메뉴 건너뛰기




Volumn 138, Issue 4, 2015, Pages 891-901

Seizure suppression through manipulating splicing of a voltage-gated sodium channel

Author keywords

Drosophila; hyperexcitability; seizure; splicing; voltage gated sodium channel

Indexed keywords

DIPYRIDAMOLE; VOLTAGE GATED SODIUM CHANNEL; DROSOPHILA PROTEIN; RENILLA LUCIFERIN 2 MONOOXYGENASE;

EID: 84929069267     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv012     Document Type: Article
Times cited : (18)

References (72)
  • 1
    • 37349022889 scopus 로고    scopus 로고
    • Rofecoxib, a selective cyclooxygen-ase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: Possible involvement of adenosinergic mechanism
    • Akula KK, Dhir A, Kulkarni SK. Rofecoxib, a selective cyclooxygen-ase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. Epilepsy Res 2008; 78: 60-70.
    • (2008) Epilepsy Res , vol.78 , pp. 60-70
    • Akula, K.K.1    Dhir, A.2    Kulkarni, S.K.3
  • 3
    • 0035064580 scopus 로고    scopus 로고
    • Induction of neonatal sodium channel II and III alphaisoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus
    • Aronica E, Yankaya B, Troost D, van Vliet EA, Lopes da Silva FH, Gorter JA. Induction of neonatal sodium channel II and III alphaisoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus. Eur J Neurosci 2001; 13: 1261-6.
    • (2001) Eur J Neurosci , vol.13 , pp. 1261-1266
    • Aronica, E.1    Yankaya, B.2    Troost, D.3    Van Vliet, E.A.4    Lopes Da Silva, F.H.5    Gorter, J.A.6
  • 4
    • 84855887150 scopus 로고    scopus 로고
    • Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models
    • Bankstahl M, Bankstahl JP, Bloms-Funke P, Loscher W. Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. Neurotoxicology 2012; 33: 127-37.
    • (2012) Neurotoxicology , vol.33 , pp. 127-137
    • Bankstahl, M.1    Bankstahl, J.P.2    Bloms-Funke, P.3    Loscher, W.4
  • 5
    • 12344269924 scopus 로고    scopus 로고
    • GO: TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes
    • Boyle EI, Weng S, Gollub J, Jin H, Botstein D, Cherry JM, et al. GO: TermFinder-open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics 2004; 20: 3710-5.
    • (2004) Bioinformatics , vol.20 , pp. 3710-3715
    • Boyle, E.I.1    Weng, S.2    Gollub, J.3    Jin, H.4    Botstein, D.5    Cherry, J.M.6
  • 7
    • 9144252016 scopus 로고    scopus 로고
    • The Gene Ontology Annotation (GOA) Database: Sharing knowledge in Uniprot with Gene Ontology
    • Database issue
    • Camon E, Magrane M, Barrell D, Lee V, Dimmer E, Maslen J, et al. The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology. Nucleic Acids Res 2004; 32 (Database issue): D262-6.
    • (2004) Nucleic Acids Res , vol.32 , pp. D262-D266
    • Camon, E.1    Magrane, M.2    Barrell, D.3    Lee, V.4    Dimmer, E.5    Maslen, J.6
  • 8
    • 0029051044 scopus 로고
    • Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones
    • Chao TI, Alzheimer C. Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones. Neuroreport 1995; 6: 1778-80.
    • (1995) Neuroreport , vol.6 , pp. 1778-1780
    • Chao, T.I.1    Alzheimer, C.2
  • 9
    • 0035102720 scopus 로고    scopus 로고
    • Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcit-ability
    • Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcit-ability. Nat Med 2001; 7: 331-7.
    • (2001) Nat Med , vol.7 , pp. 331-337
    • Chen, K.1    Aradi, I.2    Thon, N.3    Eghbal-Ahmadi, M.4    Baram, T.Z.5    Soltesz, I.6
  • 10
    • 0142184521 scopus 로고    scopus 로고
    • Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures
    • Choi JS, Kim SY, Park HJ, Cha JH, Choi YS, Kang JE, et al. Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures. Brain Res Mol Brain Res 2003; 119: 10-8.
