메뉴 건너뛰기




Volumn 10, Issue 9, 2013, Pages 3507-3513

Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the abeta amyloid peptide

Author keywords

Alzheimer's disease; amyloid; Blood brain barrier; monoclonal antibody; transferrin receptor

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; BISPECIFIC ANTIBODY; HYBRID PROTEIN; PRESENILIN; TRANSFERRIN RECEPTOR;

EID: 84883591583     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400348n     Document Type: Article
Times cited : (51)

References (32)
  • 1
    • 0028972701 scopus 로고
    • Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity
    • Cummings, B. J.; Cotman, C. W. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity Lancet 1995, 346 (8989) 1524-1528
    • (1995) Lancet , vol.346 , Issue.8989 , pp. 1524-1528
    • Cummings, B.J.1    Cotman, C.W.2
  • 3
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner, G. G.; Wong, C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochem. Biophys. Res. Commun. 1984, 120 (3) 885-890
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 8
    • 33947686655 scopus 로고    scopus 로고
    • Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation
    • Boado, R. J.; Zhang, Y.; Xia, C. F.; Pardridge, W. M. Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation Bioconjugate Chem. 2007, 18 (2) 447-455
    • (2007) Bioconjugate Chem. , vol.18 , Issue.2 , pp. 447-455
    • Boado, R.J.1    Zhang, Y.2    Xia, C.F.3    Pardridge, W.M.4
  • 9
    • 76249087751 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor
    • Boado, R. J.; Zhou, Q. H.; Lu, J. Z.; Hui, E. K.; Pardridge, W. M. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor Mol. Pharmaceutics 2010, 7, 237-244
    • (2010) Mol. Pharmaceutics , vol.7 , pp. 237-244
    • Boado, R.J.1    Zhou, Q.H.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 10
    • 0035283233 scopus 로고    scopus 로고
    • Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier
    • Zhang, Y.; Pardridge, W. M. Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier J. Neuroimmunol. 2001, 114, 168-172
    • (2001) J. Neuroimmunol. , vol.114 , pp. 168-172
    • Zhang, Y.1    Pardridge, W.M.2
  • 11
    • 0036079202 scopus 로고    scopus 로고
    • Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier
    • Schlachetzki, F.; Zhu, C.; Pardridge, W. M. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier J. Neurochem. 2002, 81, 203-206
    • (2002) J. Neurochem. , vol.81 , pp. 203-206
    • Schlachetzki, F.1    Zhu, C.2    Pardridge, W.M.3
  • 12
    • 77951086901 scopus 로고    scopus 로고
    • Safety and changes in plasma and cerebrospinal fluid amyloid β after a single administration of an amyloid β monoclonal antibody in subjects with Alzheimer disease
    • Siemers, E. R.; Friedrich, S.; Dean, R. A.; Gonzales, C. R.; Farlow, M. R.; Paul, S. M.; DeMattos, R. B. Safety and changes in plasma and cerebrospinal fluid amyloid β after a single administration of an amyloid β monoclonal antibody in subjects with Alzheimer disease Clin. Neuropharmacol. 2010, 33, 67-73
    • (2010) Clin. Neuropharmacol. , vol.33 , pp. 67-73
    • Siemers, E.R.1    Friedrich, S.2    Dean, R.A.3    Gonzales, C.R.4    Farlow, M.R.5    Paul, S.M.6    Demattos, R.B.7
  • 15
    • 79952932382 scopus 로고    scopus 로고
    • Receptor-mediated Abeta amyloid antibody targeting to Alzheimer's disease mouse brain
    • Zhou, Q. H.; Fu, A.; Boado, R. J.; Hui, E. K.-H.; Lu, J. Z.; Pardridge, W. M. Receptor-mediated Abeta amyloid antibody targeting to Alzheimer's disease mouse brain Mol. Pharmaceutics 2011, 8, 280-285
    • (2011) Mol. Pharmaceutics , vol.8 , pp. 280-285
    • Zhou, Q.H.1    Fu, A.2    Boado, R.J.3    Hui, E.K.-H.4    Lu, J.Z.5    Pardridge, W.M.6
  • 16
    • 84875803152 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice
    • Sumbria, R. K.; Zhou, Q.-H.; Hui, E.K.-W.; Lu, J. Z.; Boado, R. J.; Pardridge, W. M. Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice Mol. Pharmaceutics 2013, 10, 1425-1431
    • (2013) Mol. Pharmaceutics , vol.10 , pp. 1425-1431
    • Sumbria, R.K.1    Zhou, Q.-H.2    Hui, E.K.-W.3    Lu, J.Z.4    Boado, R.J.5    Pardridge, W.M.6
  • 17
    • 42449097992 scopus 로고    scopus 로고
    • Determination of primary structure and microheterogeneity of a β-amyloid plaque-specific antibody using high-performance LC-tandem mass spectrometry
