Strategies for carbohydrate recognition by the mannose 6-phosphate receptors

Glycobiology

Volumn 18, Issue 9, 2008, Pages 664-678

  Dahms, Nancy M ^a   Olson, Linda J ^a   Kim, Jung Ja P ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Lectin; Lysosome; Mannose 6 phosphate receptor; Protein targeting

Indexed keywords

BETA GLUCOSIDASE II; CARBOHYDRATE; CATION DEPENDENT MANNOSE 6 PHOSPHATE; CATION INDEPENDENT MANNOSE 6 PHOSPHATE; ERLECTIN; LECTIN; LYSOSOMAL ENZYME RECEPTOR PROTEIN; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE PHOSPHOTRANSFERASE; N ACETYLGLUCOSAMINE PHOSPHOTRANSFERASE GAMMA; PROTEIN OS 9; PROTEIN XTP3 B; UNCLASSIFIED DRUG; GLYCOPROTEIN; MANNOSE PHOSPHATE; MANNOSE-6-PHOSPHATE; OLIGOSACCHARIDE; SOMATOMEDIN B RECEPTOR;

BINDING AFFINITY; CARBOHYDRATE SYNTHESIS; CRYSTAL STRUCTURE; DROSOPHILA; ENZYME SYNTHESIS; HUMAN; LIGAND BINDING; LYSOSOME; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CARBOHYDRATE METABOLISM; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN BINDING; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARBOHYDRATE METABOLISM; CRYSTALLOGRAPHY, X-RAY; GLYCOPROTEINS; HUMANS; MANNOSEPHOSPHATES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; PROTEIN BINDING; RECEPTOR, IGF TYPE 2; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 58149107948     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwn061     Document Type: Review

References (132)

1. Aeed PA, Elhammer AP. 1994. Glycosylation of recombinant prorenin in insect cells: The insect cell line Sf9 does not express the mannose 6-phosphate recognition signal. Biochemistry. 33:8793-8797.
2. Bernasconi R, Pertel T, Luban J, Molinari M. 2008. A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: Inhibiting secretion of misfolded protein conformers and enhancing their disposal. J Biol Chem. 283:16446-16454.
3. Bhamidipati A, Denic V, Quan EM, Weissman JS. 2005. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor misfolded glycoproteins in the ER lumen. Mol Cell. 19:741-751.
4. Blanchard F, Duplomb L, Raher S, Vusio P, Hoflack B, Jacques Y, Godard A. 1999. Mannose 6-phosphate/insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transduction. J Biol Chem. 274:24685-24693.
5. Blanchard F, Raher S, Duplomb L, Vusio P, Pitard V, Taupin JL, Moreau JF, Hoflack B, Minvielle S, Jacques Y, et al. 1998. The mannose 6-phosphate/insulin-like growth factor II receptor is a nanomolar affinity receptor for glycosylated human leukemia inhibitory factor. J Biol Chem. 273:20886-20893.
6. Bonifacino JS. 2004. The GGA proteins: Adaptors on the move. Nat Rev Mol Cell Biol. 5:23-32.
7. Brady RO. 2006. Enzyme replacement for lysosomal diseases. Annu Rev Med. 57:283-296.
8. Braulke T,Mieskes G. 1992. Role of protein phosphatases in insulin-like growth factor II (IGF II)-stimulated mannose 6-phosphate/IGF II receptor redistribution. J Biol Chem. 267:17347-17353.
9. Breuer P, Korner C, Boker C, Herzog A, Pohlmann R, Braulke T. 1997. Serine phosphorylation site of the 46-kDa mannose 6-phosphate receptor is required for transport to the plasma membrane in Madin-Darby canine kidney and mouse fibroblast cells. Mol Biol Cell. 8:567-576.
10. Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, et al. 2008. Structure and functional analysis of the IGF-II/IGF2R interaction. EMBO J. 27:265-276.
