In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar rats

Journal of Functional Foods

Volumn 15, Issue , 2015, Pages 294-300

  García Tejedor, Aurora ^a   Castelló Ruiz, María ^b,c   Gimeno Alcañíz, José V ^a   Manzanares, Paloma ^a   Salom, Juan B ^b,c  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Angiotensin induced hypertension; Antihypertensive peptides; In vivo ACE inhibition; Lactoferrin derived peptides; Renin angiotensin system; Wistar rat

Indexed keywords

RATTUS; RATTUS NORVEGICUS;

EID: 84929235271     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.03.039     Document Type: Article

References (35)

1. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) Scientific Opinion on the substantiation of health claims related to isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) and maintenance of normal blood pressure. EFSA Journal 2012, 10:2715-2737.
2. Fernández-Musoles R., Castelló-Ruiz M., Arce C., Manzanares P., Ivorra M.D., Salom J.B. Antihypertensive mechanism of lactoferrin-derived peptides: Angiotensin receptor blocking effect. Journal of Agricultural and Food Chemistry 2014, 62:173-181.
3. Fernández-Musoles R., López-Díez J.J., Torregrosa G., Vallés S., Alborch E., Manzanares P., Salom J.B. Lactoferricin B-derived peptides with inhibitory effects on ECE-dependent vasoconstriction. Peptides 2010, 31:1926-1933.
4. Fernández-Musoles R., Manzanares P., Burguete M.C., Alborch E., Salom J.B. In vivo angiotensin I-converting enzyme inhibition by long-term intake of antihypertensive lactoferrin hydrolysate in spontaneously hypertensive rats. Food Research International 2013, 54:627-632.
5. Fernández-Musoles R., Salom J.B., Martínez-Maqueda D., López-Díez J.J., Recio I., Manzanares P. Antihypertensive effects of lactoferrin hydrolysates: Inhibition of angiotensin- and endothelin-converting enzymes. Food Chemistry 2013, 139:994-1000.
6. Fragasso G., Maranta F., Montanaro C., Salerno A., Torlasco C., Margonato A. Pathophysiologic therapeutic targets in hypertension: A cardiological point of view. Expert Opinion on Therapeutic Targets 2012, 16:179-193.
7. Fuglsang A., Nilsson D., Nyborg N.C. Characterization of new milk-derived inhibitors of angiotensin converting enzyme in vitro and in vivo. Journal of Enzyme Inhibition and Medicinal Chemistry 2003, 18:407-412.
8. Fuglsang A., Rattray F.P., Nilsson D., Nyborg N.C. Lactic acid bacteria: Inhibition of angiotensin converting enzyme in vitro and in vivo. Antonie van Leeuwenhoek 2003, 83:27-34.
9. García-Tejedor A., Gimeno-Alcañíz J.V., Tavárez S., Alonso E., Salom J.B., Manzanares P. An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells. Journal of Functional Foods 2015, 12:45-54.
10. García-Tejedor A., Padilla B., Salom J.B., Belloch C., Manzanares P. Dairy yeasts produce milk protein-derived antihypertensive hydrolysates. Food Research International 2013, 53:203-208.
11. García-Tejedor A., Sánchez-Rivera L., Castelló-Ruiz M., Recio I., Salom J.B., Manzanares P. Novel antihypertensive lactoferrin-derived peptides produced by Kluyveromyces marxianus: Gastrointestinal stability profile and in vivo angiotensin I-converting enzyme (ACE) inhibition. Journal of Agricultural and Food Chemistry 2014, 62:1609-1616.
12. Hartmann R., Meisel H. Food-derived peptides with biological activity: From research to food applications. Current Opinion in Biotechnology 2007, 18:163-169.
13. Hernández-Ledesma B., Contreras M.M., Recio I. Antihypertensive peptides: Production, bioavailability and incorporation into foods. Advances on Colloid and Interface Science 2011, 165:23-35.
14. Hong F., Ming L., Yi S., Zhanxia L., Yongquan W., Chi L. The antihypertensive effect of peptides: A novel alternative to drugs?. Peptides 2008, 29:1062-1071.
15. Ibrahim J., Berk B.C., Hughes A.D. Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats. Clinical and Experimental Hypertension 2006, 28:57-72.
