Antihypertensive effects of lactoferrin hydrolyzates: Inhibition of angiotensin- and endothelin-converting enzymes

Food Chemistry

Volumn 139, Issue 1-4, 2013, Pages 994-1000

  Fernández Musoles, Ricardo ^a   Salom, Juan B ^b,c   Martínez Maqueda, Daniel ^d   López Díez, José Javier ^a   Recio, Isidra ^d   Manzanares, Paloma ^a  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

ACE dependent vasoconstriction; Antihypertensive effect; ECE dependent vasoconstriction; Endothelin system; Lactoferrin hydrolyzates; Renin angiotensin system; Vasopeptidase inhibitors

Indexed keywords

ACE-DEPENDENT VASOCONSTRICTION; ANTIHYPERTENSIVE EFFECT; ECE-DEPENDENT VASOCONSTRICTION; ENDOTHELIN; LACTOFERRIN; RENIN-ANGIOTENSIN SYSTEM;

BIOLOGICAL MATERIALS; PEPTIDES;

ENZYME INHIBITION;

ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN CONVERTING ENZYME; LACTOFERRIN; LACTOFERRIN HYDROLYZATE; PEPSIN A; PROTEIN HYDROLYSATE; PROTEINASE K; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; EXPERIMENTAL RABBIT; ION TRAP MASS SPECTROMETRY; MALE; NONHUMAN; RAT; VASOCONSTRICTION;

AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CAROTID ARTERIES; CATTLE; ENDOTHELINS; HYDROLYSIS; HYPERTENSION; LACTOFERRIN; MALE; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; RABBITS; RATS; RATS, INBRED SHR; VASOCONSTRICTION;

BOVINAE; RATTUS;

EID: 84875913911     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.12.049     Document Type: Article

References (32)