    • (2003) Brain Res Mol Brain Res , vol.119 , pp. 10-18
    • Choi, J.S.1    Kim, S.Y.2    Park, H.J.3    Cha, J.H.4    Choi, Y.S.5    Kang, J.E.6
  • 11
    • 33845575859 scopus 로고    scopus 로고
    • Cyclic GMP metabolism and its role in brain physiology
    • Domek-Lopacinska K, Strosznajder JB. Cyclic GMP metabolism and its role in brain physiology. J Physiol Pharmacol 2005; 56 (Suppl. 2): 15-34.
    • (2005) J Physiol Pharmacol , vol.56 , pp. 15-34
    • Domek-Lopacinska, K.1    Strosznajder, J.B.2
  • 12
    • 84879048904 scopus 로고    scopus 로고
    • NOVA-dependent regulation of cryptic NMD exons controls synap-tic protein levels after seizure
    • Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, et al. NOVA-dependent regulation of cryptic NMD exons controls synap-tic protein levels after seizure. Elife 2013; 2: e00178.
    • (2013) Elife , vol.2 , pp. e00178
    • Eom, T.1    Zhang, C.2    Wang, H.3    Lay, K.4    Fak, J.5    Noebels, J.L.6
  • 13
    • 0029091192 scopus 로고
    • Cloning and functional analysis of Tip E, a novel membrane protein that enhances Drosophila para sodium channel function
    • Feng G, Deak P, Chopra M, Hall LM. Cloning and functional analysis of Tip E, a novel membrane protein that enhances Drosophila para sodium channel function. Cell 1995; 82: 1001-11.
    • (1995) Cell , vol.82 , pp. 1001-1011
    • Feng, G.1    Deak, P.2    Chopra, M.3    Hall, L.M.4
  • 14
    • 0018822770 scopus 로고
    • Relationships between seizure activity and cyclic nucleotide levels in brain
    • Ferrendelli JA, Blank AC, Gross RA. Relationships between seizure activity and cyclic nucleotide levels in brain. Brain Res 1980; 200: 93-103.
    • (1980) Brain Res , vol.200 , pp. 93-103
    • Ferrendelli, J.A.1    Blank, A.C.2    Gross, R.A.3
  • 15
    • 80054687032 scopus 로고    scopus 로고
    • Alternative splicing modulates inactivation of type 1 voltage-gated sodium channels by toggling an amino acid in the first S3-S4 linker
    • Fletcher EV, Kullmann DM, Schorge S. Alternative splicing modulates inactivation of type 1 voltage-gated sodium channels by toggling an amino acid in the first S3-S4 linker. J Biol Chem 2011; 286: 36700-8.
    • (2011) J Biol Chem , vol.286 , pp. 36700-36708
    • Fletcher, E.V.1    Kullmann, D.M.2    Schorge, S.3
  • 16
    • 0031054294 scopus 로고    scopus 로고
    • Increase in mRNAs encoding neonatal II and III sodium channel alpha-isoforms during kainate-induced seizures in adult rat hippocampus
    • Gastaldi M, Bartolomei F, Massacrier A, Planells R, Robaglia-Schlupp A, Cau P. Increase in mRNAs encoding neonatal II and III sodium channel alpha-isoforms during kainate-induced seizures in adult rat hippocampus. Brain Res Mol Brain Res 1997; 44: 179-90.
    • (1997) Brain Res Mol Brain Res , vol.44 , pp. 179-190
    • Gastaldi, M.1    Bartolomei, F.2    Massacrier, A.3    Planells, R.4    Robaglia-Schlupp, A.5    Cau, P.6
  • 17
    • 0035050571 scopus 로고    scopus 로고
    • Resurgence of sodium channel research
    • Goldin AL. Resurgence of sodium channel research. Annu Rev Physiol 2001; 63: 871-94.