11. Brown J, Esnouf RM, Jones MA, Linnell J, Harlos K, Hassan AB, Jones EY. 2002. Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J. 21:1054-1062.
12. Brunetti CR, Burke RL, Kornfeld S, Gregory W, Masiarz FR, Dingwell KS, Johnson DC. 1994. Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors. J Biol Chem. 269:17067-17074.
13. Chavez CA, Bohnsack RN, Kudo M, Gotschall RR, Canfield WM, Dahms NM. 2007. Domain 5 of the cation-independent mannose 6-phosphate receptor preferentially binds phosphodiesters (mannose 6-phosphate N acetylglucosamine ester). Biochemistry. 46:12604-12617.
14. Chen JJ, Zhu Z, Gershon AA, Gershon MD. 2004. Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster. Cell. 119:915-926.
15. Christianson JC, Shaler TA, Tyler RE, Kopito RR. 2008. OS-9 and GRP94 delivermutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol. 10:272-282.
16. Clayton C, Hausler T, Blattner J. 1995. Protein trafficking in kinetoplastid protozoa. Microbiol Rev. 59:325-344.
17. Cruciat CM, Hassler C, Niehrs C. 2006. The MRH protein erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. J Biol Chem. 281:12986-12993.
18. Czupalla C, Mansukoski H, Riedl T, Thiel D, Krause E, Hoflack B. 2006. Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: Implications for lytic enzyme transport and bone metabolism. Mol Cell Proteomics. 5:134-143.
19. Dahms NM, Hancock MK. 2002. P-type lectins. Biochim Biophys Acta. 1572:317-340.
20. Dahms NM, Wick DA, Brzycki-Wessell MA. 1994. The bovine mannose 6-phosphate/insulin-like growth factor II receptor. Localization of the insulin-like growth factor II binding site to domains 5-11. J Biol Chem. 269:3802-3809.
21. Dell' Angelica EC, Payne GS. 2001. Intracellular cycling of lysosomal enzyme receptors. Cytoplasmic tails' tales. Cell. 106:395-398.
22. Dennes A, Cromme C, Suresh K, Kumar NS, Eble JA, Hahnenkamp A, Pohlmann R. 2005. The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors. J Biol Chem. 280:12849-12857.
23. Dennis PA, Rifkin DB. 1991. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA. 88:580-584.
24. Devi GR, Byrd JC, Slentz DH, MacDonald RG. 1998. An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6- phosphate receptor. Mol Endocrinol. 12:1661-1672.
25. Di Bacco A, Gill G. 2003. The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor. Oncogene. 22:5436-5445.
26. Distler J, Hieber V, Sahagian G, Schmickel R, Jourdian GW. 1979. Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of beta-galactosidase by fibroblasts. Proc Natl Acad Sci USA. 76:4235-4239.
27. Distler JJ, Guo JF, Jourdian GW, Srivastava OP, Hindsgaul O. 1991. The binding specificity of high and low molecular weight phosphomannosyl receptors from bovine testes. Inhibition studies with chemically synthesized 6-O-phosphorylated oligomannosides. J Biol Chem. 266:21687-21692.
28. Dittmer F, Hafner A, Ulbrich EJ, Moritz JD, Schmidt P, SchmahlW, Pohlmann R, Figura KV. 1998. I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors. Transgenic Res. 7:473-483.
29. Do H, Lee WS, Ghosh P, Hollowell T, Canfield W, Kornfeld S. 2002. Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 277:29737-29744.
30. Dodd RB, Drickamer K. 2001. Lectin-like proteins in model organisms: Implications for evolution of carbohydrate-binding activity. Glycobiology. 11:71R-79R.
31. Drickamer K. 1999. C-type lectin-like domains. Curr Opin Struct Biol 9:585-590.
32. Faust PL, Chirgwin JM, Kornfeld S. 1987. Renin, a secretory glycoprotein, acquires phosphomannosyl residues. J Cell Biol. 105:1947-1955.
