Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects

Nutrients

Volumn 7, Issue 5, 2015, Pages 3138-3153

  Draijer, Richard ^a   de Graaf, Young ^a   Slettenaar, Marieke ^a,c   de Groot, Eric ^b,d   Wright, Chris I ^a,e  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Menzis   (Netherlands)

^d Matrix II   (Netherlands)

^e Red Pharm   (United Kingdom)

Author keywords

Blood pressure; Catechins; Grape; Polyphenols; Procyanidins; Red wine; Vascular function

Indexed keywords

ANTHOCYANIN; CATECHIN; ENDOTHELIN 1; FLAVONOL DERIVATIVE; GRAPE WINE EXTRACT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PLANT EXTRACT; POLYPHENOL; PROCYANIDIN; UNCLASSIFIED DRUG; BIFLAVONOID; LIPOPROTEIN; PROANTHOCYANIDIN;

ADULT; ARTERY COMPLIANCE; ARTICLE; BLOOD PRESSURE MONITORING; CHOLESTEROL BLOOD LEVEL; COMMON COLD; CONTROLLED STUDY; CROSSOVER PROCEDURE; DENTAL CARIES; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; ELECTROCARDIOGRAM; ELEVATED BLOOD PRESSURE; FEMALE; FOOD INTAKE; HEADACHE; HUMAN; HYPERTENSION; INFLUENZA; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION; WAVEFORM; AGED; ARTERIAL STIFFNESS; BLOOD; BLOOD CLOTTING PARAMETERS; BLOOD PRESSURE; CHEMISTRY; CLINICAL TRIAL; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; VITIS; WINE;

VITACEAE;

ADULT; AGED; ANTHOCYANINS; BIFLAVONOIDS; BLOOD PRESSURE; CATECHIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIN-1; FEMALE; FLAVONOLS; HUMANS; HYPERTENSION; LIPOPROTEINS; MALE; MIDDLE AGED; PLANT EXTRACTS; PLATELET FUNCTION TESTS; POLYPHENOLS; PROANTHOCYANIDINS; VASCULAR STIFFNESS; VASODILATION; VITIS; WINE;

EID: 84929337192     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7053138     Document Type: Article

References (39)