    • (2001) Annu Rev Physiol , vol.63 , pp. 871-894
    • Goldin, A.L.1
  • 18
    • 84885170260 scopus 로고    scopus 로고
    • The effect of STAT3 inhibition on status epilep-ticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy
    • Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, et al. The effect of STAT3 inhibition on status epilep-ticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiol Dis 2014; 62: 73-85.
    • (2014) Neurobiol Dis , vol.62 , pp. 73-85
    • Grabenstatter, H.L.1    Del Angel, Y.C.2    Carlsen, J.3    Wempe, M.F.4    White, A.M.5    Cogswell, M.6
  • 19
    • 0015934086 scopus 로고
    • Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults
    • Grigliatti TA, Hall L, Rosenbluth R, Suzuki DT. Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults. Mol Gen Genet 1973; 120: 107-14.
    • (1973) Mol Gen Genet , vol.120 , pp. 107-114
    • Grigliatti, T.A.1    Hall, L.2    Rosenbluth, R.3    Suzuki, D.T.4
  • 20
    • 25644456910 scopus 로고    scopus 로고
    • Genome-wide tran-scriptional changes associated with enhanced activity in the Drosophila nervous system
    • Guan Z, Saraswati S, Adolfsen B, Littleton JT. Genome-wide tran-scriptional changes associated with enhanced activity in the Drosophila nervous system. Neuron 2005; 48: 91-107.
    • (2005) Neuron , vol.48 , pp. 91-107
    • Guan, Z.1    Saraswati, S.2    Adolfsen, B.3    Littleton, J.T.4
  • 21
    • 0027178659 scopus 로고
    • Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain
    • Gustafson TA, Clevinger EC, O'Neill TJ, Yarowsky PJ, Krueger BK. Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain. J Biol Chem 1993; 268: 18648-53.
    • (1993) J Biol Chem , vol.268 , pp. 18648-18653
    • Gustafson, T.A.1    Clevinger, E.C.2    O'Neill, T.J.3    Yarowsky, P.J.4    Krueger, B.K.5
  • 22
    • 0037178781 scopus 로고    scopus 로고
    • Raptor a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002; 110: 177-89.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5    Hidayat, S.6
  • 23
    • 34247586517 scopus 로고    scopus 로고
    • Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A
    • Heinzen EL, Yoon W, Tate SK, Sen A, Wood NW, Sisodiya SM, et al. Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am J Hum Genet 2007; 80: 876-83.
    • (2007) Am J Hum Genet , vol.80 , pp. 876-883
    • Heinzen, E.L.1    Yoon, W.2    Tate, S.K.3    Sen, A.4    Wood, N.W.5    Sisodiya, S.M.6
  • 24
    • 17444372666 scopus 로고    scopus 로고
    • Seizure suppression by gain-of-function escargot mutations
    • Hekmat-Scafe DS, Dang KN, Tanouye MA. Seizure suppression by gain-of-function escargot mutations. Genetics 2005; 169: 1477-93.
    • (2005) Genetics , vol.169 , pp. 1477-1493
    • Hekmat-Scafe, D.S.1    Dang, K.N.2    Tanouye, M.A.3
  • 25
    • 78049437928 scopus 로고    scopus 로고
    • Design and evaluation of genome-wide libraries for RNA interference screens
    • Horn T, Sandmann T, Boutros M. Design and evaluation of genome-wide libraries for RNA interference screens. Genome Biol 2010; 11: R61.
    • (2010) Genome Biol , vol.11 , pp. R61
    • Horn, T.1    Sandmann, T.2    Boutros, M.3
  • 26
    • 84883246873 scopus 로고    scopus 로고
    • Drosophila as a model for intractable epilepsy: Gilgamesh suppresses seizures in para(bss1) heterozygote flies
    • Howlett IC, Rusan ZM, Parker L, Tanouye MA. Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies. G3 (Bethesda) 2013; 3: 1399-407.
