3-Layer-based analysis of peptide-MHC interaction: In silico prediction, peptide binding affinity and T cell activation in a relevant allergen-specific model

Molecular Immunology

Volumn 46, Issue 8-9, 2009, Pages 1839-1844

  Knapp, Bernhard ^a   Omasits, Ulrich ^a   Bohle, Barbara ^a   Maillere, Bernard ^b   Ebner, Christof ^c   Schreiner, Wolfgang ^a   Jahn Schmid, Beatrice ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^c Allergie Ambulatorium Rennweg Vienna   (Austria)

Author keywords

Allergen; Art v 1; Molecular Dynamics; Peptide MHC binding; Peptide MHC class II TCR interaction; Simulation; T cell activation; T cell epitope prediction

Indexed keywords

ALLERGEN; HLA DR1 ANTIGEN; POLLEN ANTIGEN; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; DNA FLANKING REGION; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ALLERGENS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN PRESENTATION; COMPUTER SIMULATION; EPITOPE MAPPING; FORECASTING; HLA-DR ANTIGENS; HUMANS; IMAGING, THREE-DIMENSIONAL; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES;

ARTEMISIA VULGARIS;

EID: 64149087447     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.01.009     Document Type: Article

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