Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein

Bioconjugate Chemistry

Volumn 22, Issue 8, 2011, Pages 1611-1618

  Zhou, Qing Hui ^a   Lu, Jeff Zhiqiang ^b   Hui, Eric Ka Wai ^b   Boado, Ruben J ^a,b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CHAINS; CONTROLLED DRUG DELIVERY; ELECTROPHORESIS; GENETIC ENGINEERING; MAMMALS; MONOCLONAL ANTIBODIES; NEURODEGENERATIVE DISEASES; PEPTIDES; TARGETED DRUG DELIVERY;

ALZHEIMERS DISEASE; BLOOD-BRAIN BARRIER; BRAIN UPTAKE; CELL EXPRESSION; DRUG-TARGETING; FUSION PROTEINS; HEAVY CHAIN; HOST CELLS; IN-VIVO; TRANSFERRIN RECEPTORS;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN[1-40]; AVIDIN; BIOTIN; DRUG CARRIER; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G AVIDIN FUSION PROTEIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR MONOCLONAL ANTIBODY AVIDIN FUSION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD BRAIN BARRIER; BRAIN; CHO CELL; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG UPTAKE; ELECTROPHORESIS; FEMALE; FIBROBLAST; GENETIC ENGINEERING; GLYCOSYLATION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

CRICETULUS GRISEUS; MURINAE; MUS;

EID: 80051767213     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200174x     Document Type: Article

References (23)

1. Pardridge, W. M. (2008) Re-engineering biopharmaceuticals for delivery to brain with molecular Trojan horses Bioconjugate Chem. 19, 1327-1338 (Pubitemid 352032329)
2. Boado, R. J., Zhang, Y., Xia, C. F., Wang, Y., and Pardridge, W. M. (2008) Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans Bioconjugate Chem. 19, 731-739 (Pubitemid 351431405)
3. Pardridge, W. M., Kang, Y. S., Buciak, J. L., and Yang, J. (1995) Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate Pharm. Res. 12, 807-816
4. Boado, R. J., Zhang, Y., Wang, Y., and Pardridge, W. M. (2009) Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse Biotechnol. Bioeng. 102, 1251-1258
5. Glenner, G. G. and Wong, C. W. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem. Biophys. Res. Commun. 120, 885-890 (Pubitemid 14104991)
6. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249 (Pubitemid 15053619)
7. Maggio, J. E., Stimson, E. R., Ghilardi, J. R., Allen, C. J., Dahl, C. E., Whitcomb, D. C., Vigna, S. R., Vinters, H. V., Labenski, M. E., and Mantyh, P. W. (1992) Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide Proc. Natl. Acad. Sci. U. S. A. 89, 5462-5466
8. Saito, Y., Buciak, J., Yang, J., and Pardridge, W. M. (1995) Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex Proc. Natl. Acad. Sci. U. S. A. 92, 10227-10231 (Pubitemid 3001732)
9. Boado, R. J., Zhou, Q. H., Lu, J. Z., Hui, E. K., and Pardridge, W. M. (2010) Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor Mol. Pharmaceutics 7, 237-244
10. Wilchek, M. and Bayer, E. A. (1990) Applications of avidin-biotin technology: literature survey Methods Enzymol. 184, 14-45 (Pubitemid 20219729)
11. Zhou, Q. H., Boado, R. J., Lu, J. Z., Hui, E. K., and Pardridge, W. M. (2010) Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse Drug Metab. Dispos. 38, 566-572
12. Hytonen, V. P., Laitinen, O. H., Airenne, T. T., Kidron, H., Meltola, N. J., Porkka, E. J., Horha, J., Paldanius, T., Maatta, J. A., Nordlund, H. R., Johnson, M. S., Salminen, T. A., Airenne, K. J., Yla-Herttuala, S., and Kulomaa, M. S. (2004) Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli Biochem. J. 384, 385-390 (Pubitemid 39656251)
13. Airenne, K. J., Oker-Blom, C., Marjomaki, V. S., Bayer, E. A., Wilchek, M., and Kulomaa, M. S. (1997) Production of biologically active recombinant avidin in baculovirus-infected insect cells Protein Expr. Purif. 9, 100-108 (Pubitemid 27335477)
14. Penichet, M. L., Kang, Y. S., Pardridge, W. M., Morrison, S. L., and Shin, S. U. (1999) An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain J. Immunol. 163, 4421-4426 (Pubitemid 29474510)
15. Green, N. M. (1975) Avidin Adv. Protein Chem. 29, 85-133
16. Lee, H. J., Engelhardt, B., Lesley, J., Bickel, U., and Pardridge, W. M. (2000) Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse J. Pharmacol. Exp. Ther. 292, 1048-1052 (Pubitemid 30136600)
17. 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of β-amyloid plaques in Alzheimer's brains J. Med. Chem. 54, 2971-2979
18. Triguero, D., Buciak, J., and Pardridge, W. M. (1990) Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins J. Neurochem. 54, 1882-1888
19. Suzuki, T., Wu, D., Schlachetzki, F., Li, J. Y., Boado, R. J., and Pardridge, W. M. (2004) Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology J. Nucl. Med. 45, 1766-1775 (Pubitemid 47618489)
20. De Groot, A. S., Moise, L., McMurry, J. A., Wambre, E., Van Overtvelt, L., Moingeon, P., Scott, D. W., and Martin, W. (2008) Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes Blood 112, 3303-11
21. Weiner, H. L. (1994) Oral tolerance Proc. Natl. Acad. Sci. U. S. A. 91, 10762-10765 (Pubitemid 24349564)
22. Paganelli, G., Magnani, P., Zito, F., Lucignani, G., Sudati, F., Truci, G., Motti, E., Terreni, M., Pollo, B., Giovanelli, M., Canal, N., Scotti, G., Comi, G., Koch, P., Maecke, H. R., and Fazio, F. (1994) Pre-targeted immunodetection in glioma patients: tumour localization and single-photon emission tomography imaging of [99mTc]PnAO-biotin Eur. J. Nucl. Med. 21, 314-321 (Pubitemid 24106449)
23. Samuel, A., Paganelli, G., Chiesa, R., Sudati, F., Calvitto, M., Melissano, G., Grossi, A., and Fazio, F. (1996) Detection of prosthetic vascular graft infection using avidin/indium-111-biotin scintigraphy J. Nucl. Med. 37, 55-61