메뉴 건너뛰기




Volumn 45, Issue 6, 2015, Pages 1015-1026

Immunoregulatory T cell epitope peptides: The new frontier in allergy therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BEE VENOM; EPITOPE; SYNTHETIC PEPTIDE; HLA ANTIGEN CLASS 2; IMMUNOLOGIC FACTOR; PEPTIDE;

EID: 84929309946     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12554     Document Type: Review
Times cited : (77)

References (120)
  • 1
    • 84876903600 scopus 로고    scopus 로고
    • Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
    • e3.
    • Burks AW, Calderon MA, Casale T et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol 2013; 131:1288-96 e3.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 1288-1296
    • Burks, A.W.1    Calderon, M.A.2    Casale, T.3
  • 2
    • 75849127328 scopus 로고    scopus 로고
    • Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009
    • Canonica GW, Bousquet J, Casale T et al. Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009. Allergy 2009; 64(Suppl 91):1-59.
    • (2009) Allergy , vol.64 , pp. 1-59
    • Canonica, G.W.1    Bousquet, J.2    Casale, T.3
  • 3
    • 84902083555 scopus 로고    scopus 로고
    • Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper
    • Pfaar O, Demoly P, Gerth van Wijk R et al. Recommendations for the standardization of clinical outcomes used in allergen immunotherapy trials for allergic rhinoconjunctivitis: an EAACI Position Paper. Allergy 2014; 69:854-67.
    • (2014) Allergy , vol.69 , pp. 854-867
    • Pfaar, O.1    Demoly, P.2    Gerth van Wijk, R.3
  • 4
    • 50249230114 scopus 로고
    • Prophylactic inoculation against hay fever
    • Noon L. Prophylactic inoculation against hay fever. Lancet 1911; 177:1555-626.
    • (1911) Lancet , vol.177 , pp. 1555-1626
    • Noon, L.1
  • 5
    • 84906833614 scopus 로고    scopus 로고
    • Comparative efficacy and safety of subcutaneous versus sublingual immunotherapy
    • e2.
    • Bauer CS, Rank MA. Comparative efficacy and safety of subcutaneous versus sublingual immunotherapy. J Allergy Clin Immunol 2014; 134:765.e2.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 765
    • Bauer, C.S.1    Rank, M.A.2
  • 6
    • 84879836940 scopus 로고    scopus 로고
    • Effectiveness of subcutaneous versus sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review
    • Chelladurai Y, Suarez-Cuervo C, Erekosima N et al. Effectiveness of subcutaneous versus sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review. J Allergy Clin Immunol Pract 2013; 1:361-9.
    • (2013) J Allergy Clin Immunol Pract , vol.1 , pp. 361-369
    • Chelladurai, Y.1    Suarez-Cuervo, C.2    Erekosima, N.3
  • 8
    • 0019865908 scopus 로고
    • Studies on allergoids from naturally occurring allergens. III. Preparation of ragweed pollen allergoids by aldehyde modification in two steps
    • Marsh DG, Norman PS, Roebber M, Lichtenstein LM. Studies on allergoids from naturally occurring allergens. III. Preparation of ragweed pollen allergoids by aldehyde modification in two steps. J Allergy Clin Immunol 1981; 68:449-59.
    • (1981) J Allergy Clin Immunol , vol.68 , pp. 449-459
    • Marsh, D.G.1    Norman, P.S.2    Roebber, M.3    Lichtenstein, L.M.4
  • 9
    • 0023814205 scopus 로고
    • Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. II. Comparison between parameters assessing the efficacy of immunotherapy
    • Bousquet J, Maasch H, Martinot B, Hejjaoui A, Wahl R, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. II. Comparison between parameters assessing the efficacy of immunotherapy. J Allergy Clin Immunol 1988; 82:439-46.
    • (1988) J Allergy Clin Immunol , vol.82 , pp. 439-446
    • Bousquet, J.1    Maasch, H.2    Martinot, B.3    Hejjaoui, A.4    Wahl, R.5    Michel, F.B.6
  • 10
    • 0032766655 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of two preseasonal regimens of glutaraldehyde modified, tyrosine-adsorbed parietaria pollen extract over a period of three years in monosensitive patients
    • Negro JM, Wheeler AW, Hernandez J et al. Comparison of the efficacy and safety of two preseasonal regimens of glutaraldehyde modified, tyrosine-adsorbed parietaria pollen extract over a period of three years in monosensitive patients. Allergol Immunopathol (Madr) 1999; 27:153-64.
    • (1999) Allergol Immunopathol (Madr) , vol.27 , pp. 153-164
    • Negro, J.M.1    Wheeler, A.W.2    Hernandez, J.3
  • 11
    • 85006166344 scopus 로고    scopus 로고
    • Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides
    • Pellaton C, Perrin Y, Boudousquie C et al. Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides. Clin Transl Allergy 2013; 3:17.
    • (2013) Clin Transl Allergy , vol.3 , pp. 17
    • Pellaton, C.1    Perrin, Y.2    Boudousquie, C.3
  • 12
    • 84903689341 scopus 로고    scopus 로고
    • Safety and immunogenicity of immunotherapy with Bet v 1-derived contiguous overlapping peptides
    • e13.
    • Spertini F, Perrin Y, Audran R et al. Safety and immunogenicity of immunotherapy with Bet v 1-derived contiguous overlapping peptides. J Allergy Clin Immunol 2014; 134:239-40e13.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 239-240
    • Spertini, F.1    Perrin, Y.2    Audran, R.3
  • 14
    • 0035843316 scopus 로고    scopus 로고
    • Allergy and allergic diseases. Second of two parts
    • Kay AB. Allergy and allergic diseases. Second of two parts. N Engl J Med 2001; 344:109-13.