    • Perdivara, I.; Deterding, L.; Moise, A.; Tomer, K. B.; Przybylski, M. Determination of primary structure and microheterogeneity of a β-amyloid plaque-specific antibody using high-performance LC-tandem mass spectrometry Anal. Bioanal. Chem. 2008, 391, 325-336
    • (2008) Anal. Bioanal. Chem. , vol.391 , pp. 325-336
    • Perdivara, I.1    Deterding, L.2    Moise, A.3    Tomer, K.B.4    Przybylski, M.5
  • 18
    • 80355132694 scopus 로고    scopus 로고
    • Detection of neuritic plaques in Alzheimer's disease mouse model
    • DOI: 10.3791/2831
    • Ly, P. T.; Cai, F.; Song, W. Detection of neuritic plaques in Alzheimer's disease mouse model. J. Visualized Exp. 2011, 53, DOI: 10.3791/2831.
    • (2011) J. Visualized Exp. , Issue.53
    • Ly, P.T.1    Cai, F.2    Song, W.3
  • 20
    • 79952775194 scopus 로고    scopus 로고
    • Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-β immunotherapy
    • Wang, A.; Das, P.; Switzer, R. C.; Golde, T. E.; Jankowsky, J. L. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-β immunotherapy J. Neurosci. 2011, 31, 4124-4136
    • (2011) J. Neurosci. , vol.31 , pp. 4124-4136
    • Wang, A.1    Das, P.2    Switzer, R.C.3    Golde, T.E.4    Jankowsky, J.L.5
  • 23
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock, D. M.; Alamed, J.; Gottschall, P. E.; Grimm, J.; Rosenthal, A.; Pons, J.; Ronan, V.; Symmonds, K.; Gordon, M. N.; Morgan, D. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice J. Neurosci. 2006, 26, 5340-5346
    • (2006) J. Neurosci. , vol.26 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6    Ronan, V.7    Symmonds, K.8    Gordon, M.N.9    Morgan, D.10
  • 25
    • 0033528254 scopus 로고    scopus 로고
    • Intravascular infusions of soluble β-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage
    • Su, G. C.; Arendash, G. W.; Kalaria, R. N.; Bjugstad, K. B.; Mullan, M. Intravascular infusions of soluble β-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage Brain Res. 1999, 818, 105-117
    • (1999) Brain Res. , vol.818 , pp. 105-117
    • Su, G.C.1    Arendash, G.W.2    Kalaria, R.N.3    Bjugstad, K.B.4    Mullan, M.5
  • 26
    • 65649148265 scopus 로고    scopus 로고
    • Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice
    • Wilcock, D. M.; Colton, C. A. Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice CNS Neurol. Disord. Drug Targets 2009, 8, 50-64
    • (2009) CNS Neurol. Disord. Drug Targets , vol.8 , pp. 50-64
    • Wilcock, D.M.1    Colton, C.A.2
  • 29
    • 84866538826 scopus 로고    scopus 로고
    • Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
    • Bard, F.; Fox, M.; Friedrich, S.; Seubert, P.; Schenk, D.; Kinney, G. G.; Yednock, T. Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice Exp. Neurol. 2012, 238, 38-43
    • (2012) Exp. Neurol. , vol.238 , pp. 38-43
    • Bard, F.1    Fox, M.2    Friedrich, S.3    Seubert, P.4    Schenk, D.5    Kinney, G.G.6    Yednock, T.7
  • 30
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse
    • Lee, H. J.; Engelhardt, B.; Lesley, J.; Bickel, U.; Pardridge, W. M. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse J. Pharmacol. Exp. Ther. 2000, 292, 1048-1052
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 1048-1052
    • Lee, H.J.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 31
    • 0025051493 scopus 로고
    • Benzodiazepine concentrations in brain directly reflect receptor occupancy: Studies of diazepam, lorezepam, and oxazepam
    • Greenblatt, D. J.; Sethy, V. H. Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorezepam, and oxazepam Psychopharmacology 1990, 102, 373-378
    • (1990) Psychopharmacology , vol.102 , pp. 373-378
    • Greenblatt, D.J.1    Sethy, V.H.2
  • 32
    • 79959444718 scopus 로고    scopus 로고
    • Chronic dosing of mice with a transferrin receptor monoclonal antibody-GDNF fusion protein
    • Zhou, Q.-H.; Boado, R. J.; Lu, J. Z.; Hui, E.K.-W.; Pardridge, W. M. Chronic dosing of mice with a transferrin receptor monoclonal antibody-GDNF fusion protein Drug Metab. Dispos. 2011, 39, 1149-1154
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1149-1154
    • Zhou, Q.-H.1    Boado, R.J.2    Lu, J.Z.3    Hui, E.K.-W.4    Pardridge, W.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.