Clematichinenoside AR induces immunosuppression involving Treg cells in Peyers patches of rats with adjuvant induced arthritis

Journal of Ethnopharmacology

Volumn 155, Issue 2, 2014, Pages 1306-1314

  Xiong, Ying ^a   Ma, Yan ^a   Han, Wang ^a   Kodithuwakku, Nandani Darshika ^a   Liu, Li Fang ^a   Li, Feng Wen ^a   Fang, Wei Rong ^a   Li, Yun Man ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adjuvant induced arthritis; Clematichinenoside AR; Immunosuppression; Peyers patch; Rheumatoid arthritis

Indexed keywords

CD4 ANTIGEN; CLEMATICHINENOSIDE AR; CONCANAVALIN A; GLYCOSIDE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SAPONIN DERIVATIVE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TRIPTERYGIUM GLYCOSIDE; TRITERPENOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; FREUND ADJUVANT; HERBACEOUS AGENT; SAPONIN; TRITERPENE;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 LYMPHOCYTE PERCENTAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DISEASE SEVERITY; DRUG MECHANISM; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE; MALE; NONHUMAN; PEYER PATCH; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT MODEL; REGULATORY T LYMPHOCYTE; SWELLING; SYNOVIUM; TH17 CELL; UPREGULATION; ANIMAL; ARTHRITIS, EXPERIMENTAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; IMMUNOLOGY; JOINT; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; SPRAGUE DAWLEY RAT; TIME;

RATTUS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CYTOKINES; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FREUND'S ADJUVANT; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; JOINTS; MALE; PEYER'S PATCHES; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; SAPONINS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TIME FACTORS; TRITERPENES;

EID: 84906793956     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.07.028     Document Type: Article

References (45)