    • (2013) G3 (Bethesda) , vol.3 , pp. 1399-1407
    • Howlett, I.C.1    Rusan, Z.M.2    Parker, L.3    Tanouye, M.A.4
  • 27
    • 0035819540 scopus 로고    scopus 로고
    • Genomic structures of SCN2A and SCN3A-candidate genes for deafness at the DFNA16 locus
    • Kasai N, Fukushima K, Ueki Y, Prasad S, Nosakowski J, Sugata K, et al. Genomic structures of SCN2A and SCN3A-candidate genes for deafness at the DFNA16 locus. Gene 2001; 264: 113-22.
    • (2001) Gene , vol.264 , pp. 113-122
    • Kasai, N.1    Fukushima, K.2    Ueki, Y.3    Prasad, S.4    Nosakowski, J.5    Sugata, K.6
  • 28
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110: 163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 29
    • 47149109415 scopus 로고    scopus 로고
    • Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity
    • Koeller HB, Ross ME, Glickstein SB. Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. Neurobiol Dis 2008; 31: 230-41.
    • (2008) Neurobiol Dis , vol.31 , pp. 230-241
    • Koeller, H.B.1    Ross, M.E.2    Glickstein, S.B.3
  • 30
    • 0030657505 scopus 로고    scopus 로고
    • Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coad-ministered with 4-biphenyl acetic acid
    • Kohno K, Niwa M, Nozaki M, Uematsu T, Fujimura H. Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coad-ministered with 4-biphenyl acetic acid. Gen Pharmacol 1997; 29: 767-70.
    • (1997) Gen Pharmacol , vol.29 , pp. 767-770
    • Kohno, K.1    Niwa, M.2    Nozaki, M.3    Uematsu, T.4    Fujimura, H.5
  • 31
    • 0034856318 scopus 로고    scopus 로고
    • Genetic suppression of seizure susceptibility in Drosophila
    • Kuebler D, Zhang H, Ren X, Tanouye MA. Genetic suppression of seizure susceptibility in Drosophila. J Neurophysiol 2001; 86: 1211-25.
    • (2001) J Neurophysiol , vol.86 , pp. 1211-1225
    • Kuebler, D.1    Zhang, H.2    Ren, X.3    Tanouye, M.A.4
  • 32
    • 84920141663 scopus 로고    scopus 로고
    • Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation
    • Lasarge CL, Danzer SC. Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front Mol Neurosci 2014; 7: 18.
    • (2014) Front Mol Neurosci , vol.7 , pp. 18
    • Lasarge, C.L.1    Danzer, S.C.2
  • 33
    • 84864475807 scopus 로고    scopus 로고
    • Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats
    • Liebenberg N, Harvey BH, Brand L, Wegener G, Brink CB. Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats. Metab Brain Dis 2012; 27: 337-40.
    • (2012) Metab Brain Dis , vol.27 , pp. 337-340
    • Liebenberg, N.1    Harvey, B.H.2    Brand, L.3    Wegener, G.4    Brink, C.B.5
  • 34
    • 84896588557 scopus 로고    scopus 로고
    • Regulation of membrane excitability: A convergence on voltage-gated sodium conductance
    • Lin WH, Baines RA. Regulation of membrane excitability: a convergence on voltage-gated sodium conductance. Mol Neurobiol 2015; 51: 57-67.
    • (2015) Mol Neurobiol , vol.51 , pp. 57-67
    • Lin, W.H.1    Baines, R.A.2
  • 35
    • 84861313370 scopus 로고    scopus 로고
    • Activity-dependent alternative splicing increases persistent sodium current and promotes seizure
    • Lin WH, Gunay C, Marley R, Prinz AA, Baines RA. Activity-dependent alternative splicing increases persistent sodium current and promotes seizure. J Neurosci 2012; 32: 7267-77.
    • (2012) J Neurosci , vol.32 , pp. 7267-7277
    • Lin, W.H.1    Gunay, C.2    Marley, R.3    Prinz, A.A.4    Baines, R.A.5
  • 36
    • 70349276778 scopus 로고    scopus 로고
    • Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, in-activation, and persistent current
    • Lin WH, Wright DE, Muraro NI, Baines RA. Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, in-activation, and persistent current. J Neurophysiol 2009; 102: 1994-2006.