33. Freeze HH. 1986. Modifications of lysosomal enzymes in Dictyostelium discoideum. Mol Cell Biochem. 72:47-65.
34. Futerman AH, van Meer G. 2004. The cell biology of lysosomal storage disorders. Nat Rev Mol Cell Biol. 5:554-565.
35. Gabel CA, Costello CE, Reinhold VN, Kurz L, Kornfeld S. 1984. Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins. J Biol Chem. 259:13762-13769.
36. Gabel CA, Dubey L, Steinberg SP, Sherman D, Gershon MD, Gershon AA. 1989. Varicella-zoster virus glycoprotein oligosaccharides are phosphorylated during posttranslational maturation. J Virol. 63:4264-4276.
37. Gary-Bobo M, Nirde P, Jeanjean A, Morere A, Garcia M. 2007. Mannose 6-phosphate receptor targeting and its applications in human diseases. Curr Med Chem. 14:2945-2953.
38. Gaszner M, Udvardy A. 1991. Purification of a lysosomal DNase from Drosophila melanogaster. Biochem Biophys Res Commun. 181:44-50.
39. Ghosh P, Dahms NM, Kornfeld S. 2003. Mannose 6-phosphate receptors: New twists in the tale. Nat Rev Mol Cell Biol. 4:202-213.
40. Ghosh P, Kornfeld S. 2004. The GGA proteins: Key players in protein sorting at the trans-Golgi network. Eur J Cell Biol. 83:257-262.
41. Godar S, Horejsi V, Weidle UH, Binder BR, Hansmann C, Stockinger H. 1999. M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-beta1. Eur J Immunol. 29:1004-1013.
42. Griffiths GM, Isaaz S. 1993. Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol. 120:885-896.
43. Hancock MK, Haskins DJ, Sun G, Dahms NM. 2002. Identification of residues essential for carbohydrate recognition by the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem. 277:11255-11264.
44. Hancock MK, Yammani RD, Dahms NM. 2002. Localization of the carbohydrate recognition sites of the insulin-like growth factor II/mannose 6-phosphate receptor to domains 3 and 9 of the extracytoplasmic region. J Biol Chem. 277:47205-47212.
45. Hasilik A, Klein U, Waheed A, Strecker G, von Figura K. 1980. Phosphorylated oligosaccharides in lysosomal enzymes: Identification of alpha-N-acetylglucosamine(1)phospho(6)mannose diester groups. Proc Natl Acad Sci USA. 77:7074-7078.
46. Hickman S, Neufeld EF. 1972. A hypothesis for I-cell disease: Defective hydrolases that do not enter lysosomes. Biochem Biophys Res Commun 49:992-999.
47. Hoflack B, Fujimoto K, Kornfeld S. 1987. The interaction of phosphorylated oligosaccharides and lysosomal enzymeswith bovine liver cation-dependent mannose 6-phosphate receptor. J Biol Chem. 262:123-129.
48. Hoflack B, Kornfeld S. 1985. Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-kDa mannose 6-phosphate receptor: Evidence for the existence of a second mannose 6-phosphate receptor. Proc Natl Acad Sci USA. 82:4428-4432.
49. Huete-Perez JA, Engel JC, Brinen LS, Mottram JC, McKerrow JH. 1999. Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. J Biol Chem. 274:16249-16256.
50. Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C. 2000. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation. Proc Natl Acad Sci USA. 97:8439-8444.
51. Imort M, Zuhlsdorf M, Feige U, Hasilik A, von Figura K. 1983. Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin. Biochem J. 214:671-678.
52. Journet A, Chapel A, Kieffer S, Louwagie M, Luche S, Garin J. 2000. Towards a human repertoire of monocytic lysosomal proteins. Electrophoresis. 21:3411-3419.
