Optogenetic control of hypocretin (Orexin) neurons and arousal circuits

Current Topics in Behavioral Neurosciences

Volumn 25, Issue , 2015, Pages 367-378

  De Lecea, Luis ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Awakenings; Hypnotics; Hypothalamus; In vivo recordings; Knockout animals; Narcolepsy; Neuropeptides; Sleep wake cycle

Indexed keywords

OREXIN; NEUROPEPTIDE; SIGNAL PEPTIDE;

AROUSAL; ARTICLE; BRAIN FUNCTION; HUMAN; HYPOTHALAMUS FUNCTION; LOCUS CERULEUS; NERVE CELL; NEUROTRANSMITTER RELEASE; OPTOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SLEEP INDUCTION; SLEEP WAKING CYCLE; ANIMAL; PHYSIOLOGY; PROCEDURES; SLEEP;

ANIMALS; AROUSAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; OPTOGENETICS; OREXINS; SLEEP;

EID: 84929610264     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2014_364     Document Type: Article

References (55)

1. Adamantidis AR, Zhang F, Aravanis AM et al (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450:420-424
2. Adamantidis A, Carter MC, de Lecea L (2010) Optogenetic deconstruction of sleep-wake circuitry in the brain. Front Mol Neurosci 2:31
3. Armbruster BN, Li X, Pausch MH et al (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. In: Proceedings of the national academy of sciences of the United States of America, vol 104, pp 5163-5168
4. Aston-Jones G, Bloom FE (1981a) Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1:876-886
5. Aston-Jones G, Bloom FE (1981b) Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci 1:887-900
6. Berridge CW (2008) Noradrenergic modulation of arousal. Brain Res Rev 58:1-17
7. Berridge CW, Espana RA (2000) Synergistic sedative effects of noradrenergic alpha(1)-and betareceptor blockade on forebrain electroencephalographic and behavioral indices. Neuroscience 99:495-505
8. Berridge CW, Foote SL (1991) Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J Neurosci 11:3135-3145
9. Bourgin P, Huitron-Resendiz S, Spier AD et al (2000) Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci 20:7760-7765
10. Carter ME, de Lecea L (2011) Optogenetic investigation of neural circuits in vivo. Trends Mol Med 17:197-206
11. Carter ME, Borg JS, de Lecea L (2009a) The brain hypocretins and their receptors: mediators of allostatic arousal. Curr Opin Pharmacol 9:39-45
12. Carter ME, Adamantidis A, Ohtsu H et al (2009b) Sleep homeostasis modulates hypocretinmediated sleep-to-wake transitions. J Neurosci 29:10939-10949
13. Carter ME, Yizhar O, Chikahisa S et al (2010) Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci 13:1526-1533
14. Carter ME, Brill J, Bonnavion P et al (2012) Mechanism for hypocretin-mediated sleep-to-wake transitions. In: Proceedings of the national academy of sciences of the United States of America
15. Chemelli RM, Willie JT, Sinton CM et al (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451
16. Cirelli C, Pompeiano M, Tononi G (1996) Neuronal gene expression in the waking state: a role for the locus coeruleus. Science 274:1211-1215
17. Constantinople CM, Bruno RM (2011) Effects and mechanisms of wakefulness on local cortical networks. Neuron 69:1061-1068
18. de Lecea L, Huerta R (2014) Hypocretin (orexin) regulation of sleep-to-wake transitions. Front Pharmacol 5:16
19. de Lecea L, Kilduff TS, Peyron C et al (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. In: Proceedings of the national academy of sciences of the United States of America, vol 95 pp 322-327
20. Eriksson KS, Sergeeva O, Brown RE et al (2001) Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 21:9273-9279
21. Grivel J, Cvetkovic V, Bayer L et al (2005) The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. J Neurosci 25:4127-4130
22. Gulyani S, Wu MF, Nienhuis R et al (2002) Cataplexy-related neurons in the amygdala of the narcoleptic dog. Neuroscience 112:355-365
23. Hagan JJ, Leslie RA, Patel S et al (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. In: Proceedings of the national academy of sciences of the United States of America, vol 96, pp 10911-10916
24. Hassani OK, Lee MG, Jones BE (2009) Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. In: Proceedings of the national academy of sciences of the United States of America, vol 106, pp 2418-2422
