Novel antihypertensive lactoferrin-derived peptides produced by Kluyveromyces marxianus: Gastrointestinal stability profile and in vivo angiotensin I-converting enzyme (ACE) inhibition

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 7, 2014, Pages 1609-1616

  García Tejedor, Aurora ^a   Sánchez Rivera, Laura ^b   Castelló Ruiz, María ^c,d   Recio, Isidra ^b   Salom, Juan B ^c,d   Manzanares, Paloma ^a  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

antihypertensive effect; gastrointestinal digestion; in vivo ACE inhibition; Kluyveromyces marxianus; lactoferrin derived peptides

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LACTOFERRIN; PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOTRANSFORMATION; BLOOD PRESSURE; CATTLE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; HUMAN; HYPERTENSION; KLUYVEROMYCES; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ADMINISTRATION, ORAL; AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOTRANSFORMATION; BLOOD PRESSURE; CATTLE; HUMANS; HYPERTENSION; KLUYVEROMYCES; LACTOFERRIN; MALE; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, INBRED SHR;

BLOOD PRESSURE; CHROMATOGRAPHY; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; PEPTIDES; PROTEINS;

ACE INHIBITION; ANTIHYPERTENSIVE EFFECT; GASTROINTESTINAL DIGESTION; KLUYVEROMYCES MARXIANUS; LACTOFERRIN;

ENZYME INHIBITION;

BOVINAE; KLUYVEROMYCES MARXIANUS; RATTUS;

EID: 84894422010     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4053868     Document Type: Article

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