53. Journet A, Chapel A, Kieffer S, Roux F, Garin J. 2002. Proteomic analysis of human lysosomes: Application to monocytic and breast cancer cells. Proteomics. 2:1026-1040.
54. Kang JX, Li Y, Leaf A. 1997. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. Proc Natl Acad Sci USA. 94:13671-13676.
55. Kaplan A, Achord DT, SlyWS. 1977. Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts. Proc Natl Acad Sci USA. 74:2026-2030.
56. Kasper D, Dittmer F, von Figura K, Pohlmann R. 1996. Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes. J Cell Biol. 134:615-623.
57. Kim W, Spear ED, Ng DT. 2005. Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol Cell. 19:753-764.
58. Kimura Y, Nakazawa M, Yamada M. 1998. Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. J Biochem. 123:876-882.
59. Kornfeld S, Sly WS. 2001. I cell disease and pseudo-Hurler polydystrophy: Disorders of lysosomal enzyme phosphorylation and localization. In: Scriver CR, Beaudet AL, SlyWS, Valle D, editors. Metabolic and Molecular Bases of Inherited Diseases. New York: McGraw-Hill. pp. 3469-3482.
60. Kreiling JL, Byrd JC, Deisz RJ, Mizukami IF, Todd RF 3rd3rd, MacDonald RG. 2003. Binding of Urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: Contrasting interactions of full-length and soluble forms of uPAR. J Biol Chem. 278:20628-20637.
61. Kudo M, Brem MS, Canfield WM. 2006. Mucolipidosis II (I-cell disease) and mucolipidosis IIIA (classical pseudo-hurler polydystrophy) are caused by mutations in the GlcNAc-phosphotransferase alpha/beta-subunits precursor gene. Am J Hum Genet. 78:451-463.
62. Lakshmi YU, Radha Y, Hille-Rehfeld A, von Figura K, Kumar NS. 1999. Identification of the putative mannose 6-phosphate receptor protein (MPR 300) in the invertebrate unio. Biosci Rep. 19:403-409.
63. Lang L, Couso R, Kornfeld S. 1986. Glycoprotein phosphorylation in simple eucaryotic organisms. Identification of UDP-GlcNAc:gLycoprotein N-acetylglucosamine-1-phosphotransferase activity and analysis of substrate specificity. J Biol Chem. 261:6320-6325.
64. Lazzarino DA, Gabel CA. 1988. Biosynthesis of the mannose 6-phosphate recognition marker in transport-impaired mouse lymphoma cells. Demonstration of a two-step phosphorylation. J Biol Chem. 263:10118-10126.
65. Le Borgne R, Hoflack B. 1998. Protein transport from the secretory to the endocytic pathway in mammalian cells. Biochim Biophys Acta. 1404:195-209.
66. Lee SJ, Nathans D. 1988. Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors. J Biol Chem. 263:3521-3527.
67. Lee WS, Payne BJ, Gelfman CM, Vogel P, Kornfeld S. 2007. Murine UDP-GlcNAc: Lysosomal enzyme N acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases. J Biol Chem. 282:27198-27203.
68. Leksa V, Godar S, Cebecauer M, Hilgert I, Breuss J, Weidle UH, Horejsi V, Binder BR, StockingerH. 2002. The N terminus of mannose 6-phosphate/ insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration. J Biol Chem. 277:40575-40582.
69. Lemansky P, Fester I, Smolenova E, Uhlander C, Hasilik A. 2007. The cation-independent mannose 6-phosphate receptor is involved in lysosomal delivery of serglycin. J Leukoc Biol. 81:1149-1158.
70. Linnell J, Groeger G, Hassan AB. 2001. Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/ mannose 6-phosphate receptor. The effects of domain 13 and pH. J Biol Chem. 276:23986-23991.
71. Ludwig T, Eggenschwiler J, Fisher P, D Ercole AJ, Davenport ML, Efstratiadis A. 1996. Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol. 177:517-535.