    • (2001) N Engl J Med , vol.344 , pp. 109-113
    • Kay, A.B.1
  • 15
    • 0035804276 scopus 로고    scopus 로고
    • Allergy and allergic diseases. First of two parts
    • Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med 2001; 344:30-7.
    • (2001) N Engl J Med , vol.344 , pp. 30-37
    • Kay, A.B.1
  • 16
    • 84895196467 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens
    • Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol 2014; 133:621-31.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 621-631
    • Akdis, M.1    Akdis, C.A.2
  • 17
    • 84856416212 scopus 로고    scopus 로고
    • Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
    • e1-7.
    • Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol 2012; 129:544-51 e1-7.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 544-551
    • Wambre, E.1    DeLong, J.H.2    James, E.A.3    LaFond, R.E.4    Robinson, D.5    Kwok, W.W.6
  • 18
    • 84896729297 scopus 로고    scopus 로고
    • Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner
    • e7.
    • Wambre E, DeLong JH, James EA et al. Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner. J Allergy Clin Immunol 2014; 133:872-9 e7.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 872-879
    • Wambre, E.1    DeLong, J.H.2    James, E.A.3
  • 19
    • 34548237449 scopus 로고    scopus 로고
    • Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    • Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007; 120:707-13.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 707-713
    • Bohle, B.1    Kinaciyan, T.2    Gerstmayr, M.3    Radakovics, A.4    Jahn-Schmid, B.5    Ebner, C.6
  • 20
    • 77954309823 scopus 로고    scopus 로고
    • Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis
    • Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L. Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis. Clin Immunol 2010; 136:292-301.
    • (2010) Clin Immunol , vol.136 , pp. 292-301
    • Han, D.1    Wang, C.2    Lou, W.3    Gu, Y.4    Wang, Y.5    Zhang, L.6
  • 21
    • 42049094601 scopus 로고    scopus 로고
    • Effect of house dust mite immunotherapy on transforming growth factor beta1-producing T cells in asthmatic children
    • Ajduk J, Marinic I, Aberle N, Rabatic S, Gagro A. Effect of house dust mite immunotherapy on transforming growth factor beta1-producing T cells in asthmatic children. Ann Allergy Asthma Immunol 2008; 100:314-22.
    • (2008) Ann Allergy Asthma Immunol , vol.100 , pp. 314-322
    • Ajduk, J.1    Marinic, I.2    Aberle, N.3    Rabatic, S.4    Gagro, A.5
  • 22
    • 77949393210 scopus 로고    scopus 로고
    • Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells
    • Scadding GW, Shamji MH, Jacobson MR et al. Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B cells. Clin Exp Allergy 2010; 40:598-606.
    • (2010) Clin Exp Allergy , vol.40 , pp. 598-606
    • Scadding, G.W.1    Shamji, M.H.2    Jacobson, M.R.3
  • 23
    • 84875725016 scopus 로고    scopus 로고
    • IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses
    • van de Veen W, Stanic B, Yaman G et al. IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. J Allergy Clin Immunol 2013; 131:1204-12.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 1204-1212
    • van de Veen, W.1    Stanic, B.2    Yaman, G.3
  • 24
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: flexibility in the face of changing circumstances
    • Murphy KM, Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 2010; 11:674-80.
    • (2010) Nat Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 25
    • 73849110167 scopus 로고    scopus 로고
    • Heterogeneity and plasticity of T helper cells
    • Zhu J, Paul WE. Heterogeneity and plasticity of T helper cells. Cell Res 2010; 20:4-12.
    • (2010) Cell Res , vol.20 , pp. 4-12
    • Zhu, J.1    Paul, W.E.2
  • 26
    • 0027717415 scopus 로고
    • Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes
    • Verhoef A, Higgins JA, Thorpe CJ et al. Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993; 5:1589-97.
    • (1993) Int Immunol , vol.5 , pp. 1589-1597
    • Verhoef, A.1    Higgins, J.A.2    Thorpe, C.J.3
  • 27
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358:155-7.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 28
    • 0027250618 scopus 로고
    • In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens
    • Wedderburn LR, O'Hehir RE, Hewitt CR, Lamb JR, Owen MJ. In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens. Proc Natl Acad Sci USA 1993; 90:8214-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8214-8218
    • Wedderburn, L.R.1    O'Hehir, R.E.2    Hewitt, C.R.3    Lamb, J.R.4    Owen, M.J.5
  • 29
    • 77956209086 scopus 로고    scopus 로고
    • Tracking antigen-specific T-cells during clinical tolerance induction in humans
    • Aslam A, Chan H, Warrell DA, Misbah S, Ogg GS. Tracking antigen-specific T-cells during clinical tolerance induction in humans. PLoS One 2010; 5:e11028.
    • (2010) PLoS One , vol.5
    • Aslam, A.1    Chan, H.2    Warrell, D.A.3    Misbah, S.4    Ogg, G.S.5
  • 30
    • 0030039463 scopus 로고    scopus 로고
    • Regulation of cytokine and chemokine transcription in a human TH2 type T-cell clone during the induction phase of anergy
    • O'Hehir RE, Lake RA, Schall TJ, Yssel H, Panagiotopoulou E, Lamb JR. Regulation of cytokine and chemokine transcription in a human TH2 type T-cell clone during the induction phase of anergy. Clin Exp Allergy 1996; 26:20-7.
