Effectiveness of subcutaneous versus sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: A systematic review

Journal of Allergy and Clinical Immunology: In Practice

Volumn 1, Issue 4, 2013, Pages 361-369

  Chelladurai, Yohalakshmi ^a   Suarez Cuervo, Catalina ^a   Erekosima, Nkiruka ^a   Kim, Julia M ^a   Ramanathan, Murugappan ^a   Segal, Jodi B ^a   Lin, Sandra Y ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergen specific immunotherapy; Allergic asthma; Allergic rhinitis; Allergic rhinoconjunctivitis; Atopy; RCT; SCIT; SLIT; Subcutaneous immunotherapy; Sublingual immunotherapy

Indexed keywords

IMMUNOMODULATING AGENT;

ADOLESCENT; ADULT; ALLERGIC RHINITIS; ANAPHYLAXIS; ARTICLE; ASTHMA; CHILD; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; DRUG FATALITY; DRUG SAFETY; DRUG USE; EVIDENCE BASED MEDICINE; FEMALE; GASTROINTESTINAL SYMPTOM; HOUSE DUST ALLERGY; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POLLEN ALLERGY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT DISEASE; SCHOOL CHILD; SCORING SYSTEM; SUBCUTANEOUS IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ALLERGEN-SPECIFIC IMMUNOTHERAPY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ALLERGIC RHINOCONJUNCTIVITIS; ATOPY; SUBCUTANEOUS IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY;

ADOLESCENT; ADULT; ASTHMA; CHILD; CLINICAL TRIALS AS TOPIC; CONJUNCTIVITIS, ALLERGIC; DESENSITIZATION, IMMUNOLOGIC; HUMANS; INJECTIONS, SUBCUTANEOUS; RHINITIS, ALLERGIC, PERENNIAL; SUBLINGUAL IMMUNOTHERAPY;

EID: 84879836940     PISSN: 22132198     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaip.2013.04.005     Document Type: Article

References (31)

