Recent advances in application of biosensors in tissue engineering

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Hasan, Anwarul ^a,b,c   Nurunnabi, Md ^d   Morshed, Mahboob ^e   Paul, Arghya ^b,c,f   Polini, Alessandro ^b,c   Kuila, Tapas ^g   Al Hariri, Moustafa ^a   Lee, Yong Kyu ^d   Jaffa, Ayad A ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Chungju National University   (South Korea)

^e DEPARTMENT OF PHARMACOLOGY   (Malaysia)

^f University of Kansas   (United States)

^g CSIR CENTRAL MECHANICAL ENGINEERING RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ALBUMIN; ALPHA FETOPROTEIN; ANTIBODY; CARBON NANOTUBE; GAMMA INTERFERON; GLUCOSE; GRAPHENE; HYDROGEN PEROXIDE; LACTOSE; NUCLEIC ACID; QUANTUM DOT; TUMOR NECROSIS FACTOR ALPHA; ENZYME;

ARTICLE; BIOSENSOR; CELL ORGANELLE; ELECTROCHEMICAL ANALYSIS; MICROFLUIDICS; MICROORGANISM; OPTICAL BIOSENSOR; TISSUE ENGINEERING; CHEMISTRY; CLASSIFICATION; GENETIC PROCEDURES; HUMAN; ISOLATION AND PURIFICATION; PROCEDURES;

ADENOSINE; ANTIBODIES; BIOSENSING TECHNIQUES; ENZYMES; GLUCOSE; HUMANS; HYDROGEN PEROXIDE; QUANTUM DOTS; TISSUE ENGINEERING;

EID: 84929056256     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/307519     Document Type: Article

References (186)