    • (1996) Clin Exp Allergy , vol.26 , pp. 20-27
    • O'Hehir, R.E.1    Lake, R.A.2    Schall, T.J.3    Yssel, H.4    Panagiotopoulou, E.5    Lamb, J.R.6
  • 31
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • Hoyne GF, Askonas BA, Hetzel C, Thomas WR, Lamb JR. Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int Immunol 1996; 8:335-42.
    • (1996) Int Immunol , vol.8 , pp. 335-342
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 32
    • 0023589956 scopus 로고
    • Cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite): a comparison of T- and B-cell antigen recognition
    • O'Hehir RE, Young DB, Kay AB, Lamb JR. Cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite): a comparison of T- and B-cell antigen recognition. Immunology 1987; 62:635-40.
    • (1987) Immunology , vol.62 , pp. 635-640
    • O'Hehir, R.E.1    Young, D.B.2    Kay, A.B.3    Lamb, J.R.4
  • 33
    • 0001374429 scopus 로고
    • Cell culture: lymphocyte clones
    • Albert WHW, Staines NA, eds. Springer-Verlag: Heidelberg
    • O'Hehir RE, Askonas BA, Lamb JR. Cell culture: lymphocyte clones. In: Albert WHW, Staines NA, eds. Methods of immunological analysis 3. Springer-Verlag: Heidelberg, 1993:120-38.
    • (1993) Methods of immunological analysis 3 , pp. 120-138
    • O'Hehir, R.E.1    Askonas, B.A.2    Lamb, J.R.3
  • 36
    • 77955484239 scopus 로고    scopus 로고
    • Molecular determinants of T cell epitope recognition to the common Timothy grass allergen
    • Oseroff C, Sidney J, Kotturi MF et al. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol 2010; 185:943-55.
    • (2010) J Immunol , vol.185 , pp. 943-955
    • Oseroff, C.1    Sidney, J.2    Kotturi, M.F.3
  • 37
    • 77952685343 scopus 로고    scopus 로고
    • Direct ex vivo analysis of allergen-specific CD4+ T cells
    • e1.
    • Kwok WW, Roti M, Delong JH et al. Direct ex vivo analysis of allergen-specific CD4+ T cells. J Allergy Clin Immunol 2010; 125:1407-9 e1.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1407-1409
    • Kwok, W.W.1    Roti, M.2    Delong, J.H.3
  • 38
    • 84915749618 scopus 로고    scopus 로고
    • HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells
    • Van Hemelen D, Mahler V, Fischer G et al. HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells. Allergy 2015; 70:49-58.
    • (2015) Allergy , vol.70 , pp. 49-58
    • Van Hemelen, D.1    Mahler, V.2    Fischer, G.3
  • 39
    • 77955634105 scopus 로고    scopus 로고
    • Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease
    • 41ra51
    • Tye-Din JA, Stewart JA, Dromey JA et al. Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease. Sci Transl Med 2010; 2:41ra51.
    • (2010) Sci Transl Med , vol.2
    • Tye-Din, J.A.1    Stewart, J.A.2    Dromey, J.A.3
  • 40
    • 54849410237 scopus 로고    scopus 로고
    • Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes.[see comment]
    • Bateman EA, Ardern-Jones MR, Ogg GS. Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes.[see comment]. Clin Exp Allergy 2008; 38:1760-8.
    • (2008) Clin Exp Allergy , vol.38 , pp. 1760-1768
    • Bateman, E.A.1    Ardern-Jones, M.R.2    Ogg, G.S.3
  • 41
    • 84870978883 scopus 로고    scopus 로고
    • The identification of potentially pathogenic and therapeutic epitopes from common human allergens
    • Schulten V, Oseroff C, Alam R et al. The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol 2013; 110:7-10.
    • (2013) Ann Allergy Asthma Immunol , vol.110 , pp. 7-10
    • Schulten, V.1    Oseroff, C.2    Alam, R.3
  • 42
    • 83155164579 scopus 로고    scopus 로고
    • Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy?
    • Lundegaard C, Lund O, Nielsen M. Predictions versus high-throughput experiments in T-cell epitope discovery: competition or synergy? Expert Rev Vaccines 2012; 11:43-54.
    • (2012) Expert Rev Vaccines , vol.11 , pp. 43-54
    • Lundegaard, C.1    Lund, O.2    Nielsen, M.3
  • 44
    • 84864566639 scopus 로고    scopus 로고
    • Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background
    • Knapp B, Fischer G, Van Hemelen D et al. Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background. BMC Immunol 2012; 13:43.
    • (2012) BMC Immunol , vol.13 , pp. 43
    • Knapp, B.1    Fischer, G.2    Van Hemelen, D.3
  • 45
    • 64149087447 scopus 로고    scopus 로고
    • 3-Layer-based analysis of peptide-MHC interaction: in silico prediction, peptide binding affinity and T cell activation in a relevant allergen-specific model
    • Knapp B, Omasits U, Bohle B et al. 3-Layer-based analysis of peptide-MHC interaction: in silico prediction, peptide binding affinity and T cell activation in a relevant allergen-specific model. Mol Immunol 2009; 46:1839-44.
    • (2009) Mol Immunol , vol.46 , pp. 1839-1844
    • Knapp, B.1    Omasits, U.2    Bohle, B.3
  • 46
    • 0029586024 scopus 로고
    • Fine chemical modifications at N- and C-termini enhance peptide presentation to T cells by increasing the lifespan of both free and MHC-complexed peptides
    • Maillere B, Mourier G, Herve M, Menez A. Fine chemical modifications at N- and C-termini enhance peptide presentation to T cells by increasing the lifespan of both free and MHC-complexed peptides. Mol Immunol 1995; 32:1377-85.