    • (2009) J Neurophysiol , vol.102 , pp. 1994-2006
    • Lin, W.H.1    Wright, D.E.2    Muraro, N.I.3    Baines, R.A.4
  • 37
    • 0029845174 scopus 로고    scopus 로고
    • Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment
    • Liu W, Bi X, Tocco G, Baudry M, Schreiber SS. Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment. Neuroreport 1996; 7: 2785-9.
    • (1996) Neuroreport , vol.7 , pp. 2785-2789
    • Liu, W.1    Bi, X.2    Tocco, G.3    Baudry, M.4    Schreiber, S.S.5
  • 39
    • 79953705357 scopus 로고    scopus 로고
    • Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma
    • Loscher W, Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011; 52: 657-78.
    • (2011) Epilepsia , vol.52 , pp. 657-678
    • Loscher, W.1    Schmidt, D.2
  • 41
    • 84878396610 scopus 로고    scopus 로고
    • Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment
    • Macias M, Blazejczyk M, Kazmierska P, Caban B, Skalecka A, Tarkowski B, et al. Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS One 2013; 8: e64455.
    • (2013) PLoS One , vol.8 , pp. e64455
    • MacIas, M.1    Blazejczyk, M.2    Kazmierska, P.3    Caban, B.4    Skalecka, A.5    Tarkowski, B.6
  • 42
    • 79959959081 scopus 로고    scopus 로고
    • Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant
    • Marley R, Baines RA. Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. J Neurophysiol 2011; 106: 18-29.
    • (2011) J Neurophysiol , vol.106 , pp. 18-29
    • Marley, R.1    Baines, R.A.2
  • 44
    • 79955698518 scopus 로고    scopus 로고
    • A role for opioid system in the proconvulsant effects of sildenafil on the pentylenetetrazole-induced clonic seizure in mice
    • Montaser-Kouhsari L, Payandemehr B, Gholipour T, Ziai P, Nabavizadeh P, Ghasemi A, et al. A role for opioid system in the proconvulsant effects of sildenafil on the pentylenetetrazole-induced clonic seizure in mice. Seizure 2011; 20: 409-13.
    • (2011) Seizure , vol.20 , pp. 409-413
    • Montaser-Kouhsari, L.1    Payandemehr, B.2    Gholipour, T.3    Ziai, P.4    Nabavizadeh, P.5    Ghasemi, A.6
  • 45
    • 23844483215 scopus 로고    scopus 로고
    • Identification of JAK/STAT signalling components by genome-wide RNA interference
    • Muller P, Kuttenkeuler D, Gesellchen V, Zeidler MP, Boutros M. Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 2005; 436: 871-5.
    • (2005) Nature , vol.436 , pp. 871-875
    • Muller, P.1    Kuttenkeuler, D.2    Gesellchen, V.3    Zeidler, M.P.4    Boutros, M.5
  • 46
    • 0031779334 scopus 로고    scopus 로고
    • Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy
    • Nagy Z, Esiri MM. Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy. Exp Neurol 1998; 150: 240-7.
    • (1998) Exp Neurol , vol.150 , pp. 240-247
    • Nagy, Z.1    Esiri, M.M.2
  • 47
    • 84884375759 scopus 로고    scopus 로고
    • Effect of sildenafil, a selective phosphodiesterase 5 inhibitor, on the anticon-vulsant action of some antiepileptic drugs in the mouse 6-Hz psy-chomotor seizure model
    • Nieoczym D, Socala K, Jedziniak P, Olejnik M, Wlaz P. Effect of sildenafil, a selective phosphodiesterase 5 inhibitor, on the anticon-vulsant action of some antiepileptic drugs in the mouse 6-Hz psy-chomotor seizure model. Prog Neuropsychopharmacol Biol Psychiatry 2013; 47: 104-10.
