Therapeutic effects of total steroid saponin extracts from the rhizome of Dioscorea zingiberensis C.H.Wright in Freund's complete adjuvant induced arthritis in rats

International Immunopharmacology

Volumn 23, Issue 2, 2014, Pages 407-416

  Zhang, Xin Xin ^a   Ito, Yoichiro ^b   Liang, Jin Ru ^a   Liu, Jian Li ^a   He, Jiao ^a   Sun, Wen Ji ^a  

^a NORTHWEST UNIVERSITY   (China)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Adjuvant induced arthritis; Dioscorea zingiberensis C.H.Wright; Lipopolysaccharide; NF B; Total steroid saponins

Indexed keywords

ANTIRHEUMATIC AGENT; CYCLOOXYGENASE 2; FREUND ADJUVANT; I KAPPA B ALPHA; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MALONALDEHYDE; METHOTREXATE; NITRIC OXIDE; PROSTAGLANDIN E2; SAPONIN; STEROID; SUPEROXIDE DISMUTASE; SYNAPTOTAGMIN I; TOTAL STEROID SAPONIN EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PLANT EXTRACT;

ADJUVANT ARTHRITIS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE RELEASE; DIOSCOREA ZINGIBERENSIS; DRUG MEGADOSE; IN VITRO STUDY; IN VIVO STUDY; LEG SWELLING; LOW DRUG DOSE; MACROPHAGE; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; RHIZOME; THERAPY EFFECT; YAM; ANIMAL; ARTHRITIS; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS; DIOSCOREA; DOSE-RESPONSE RELATIONSHIP, DRUG; FREUND'S ADJUVANT; METHOTREXATE; MOLECULAR STRUCTURE; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME; SAPONINS; STEROIDS;

EID: 84912526714     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.07.018     Document Type: Article

References (33)