    • (1995) Mol Immunol , vol.32 , pp. 1377-1385
    • Maillere, B.1    Mourier, G.2    Herve, M.3    Menez, A.4
  • 47
    • 77949265993 scopus 로고    scopus 로고
    • Naturally processed T cell-activating peptides of the major birch pollen allergen
    • 8 e1-8 e2.
    • Mutschlechner S, Egger M, Briza P et al. Naturally processed T cell-activating peptides of the major birch pollen allergen. J Allergy Clin Immunol 2010; 125:711-8, 8 e1-8 e2.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 711-718
    • Mutschlechner, S.1    Egger, M.2    Briza, P.3
  • 49
    • 84865728489 scopus 로고    scopus 로고
    • The immune epitope database: a historical retrospective of the first decade
    • Salimi N, Fleri W, Peters B, Sette A. The immune epitope database: a historical retrospective of the first decade. Immunology 2012; 137:117-23.
    • (2012) Immunology , vol.137 , pp. 117-123
    • Salimi, N.1    Fleri, W.2    Peters, B.3    Sette, A.4
  • 51
    • 84864815974 scopus 로고    scopus 로고
    • Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data
    • Vaughan K, Greenbaum J, Kim Y et al. Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data. J Allergy (Cairo) 2010; 2010:628026.
    • (2010) J Allergy (Cairo) , vol.2010 , pp. 628026
    • Vaughan, K.1    Greenbaum, J.2    Kim, Y.3
  • 52
    • 0024428816 scopus 로고
    • How some T cells escape tolerance induction
    • Gammon G, Sercarz E. How some T cells escape tolerance induction. Nature 1989; 342:183-5.
    • (1989) Nature , vol.342 , pp. 183-185
    • Gammon, G.1    Sercarz, E.2
  • 53
    • 84864100088 scopus 로고    scopus 로고
    • Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1
    • Etto T, de Boer C, Prickett S et al. Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1. Int Arch Allergy Immunol 2012; 159:355-66.
    • (2012) Int Arch Allergy Immunol , vol.159 , pp. 355-366
    • Etto, T.1    de Boer, C.2    Prickett, S.3
  • 55
    • 21344438163 scopus 로고    scopus 로고
    • Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens
    • Jahn-Schmid B, Radakovics A, Luttkopf D et al. Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol 2005; 116:213-9.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 213-219
    • Jahn-Schmid, B.1    Radakovics, A.2    Luttkopf, D.3
  • 56
    • 20044390815 scopus 로고    scopus 로고
    • Identification of human T cell epitopes in Japanese cypress pollen allergen, Cha o 1, elucidates the intrinsic mechanism of cross-allergenicity between Cha o 1 and Cry j 1, the major allergen of Japanese cedar pollen, at the T cell level
    • Sone T, Dairiki K, Morikubo K et al. Identification of human T cell epitopes in Japanese cypress pollen allergen, Cha o 1, elucidates the intrinsic mechanism of cross-allergenicity between Cha o 1 and Cry j 1, the major allergen of Japanese cedar pollen, at the T cell level. Clin Exp Allergy 2005; 35:664-71.
    • (2005) Clin Exp Allergy , vol.35 , pp. 664-671
    • Sone, T.1    Dairiki, K.2    Morikubo, K.3
  • 57
    • 0029559917 scopus 로고
    • T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens
    • Schenk S, Breiteneder H, Susani M et al. T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens. J Allergy Clin Immunol 1995; 96:986-96.
    • (1995) J Allergy Clin Immunol , vol.96 , pp. 986-996
    • Schenk, S.1    Breiteneder, H.2    Susani, M.3
  • 58
    • 6344225313 scopus 로고    scopus 로고
    • Hypoallergenic variants of the major latex allergen Hev b 6.01 retaining human T lymphocyte reactivity
    • Drew AC, Eusebius NP, Kenins L et al. Hypoallergenic variants of the major latex allergen Hev b 6.01 retaining human T lymphocyte reactivity. J Immunol 2004; 173:5872-9.
    • (2004) J Immunol , vol.173 , pp. 5872-5879
    • Drew, A.C.1    Eusebius, N.P.2    Kenins, L.3
  • 59
    • 84878356872 scopus 로고    scopus 로고
    • Ara h 1 CD4+ T-cell epitope-based peptides: candidates for a peanut allergy therapeutic
    • Prickett SR, Voskamp AL, Phan T et al. Ara h 1 CD4+ T-cell epitope-based peptides: candidates for a peanut allergy therapeutic. Clin Exp Allergy 2013; 43:684-97.
    • (2013) Clin Exp Allergy , vol.43 , pp. 684-697
    • Prickett, S.R.1    Voskamp, A.L.2    Phan, T.3
  • 60
    • 78650901420 scopus 로고    scopus 로고
    • Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy
    • e1-14.
    • Worm M, Lee HH, Kleine-Tebbe J et al. Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. J Allergy Clin Immunol 2011; 127:89-97, e1-14.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 89-97
    • Worm, M.1    Lee, H.H.2    Kleine-Tebbe, J.3
  • 61
    • 85027938929 scopus 로고    scopus 로고
    • Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children
    • Santos AF, Douiri A, Becares N et al. Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children. J Allergy Clin Immunol 2014; 134:645-52.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 645-652
    • Santos, A.F.1    Douiri, A.2    Becares, N.3
  • 62
    • 0023720830 scopus 로고
    • MHC class II restriction specificity of cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite)
    • O'Hehir RE, Eckels DD, Frew AJ, Kay AB, Lamb JR. MHC class II restriction specificity of cloned human T lymphocytes reactive with Dermatophagoides farinae (house dust mite). Immunology 1988; 64:627-31.