1. A. Abubakar, T. Saito, H. Kitazawa, Y. Kawai, and T. Itoh Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion Journal of Dairy Science 81 1998 3131 3138
2. B. Battistini, B. Ayach, S. Molez, A. Blouin, and A.Y. Jeng Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats Clinical Science (London) 103 Suppl. 48 2002 363S 366S
3. B. Battistini, P. Daull, and A.Y. Jeng CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme Cardiovascular Drug Review 23 2005 317 330
4. R.M. Carey, and H.M. Siragy Newly recognized components of the renin-angiotensin system: Potential roles in cardiovascular and renal regulation Endocrine Reviews 24 2003 261 271
5. J.M. Centeno, M.C. Burguete, M. Castelló-Ruiz, M. Enrique, S. Vallés, and J.B. Salom Lactoferricin-related peptides with inhibitory effects on ACE-dependent vasoconstriction Journal of Agricultural and Food Chemistry 54 2006 5323 5329
6. H.S. Cheung, F.L. Wang, M.A. Ondetti, E.F. Sabo, and D.W. Cushman Binding of peptide substrates and inhibitors of angiotensin-converting enzyme: Importance of the COOH-terminal dipeptide sequence Journal of Biological Chemistry 255 1980 401 407
7. M.M. Contreras, R. Carrón, M.J. Montero, M. Ramos, and I. Recio Novel casein-derived peptides with antihypertensive activity International Dairy Journal 19 2009 566 573
8. W. Ebeling, N. Henrich, M. Klockow, H. Metz, H.D. Orth, and H. Lang Proteinase K from Tritirachium album Limber European Journal of Biochemistry 47 1974 91 97
9. R. Fernández-Musoles, J.J. López-Díez, G. Torregrosa, S. Vallés, E. Alborch, and P. Manzanares Lactoferricin B-derived peptides with inhibitory effects on ECE-dependent vasoconstriction Peptides 31 2010 1926 1933
10. A. Fuglsang, D. Nilsson, and N.C. Nyborg Characterization of new milk-derived inhibitors of angiotensin converting enzyme in vitro and in vivo Journal of Enzyme Inhibition and Medicinal Chemistry 18 2003 407 412
11. J.L. Gifford, H.N. Hunter, and H.J. Vogel Lactoferricin, a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties Cellular and Molecular Life Sciences 62 2005 2588 2598
12. N.-Y. Lee, J.-T. Cheng, T. Enomoto, and I. Nakamura The antihypertensive activity of angiotensin-converting enzyme inhibitory peptide containing in bovine lactoferrin Chinese Journal of Physiology 49 2006 67 73
13. G.H. Li, G.W. Le, Y.H. Shi, and S. Shrestha Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects Nutrition Research 24 2004 469 486
14. X. Liu, M. Zhang, C. Zhang, and C. Liu Angiotensin converting enzyme (ACE) inhibitory, antihypertensive and antihyperlipidaemic activities of protein hydrolysates from Rhopilema esculentum Food Chemistry 134 2012 2134 2140
15. W. Maes, J. van Camp, V. Vermeirssen, M. Hemeryck, J.M. Ketelslegers, and J. Schrezenmeir Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells Regulatory Peptides 118 2004 105 109
16. D. Martínez-Maqueda, B. Miralles, S. de Pascual-Teresa, I. Reverón, R. Muñoz, and I. Recio Food-derived peptides stimulate mucin secretion and gene expression in intestinal cells Journal of Agricultural and Food Chemistry 60 2012 8600 8605
17. M. Okitsu, A. Morita, M. Kakitani, M. Okada, and H. Yokogoshi Inhibition of the endothelin-converting enzyme by pepsin digests of food proteins Bioscience, Biotechnology, and Biochemistry 59 1995 325 326
18. S. Rao, J. Sun, Y. Liu, H. Zeng, Y. Su, and Y. Yang ACE inhibitory peptides and antioxidant peptides derived from in vitro digestion hydrolysates of hen egg white lysozyme Food Chemistry 135 2012 1245 1252
19. R. Rojas-Ronquillo, A. Cruz-Guerrero, A. Flores-Nájera, G. Rodríguez-Serrano, L. Gómez-Ruiz, and J.P. Reyes-Grajeda Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota International Dairy Journal 26 2012 147 154
20. D. Rousseau-Ralliard, F. Goirand, S. Tardivel, A. Lucas, F. Algaron, and D. Mollé Inhibitory effect of S1- and S2-casein hydrolysates on angiotensin I-converting enzyme in human endothelial cells in vitro, rat aortic tissue ex vivo, and renovascular hypertensive rats in vivo Journal of Dairy Science 93 2010 2906 2921
21. P. Ruiz-Giménez, M.C. Burguete, M. Castelló-Ruiz, F. Marcos, J.B. Salom, and S. Vallés Bovine lactoferrin pepsin hydrolysate exerts inhibitory effect on ACE-dependent vasoconstriction International Dairy Journal 17 2007 1212 1215
22. P. Ruiz-Giménez, A. Ibáñez, J.B. Salom, J.F. Marcos, J.J. López-Díez, and S. Vallés Antihypertensive properties of lactoferricin B-derived peptides Journal of Agricultural and Food Chemistry 58 2010 6721 6727
23. P. Ruiz-Giménez, J.B. Salom, J.F. Marcos, S. Vallés, D. Martínez-Maqueda, and I. Recio Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides Food Chemistry 131 2012 266 273
24. E.L. Schiffrin Vascular endothelin in hypertension Vascular Pharmacology 43 2005 19 29
25. M.A. Sentandreu, and F. Toldrá A rapid, simple and sensitive fluorescence method for the assay of angiotensin-I converting enzyme Food Chemistry 97 2006 546 554
26. C.R. Tirapelli, M.H. Fecteau, J.C. Honore, E. Legros, F. Gobeil, and P. D'Orleans-Juste Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta British Journal of Pharmacology 148 2006 527 535
27. C.C. Udenigwe, A.P. Adebiyi, A. Doyen, H. Li, L. Bazinet, and R.E. Aluko Low molecular weight flaxseed protein-derived arginine-containing peptides reduced blood pressure of spontaneously hypertensive rats faster than amino acid form of arginine and native flaxseed protein Food Chemistry 132 2012 468 475
28. C.C. Udenigwe, and R.E. Aluko Antioxidant and angiotensin converting enzyme inhibitory properties of a flaxseed protein-derived high Fischer ratio peptide mixture Journal of Agricultural and Food Chemistry 58 2010 4762 4768
29. C.C. Udenigwe, Y.-S. Lin, W.-C. Hou, and R.E. Aluko Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions Journal of Functional Foods 1 2009 199 207
30. Z. Vastag, L. Popovic, S. Popovic, V. Krimer, and D. Pericin Production of enzymatic hydrolysates with antioxidant and angiotensin-I converting enzyme inhibitory activity from pumpkin oil cake protein isolate Food Chemistry 124 2011 1316 1321
31. V. Vermeirssen, J. van Camp, and W. Verstraete Bioavailability of angiotensin I converting enzyme inhibitory peptides British Journal of Nutrition 92 2004 357 366
32. B. Williams The changing face of hypertension treatment: Treatment strategies from the 2007 ESH/ESC hypertension Guidelines Journal of Hypertension 27 Suppl. 3 2009 S19 S26