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.47 , pp. 104-110
    • Nieoczym, D.1    Socala, K.2    Jedziniak, P.3    Olejnik, M.4    Wlaz, P.5
  • 48
    • 0038185246 scopus 로고    scopus 로고
    • Exploring new gene discoveries in idiopathic generalized epilepsy
    • Noebels JL. Exploring new gene discoveries in idiopathic generalized epilepsy. Epilepsia 2003; 44 (Suppl 2): 16-21.
    • (2003) Epilepsia , vol.44 , pp. 16-21
    • Noebels, J.L.1
  • 51
    • 79951548110 scopus 로고    scopus 로고
    • Drosophila as a model for epilepsy: Bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures
    • Parker L, Padilla M, Du Y, Dong K, Tanouye MA. Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Genetics 2011b; 187: 523-34.
    • (2011) Genetics , vol.187 , pp. 523-534
    • Parker, L.1    Padilla, M.2    Du, Y.3    Dong, K.4    Tanouye, M.A.5
  • 52
    • 28744432192 scopus 로고    scopus 로고
    • Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus
    • Pavlova T, Stepanichev M, Gulyaeva N. Pentylenetetrazole kindling induces neuronal cyclin B1 expression in rat hippocampus. Neurosci Lett 2006; 392: 154-8.
    • (2006) Neurosci Lett , vol.392 , pp. 154-158
    • Pavlova, T.1    Stepanichev, M.2    Gulyaeva, N.3
  • 53
    • 8544273283 scopus 로고    scopus 로고
    • Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia
    • Raymond CK, Castle J, Garrett-Engele P, Armour CD, Kan Z, Tsinoremas N, et al. Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia. J Biol Chem 2004; 279: 46234-41.
    • (2004) J Biol Chem , vol.279 , pp. 46234-46241
    • Raymond, C.K.1    Castle, J.2    Garrett-Engele, P.3    Armour, C.D.4    Kan, Z.5    Tsinoremas, N.6
  • 54
    • 1342344614 scopus 로고    scopus 로고
    • Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants
    • Reynolds ER, Stauffer EA, Feeney L, Rojahn E, Jacobs B, McKeever C. Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. J Neurobiol 2004; 58: 503-13.
    • (2004) J Neurobiol , vol.58 , pp. 503-513
    • Reynolds, E.R.1    Stauffer, E.A.2    Feeney, L.3    Rojahn, E.4    Jacobs, B.5    McKeever, C.6
  • 55
    • 84875258395 scopus 로고    scopus 로고
    • MTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy
    • Russo E, Citraro R, Donato G, Camastra C, Iuliano R, Cuzzocrea S, et al. mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy. Neuropharmacology 2013; 69: 25-36.
    • (2013) Neuropharmacology , vol.69 , pp. 25-36
    • Russo, E.1    Citraro, R.2    Donato, G.3    Camastra, C.4    Iuliano, R.5    Cuzzocrea, S.6
  • 56
    • 0026055009 scopus 로고
    • Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs
    • Sarao R, Gupta SK, Auld VJ, Dunn RJ. Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs. Nucleic Acids Res 1991; 19: 5673-9.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5673-5679
    • Sarao, R.1    Gupta, S.K.2    Auld, V.J.3    Dunn, R.J.4
  • 57
    • 33244476694 scopus 로고    scopus 로고
    • Natural history of treated childhood-onset epilepsy: Prospective, long-term population-based study
    • Sillanpaa M, Schmidt D. Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study. Brain 2006; 129 (Pt 3): 617-24.
    • (2006) Brain , vol.129 , pp. 617-624
    • Sillanpaa, M.1    Schmidt, D.2
  • 58
    • 33947303357 scopus 로고    scopus 로고
    • Seizure suppression by top1 mutations in Drosophila
    • Song J, Hu J, Tanouye M. Seizure suppression by top1 mutations in Drosophila. J Neurosci 2007; 27: 2927-37.
    • (2007) J Neurosci , vol.27 , pp. 2927-2937
    • Song, J.1    Hu, J.2    Tanouye, M.3
  • 59
    • 53249098386 scopus 로고    scopus 로고
    • DNA topoisomerase i inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy
    • Song J, Parker L, Hormozi L, Tanouye MA. DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. Neuroscience 2008; 156: 722-8.