    • (1988) Immunology , vol.64 , pp. 627-631
    • O'Hehir, R.E.1    Eckels, D.D.2    Frew, A.J.3    Kay, A.B.4    Lamb, J.R.5
  • 63
    • 0025003823 scopus 로고
    • Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes
    • O'Hehir RE, Mach B, Berte C et al. Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes. Int Immunol 1990; 2:885-92.
    • (1990) Int Immunol , vol.2 , pp. 885-892
    • O'Hehir, R.E.1    Mach, B.2    Berte, C.3
  • 64
    • 0026459617 scopus 로고
    • Peptide-induced nonresponsiveness of HLA-DP restricted human T cells reactive with Dermatophagoides spp. (house dust mite)
    • Higgins JA, Lamb JR, Marsh SG et al. Peptide-induced nonresponsiveness of HLA-DP restricted human T cells reactive with Dermatophagoides spp. (house dust mite). J Allergy Clin Immunol 1992; 90:749-56.
    • (1992) J Allergy Clin Immunol , vol.90 , pp. 749-756
    • Higgins, J.A.1    Lamb, J.R.2    Marsh, S.G.3
  • 65
    • 84879023453 scopus 로고    scopus 로고
    • A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population
    • McKinney DM, Southwood S, Hinz D et al. A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population. Immunogenetics 2013; 65:357-70.
    • (2013) Immunogenetics , vol.65 , pp. 357-370
    • McKinney, D.M.1    Southwood, S.2    Hinz, D.3
  • 66
    • 85017728570 scopus 로고    scopus 로고
    • ® Class II Rapid Epitope Discovery System (Last accessed 24 April 2015).
    • ® Class II Rapid Epitope Discovery System (Last accessed 24 April 2015). Available from: https://www.proimmune.com/ecommerce/page.php?page=reveal_class2.
  • 67
    • 84857822895 scopus 로고    scopus 로고
    • MHC class II tetramers
    • Nepom GT. MHC class II tetramers. J Immunol 2012; 188:2477-82.
    • (2012) J Immunol , vol.188 , pp. 2477-2482
    • Nepom, G.T.1
  • 68
    • 84860415012 scopus 로고    scopus 로고
    • Interaction of allergens, major histocompatibility complex molecules, and T cell receptors: a 'menage a trois' that opens new avenues for therapeutic intervention in type I allergy
    • Jahn-Schmid B, Pickl WF, Bohle B. Interaction of allergens, major histocompatibility complex molecules, and T cell receptors: a 'menage a trois' that opens new avenues for therapeutic intervention in type I allergy. Int Arch Allergy Immunol 2011; 156:27-42.
    • (2011) Int Arch Allergy Immunol , vol.156 , pp. 27-42
    • Jahn-Schmid, B.1    Pickl, W.F.2    Bohle, B.3
  • 69
    • 84858438417 scopus 로고    scopus 로고
    • Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles
    • Crack LR, Chan HW, McPherson T, Ogg GS. Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles. Clin Exp Dermatol 2012; 37:266-76.
    • (2012) Clin Exp Dermatol , vol.37 , pp. 266-276
    • Crack, L.R.1    Chan, H.W.2    McPherson, T.3    Ogg, G.S.4
  • 70
    • 0032935079 scopus 로고    scopus 로고
    • Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons
    • Friedl-Hajek R, Spangfort MD, Schou C, Breiteneder H, Yssel HJoost van Neerven RJ. Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons. Clin Exp Allergy 1999; 29:478-87.
    • (1999) Clin Exp Allergy , vol.29 , pp. 478-487
    • Friedl-Hajek, R.1    Spangfort, M.D.2    Schou, C.3    Breiteneder, H.4    Yssel, H.5    Joost van Neerven, R.J.6
  • 73
    • 0026571223 scopus 로고
    • T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones
    • Yssel H, Johnson KE, Schneider PV et al. T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones. J Immunol 1992; 148:738-45.
    • (1992) J Immunol , vol.148 , pp. 738-745
    • Yssel, H.1    Johnson, K.E.2    Schneider, P.V.3
  • 74
    • 0037114172 scopus 로고    scopus 로고
    • HLA-DP4, the most frequent HLA II molecule, defines a new supertype of peptide-binding specificity
    • Castelli FA, Buhot C, Sanson A et al. HLA-DP4, the most frequent HLA II molecule, defines a new supertype of peptide-binding specificity. J Immunol 2002; 169:6928-34.
    • (2002) J Immunol , vol.169 , pp. 6928-6934
    • Castelli, F.A.1    Buhot, C.2    Sanson, A.3
  • 75
    • 0025909134 scopus 로고
    • Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy
    • O'Hehir RE, Yssel H, Verma S, de Vries JE, Spits H, Lamb JR. Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy. Int Immunol 1991; 3:819-26.
    • (1991) Int Immunol , vol.3 , pp. 819-826
    • O'Hehir, R.E.1    Yssel, H.2    Verma, S.3    de Vries, J.E.4    Spits, H.5    Lamb, J.R.6
  • 76
    • 0025804289 scopus 로고
    • Functional inactivation of Dermatophagoides spp. (house dust mite) reactive human T-cell clones
    • O'Hehir RE, Aguilar BA, Schmidt TJ, Gollnick SO, Lamb JR. Functional inactivation of Dermatophagoides spp. (house dust mite) reactive human T-cell clones. Clin Exp Allergy 1991; 21:209-15.