1. O'Keefe, J. H.; Bhatti, S. K.; Bajwa, A.; DiNicolantonio, J. J.; Lavie, C. J. Alcohol and cardiovascular health: The dose makes the poison or the remedy. Mayo Clin. Proc. 2014, 89, 382-393.
2. Chiva-Blanch, G.; Arranz, S.; Lamuela-Raventos, R. M.; Estruch, R. Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: Evidences from human studies. Alcohol. Alcohol. 2013, 48, 270-277.
3. Rothwell, J. A.; Perez-Jimenez, J.; Neveu, V.; Medina-Remon, A.; M'hiri, N.; Garcia-Lobato, P.; Manach, C.; Knox, C.; Eisner, R.; Wishart, D. S.; Scalbert, A. Phenol-Explorer 3. 0: A major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford) 2013, 2013, bat070.
4. Larsson, S. C. Coffee, tea, and cocoa and risk of stroke. Stroke 2014, 45, 309-314.
5. Yang, C. S.; Hong, J. Prevention of chronic diseases by tea: Possible mechanisms and human relevance. Annu. Rev. Nutr. 2013, 33, 161-181.
6. Van Mierlo, L. A.; Zock, P. L.; van der Knaap, H. C.; Draijer, R. Grape polyphenols do not affect vascular function in healthy men. J. Nutr. 2010, 140, 1769-1773.
7. Botden, I. P.; Draijer, R.; Westerhof, B. E.; Rutten, J. H.; Langendonk, J. G.; Sijbrands, E. J.; Danser, A. H.; Zock, P. L.; van den Meiracker, A. H. Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. Am. J. Hypertens. 2012, 25, 718-723.
8. Ward, N. C.; Hodgson, J. M.; Croft, K. D.; Burke, V.; Beilin, L. J.; Puddey, I. B. The combination of vitamin C and grape-seed polyphenols increases blood pressure: A randomized, double-blind, placebo-controlled trial. J. Hypertens. 2005, 23, 427-434.
9. Mellen, P. B.; Daniel, K. R.; Brosnihan, K. B.; Hansen, K. J.; Herrington, D. M. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. J. Am. Coll. Nutr. 2010, 29, 469-475.
10. Droste, D. W.; Iliescu, C.; Vaillant, M.; Gantenbein, M.; De, B. N.; Lieunard, C.; Velez, T.; Meyer, M.; Guth, T.; Kuemmerle, A.; Chioti, A. A daily glass of red wine and lifestyle changes do not affect arterial blood pressure and heart rate in patients with carotid arteriosclerosis after 4 and 20 weeks. Cerebrovasc. Dis. Extra 2013, 3, 121-129.
11. Chiva-Blanch, G.; Urpi-Sarda, M.; Ros, E.; Arranz, S.; Valderas-Martinez, P.; Casas, R.; Sacanella, E.; Llorach, R.; Lamuela-Raventos, R. M.; Andres-Lacueva, C.; Estruch, R. Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: Short communication. Circ. Res. 2012, 111, 1065-1068.
12. Dohadwala, M. M.; Hamburg, N. M.; Holbrook, M.; Kim, B. H.; Duess, M. A.; Levit, A.; Titas, M.; Chung, W. B.; Vincent, F. B.; Caiano, T. L.; Frame, A. A.; Keaney, J. F., Jr.; Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am. J. Clin. Nutr. 2010, 92, 1052-1059.
13. Scalbert, A.; Williamson, G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000, 130, 2073S-2085S.
14. Van Dorsten, F. A.; Grun, C. H.; van Velzen, E. J.; Jacobs, D. M.; Draijer, R.; van Duynhoven, J. P. The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics. Mol. Nutr. Food Res. 2010, 54, 897-908.
15. Hoeks, A. P.; Reneman, R. S. Biophysical principles of vascular diagnosis. J. Clin. Ultrasound 1995, 23, 71-79.
16. Hamburg, N. M.; Palmisano, J.; Larson, M. G.; Sullivan, L. M.; Lehman, B. T.; Vasan, R. S.; Levy, D.; Mitchell, G. F.; Vita, J. A.; Benjamin, E. J. Relation of brachial and digital measures of vascular function in the community: the Framingham heart study. Hypertension 2011, 57, 390-396.
17. Lewington, S.; Clarke, R.; Qizilbash, N.; Peto, R.; Collins, R. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002, 360, 1903-1913.
18. Widlansky, M. E.; Hamburg, N. M.; Anter, E.; Holbrook, M.; Kahn, D. F.; Elliott, J. G.; Keaney, J. F., Jr.; Vita, J. A. Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J. Am. Coll. Nutr. 2007, 26, 95-102.