72. Ludwig T, Munier-Lehmann H, Bauer U, Hollinshead M, Ovitt C, Lobel P, Hoflack B. 1994. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts. EMBO J. 13:3430-3437.
73. Marron-Terada PG, Hancock MK, Haskins DJ, Dahms NM. 2000. Recognition of Dictyostelium discoideum lysosomal enzymes is conferred by the amino-terminal carbohydrate binding site of the insulin-like growth factor II/mannose 6-phosphate receptor. Biochemistry. 39:2243-2253.
74. Meikle PJ, Hopwood JJ. 2003. Lysosomal storage disorders: Emerging therapeutic options require early diagnosis. Eur J Pediatr. 162:S34-S37.
75. Meresse S, Hoflack B. 1993. Phosphorylation of the cation-independent mannose 6-phosphate receptor is closely associated with its exit from the trans-Golgi network. J Cell Biol. 120:67-75.
76. Moretti S, Armougom F, Wallace IM, Higgins DG, Jongeneel CV, Notredame C. 2007. TheM-Coffee web server: A meta-method for computing multiple sequence alignments by combining alternative alignment methods. Nucleic Acids Res. 35:W645-W648.
77. Mullins C, Bonifacino JS. 2001. The molecular machinery for lysosome biogenesis. Bioessays. 23:333-343.
78. Munier-Lehmann H, Mauxion F, Bauer U, Lobel P, Hoflack B. 1996. Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting. J Biol Chem. 271:15166-15174.
79. Munro S. 2001. The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins. Curr Biol. 11:R499-R501.
80. Nadimpalli SK, Padmanabhan N, Koduru S. 2004. Biochemical and immunological characterization of a glycosylated alpha-fucosidase from the invertebrate Unio: Interaction of the enzyme with its in vivo binding partners. Protein Expr Purif. 37:279-287.
81. Nadimpalli SK, von Figura K. 2002. Identification of the putative mannose 6-phosphate receptor (MPR 46) protein in the invertebrate mollusc. Biosci Rep. 22:513-521.
82. Natowicz MR, Chi MM, Lowry OH, Sly WS. 1979. Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts. Proc Natl Acad Sci USA. 76:4322-4326.
83. Neufeld EF. 1991. Lysosomal storage diseases. Annu Rev Biochem. 60:257-280.
84. Ni X, Canuel M, Morales CR. 2006. The sorting and trafficking of lysosomal proteins. Histol Histopathol. 21:899-913.
85. Nolan CM, McCarthy K, Eivers E, Jirtle RL, Byrnes L. 2006. Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Dev Genes Evol. 216:144-151.
86. Nykjaer A, Christensen EI, Vorum H, Hager H, Petersen CM, Roigaard H, Min HY, Vilhardt F, Moller LB, Kornfeld S, et al. 1998. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. J Cell Biol 141:815-828.
87. Olson LJ, Dahms NM, Kim JJ. 2004. The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. J Biol Chem. 279:34000-34009.
88. Olson LJ, Hancock MK, Dix D, Kim J-JP, Dahms NM. 1999. Mutational analysis of the binding site residues of the bovine cation-dependent mannose 6-phosphate receptor. J Biol Chem. 274:36905-36911.
89. Olson LJ, Hindsgaul O, Dahms NM, Kim JJ. 2008. Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. J Biol Chem. 283:10124-10134.
90. Olson LJ, Yammani RD, Dahms NM, Kim JJ. 2004. Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor. EMBO J. 23:2019-2028.
91. Olson LJ, Zhang J, Dahms NM, Kim J-JP. 2002. Twists and turns of the CD-MPR: Ligand-bound versus ligand-free receptor. J Biol Chem. 277:10156-10161.
92. Olson LJ, Zhang J, Lee YC, Dahms NM, Kim, J-JP. 1999. Structural basis for recognition of phosphorylated high mannose oligosaccharides by the cation-dependent mannose 6-phosphate receptor. J Biol Chem. 274:29889-29896.