1. Nathan R.A. The burden of allergic rhinitis. Allergy Asthma Proc 2007, 28:3-9.
2. Wright A.L., Holberg C.J., Martinez F.D., Halonen M., Morgan W., Taussig L.M. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics 1994, 94:895-901.
3. Min Y.G. The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res 2010, 2:65-76.
4. Brozek J.L., Bousquet J., Baena-Cagnani C.E., Bonini S., Canonica G.W., Casale T.B., et al. Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines: 2010 revision. JAllergy Clin Immunol 2010, 126:466-476.
5. Fanta C.H. Asthma. NEngl J Med 2009, 360:1002-1014.
6. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma-summary report 2007. JAllergy Clin Immunol 2007, 120:S94-138.
7. Gergen P.J., Arbes S.J., Calatroni A., Mitchell H.E., Zeldin D.C. Total ige levels and asthma prevalence in the us population: results from the National Health and Nutrition Examination Survey 2005-2006. JAllergy Clin Immunol 2009, 124:447-453.
8. Bousquet J., Lockey R., Malling H.J., Alvarez-Cuesta E., Canonica G.W., Chapman M.D., et al. Allergen immunotherapy: therapeutic vaccines for allergic diseases. World Health Organization. American Academy of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 1998, 81:401-405.
9. Passalacqua G., Compalati E., Canonica G.W. Advances in allergen-specific immunotherapy. Curr Drug Targets 2009, 10:1255-1262.
10. Durham S.R. Mechanisms of immunotherapy. Drugs Today (Barc) 2008, 44(Suppl B):93-94.
11. Adkinson N.F. Desensitization for drug hypersensitivity. JAllergy Clin Immunol 2008, 122:581-582.
12. Sabin B.R., Saltoun C.A., Avila P.C. Advances in upper airway diseases and allergen immunotherapy. JAllergy Clin Immunol 2011, 127:342-350.
13. O'Mahony L., Akdis M., Crameri R., Akdis C.A. Novel immunotherapeutic approaches for allergy and asthma. Autoimmunity 2010, 43:493-503.
14. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Chapter 8: Assessing risk of bias in included studies. The Cochrane Collaboration, 2011. Available from: Accessed May 29, 2013. http://www.cochrane.org/sites/default/files/uploads/handbook/Handbook510 pdf_Ch08_RiskOfBias.pdf.
15. Lundh A., Sismondo S., Lexchin J., Busuioc O.A., Bero L. Industry sponsorship and research outcome. Cochrane Database Syst Rev 2012, 12:MR000033.
16. Drugs and devices look more effective in studies sponsored by industry. BMJ 2012, 345:e8386.
17. Atkins D., Best D., Briss P.A., Eccles M., Falck-Ytter Y., Flottorp S., et al. Grading quality of evidence and strength of recommendations. BMJ 2004, 328:1490. GRADE Working Group.
18. Khinchi M.S., Poulsen L.K., Carat F., Andre C., Hansen A.B., Malling H.J. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy 2004, 59:45-53.
19. Mungan D., Misirligil Z., Gurbuz L. Comparison of the efficacy of subcutaneous and sublingual immunotherapy in mite-sensitive patients with rhinitis and asthma-a placebo controlled study. Ann Allergy Asthma Immunol 1999, 82:485-490.
20. Yukselen A., Kendirli S.G., Yilmaz M., Altintas D.U., Karakoc G.B. Effect of one-year subcutaneous and sublingual immunotherapy on clinical and laboratory parameters in children with rhinitis and asthma: a randomized, placebo-controlled, double-blind, double-dummy study. Int Arch Allergy Immunol 2011, 157:288-298.
21. Keles S., Karakoc-Aydiner E., Ozen A., Izgi A.G., Tevetoglu A., Akkoc T., et al. Anovel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes. JAllergy Clin Immunol 2011, 128:808-815.e807.
22. Mauro M., Russello M., Incorvaia C., Gazzola G.B., Di Cara G., Frati F. Comparison of efficacy, safety and immunologic effects of subcutaneous and sublingual immunotherapy in birch pollinosis: a randomized study. Eur Ann Allergy Clin Immunol 2007, 39:119-122.
23. Piazza I., Bizzaro N. Humoral response to subcutaneous, oral, and nasal immunotherapy for allergic rhinitis due to dermatophagoides pteronyssinus. Ann Allergy 1993, 71:461-469.
24. Tahamiler R., Saritzali G., Canakcioglu S., Ozcora E., Dirican A. Comparison of the long-term efficacy of subcutaneous and sublingual immunotherapies in perennial rhinitis. ORL J Otorhinolaryngol Relat Spec 2008, 70:144-150.
25. Eifan A., Akkoc T., Yildiz A., Keles S., Tevetoglu A., Izgi A., et al. Clinical efficacy and immunological mechanisms of sublingual and subcutaneous specific immunotherapy in asthmatic/rhinitis children sensitised to house dust mite: an open randomised controlled study. Clin Exp Allergy 2010, 40:922-932.
26. Matricardi P.M., Kuna P., Panetta V., Wahn U., Narkus A. Subcutaneous immunotherapy and pharmacotherapy in seasonal allergic rhinitis: a comparison based on meta-analyses. JAllergy Clin Immunol 2011, 128:791-799.e796.
27. Calderon M.A., Alves B., Jacobson M., Hurwitz B., Sheikh A., Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007, CD001936.
28. Abramson M.J., Puy R.M., Weiner J.M. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev 2010, CD001186.
29. Wilson D.R., Torres L.I., Durham S.R. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev 2003, CD002893.
30. Radulovic S., Wilson D., Calderon M., Durham S. Systematic reviews of sublingual immunotherapy (slit). Allergy 2011, 66:740-752.
31. Di Bona D., Plaia A., Leto-Barone M.S., La Piana S., Di Lorenzo G. Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis-based comparison. JAllergy Clin Immunol 2012, 130:1097-1107.e1092.