1. J.D. Ahlers, and I.M. Belyakov Molecular pathways regulating CD4(+) T cell differentiation, anergy and memory with implications for vaccines Trends in Molecular Medicine 16 2010 478 491
2. F. Behrens, A. Himsel, S. Rehart, J. Stanczyk, B. Beutel, S.Y. Zimmermann, U. Koehl, B. Moller, S. Gay, J.P. Kaltwasser, J.M. Pfeilschifter, and H.H. Radeke Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis Annals of the Rheumatic Diseases 66 2007 1151 1156
3. P.D. Biondo, S. Goruk, M.R. Ruth, E. O'Connell, and C.J. Field Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune function International Immunopharmacology 8 2008 1134 1142
4. W. Chen, W. Jin, N. Hardegen, K.J. Lei, L. Li, N. Marinos, G. McGrady, and S.M. Wahl Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 The Journal of Experimental Medicine 198 2003 1875 1886
5. W. Dong, and P. Zhu Functional niche of inflamed synovium for Th17-cell expansion and activation in rheumatoid arthritis: implication to clinical therapeutics Autoimmunity Reviews 11 2012 844 851
6. J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nature Immunology 4 2003 330 336
7. Q. Fu, K. Zan, M. Zhao, S. Zhou, S. Shi, Y. Jiang, and P. Tu Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity Journal of Natural Products 73 2010 1234 1239
8. R.S. Gilbert, R. Kobayashi, S. Sekine, and K. Fujihashi Functional transforming growth factor-beta receptor type II expression by CD4+ T cells in Peyer's patches is essential for oral tolerance induction PLoS One 6 2011 e27501
9. N.J. Gullick, H.G. Evans, L.D. Church, D.M. Jayaraj, A. Filer, B.W. Kirkham, and L.S. Taams Linking power Doppler ultrasound to the presence of th17 cells in the rheumatoid arthritis joint PLoS One 5 2010 e12516
10. W. Han, Y. Xiong, Y. Li, W. Fang, Y. Ma, L. Liu, F. Li, and X. Zhu Anti-arthritic effects of clematichinenoside (AR-6) on PI3K/Akt signaling pathway and TNF-alpha associated with collagen-induced arthritis Le Pharmacien Biologiste 51 2013 13 22
11. Y.J. Heo, Y.B. Joo, H.J. Oh, M.K. Park, Y.M. Heo, M.L. Cho, S.K. Kwok, J.H. Ju, K.S. Park, S.G. Cho, S.H. Park, H.Y. Kim, and J.K. Min IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients Immunology Letters 127 2010 150 156
12. A. Hot, S. Zrioual, V. Lenief, and P. Miossec IL-17 and tumour necrosis factor alpha combination induces a HIF-1alpha-dependent invasive phenotype in synoviocytes Annals of the Rheumatic Diseases 71 2012 1393 1401
13. M.S. Hsieh, K.T. Wang, S.H. Tseng, C.J. Lee, C.H. Chen, and C.C. Wang Using 18F-FDG microPET imaging to measure the inhibitory effects of Clematis chinensis Osbeck on the pro-inflammatory and degradative mediators associated with inflammatory arthritis Journal of Ethnopharmacology 136 2011 511 517
14. Z. Huang, B. Yang, Y. Shi, B. Cai, Y. Li, W. Feng, Y. Fu, L. Luo, and L. Wang Anti-TNF-alpha therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis Cellular Immunology 279 2012 25 29
15. I.I. Ivanov, B.S. McKenzie, L. Zhou, C.E. Tadokoro, A. Lepelley, J.J. Lafaille, D.J. Cua, and D.R. Littman The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 2006 1121 1133
16. C.H. Kim Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system Experimental Hematology 34 2006 1033 1040
17. N. Kong, Q. Lan, M. Chen, T. Zheng, W. Su, J. Wang, Z. Yang, R. Park, G. Dagliyan, P.S. Conti, D. Brand, Z. Liu, H. Zou, W. Stohl, and S.G. Zheng Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells Annals of the Rheumatic Diseases 71 2012 1567 1572
18. R.Y. Lan, I.R. Mackay, and M.E. Gershwin Regulatory T cells in the prevention of mucosal inflammatory diseases: patrolling the border Journal of Autoimmunity 29 2007 272 280
19. F. Li, D. Wang, P. Xu, J. Wu, L. Liu, and X. Liu Identification of the metabolites of anti-inflammatory compound clematichinenoside AR in rat intestinal microflora Biomedical Chromatography: BMC 27 2013 1767 1774
20. L.F. Liu, X.L. Ma, Y.X. Wang, F.W. Li, Y.M. Li, Z.Q. Wan, and Q.L. Tang Triterpenoid saponins from the roots of Clematis chinensis Osbeck Journal of Asian Natural Products Research 11 2009 389 396
21. Y. Lu, J. Xiao, Z.W. Wu, Z.M. Wang, J. Hu, H.Z. Fu, Y.Y. Chen, and R.Q. Qian Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 19 2012 882 889
22. X. Luo, L.L. Li, S.S. Zhang, J.L. Lu, Y. Zeng, H.Y. Zhang, and M. Xiang Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice Journal of Ethnopharmacology 138 2011 523 529
23. X. Ma, L. Xie, L. Liu, Q. Tang, Z. Wan, and Y. Li Simultaneous quantification of seven main triterpenoid saponins in Radix et Rhizoma Clematidis by LC-ELSD Chromatographia 69 2009 437 443