1. M. Nurunnabi, K. J. Cho, J. S. Choi, K. M. Huh, and Y. Lee, "Targeted near-IR QDs-loaded micelles for cancer therapy and imaging, " Biomaterials, vol. 31, no. 20, pp. 5436-5444, 2010.
2. B. D. Malhotra, R. Singhal, A. Chaubey, S. K. Sharma, and A. Kumar, "Recent trends in biosensors, " Current Applied Physics, vol. 5, no. 2, pp. 92-97, 2005.
3. A. Hasan, A. Memic, N. Annabi et al., "Electrospun scaffolds for tissue engineering of vascular grafts, " Acta Biomaterialia, vol. 10, pp. 11-25, 2014.
4. A. Hasan, K. Ragaert, W. Swieszkowski et al., "Biomechanical properties of native and tissue engineered heart valve constructs, " Journal of Biomechanics, vol. 47, no. 9, 2013.
5. Z. Khatun, M. Nurunnabi, K. J. Cho, and Y. Lee, "Oral delivery of near-infrared quantum dot loaded micelles for noninvasive biomedical imaging, " ACS AppliedMaterials and Interfaces, vol. 4, no. 8, pp. 3880-3887, 2012.
6. Z. Khatun, M. Nurunnabi, K. J. Cho, and Y. Lee, "Imaging of the GI tract by QDs loaded heparin-deoxycholic acid (DOCA) nanoparticles, " Carbohydrate Polymers, vol. 90, no. 4, pp. 1461-1468, 2012.
7. J. S. Kim, K. J. Cho, T. H. Tran et al., "In vivo NIR imaging with CdTe/CdSe quantum dots entrapped in PLGA nanospheres, " Journal of Colloid and Interface Science, vol. 353, no. 2, pp. 363-371, 2011.
8. A. Malima, S. Siavoshi, T. Musacchio et al., "Highly sensitive microscale in vivo sensor enabled by electrophoretic assembly of nanoparticles for multiple biomarker detection, " Lab on a Chip, vol. 12, no. 22, pp. 4748-4754, 2012.
9. B. N. G. Giepmans, S. R. Adams, M. H. Ellisman, and R. Y. Tsien, "The fluorescent toolbox for assessing protein location and function, " Science, vol. 312, no. 5771, pp. 217-224, 2006.
10. W. C. W. Chan and S. Nie, "Quantum dot bioconjugates for ultrasensitive nonisotopic detection, " Science, vol. 281, no. 5385, pp. 2016-2018, 1998.
11. M. Tomasulo, I. Yildiz, S. L. Kaanumalle, and F. M. Raymo, "pHsensitive ligand for luminescent quantum dots, " Langmuir, vol. 22, no. 24, pp. 10284-10290, 2006.
12. H.-Y. Xie, J.-G. Liang, Z.-L. Zhang, Y. Liu, Z.-K. He, and D.-W. Pang, "Luminescent CdSe-ZnS quantum dots as selective Cu2+ probe, " Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy, vol. 60, no. 11, pp. 2527-2530, 2004.
13. J. L. Arlett, E. B. Myers, and M. L. Roukes, "Comparative advantages of mechanical biosensors, " Nature Nanotechnology, vol. 6, no. 4, pp. 203-215, 2011.
14. F-A. Kauffer, C. Merlin, L. Balan, and R. Schneider, "Incidence of the core composition on the stability, the ROS production and the toxicity of CdSe quantum dots, " Journal of Hazardous Materials, vol. 268, pp. 246-255, 2014.
15. H. Mattoussi, J. M. Mauro, E. R. Goldman et al., "Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein, " Journal of theAmericanChemical Society, vol. 122, no. 49, pp. 12142-12150, 2000.
16. H. Yeh, Y. Ho, and T. Wang, "Quantum dot-mediated biosensing assays for specific nucleic acid detection, " Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 1, no. 2, pp. 115-121, 2005.
17. S. Cosnier, "Biomolecule immobilization on electrode surfaces by entrapment or attachment to electrochemically polymerized films. A review, " Biosensors and Bioelectronics, vol. 14, no. 5, pp. 443-456, 1999.
18. H. T. Tien, S. H. Wurster, and A. L. Ottova, "Electrochemistry of supported bilayer lipid membranes: background and techniques for biosensor development, " Bioelectrochemistry and Bioenergetics, vol. 42, no. 1, pp. 77-94, 1997.
19. S. F. D'Souza, "Immobilization and stabilization of biomaterials for biosensor applications, " Applied Biochemistry and Biotechnology, vol. 96, no. 1-3, pp. 225-238, 2001.
20. K. Riedel, "Microbial biosensors based on oxygen electrodes, " in Enzyme and Microbial Biosensors, A. Mulchandani and K. Rogers, Eds., pp. 199-223, Humana Press, 1998.