25. Hinard V, Mikhail C, Pradervand S et al (2012) Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci 32:12506-12517
26. Hunsley MS, Curtis WR, Palmiter RD (2006) Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin. Genes Brain Behav 5:451-457
27. John J, Wu MF, Boehmer LN et al (2004) Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 42:619-634
28. Kalogiannis M, Grupke SL, Potter PE et al (2010) Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci 32:130-142
29. Kalogiannis M, Hsu E, Willie JT et al (2011) Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. PLoS One 6:e18697
30. Lee MG, Hassani OK, Jones BE (2005) Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25:6716-6720
31. Li J, Hu Z, de Lecea L (2014) The hypocretins/orexins: integrators of multiple physiological functions. Br J Pharmacol 171:332-350
32. Lin L, Faraco J, Li R et al (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365-376
33. Liu M, Blanco-Centurion C, Konadhode R et al (2011) Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci 31:6028-6040
34. Matsuki T, Nomiyama M, Takahira H et al (2009) Selective loss of GABA(B) receptors in orexinproducing neurons results in disrupted sleep/wakefulness architecture. In: Proceedings of the national academy of sciences of the United States of America, vol 106, pp 4459-4464
35. Mieda M, Willie JT, Hara J et al (2004) Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. In: Proceedings of the national academy of sciences of the United States of America, vol 101, pp 4649-4654
36. Mieda M, Hasegawa E, Kisanuki YY et al (2011) Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci 31:6518-6526
37. Mileykovskiy BY, Kiyashchenko LI, Siegel JM (2005) Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46:787-798
38. Mochizuki T, Arrigoni E, Marcus JN et al (2011) Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. In: Proceedings of the national academy of sciences of the United States of America, vol 108, pp 4471-4476
39. Modirrousta M, Mainville L, Jones BE (2005) Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci 21:2807-2816
40. Moruzzi G, Magoun HW (1949) Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1:455-473
41. Rolls A, Colas D, Adamantidis A et al (2011) Optogenetic disruption of sleep continuity impairs memory consolidation. In: Proceedings of the national academy of sciences of the United States of America, vol 108, pp 13305-13310
42. Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171-181
43. Sakurai T, Amemiya A, Ishii M et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585
44. Sasaki K, Suzuki M, Mieda M et al (2011) Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS ONE 6:e20360
45. Scammell TE, Willie JT, Guilleminault C et al (2009) A consensus definition of cataplexy in mouse models of narcolepsy. Sleep 32:111-116
46. Schone C, Apergis-Schoute J, Sakurai T et al (2014) Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons. Cell reports 7:697-704
47. Steriade M, McCarley R (1990) Brainstem control of wakefulness and sleep. Plenum, New York
48. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-685
49. Takahashi K, Lin JS, Sakai K (2008) Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse. Neuroscience 153:860-870
50. Trivedi P, Yu H, MacNeil DJ et al (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438:71-75
51. Tsunematsu T, Kilduff TS, Boyden ES et al (2011) Acute optogenetic silencing of orexin/ hypocretin neurons induces slow-wave sleep in mice. J Neurosci 31:10529-10539
52. Tsunematsu T, Tabuchi S, Tanaka KF et al (2013) Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice. Behav Brain Res 255:64-74
53. Vazey EM, Aston-Jones G (2014) Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia. In: Proceedings of the national academy of sciences of the United States of America, vol 111, pp 3859-3864
54. Willie JT, Chemelli RM, Sinton CM et al (2003) Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38:715-730
55. Willie JT, Takahira H, Shibahara M et al (2011) Ectopic overexpression of orexin alters sleep/ wakefulness states and muscle tone regulation during REM sleep in mice. J Mol Neurosci 43:155-161