Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in sanfilippo type a cells

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2928-2934

  Boado, Ruben J ^a   Lu, Jeff Zhiqiang ^a   Hui, Eric Ka Wai ^a   Pardridge, William M ^a  

^a ArmaGen Technologies Inc   (United States)

Author keywords

blood brain barrier; drug delivery; fusion protein; lysosomal storage; sulfamidase

Indexed keywords

BOLTON HUNTER REAGENT I 125; GLYCOSAMINOGLYCAN; HYBRID PROTEIN; INSULIN RECEPTOR ANTIBODY; INSULIN RECEPTOR ANTIBODY SULFAMIDASE; SULFATE; UNCLASSIFIED DRUG; HYDROLASE; IMMUNOGLOBULIN G; INSULIN RECEPTOR; MONOCLONAL ANTIBODY; N-SULFOGLUCOSAMINE SULFOHYDROLASE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CALCULATION; CELL TYPE; CHO CELL LINE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HUMAN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SANFILIPPO TYPE A CELL; WESTERN BLOTTING; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; ENZYME REPLACEMENT; GENETICS; HAMSTER; MALE; METABOLISM; MUCOPOLYSACCHARIDOSIS III; MUTATION; PERMEABILITY; PROCEDURES; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME REPLACEMENT THERAPY; FIBROBLASTS; GLYCOSAMINOGLYCANS; HYDROLASES; IMMUNOGLOBULIN G; LYSOSOMES; MACACA MULATTA; MALE; MICROSCOPY, CONFOCAL; MUCOPOLYSACCHARIDOSIS III; MUTATION; PERMEABILITY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS;

EID: 84905511762     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500258p     Document Type: Article

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