    • (1991) Clin Exp Allergy , vol.21 , pp. 209-215
    • O'Hehir, R.E.1    Aguilar, B.A.2    Schmidt, T.J.3    Gollnick, S.O.4    Lamb, J.R.5
  • 77
    • 0028841786 scopus 로고
    • Peptide-induced anergy in allergen-specific human Th2 cells results in lack of cytokine production and B cell help for IgE synthesis. Reversal by IL-2, not by IL-4 or IL-13
    • Fasler S, Aversa G, Terr A, Thestrup-Pedersen K, de Vries JE, Yssel H. Peptide-induced anergy in allergen-specific human Th2 cells results in lack of cytokine production and B cell help for IgE synthesis. Reversal by IL-2, not by IL-4 or IL-13. J Immunol 1995; 155:4199-206.
    • (1995) J Immunol , vol.155 , pp. 4199-4206
    • Fasler, S.1    Aversa, G.2    Terr, A.3    Thestrup-Pedersen, K.4    de Vries, J.E.5    Yssel, H.6
  • 78
    • 0027225494 scopus 로고
    • CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide
    • Lake RA, O'Hehir RE, Verhoef A, Lamb JR. CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide. Int Immunol 1993; 5:461-6.
    • (1993) Int Immunol , vol.5 , pp. 461-466
    • Lake, R.A.1    O'Hehir, R.E.2    Verhoef, A.3    Lamb, J.R.4
  • 79
    • 0031179647 scopus 로고    scopus 로고
    • Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities
    • Faith A, Akdis CA, Akdis M, Simon HU, Blaser K. Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities. J Immunol 1997; 159:53-60.
    • (1997) J Immunol , vol.159 , pp. 53-60
    • Faith, A.1    Akdis, C.A.2    Akdis, M.3    Simon, H.U.4    Blaser, K.5
  • 80
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
    • Hoyne GF, O'Hehir RE, Wraith DC, Thomas WR, Lamb JR. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med 1993; 178:1783-8.
    • (1993) J Exp Med , vol.178 , pp. 1783-1788
    • Hoyne, G.F.1    O'Hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 82
    • 0027323846 scopus 로고
    • Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I
    • Briner TJ, Kuo MC, Keating KM, Rogers BL, Greenstein JL. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc Natl Acad Sci USA 1993; 90:7608-12.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7608-7612
    • Briner, T.J.1    Kuo, M.C.2    Keating, K.M.3    Rogers, B.L.4    Greenstein, J.L.5
  • 83
    • 0031054483 scopus 로고    scopus 로고
    • Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1
    • Bauer L, Bohle B, Jahn-Schmid B et al. Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1. Clin Exp Immunol 1997; 107:536-41.
    • (1997) Clin Exp Immunol , vol.107 , pp. 536-541
    • Bauer, L.1    Bohle, B.2    Jahn-Schmid, B.3
  • 84
    • 34548245023 scopus 로고    scopus 로고
    • Intraoral administration of a T-cell epitope peptide induces immunological tolerance in Cry j 2-sensitized mice
    • Yoshitomi T, Nakagami Y, Hirahara K, Taniguchi Y, Sakaguchi M, Yamashita M. Intraoral administration of a T-cell epitope peptide induces immunological tolerance in Cry j 2-sensitized mice. J Pept Sci 2007; 13:499-503.
    • (2007) J Pept Sci , vol.13 , pp. 499-503
    • Yoshitomi, T.1    Nakagami, Y.2    Hirahara, K.3    Taniguchi, Y.4    Sakaguchi, M.5    Yamashita, M.6
  • 85
    • 0032416930 scopus 로고    scopus 로고
    • Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2-primed mice
    • Hirahara K, Saito S, Serizawa N et al. Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2-primed mice. J Allergy Clin Immunol 1998; 102:961-7.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 961-967
    • Hirahara, K.1    Saito, S.2    Serizawa, N.3
  • 86
    • 34548242742 scopus 로고    scopus 로고
    • Intranasal immunization with a dominant T-cell epitope peptide of a major allergen of olive pollen prevents mice from sensitization to the whole allergen
    • Marazuela EG, Rodriguez R, Fernandez-Garcia H, Garcia MS, Villalba M, Batanero E. Intranasal immunization with a dominant T-cell epitope peptide of a major allergen of olive pollen prevents mice from sensitization to the whole allergen. Mol Immunol 2008; 45:438-45.
    • (2008) Mol Immunol , vol.45 , pp. 438-445
    • Marazuela, E.G.1    Rodriguez, R.2    Fernandez-Garcia, H.3    Garcia, M.S.4    Villalba, M.5    Batanero, E.6
  • 87
    • 0031939202 scopus 로고    scopus 로고
    • Antibody responses to bee melittin (Api m 4) and hornet antigen 5 (Dol m 5) in mice treated with the dominant T-cell epitope peptides
    • King TP, Lu G, Agosto H. Antibody responses to bee melittin (Api m 4) and hornet antigen 5 (Dol m 5) in mice treated with the dominant T-cell epitope peptides. J Allergy Clin Immunol 1998; 101:397-403.
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 397-403
    • King, T.P.1    Lu, G.2    Agosto, H.3
  • 88
    • 0034665515 scopus 로고    scopus 로고
    • Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice
    • Astori M, von Garnier C, Kettner A, Dufour N, Corradin G, Spertini F. Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice. J Immunol 2000; 165:3497-505.
    • (2000) J Immunol , vol.165 , pp. 3497-3505
    • Astori, M.1    von Garnier, C.2    Kettner, A.3    Dufour, N.4    Corradin, G.5    Spertini, F.6
  • 89
    • 67650492400 scopus 로고    scopus 로고
    • Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression
    • Campbell JD, Buckland KF, McMillan SJ et al. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med 2009; 206:1535-47.