93. Pohlmann R, Boeker MW, von Figura K. 1995. The two mannose 6-phosphate receptors transport distinct complements of lysosomal proteins. J Biol Chem. 270:27311-27318.
94. Pohlmann R,Waheed A, Hasilik A, von Figura K. 1982. Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus. J Biol Chem. 257:5323-5325.
95. Purchio AF, Cooper JA, Brunner AM, Lioubin MN, Gentry LE, Kovacina KS, Roth RA, Marquardt H. 1988. Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor. J Biol Chem. 263:14211-14215.
96. Qian M, Sleat DE, Zheng H, Moore D, Lobel P. 2008. Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors. Mol Cell Proteomics. 7:58-70.
97. Reddy ST, Chai W, Childs RA, Page JD, Feizi T, Dahms NM. 2004. Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor. J Biol Chem. 279:38658-38667.
98. Reitman ML, Kornfeld S. 1981. Lysosomal enzyme targeting. N Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes. J Biol Chem. 256:11977-11980.
99. Roberts DL, Weix DJ, Dahms NM, Kim J-JP 1998. Molecular basis of lysosomal enzyme recognition: Three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. Cell. 93:639-648.
100. Rohrer J, Kornfeld R. 2001. Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network. Mol Biol Cell. 12:1623-1631.
101. Rohrer J, Schweizer A, Johnson KF, Kornfeld S. 1995. A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. J Cell Biol. 130:1297-1306.
102. Schellens JP, Saftig P, von Figura K, Everts V. 2003. Deficiency of mannose 6-phosphate receptors and lysosomal storage: A morphometric analysis of hepatocytes of neonatal mice. Cell Biol Int. 27:897-902.
103. Schmidt B, Kiecke-Siemsen C, Waheed A, Braulke T, von Figura K. 1995. Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor. J Biol Chem. 270:14975-14982.
104. Sleat DE, Lackland H, Wang Y, Sohar I, Xiao G, Li H, Lobel P. 2005. The human brain mannose 6-phosphate glycoproteome: A complex mixture composed of multiple isoforms of many soluble lysosomal proteins. Proteomics. 5:1520-1532 [erratum appears in Proteomics. 2005. 5(8):2272].
105. Sleat DE, Lobel P. 1997. Ligand binding specificities of the two mannose 6-phosphate receptors. J Biol Chem. 272:731-738.
106. Sleat DE, Wang Y, Sohar I, Lackland H, Li Y, Li H, Zheng H, Lobel P. 2006. Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal awide range of lysosomal and non-lysosomal proteins. Mol Cell Proteomics. 5:1942-1956.
107. Sleat DE, Zheng H, Lobel P. 2007. The human urine mannose 6-phosphate glycoproteome. Biochim Biophys Acta. 1774:368-372.
108. Sohar I, Sleat D, Gong Liu C, Ludwig T, Lobel P. 1998. Mouse mutants lacking the cation-independent mannose 6- phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: Comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice. Biochem J. 330:903-908.
109. Steet R, Lee WS, Kornfeld S. 2005. Identification of the minimal lysosomal enzyme recognition domain in cathepsin d. J Biol Chem. 280:33318-33323.
110. Stein M, Zijderhand-Bleekemolen JE, Geuze H, Hasilik A, von Figura K. 1987. Mr 46,000 mannose 6-phosphate specific receptor: Its role in targeting of lysosomal enzymes. EMBO J. 6:2677-2681.
111. Sun G, Zhao H, Kalyanaraman B, Dahms NM. 2005. Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor. Glycobiology. 15:1136-1149.
112. Szathmary R, Bielmann R, Nita-Lazar M, Burda P, Jakob CA. 2005. Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD. Mol Cell. 19:765-775.
