The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts

Immunology Letters

Volumn 165, Issue 2, 2015, Pages 90-101

  Schilter, Heidi ^a   Cantemir Stone, Carmen Z ^b   Leksa, Vladimir ^c,d   Ohradanova Repic, Anna ^c   Findlay, Alison D ^a   Deodhar, Mandar ^a   Stockinger, Hannes ^c   Song, Xiaomin ^e   Molloy, Mark ^e   Marsh, Clay B ^b   Jarolimek, Wolfgang ^a,f  

^a Drug Discovery   (Australia)

^b OHIO STATE UNIVERSITY   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d INSTITUTE OF CHEMISTRY   (Slovakia)

^e MACQUARIE UNIVERSITY   (Australia)

^f UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

Fibroblasts; Idiopathic pulmonary fibrosis; M6P; Mannose 6 phosphate; PXS64; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; PXS 64; SOMATOMEDIN B RECEPTOR; TENASCIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; ACTA2 PROTEIN, HUMAN; ACTIN; BIOLOGICAL MARKER; IGF2 PROTEIN, HUMAN; MANNOSE PHOSPHATE; MANNOSE-6-PHOSPHATE; PRODRUG; PXS25 COMPOUND; SOMATOMEDIN B;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROBLAST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; AIRWAY REMODELING; ANIMAL; BIOAVAILABILITY; CELL LINE; CHEMISTRY; DRUG EFFECTS; FIBROBLAST; GENETICS; IDIOPATHIC PULMONARY FIBROSIS; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; PATHOLOGY; PROTEOMICS; SYNTHESIS;

ACTINS; AIRWAY REMODELING; ANIMALS; BIOLOGICAL AVAILABILITY; BIOMARKERS; CELL LINE; COLLAGEN; FIBROBLASTS; FIBRONECTINS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INSULIN-LIKE GROWTH FACTOR II; LUNG; MANNOSEPHOSPHATES; MICE; MICE, KNOCKOUT; PRODRUGS; PROTEOMICS; SIGNAL TRANSDUCTION; TENASCIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84929191539     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2015.04.003     Document Type: Article

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