    • Cakebread, J.A.1    Xu, Y.2    Grainge, C.3    Kehagia, V.4    Howarth, P.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.