Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro

International Immunopharmacology

Volumn 27, Issue 1, 2015, Pages 138-147

  Tao, Weiwei ^a   Su, Qiang ^a   Wang, Hanqin ^b   Guo, Shen ^a   Chen, Yanyan ^a   Duan, Jinao ^a   Wang, Shumin ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Acute lung injury; Apoptosis; Inflammation; Platycodin D

Indexed keywords

ANTIINFLAMMATORY AGENT; BLEOMYCIN; CASPASE 3; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PLATYCODIN D; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IMMUNOSUPPRESSIVE AGENT; LIPID-LINKED OLIGOSACCHARIDES; TRITERPENE; TUMOR NECROSIS FACTOR;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRY WEIGHT; ENZYME ACTIVITY; FEMALE; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE COUNT; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; LUNG WEIGHT; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PLATYCODON; PNEUMONIA;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; BLEOMYCIN; CELL LINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; NF-KAPPA B; PLATYCODON; PNEUMONIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SAPONINS; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929324415     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.05.005     Document Type: Article

References (38)

1. Z. San, Y. Fu, W. Li, E. Zhou, Y. Li, X. Song, et al. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice Int. Immunopharmacol. 19 2014 342 350
2. L. Chen, L. Zhao, C. Zhang, and Z. Lan Protective effect of p-cymene on lipopolysaccharide-induced acute lung injury in mice Inflammation 37 2014 358 364
3. M.A. Matthay, G.A. Zimmerman, C. Esmon, J. Bhattacharya, B. Coller, C.M. Doerschuk, et al. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group Am. J. Respir. Crit. Care Med. 167 2003 1027 1035
4. J. Wang, Y.T. Liu, L. Xiao, L. Zhu, Q. Wang, and T. Yan Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway Inflammation 37 2014 2085 2090
5. M. Xu, F.L. Cao, Y.F. Zhang, L. Shan, X.L. Jiang, X.J. An, et al. Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice Acta Pharmacol. Sin. 36 2015 179 187
6. W. Li, H. Huang, X. Niu, T. Fan, H. Hu, Y. Li, et al. Tetrahydrocoptisine protects rats from LPS-induced acute lung injury Inflammation 37 2014 2106 2115
7. T. Lou, W. Jiang, D. Xu, T. Chen, and Y. Fu Inhibitory effects of polydatin on lipopolysaccharide-stimulated RAW 264.7 cells Inflammation 38 3 2015 1213 1220
8. P. Pratheeshkumar, Y.O. Son, S.P. Divya, R.V. Roy, J.A. Hitron, L. Wang, et al. Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways Toxicol. Appl. Pharmacol. 281 2014 230 241
9. E. Zhou, Y. Li, M. Yao, Z. Wei, Y. Fu, and Z. Yang Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms Int. Immunopharmacol. 23 2014 121 126
10. X.X. Zhang, Y. Ito, J.R. Liang, J.L. Liu, J. He, and W.J. Sun Therapeutic effects of total steroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H. Wright in Freund's complete adjuvant induced arthritis in rats Int. Immunopharmacol. 23 2014 407 416
11. Y. Tang, C. Hu, and Y. Liu Effect of bioactive peptide of Carapax Trionycis on TGF-beta1-induced intracellular events in hepatic stellate cells J. Ethnopharmacol. 148 2013 69 73
12. Y. Xiong, Y. Ma, W. Han, N.D. Kodithuwakku, L.F. Liu, F.W. Li, et al. Clematichinenoside AR induces immunosuppression involving Treg cells in Peyers patches of rats with adjuvant induced arthritis J. Ethnopharmacol. 155 2014 1306 1314
13. L.L. Reber, F. Daubeuf, G. Pejler, M. Abrink, and N. Frossard Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism J. Immunol. 192 2014 1847 1854
14. G. Dos Santos, M.R. Rogel, M.A. Baker, J.R. Troken, D. Urich, L. Morales-Nebreda, et al. Vimentin regulates activation of the NLRP3 inflammasome Nat. Commun. 6 2015 6574
15. L.K. Han, B.J. Xu, Y. Kimura, Y. Zheng, and H. Okuda Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity J. Nutr. 130 2000 2760 2764