21. J. L. Marty, D. Olive, and Y. Asano, "Measurement of BOD: correlation between 5-day BOD and commercial BOD biosensor values, " Environmental Technology, vol. 18, no. 3, pp. 333-337, 1997.
22. R. Rizzuto, P. Pinton, M. Brini, A. Chiesa, L. Filippin, and T. Pozzan, "Mitochondria as biosensors of calcium microdomains, " Cell Calcium, vol. 26, no. 5, pp. 193-199, 1999.
23. E. Kress-Rogers and C. J. B. Brimelow, Instrumentation and Sensors for the Food Industry, Woodhead, Cambridge, UK, 2nd edition, 2001.
24. A. Turner, I. Karube, and G. S. Wilson, Biosensors: Fundamentals and Applications, Oxford University Press, Oxford, UK, 1987.
25. M. Campas, R. Carpentier, and R. Rouillon, "Plant tissue-and photosynthesis-based biosensors, " Biotechnology Advances, vol. 26, no. 4, pp. 370-378, 2008.
26. S. E. Hufton, P. T. Moerkerk, E. V. Meulemans, A. de Bruine, J. Arends, and H. R. Hoogenboom, "Phage display of cDNA repertoires: the pVI display system and its applications for the selection of immunogenic ligands, " Journal of Immunological Methods, vol. 231, no. 1-2, pp. 39-51, 1999.
27. M. D. Marazuela and M. C. Moreno-Bondi, "Fiber-optic biosensors-an overview, " Analytical and Bioanalytical Chemistry, vol. 372, no. 5-6, pp. 664-682, 2002.
28. H. Nakamura and I. Karube, "Current research activity in biosensors, " Analytical and Bioanalytical Chemistry, vol. 377, no. 3, pp. 446-468, 2003.
29. O. Lazcka, F. J. D. Campo, and F. X. Munoz, "Pathogen detection: a perspective of traditionalmethods and biosensors, " Biosensors and Bioelectronics, vol. 22, no. 7, pp. 1205-1217, 2007.
30. H. J. Watts, C. R. Lowe, and D. V. Pollard-Knight, "Optical biosensor for monitoring microbial cells, " Analytical Chemistry, vol. 66, no. 15, pp. 2465-2470, 1994.
31. I. R. D. C. Jose and P. C. Ralph, Biosensors. Encyclopedia of Agricultural, Food, and Biological Engineering, Taylor and Francis, Oxford, UK, 2nd edition, 2010.
32. E. Kress-Rogers, Handbook of Biosensors and Electronic Noses: Medicine, Food, and the Environment, CRC Press, 1996.
33. A. P. F. Turner, "Biosensors: sense and sensibility, " Chemical Society Reviews, vol. 42, no. 8, pp. 3184-3196, 2013.
34. I. Wheeldon, A. Farhadi, A. G. Bick, E. Jabbari, and A. Khademhosseini, "Nanoscale tissue engineering: spatial control over cell-materials interactions, " Nanotechnology, vol. 22, no. 21, Article ID 212001, 2011.
35. Y. Wang, Q. Chen, and X. Zeng, "Potentiometric biosensor for studying hydroquinone cytotoxicity in vitro, " Biosensors and Bioelectronics, vol. 25, no. 6, pp. 1356-1362, 2010.
36. E.-H. Yoo and S.-Y. Lee, "Glucose biosensors: an overviewof use in clinical practice, " Sensors, vol. 10, no. 5, pp. 4558-4576, 2010.
37. S. Borgmann, A. Schulte, S. Neugebauer, and W. Schuhmann, "Amperometric biosensors, " in Advances in Electrochemical Science and Engineering, pp. 1-83, Wiley-VCH, New York, NY, USA, 2011.
38. V. Scognamiglio, A. Scire, V. Aurilia et al., "A strategic fluorescence labeling of D-galactose/D-glucose-binding protein from Escherichia coli helps to shed light on the protein structural stability and dynamics, " Journal of Proteome Research, vol. 6, no. 11, pp. 4119-4126, 2007.
39. S. DAuria, A. Ausili, A. Marabotti et al., "Binding of glucose to the D-galactose/D-glucose-binding protein fromEscherichia coli restores the native protein secondary structure and thermostability that are lost upon calcium depletion, " The Journal of Biochemistry, vol. 139, no. 2, pp. 213-221, 2006.
40. C. J. Jeffery, "Engineering periplasmic ligand binding proteins as glucose nanosensors, " Nano Reviews, vol. 2, 2011.
41. D. B. Sacks, M. Arnold, G. L. Bakris et al., "Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus, " Diabetes Care, vol. 34, no. 6, pp. e61-e99, 2011.
42. C. Chou, C. Y. Han, W. C. Kuo, Y. C. Huang, C. M. Feng, and J. C. Shyu, "Noninvasive glucose monitoring in vivo with an optical heterodyne polarimeter, " Applied Optics, vol. 37, no. 16, pp. 3553-3557, 1998.
