Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway

Toxicology and Applied Pharmacology

Volumn 281, Issue 1, 2014, Pages 118-124

  Luan, Xin ^a   Gao, Yun Ge ^a   Guan, Ying Yun ^a   Xu, Jian Rong ^a   Lu, Qin ^a   Zhao, Mei ^b   Liu, Ya Rong ^a   Liu, Hai Jun ^a   Fang, Chao ^a   Chen, Hong Zhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI UNIVERSITY OF MEDICINE AND HEALTH SCIENCES   (China)

Author keywords

Antiangiogenic cancer therapy; Chick embryo chorioallantoic membrane; Platycodin D; Triterpenoid; Tumor angiogenesis; VEGFR2

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANGIOGENESIS INHIBITOR; FOCAL ADHESION KINASE; JANUS KINASE 2; PHOSPHOLIPASE C GAMMA1; PLATYCODIN D; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; SAPONIN; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER SIZE; CAPILLARY DENSITY; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL VIABILITY; CHICK EMBRYO; CHORIOALLANTOIS; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CAMPANULACEAE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE; TUMOR VOLUME;

ANGIOGENESIS INHIBITORS; ANIMALS; CAMPANULACEAE; CELL LINE, TUMOR; CELL SURVIVAL; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84908231749     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.09.009     Document Type: Article

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