24. S.J. Moon, J.S. Park, Y.J. Heo, C.M. Kang, E.K. Kim, M.A. Lim, J.G. Ryu, S.J. Park, K.S. Park, Y.C. Sung, S.H. Park, H.Y. Kim, J.K. Min, and M.L. Cho In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis Experimental & Molecular Medicine 45 2013 e46
25. E.M. Moran, R. Mullan, J. McCormick, M. Connolly, O. Sullivan, O. Fitzgerald, B. Bresnihan, D.J. Veale, and U. Fearon Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies Arthritis Research & Therapy 11 2009 R113
26. K. Nagatani, K. Sagawa, Y. Komagata, and K. Yamamoto Peyers patch dendritic cells capturing oral antigen interact with antigen-specific T cells and induce gut-homing CD4(+)CD25(+) regulatory T cells in Peyers patches Annals of the New York Academy of Sciences 1029 2004 366 370
27. K.S. Park, M.J. Park, M.L. Cho, S.K. Kwok, J.H. Ju, H.J. Ko, S.H. Park, and H.Y. Kim Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis Modern Rheumatology/the Japan Rheumatism Association 19 2009 581 589
28. M.J. Park, S.Y. Min, K.S. Park, Y.G. Cho, M.L. Cho, Y.O. Jung, H.S. Park, S.H. Chang, S.G. Cho, J.K. Min, S.H. Park, and H.Y. Kim Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer's patches in an orally tolerized, collagen-induced arthritis mouse model Arthritis Research & Therapy 10 2008 R11
29. C. Peng, P.K. Perera, Y.M. Li, W.R. Fang, L.F. Liu, and F.W. Li Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-kappaB, TNF-alpha, and COX-2 in collagen-induced arthritis in rat Rheumatology International 32 2012 3119 3125
30. S. Raghavan, D. Cao, M. Widhe, K. Roth, J. Herrath, M. Engstrom, G. Roncador, A.H. Banham, C. Trollmo, A.I. Catrina, and V. Malmstrom FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment Annals of the Rheumatic Diseases 68 2009 1908 1915
31. M. Seki, S. Oomizu, K.M. Sakata, A. Sakata, T. Arikawa, K. Watanabe, K. Ito, K. Takeshita, T. Niki, N. Saita, N. Nishi, A. Yamauchi, S. Katoh, A. Matsukawa, V. Kuchroo, and M. Hirashima Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis Clinical Immunology (Orlando, Fla.) 127 2008 78 88
32. S. Shi, D. Jiang, C. Dong, and P. Tu Triterpene saponins from clematis mandshurica Journal of Natural Products 69 2006 1591 1595
33. J.W. Simecka Mucosal immunity of the gastrointestinal tract and oral tolerance Advanced Drug Delivery Reviews 34 1998 235 259
34. State Pharmacopoeia Committee of Peoples Republic of China Pharmacopoeia of Peoples Republic of China 2010 China Medical Science Press Beijing 234 235
35. N. Takayama, O. Igarashi, M.N. Kweon, and H. Kiyono Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea Clinical Immunology (Orlando, Fla.) 123 2007 199 208
36. C. Wang, S.G. Kang, J. Lee, Z. Sun, and C.H. Kim The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut Mucosal Immunology 2 2009 173 183
37. D.W. Wang, J. Zhang, P. Li, F. Li, and X.D. Liu Study on intestinal absorption of clematichinenoside AR in rats by in-situ single-pass perfusion model Chinese Journal of New Drugs 21 2012 800 803
38. L. Wieten, R. Van der Zee, R. Spiering, J. Wagenaar-Hilbers, P. Van Kooten, F. Broere, and W. Van Eden A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis Arthritis and Rheumatism 62 2010 1026 1035
39. W. Wu, X. Gao, X. Xu, Y. Luo, M. Liu, Y. Xia, and Y. Dai Saponin-rich fraction from Clematis chinensis Osbeck roots protects rabbit chondrocytes against nitric oxide-induced apoptosis via preventing mitochondria impairment and caspase-3 activation Cytotechnology 65 2013 287 295
40. W. Wu, X. Xu, Y. Dai, and L. Xia Therapeutic effect of the saponin fraction from Clematis chinensis Osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage Phytotherapy Research: PTR 24 2010 538 546
41. Z. Zhang, Y. Ding, W. Li, B. Song, and R. Yang Interleukin-17A- or tumor necrosis factor alpha-mediated increase in proliferation of T cells cocultured with synovium-derived mesenchymal stem cells in rheumatoid arthritis Arthritis Research & Therapy 15 2013 R169
42. Y. Zhong, A. Cantwell, and P.H. Dube Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut Infection and Immunity 78 2010 3716 3725
43. J. Zhou, C. Xiao, L. Zhao, H. Jia, N. Zhao, C. Lu, D. Yang, J.C. Tang, A.S. Chan, and A.P. Lu The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis International Immunopharmacology 6 2006 198 203
44. Y. Zhou, Y. Guan, J. Shi, X. Zhang, L. Yao, and L. Liu Development and validation of a chromatographic method for determining Clematichinenoside AR and related impurities Chemistry Central Journal 6 2012 150
45. S. Zrioual, M.L. Toh, A. Tournadre, Y. Zhou, M.A. Cazalis, A. Pachot, V. Miossec, and P. Miossec IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood Journal of Immunology (Baltimore, Md.: 1950) 180 2008 655 663