113. Tabas I, Kornfeld S. 1980. Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues. J Biol Chem. 255:6633-6639.
114. Tomoda H, Ohsumi Y, Ichikawa Y, Srivastava OP, Kishimoto Y, Lee YC. 1991. Binding specificity of D-mannose 6-phosphate receptor of rabbit alveolar macrophages. Carbohydr Res. 213:37-46.
115. Tong PY, Gregory W, Kornfeld S. 1989. Ligand interactions of the cation-independent mannose 6-phosphate receptor. The stoichiometry of mannose 6-phosphate binding. J Biol Chem. 264:7962-7969.
116. Tong PY, Kornfeld S. 1989. Ligand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor. J Biol Chem. 264:7970-7975.
117. Uson I, Schmidt B, von Bulow R, Grimme S, von Figura K, Dauter M, Rajashankar KR, Dauter Z, Sheldrick GM. 2003. Locating the anomalous scatterer substructures in halide and sulfur phasing. Acta Crystallogr D Biol Crystallogr. 59:57-66.
118. van Kesteren CA, Danser AH, Derkx FH, Dekkers DH, Lamers JM, Saxena PR, Schalekamp MA. 1997. Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells. Hypertension. 30:1389-1396.
119. Varki A, Kornfeld S. 1980. Structural studies of phosphorylated high mannosetype oligosaccharides. J Biol Chem. 255:10847-10858.
120. Varki A, Kornfeld S. 1981. Purification and characterization of rat liver alpha-N-acetylglucosaminyl phosphodiesterase. J Biol Chem 256:9937-9943.
121. Varki A, Sherman W, Kornfeld S. 1983. Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D-glucosamine-1-phosphodiester N acetylglucosaminidase (formerly called alpha-N acetylglucosaminylphosphodiesterase) and lysosomal alpha-Nacetylglucosaminidase. Arch Biochem Biophys. 222:145-149.
122. Vellodi A. 2004. Lysosomal storage disorders. Br J Haematol. 128:413-431.
123. Waheed A, Hasilik A, von Figura K. 1981. Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N acetylglucosaminyl phosphodiesterase. J Biol Chem. 256:5717-5721.
124. Waheed A, Hasilik A, von Figura K. 1982. UDP-N-acetylglucosamine: lysosomal enzyme precursor N-acetylglucosamine- 1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme. J Biol Chem. 257:12322-12331.
125. Wallace IM, O'Sullivan O, Higgins DG, Notredame C. 2006. M-Coffee: Combining multiple sequence alignment methods with T-Coffee. Nucleic Acids Res. 34:1692-1699.
126. Warner JB, Thalhauser C, Tao K, Sahagian GG. 2002. Role of N linked oligosaccharide flexibility in mannose phosphorylation of lysosomal enzyme cathepsin L. J Biol Chem. 277:41897-41905.
127. Watanabe H, Grubb JH, Sly WS. 1990. The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase. Proc Natl Acad Sci USA. 87:8036-8040.
128. Wendland M, von Figura K, Pohlmann R. 1991. Mutational analysis of disulfide bridges in the Mr 46,000 mannose 6-phosphate receptor. Localization and role for ligand binding. J Biol Chem. 266:7132-7136.
129. Wendland M,Waheed A, von Figura K, Pohlmann R. 1991. Mr 46,000 mannose 6-phosphate receptor. The role of histidine and arginine residues for binding of ligand. J Biol Chem. 266:2917-2923.
130. Westlund B, Dahms NM, Kornfeld S. 1991. The bovine mannose 6-phosphate/ insulin-like growth factor II receptor. Localization of mannose 6-phosphate binding sites to domains 1-3 and 7-11 of the extracytoplasmic region. J Biol Chem. 266:23233-23239.
131. Whyte JR, Munro S. 2001. A yeast homolog of the mammalian mannose 6-phosphate receptors contributes to the sorting of vacuolar hydrolases. Curr Biol. 11:1074-1078.
132. Wood RJ, Hulett MD. 2008. Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation. J Biol Chem. 283:4165-4176.