Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice

Acta Pharmacologica Sinica

Volumn 36, Issue 2, 2015, Pages 179-187

  Xu, Min ^a   Cao, Fa Le ^a   Zhang, Yu Fei ^b   Shan, Liang ^c   Jiang, Xiao Ling ^a   An, Xiao Jing ^b   Xu, Wei ^a   Liu, Xiu Zhi ^a   Wang, Xiao Yan ^a  

^a Department of Pathology ^*  (China)

^b Intensive Care Unit of Ninth Hospital   (China)

^c 88th Hospital of PLA   (China)

Author keywords

apoptosis; bronchoalveolar lavage fluid; Hif 1 ; inflammation; lipopolysaccharide; lung injury; NF B; Salvia miltiorrhiza Bunge; Tanshinone IIA

Indexed keywords

CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PROTEIN BCL 2; TANSHINONE IIA; TUMOR NECROSIS FACTOR ALPHA; ABIETANE DERIVATIVE; TANSHINONE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HISTOLOGY; INFLAMMATION; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN CONTENT; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; DITERPENES, ABIETANE; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C;

EID: 84922181144     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.112     Document Type: Article

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