16. Jäkälä P., Hakala A., Turpeinen A.M., Korpela R., Vapaatalo H. Casein-derived bioactive tripeptides Ile-Pro-Pro and Val-Pro-Pro attenuate the development of hypertension and improve endothelial function in salt-loaded Goto-Kakizaki rats. Journal of Functional Foods 2009, 1:366-374.
17. Kobayashi K., Imanishi T., Akasaka T. Endothelial progenitor cell differentiation and senescence in an angiotensin II-infusion rat model. Hypertension Research 2006, 29:449-455.
18. Korhonen H. Milk-derived bioactive peptides: From science to applications. Journal of Functional Foods 2009, 1:177-187.
19. Levens N.R., Peach M.J., Vaughan E.D., Weed W.C., Carey R.M. Responses of blood pressure and angiotensin-converting enzyme activity to acute captopril administration in normotensive and hypertensive rats. Endocrinology 1981, 108:536-544.
20. Liu J.C., Hsu F.L., Tsai J.C., Chan P., Liu J.Y., Thomas G.N., Tomlinson B., Lo M.Y., Lin J.Y. Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme. Life Sciences 2003, 73:1543-1555.
21. Lu J., Sawano Y., Miyakawa T., Xue Y.L., Cai M.Y., Egashira Y., Ren D.F., Tanokura M. One-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats. Journal of Agricultural and Food Chemistry 2011, 59:559-563.
22. Martínez-Maqueda D., Miralles B., Recio I., Hernández-Ledesma B. Antihypertensive peptides from food proteins: A review. Food & Function 2012, 3:350-361.
23. Obernier J.A., Baldwin R.L. Establishing an appropriate period of acclimatization following transportation of laboratory animals. ILAR Journal 2006, 47:364-369.
24. Prasad K. Secoisolariciresinol diglucoside (SDG) isolated from flaxseed, an alternative to ACE inhibitors in the treatment of hypertension. International Journal of Angiology 2013, 22:235-238.
25. Roberfroid M.B. Global view on functional foods: European perspectives. British Journal of Nutrition 2002, 88:S133-S138.
26. Ruilope L.M. Current challenges in the clinical management of hypertension. Nature Reviews Cardiology 2011, 9:267-275.
27. Ruiz-Giménez P., Ibáñez A., Salom J.B., Marcos J.F., López-Díez J.J., Vallés S., Torregrosa G., Alborch E., Manzanares P. Antihypertensive properties of lactoferricin B-derived peptides. Journal of Agricultural and Food Chemistry 2010, 58:6721-6727.
28. Ruiz-Giménez P., Salom J.B., Marcos J.F., Vallés S., Martínez-Maqueda D., Recio I., Torregrosa G., Alborch E., Manzanares P. Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides. Food Chemistry 2012, 131:266-273.
29. Tavares T., Sevilla M.Á., Montero M.J., Carrón R., Malcata F.X. Acute effect of whey peptides upon blood pressureof hypertensive rats, and relationship with their angiotensin-converting enzyme inhibitory activity. Molecular Nutrition & Food Research 2012, 56:316-324.
30. Textor S.C., Brunner H.R., Gavras H. Converting enzyme inhibition during chronic angiotensin II infusion in rats. Evidence against a nonangiotensin mechanism. Hypertension 1981, 3:269-276.
31. Udenigwe C.C., Mohan A. Mechanisms of food protein derived antihypertensive peptides other than ACE inhibition. Journal of Functional Foods 2014, 8C:45-52.
32. Van den Buuse M. Circadian rhythms of blood pressure and heart rate in conscious rats: Effects of light cycle shift and timed feeding. Physiology & Behaviour 1999, 68:9-15.
33. Waghulde H., Mohan M., Kasture S., Balaraman R. Punica granatum attenuates angiotensin-II induced hypertension in Wistar rats. International Journal of PharmTech Research 2010, 2:60-67.
34. Wang X., Wang L., Cheng X., Zhou J., Tang X., Mao X.Y. Hypertension-attenuating effect of whey protein hydrolysate on spontaneously hypertensive rats. Food Chemistry 2012, 134:122-126.
35. Yang H.Y., Yang S.C., Chen J.R., Tzeng Y.H., Han B.C. Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats. British Journal of Nutrition 2004, 92:507-512.