16. L.K. Han, Y.N. Zheng, B.J. Xu, H. Okuda, and Y. Kimura Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice J. Nutr. 132 2002 2241 2245
17. Y.P. Kim, E.B. Lee, S.Y. Kim, D. Li, H.S. Ban, S.S. Lim, et al. Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum Planta Med. 67 2001 362 364
18. X. Luan, Y.G. Gao, Y.Y. Guan, J.R. Xu, Q. Lu, M. Zhao, et al. Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway Toxicol. Appl. Pharmacol. 281 2014 118 124
19. S.S. Choi, E.J. Han, T.H. Lee, J.K. Lee, K.J. Han, H.K. Lee, et al. Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse Planta Med. 68 2002 794 798
20. T. Chen, J. Gao, P. Xiang, Y. Chen, J. Ji, P. Xie, et al. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance Int. Immunopharmacol. 26 2 2015 338 348
21. Y. Kumazawa, K. Kawaguchi, and H. Takimoto Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha Curr. Pharm. Des. 12 2006 4271 4279
22. F. Yunhe, L. Bo, F. Xiaosheng, L. Fengyang, L. Dejie, L. Zhicheng, et al. The effect of magnolol on the Toll-like receptor 4/nuclear factor kappaB signaling pathway in lipopolysaccharide-induced acute lung injury in mice Eur. J. Pharmacol. 689 2012 255 261
23. W.Y. Chen, Y.C. Huang, M.L. Yang, C.Y. Lee, C.J. Chen, C.H. Yeh, et al. Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation Int. Immunopharmacol. 22 2014 409 413
24. S. Gou, T. Zhu, W. Wang, M. Xiao, X.C. Wang, and Z.H. Chen Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-kappaB in mice Int. Immunopharmacol. 22 2014 498 504
25. H. Cao, X. Zhou, J. Zhang, X. Huang, Y. Zhai, X. Zhang, et al. Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-kappaB expression and regulating Th1/Th2 balance Toxicol. Lett. 224 2014 387 394
26. Z. Tianzhu, Y. Shihai, and D. Juan The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3 inflammasome Inflammation 37 2014 1976 1983
27. L. Zhang, Y. Ren, C. Yang, Y. Guo, X. Zhang, G. Hou, et al. Wogonoside ameliorates lipopolysaccharide-induced acute lung injury in mice Inflammation 37 2014 2006 2012
28. D. Wei, and Z. Huang Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice Inflammation 37 2014 1307 1316
29. Y.L. Liu, Y.J. Liu, Y. Liu, X.S. Li, S.H. Liu, Y.G. Pan, et al. Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways Int. Immunopharmacol. 23 2014 649 657
30. T. Chen, Y. Mou, J. Tan, L. Wei, Y. Qiao, T. Wei, et al. The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice Int. Immunopharmacol. 25 2015 55 64
31. M. Huo, R. Gao, L. Jiang, X. Cui, L. Duan, X. Deng, et al. Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models Int. Immunopharmacol. 15 2013 442 449
32. N. Arizmendi, L. Puttagunta, K.L. Chung, C. Davidson, J. Rey-Parra, D.V. Chao, et al. Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis Respir. Res. 15 2014 71
33. R. Roychaudhuri, A.H. Hergrueter, F. Polverino, M.E. Laucho-Contreras, K. Gupta, N. Borregaard, et al. ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury J. Immunol. 193 2014 2469 2482
34. X. Xie, S. Sun, W. Zhong, L.W. Soromou, X. Zhou, M. Wei, et al. Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice Int. Immunopharmacol. 19 2014 103 109
35. M. Han, Y. Jiang, K. Lao, X. Xu, S. Zhan, Y. Wang, et al. sHLA-G involved in the apoptosis of decidual natural killer cells following Toxoplasma gondii infection Inflammation 37 2014 1718 1727
36. Y.W. Chang, Y.F. Zhao, Y.L. Cao, W. Gu, J. Pang, and H.S. Zhan Bufalin exerts inhibitory effects on IL-1beta-mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes Inflammation 37 2014 1552 1559
37. T.Y. Jang, C.S. Park, K.S. Kim, M.J. Heo, and Y.H. Kim Benzaldehyde suppresses murine allergic asthma and rhinitis Int. Immunopharmacol. 22 2014 444 450
38. W. Liu, W. Guo, L. Guo, Y. Gu, P. Cai, N. Xie, et al. Andrographolide sulfonate ameliorates experimental colitis in mice by inhibiting Th1/Th17 response Int. Immunopharmacol. 20 2014 337 345