1. J. Zuo, Y. Xia, X. Li, and J.W. Chen Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat J Ethnopharmacol 153 2014 352 358
2. C.J. Zheng, X.X. Zhao, H.W. Ai, B. Lin, T. Han, and Y.P. Jiang Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats Phytomedicine 21 2014 838 846
3. L.T. Lee, Y.F. Tsai, N.Y. Hu, C.W. Wang, K.K. Huang, and J.K. Hsiao Anti-arthritis effect of mangostins from G. mangostana Biomed Prev Nutr 3 2013 227 232
4. M.V.K. Patil, A.D. Kandhare, and S.D. Bhise Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis Biomed Aging Pathol 2 2012 6 15
5. G. Sinduhu, M. Ratheesh, G.L. Shyni, B. Nambisan, and A. Helen Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats Int Immunopharmacol 12 2012 205 211
6. Y.Q. Zhang, W. Xu, H. Li, X. Zhang, Y.F. Xia, and K.D. Chu Therapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in rats J Ethnopharmacol 145 2013 699 705
7. R. Raveendhara, M.D.F.A.G.E. Bannuru, E. Elizaveta, M.D.M.S. Vaysbrot, C. Matthew, and B.A. Sullivan Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: a systematic review and meta-analysis Semin Arthritis Rheum 43 2014 593 599
8. R.C. Wood III, J.E. Wyatt, K.W. Bullins, A.V. Hanley, G.A. Hanley, and J.W. Denham Effects of rebamipide on nephrotoxicity associated with selected. NSAIDs in rats Eur J Pharmacol 54 2013 138 146
9. L. Wang, G.B. Zhou, P. Liu, J.H. Song, Y. Liang, and X.J. Yan Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia Proc Natl Acad Sci U S A 105 2008 4826 4831
10. X. Liang, X. Chen, Q. Liang, H. Zhang, P. Hu, and Y. Wang Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats J Proteome Res 10 2011 790 799
11. R. Yue, L. Zhao, Y.H. Hu, P. Jiang, S.P. Wang, and L. Xiang Rapid-resolution liquid chromatography TOF-MS for urine metabolomic analysis of collagen-induced arthritis in rats and its applications J Ethnopharmacol 145 2013 465 475
12. H. Li, W. Huang, Y.Q. Wen, G.H. Gong, Q.B. Zhao, and G. Yu Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H.Wright Fitoterapia 81 2010 1147 1156
13. Y.L. Wei, Y.S. Xu, X. Han, Y. Qi, L.N. Xu, and Y.W. Xu Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway Food Chem Toxicol 59 2013 118 128
14. X.X. Zhang, J.R. Liang, J.L. Liu, Y. Zhao, J. Gao, and W.J. Sun Quality control and identification of steroid saponins from Dioscorea zingiberensis C.H. Wright by fingerprint with HPLC-ELSD and HPLC-ESI-quadrupole/time-of-fight tandem mass spectrometry J Pharm Biomed Anal 91 2014 46 59
15. N. Jia, Y.W. Li, Y. Wu, X.X. Zhang, G.M. Hur, and M.M. Xi Comparison of the anti-inflammatory and analgesic effects of Gentiana macrophylla Pall. and Gentiana straminea Maxim., and identification of their active constituents J Ethnopharmacol 144 2012 638 645
16. J.S. Shin, Y.S. Noh, Y.S. Lee, Y.W. Cho, N.I. Baek, and M.S. Choi Arvelexin from Brassica rapa suppresses NF-kappaB-regulated pro-inflammatory gene expression by inhibiting activation of IkappaB kinase Br J Pharmacol 164 2011 145 158
17. M. Xue, Z.Z. Jiang, T. Wu, J. Li, L. Zhang, and Y. Zhao Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats Phytomedicine 19 2012 998 1006
18. A. Vysakh, M. Ratheesh, T.P. Rajmohanan, C. Pramod, S. Premlal, and B. Girish kumar Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action Int Immunopharmacol 20 2014 124 130
19. R. Refaat, M. Salama, E.A. Meguid, A.E. Sarha, and M. Gowayed Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats Eur J Pharmacol 698 2013 421 428
20. B. Lin, H. Zhang, X.X. Zhao, K. Rahman, Y. Wang, and X.Q. Ma Inhibitory effects of the root extract of Litsea cubeba (lour.) pers. on adjuvant arthritis in rats J Ethnopharmacol 147 2013 327 334
21. X.Y. Huang, X.M. Zhang, F.H. Chen, L.L. Zhou, X.F. Deng, and Y.J. Liu Anti-proliferative effect of recombinant human endostatin on synovial fibroblasts in rats with adjuvant arthritis Eur J Pharmacol 723 2014 7 14
22. X.H. Qu, Z.J. Zhai, X.Q. Liu, H.W. Li, Z.X. Ouyang, and C.L. Wu Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades Biochem Biophys Res Commun 443 2014 658 665
23. D.H. Jung, H.J. Park, H.E. Byun, Y.M. Park, T.W. Kim, and B.O. Kim Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation Int Immunopharmacol 10 2010 1047 1054
24. S.J. Heo, J.Y. Jang, B.R. Ye, M.S. Kim, W.J. Yoon, and C.H. Oh Chromene suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells Food Chem Toxicol 67 2014 169 175
25. C.C. Hsu, J.C. Lien, C.W. Chang, C.H. Chang, S.C. Kuo, and T.F. Huang Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation Biochem Pharmacol 85 2013 385 395
26. X.M. Chen, J. Xia, T. Zhou, Q. Yuan, W.F. Zhang, and C.P. Hu Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis 2 in rats Int Immunopharmacol 16 2013 322 331
27. A.A. Abdin, M.S.A. Ei-Halim, S.E. Hedeya, and A.A.E. EI-Saadany Effect of atorvastatin with or without prednisolone on Freund's adjuvant Eur J Pharmacol 676 2012 34 40
28. M.S. Hayden, and S. Ghosh Shared principles in NF-κB signaling Cell 132 2008 344 362
29. V.G.M. Naidu, K.R.D. Babu, M.M. Thwin, R.L. Satish, P.V. Kumar, and P. Gopalakrishnakone RANKL targeted peptides inhibit osteoclastogenesis and attenuate adjuvant induced arthritis by inhibiting NF-κB activation and down regulating inflammatory cytokines Chem Biol Interact 203 2013 467 479
30. X.Y. Kong, C.F. Liu, C. Zhang, J. Zhao, J.Z. Wang, and H.Y. Wan The suppressive effects of Saposhnikovia divaricata (Fangfeng) chromone extract on rheumatoid arthritis via inhibition of nuclear factor-κB and mitogen activated proteinkinases activation on collagen-induced arthritis model J Ethnopharmacol 148 2013 842 850
31. H.H. Arab, and M.M. EI-Sawalhi Arvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators Toxicol Appl Pharmacol 268 2013 241 248
32. Z.Q. Liu, X.Y. Luo, G.Z. Liu, Y.P. Chen, Z.C. Wang, and Y.X. Sun In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes J Agric Food Chem 51 2003 2555 2558
33. W. Tang, and G. Eisenbrand Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine 1992 Springer-Verlag Berlin/New York