19. Schroeter, H.; Heiss, C.; Balzer, J.; Kleinbongard, P.; Keen, C. L.; Hollenberg, N. K.; Sies, H.; Kwik-Uribe, C.; Schmitz, H. H.; Kelm, M. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc. Natl. Acad. Sci. USA 2006, 103, 1024-1029.
20. Liu, Y.; Ma, W.; Zhang, P.; He, S.; Huang, D. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. Clin. Nutr. 2014, 34, 27-34.
21. Greyling, A.; Ras, R. T.; Zock, P. L.; Lorenz, M.; Hopman, M. T.; Thijssen, D. H.; Draijer, R. The Effect of Black Tea on Blood Pressure: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. PLoS ONE 2014, 9, e103247.
22. Ras, R. T.; Zock, P. L.; Draijer, R. Tea consumption enhances endothelial-dependent vasodilation: A meta-analysis. PLoS ONE 2011, 6, e16974.
23. Ried, K.; Sullivan, T. R.; Fakler, P.; Frank, O. R.; Stocks, N. P. Effect of cocoa on blood pressure. Cochrane Database Syst. Rev. 2012, 8, CD008893.
24. Kay, C. D.; Hooper, L.; Kroon, P. A.; Rimm, E. B.; Cassidy, A. Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products. Mol. Nutr. Food Res. 2012, 56, 1605-1616.
25. Hollman, P. C. Unravelling of the health effects of polyphenols is a complex puzzle complicated by metabolism. Arch. Biochem. Biophys. 2014, 559, 100-105.
26. Xu, Y.; Simon, J. E.; Welch, C.; Wightman, J. D.; Ferruzzi, M. G.; Ho, L.; Pasinetti, G. M.; Wu, Q. Survey of polyphenol constituents in grapes and grape-derived products. J. Agric. Food Chem. 2011, 59, 10586-10593.
27. Stein, J. H.; Keevil, J. G.; Wiebe, D. A.; Aeschlimann, S.; Folts, J. D. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999, 100, 1050-1055.
28. Siasos, G.; Tousoulis, D.; Kokkou, E.; Oikonomou, E.; Kollia, M. E.; Verveniotis, A.; Gouliopoulos, N.; Zisimos, K.; Plastiras, A.; Maniatis, K.; Stefanadis, C. Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. Am. J. Hypertens. 2014, 27, 38-45.
29. Barona, J.; Aristizabal, J. C.; Blesso, C. N.; Volek, J. S.; Fernandez, M. L. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J. Nutr. 2012, 142, 1626-1632.
30. Silberberg, M.; Morand, C.; Manach, C.; Scalbert, A.; Remesy, C. Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism. Life Sci. 2005, 77, 3156-3167.
31. Wang, P.; Heber, D.; Henning, S. M. Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo. Food Funct. 2012, 3, 635-642.
32. Li, S. H.; Tian, H. B.; Zhao, H. J.; Chen, L. H.; Cui, L. Q. The acute effects of grape polyphenols supplementation on endothelial function in adults: Meta-analyses of controlled trials. PLoS ONE 2013, 8, e69818.
33. Zhu, Y.; Xia, M.; Yang, Y.; Liu, F.; Li, Z.; Hao, Y.; Mi, M.; Jin, T.; Ling, W. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin. Chem. 2011, 57, 1524-1533.
34. Botden, I. P.; Langendonk, J. G.; Meima, M. E.; Boomsma, F.; Seynhaeve, A. L.; ten Hagen, T. L.; Jan Danser, A. H.; Sijbrands, E. J. Daily red wine consumption improves vascular function by a soluble guanylyl cyclase-dependent pathway. Am. J. Hypertens. 2011, 24, 162-168.
35. Corder, R.; Mullen, W.; Khan, N. Q.; Marks, S. C.; Wood, E. G.; Carrier, M. J.; Crozier, A. Oenology: Red wine procyanidins and vascular health. Nature 2006, 444, 566.
36. Kiviniemi, T. O.; Saraste, A.; Lehtimaki, T.; Toikka, J. O.; Saraste, M.; Raitakari, O. T.; Hartiala, J. J.; Viikari, J.; Koskenvuo, J. W. Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine. Atherosclerosis 2010, 211, 283-286.
37. Bachmair, E. M.; Ostertag, L. M.; Zhang, X.; de Roos, B. Dietary manipulation of platelet function. Pharmacol. Ther. 2014, 144, 97-103.
38. Hooper, L.; Kroon, P. A.; Rimm, E. B.; Cohn, J. S.; Harvey, I.; Le Cornu, K. A.; Ryder, J. J.; Hall, W. L.; Cassidy, A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: A meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2008, 88, 38-50.
39. Hansen, A. S.; Marckmann, P.; Dragsted, L. O.; Finne Nielsen, I. L.; Nielsen, S. E.; Gronbaek, M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur. J. Clin. Nutr. 2005, 59, 449-455.