    • (2009) J Exp Med , vol.206 , pp. 1535-1547
    • Campbell, J.D.1    Buckland, K.F.2    McMillan, S.J.3
  • 90
    • 83555161730 scopus 로고    scopus 로고
    • Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb/c mouse model of egg allergy
    • Rupa P, Mine Y. Oral immunotherapy with immunodominant T-cell epitope peptides alleviates allergic reactions in a Balb/c mouse model of egg allergy. Allergy 2012; 67:74-82.
    • (2012) Allergy , vol.67 , pp. 74-82
    • Rupa, P.1    Mine, Y.2
  • 91
    • 84896745654 scopus 로고    scopus 로고
    • Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation
    • Till SJ, Raynsford EJ, Reynolds CJ et al. Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax 2014; 69:335-45.
    • (2014) Thorax , vol.69 , pp. 335-345
    • Till, S.J.1    Raynsford, E.J.2    Reynolds, C.J.3
  • 92
    • 0030802812 scopus 로고    scopus 로고
    • Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression
    • Hoyne GF, Jarnicki AG, Thomas WR, Lamb JR. Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. Int Immunol 1997; 9:1165-73.
    • (1997) Int Immunol , vol.9 , pp. 1165-1173
    • Hoyne, G.F.1    Jarnicki, A.G.2    Thomas, W.R.3    Lamb, J.R.4
  • 93
    • 84873308942 scopus 로고    scopus 로고
    • Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation
    • Mackenzie KJ, Fitch PM, Leech MD et al. Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation. Immunology 2013; 138:258-68.
    • (2013) Immunology , vol.138 , pp. 258-268
    • Mackenzie, K.J.1    Fitch, P.M.2    Leech, M.D.3
  • 94
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Muller U, Akdis CA, Fricker M et al. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 1998; 101:747-54.
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 747-754
    • Muller, U.1    Akdis, C.A.2    Fricker, M.3
  • 95
    • 0037395291 scopus 로고    scopus 로고
    • Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial
    • Fellrath JM, Kettner A, Dufour N et al. Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial. J Allergy Clin Immunol 2003; 111:854-61.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 854-861
    • Fellrath, J.M.1    Kettner, A.2    Dufour, N.3
  • 96
    • 0028287894 scopus 로고
    • Immunotherapy with T-cell-reactive peptides derived from allergens
    • Wallner BP, Gefter ML. Immunotherapy with T-cell-reactive peptides derived from allergens. Allergy 1994; 49:302-8.
    • (1994) Allergy , vol.49 , pp. 302-308
    • Wallner, B.P.1    Gefter, M.L.2
  • 98
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • Haselden BM, Kay AB, Larche M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 1999; 189:1885-94.
    • (1999) J Exp Med , vol.189 , pp. 1885-1894
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 100
    • 0030444839 scopus 로고    scopus 로고
    • Fel d 1 peptides: effect on skin tests and cytokine synthesis in cat-allergic human subjects
    • Simons FE, Imada M, Li Y, Watson WT, HayGlass KT. Fel d 1 peptides: effect on skin tests and cytokine synthesis in cat-allergic human subjects. Int Immunol 1996; 8:1937-45.
    • (1996) Int Immunol , vol.8 , pp. 1937-1945
    • Simons, F.E.1    Imada, M.2    Li, Y.3    Watson, W.T.4    HayGlass, K.T.5
  • 101
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial
    • Oldfield WL, Larche M, Kay AB. Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 2002; 360:47-53.
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 102
    • 33846949713 scopus 로고    scopus 로고
    • Peptide immunotherapy for allergic diseases
    • Larche M. Peptide immunotherapy for allergic diseases. Allergy 2007; 62:325-31.
    • (2007) Allergy , vol.62 , pp. 325-331
    • Larche, M.1
  • 103
    • 80053546277 scopus 로고    scopus 로고
    • T cell epitope-based allergy vaccines
    • Larche M. T cell epitope-based allergy vaccines. Curr Top Microbiol Immunol 2011; 352:107-19.
    • (2011) Curr Top Microbiol Immunol , vol.352 , pp. 107-119
    • Larche, M.1
  • 104
    • 84884241859 scopus 로고    scopus 로고
    • Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis
    • Worm M, Patel D, Creticos PS. Cat peptide antigen desensitisation for treating cat allergic rhinoconjunctivitis. Expert Opin Investig Drugs 2013; 22:1347-57.
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 1347-1357
    • Worm, M.1    Patel, D.2    Creticos, P.S.3
  • 105
    • 4644257344 scopus 로고    scopus 로고
    • Cat allergen peptide immunotherapy reduces CD4(+) T cell responses to cat allergen but does not alter suppression by CD4(+) CD25(+) T cells: a double-blind placebo-controlled study
    • Smith TR, Alexander C, Kay AB, Larche M, Robinson DS. Cat allergen peptide immunotherapy reduces CD4(+) T cell responses to cat allergen but does not alter suppression by CD4(+) CD25(+) T cells: a double-blind placebo-controlled study. Allergy 2004; 59:1097-101.
    • (2004) Allergy , vol.59 , pp. 1097-1101
    • Smith, T.R.1    Alexander, C.2    Kay, A.B.3    Larche, M.4    Robinson, D.S.5
  • 106
    • 84927775059 scopus 로고    scopus 로고
    • Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects
    • Couroux P, Patel D, Armstrong K, Larche M, Hafner RP. Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy 2015; 45:974-81.
    • (2015) Clin Exp Allergy , vol.45 , pp. 974-981
    • Couroux, P.1    Patel, D.2    Armstrong, K.3    Larche, M.4    Hafner, R.P.5
  • 108
    • 56749096284 scopus 로고    scopus 로고
    • Sublingual immunotherapy: what have we learnt from the 'big trials'?
