Re-engineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse

Molecular Pharmaceutics

Volumn 7, Issue 6, 2010, Pages 2148-2155

  Zhou, Qing Hui ^a   Boado, Ruben J ^a,b   Lu, Jeff Zhiqiang ^b   Hui, Eric Ka Wai ^b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; ERYTHROPOIETIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CHO CELL; CHROMATOGRAPHY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG UPTAKE; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; RECEPTOR AFFINITY; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; ERYTHROPOIETIN; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED C57BL; PROTEIN ENGINEERING; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649949022     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1001763     Document Type: Article

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