    • (2008) Neuroscience , vol.156 , pp. 722-728
    • Song, J.1    Parker, L.2    Hormozi, L.3    Tanouye, M.A.4
  • 61
    • 37749029721 scopus 로고    scopus 로고
    • Persistent sodium current and its role in epilepsy
    • Stafstrom CE. Persistent sodium current and its role in epilepsy. Epilepsy Curr 2007; 7: 15-22.
    • (2007) Epilepsy Curr , vol.7 , pp. 15-22
    • Stafstrom, C.E.1
  • 62
    • 0032167481 scopus 로고    scopus 로고
    • Valproate selectively reduces the persistent fraction of Na+ current in neocor-tical neurons
    • Taverna S, Mantegazza M, Franceschetti S, Avanzini G. Valproate selectively reduces the persistent fraction of Na+ current in neocor-tical neurons. Epilepsy Res 1998; 32: 304-8.
    • (1998) Epilepsy Res , vol.32 , pp. 304-308
    • Taverna, S.1    Mantegazza, M.2    Franceschetti, S.3    Avanzini, G.4
  • 63
    • 0032921489 scopus 로고    scopus 로고
    • Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: A modulator of in vivo programmed cell death?
    • Timsit S, Rivera S, Ouaghi P, Guischard F, Tremblay E, Ben-Ari Y, et al. Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death? Eur J Neurosci 1999; 11: 263-78.
    • (1999) Eur J Neurosci , vol.11 , pp. 263-278
    • Timsit, S.1    Rivera, S.2    Ouaghi, P.3    Guischard, F.4    Tremblay, E.5    Ben-Ari, Y.6
  • 65
    • 33749056769 scopus 로고    scopus 로고
    • An RNA map predicting Nova-dependent splicing regulation
    • Ule J, Stefani G, Mele A, Ruggiu M, Wang X, Taneri B, et al. An RNA map predicting Nova-dependent splicing regulation. Nature 2006; 444: 580-6.
    • (2006) Nature , vol.444 , pp. 580-586
    • Ule, J.1    Stefani, G.2    Mele, A.3    Ruggiu, M.4    Wang, X.5    Taneri, B.6
  • 66
    • 33644873636 scopus 로고    scopus 로고
    • Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis
    • Waltereit R, Welzl H, Dichgans J, Lipp HP, Schmidt WJ, Weller M. Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis. J Neurochem 2006; 96: 407-13.
    • (2006) J Neurochem , vol.96 , pp. 407-413
    • Waltereit, R.1    Welzl, H.2    Dichgans, J.3    Lipp, H.P.4    Schmidt, W.J.5    Weller, M.6
  • 67
    • 80755187943 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy
    • Xu Z, Xue T, Zhang Z, Wang X, Xu P, Zhang J, et al. Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy. Neurochem Res 2011; 36: 2208-15.
    • (2011) Neurochem Res , vol.36 , pp. 2208-2215
    • Xu, Z.1    Xue, T.2    Zhang, Z.3    Wang, X.4    Xu, P.5    Zhang, J.6
  • 69
    • 0024318132 scopus 로고
    • Chemical kindling induced by cAMP and transfer to electrical kindling
    • Yokoyama N, Mori N, Kumashiro H. Chemical kindling induced by cAMP and transfer to electrical kindling. Brain Res 1989; 492: 158-62.
    • (1989) Brain Res , vol.492 , pp. 158-162
    • Yokoyama, N.1    Mori, N.2    Kumashiro, H.3
  • 70
    • 27144464110 scopus 로고    scopus 로고
    • Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells
    • Yue C, Remy S, Su H, Beck H, Yaari Y. Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. J Neurosci 2005; 25: 9704-20.
    • (2005) J Neurosci , vol.25 , pp. 9704-9720
    • Yue, C.1    Remy, S.2    Su, H.3    Beck, H.4    Yaari, Y.5
  • 71
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 2008; 63: 444-53.
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 72


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.