    • Durham SR. Sublingual immunotherapy: what have we learnt from the 'big trials'? Curr Opin Allergy Clin Immunol 2008; 8:577-84.
    • (2008) Curr Opin Allergy Clin Immunol , vol.8 , pp. 577-584
    • Durham, S.R.1
  • 109
    • 84909635220 scopus 로고    scopus 로고
    • Safety and Tolerability of Escalating Doses of House Dust Mite- Peptide Antigen Desensitization (HDM-PAD)
    • Larche M, Hickey P, Hebert J, Hafner R. Safety and Tolerability of Escalating Doses of House Dust Mite- Peptide Antigen Desensitization (HDM-PAD). J Allergy Clin Immunol 2013; 131:AB37.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. AB37
    • Larche, M.1    Hickey, P.2    Hebert, J.3    Hafner, R.4
  • 110
    • 84927615385 scopus 로고    scopus 로고
    • Four doses of Der p derived synthetic peptide immuno-regulatory epitopes over 3 months results in a persistent treatment effect at 1 year on symptoms of House Dust Mite allergy
    • Hafner RP, Couroux P, Armstrong K, Salapatek AM, Patel D, Larche M. Four doses of Der p derived synthetic peptide immuno-regulatory epitopes over 3 months results in a persistent treatment effect at 1 year on symptoms of House Dust Mite allergy. Allergy 2014; 69:31-2.
    • (2014) Allergy , vol.69 , pp. 31-32
    • Hafner, R.P.1    Couroux, P.2    Armstrong, K.3    Salapatek, A.M.4    Patel, D.5    Larche, M.6
  • 111
    • 84927604970 scopus 로고    scopus 로고
    • A short course of synthetic peptide immuno-regulatory epitopes derived from grass allergens leads to a reduction in grass allergy symptoms
    • Ellis AK, Frankish CW, Armstrong K et al. A short course of synthetic peptide immuno-regulatory epitopes derived from grass allergens leads to a reduction in grass allergy symptoms. Allergy 2014; 69:32.
    • (2014) Allergy , vol.69 , pp. 32
    • Ellis, A.K.1    Frankish, C.W.2    Armstrong, K.3
  • 112
    • 84889608898 scopus 로고    scopus 로고
    • Validation of peptide immunotherapy as a new approach in the treatment of allergic rhinoconjunctivitis: the clinical benefits of treatment with Amb a 1-derived T cell epitopes
    • Hafner R, Salapatek A, Patel D, Larche M, Laidler P. Validation of peptide immunotherapy as a new approach in the treatment of allergic rhinoconjunctivitis: the clinical benefits of treatment with Amb a 1-derived T cell epitopes. J Allergy Clin Immunol 2012; 129:AB368.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. AB368
    • Hafner, R.1    Salapatek, A.2    Patel, D.3    Larche, M.4    Laidler, P.5
  • 113
    • 84919682478 scopus 로고    scopus 로고
    • Mechanisms of peptide immunotherapy in allergic airways disease
    • Larche M. Mechanisms of peptide immunotherapy in allergic airways disease. Ann Am Thorac Soc 2014; 11(Suppl 5):S292-6.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. S292-S296
    • Larche, M.1
  • 114
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M, Wraith DC. Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2005; 11:S69-76.
    • (2005) Nat Med , vol.11 , pp. S69-S76
    • Larche, M.1    Wraith, D.C.2
  • 115
    • 35348854507 scopus 로고    scopus 로고
    • Sublingual allergen immunotherapy: immunological mechanisms and prospects for refined vaccine preparation
    • O'Hehir RE, Sandrini A, Anderson GP, Rolland JM. Sublingual allergen immunotherapy: immunological mechanisms and prospects for refined vaccine preparation. Curr Med Chem 2007; 14:2235-44.
    • (2007) Curr Med Chem , vol.14 , pp. 2235-2244
    • O'Hehir, R.E.1    Sandrini, A.2    Anderson, G.P.3    Rolland, J.M.4
  • 116
    • 33645301858 scopus 로고    scopus 로고
    • Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy
    • Tarzi M, Klunker S, Texier C et al. Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy. Clin Exp Allergy 2006; 36:465-74.
    • (2006) Clin Exp Allergy , vol.36 , pp. 465-474
    • Tarzi, M.1    Klunker, S.2    Texier, C.3
  • 117
    • 18244391173 scopus 로고    scopus 로고
    • T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
    • Verhoef A, Alexander C, Kay AB, Larche M. T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med 2005; 2:e78.
    • (2005) PLoS Med , vol.2
    • Verhoef, A.1    Alexander, C.2    Kay, A.B.3    Larche, M.4
  • 118
    • 13244291456 scopus 로고    scopus 로고
    • Fel d 1-derived T cell peptide therapy induces recruitment of CD4+ CD25+; CD4+ interferon-gamma+ T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects
    • Alexander C, Ying S, Kay AB, Larche M. Fel d 1-derived T cell peptide therapy induces recruitment of CD4+ CD25+; CD4+ interferon-gamma+ T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects. Clin Exp Allergy 2005; 35:52-8.
    • (2005) Clin Exp Allergy , vol.35 , pp. 52-58
    • Alexander, C.1    Ying, S.2    Kay, A.B.3    Larche, M.4
  • 120
    • 2142760975 scopus 로고    scopus 로고
    • Tolerance induced by allergen immunotherapy
    • Plaut M, Rotrosen D. Tolerance induced by allergen immunotherapy. Clin Allergy Immunol 2004; 18:681-702.
    • (2004) Clin Allergy Immunol , vol.18 , pp. 681-702
    • Plaut, M.1    Rotrosen, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.