43. B. H. Malik and G. L. Cote, "Real-time, closed-loop dualwavelength optical polarimetry for glucose monitoring, " Journal of Biomedical Optics, vol. 15, no. 1, Article ID017002, 2010.
44. H. M. Heise, R. Marbach, and F. A. Gries, "Noninvasive blood glucose sensors based on near-infrared spectroscopy, " Artificial Organs, vol. 18, no. 6, pp. 439-447, 1994.
45. K. Maruo, M. Tsurugi, M. Tamura, and Y. Ozaki, "In vivo noninvasive measurement of blood glucose by near-infrared diffuse-reflectance spectroscopy, " Applied Spectroscopy, vol. 57, no. 10, pp. 1236-1244, 2003.
46. C. Vranic, A. Fomichova, N. Gretz et al., "Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopy in vitro, "TheAnalyst, vol. 136, no. 6, pp. 1192-1198, 2011.
47. I. Gabriely, R. Wozniak, M. Mevorach, J. Kaplan, Y. Aharon, and H. Shamoon, "Transcutaneous glucosemeasurement using near-infrared spectroscopy during hypoglycemia, " Diabetes Care, vol. 22, no. 12, pp. 2026-2032, 1999.
48. C. D. Malchoff, K. Shoukri, J. I. Landau, and J. M. Buchert, "A novel noninvasive blood glucose monitor, " Diabetes Care, vol. 25, no. 12, pp. 2268-2275, 2002.
49. P. Zheng, C. E. Kramer, C. W. Barnes, J. R. Braig, and B. B. Sterling, "Noninvasive glucose determination by oscillating thermal gradient spectrometry, " Diabetes Technology and Therapeutics, vol. 2, no. 1, pp. 17-25, 2000.
50. J. Kottmann, J. M. Rey, J. Luginbuhl, E. Reichmann, and M. W. Sigrist, "Glucose sensing in human epidermis using midinfrared photoacoustic detection, " Biomedical Optics Express, vol. 3, no. 4, pp. 667-680, 2012.
51. R. J. McNichols and G. L. Cote, "Optical glucose sensing in biological fluids: an overview, " Journal of Biomedical Optics, vol. 5, no. 1, pp. 5-16, 2000.
52. A. Tura, A. Maran, and G. Pacini, "Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria, " Diabetes Research and Clinical Practice, vol. 77, no. 1, pp. 16-40, 2007.
53. V. Tuchin, Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, Taylor and Francis, 2008.
54. C. Pouchert, Aldrich Library of Infrared Spectra, AldrichChemical Co., 1981.
55. H. A. MacKenzie, H. S. Ashton, S. Spiers et al., "Advances in photoacoustic noninvasive glucose testing, " Clinical Chemistry, vol. 45, no. 9, pp. 1587-1595, 1999.
56. W. B. Martin, S. Mirov, and R. Venugopalan, "Using two discrete frequencieswithin the middle infrared to quantitatively determine glucose in serum, " Journal of Biomedical Optics, vol. 7, no. 4, pp. 613-617, 2002.
57. W. B. Martin, S. Mirov, and R. Venugopalan, "Middle infrared, quantum cascade laser optoelectronic absorption system for monitoring glucose in serum, " Applied Spectroscopy, vol. 59, no. 7, pp. 881-884, 2005.
58. X. Guo, A. Mandelis, and B. Zinman, "Noninvasive glucose detection in human skin using wavelength modulated differential laser photothermal radiometry, " Biomedical Optics Express, vol. 3, no. 11, pp. 3012-3021, 2012.
59. A. Mandelis and X. Guo, "Wavelength-modulated differential photothermal radiometry: theory and experimental applications to glucose detection in water, " Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, vol. 84, no. 4, Article ID 041917, 2011.
60. K. K. Jain, "Applications of nanobiotechnology in clinical diagnostics, " Clinical Chemistry, vol. 53, no. 11, pp. 2002-2009, 2007.
61. V. Scognamiglio, "Nanotechnology in glucose monitoring: advances and challenges in the last 10 years, " Biosensors and Bioelectronics, vol. 47, pp. 12-25, 2013.
62. A. S. Rad, A. Mirabi, E. Binaian, and H. Tayebi, "A review on glucose and hydrogen peroxide biosensor based on modified electrode included silver nanoparticles, " International Journal of Electrochemical Science, vol. 6, no. 8, pp. 3671-3683, 2011.
63. T. Gu and Y. Hasebe, "DNA-Cu(II) poly(amine) complex membrane as novel catalytic layer for highly sensitive amperometric determination of hydrogen peroxide, " Biosensors and Bioelectronics, vol. 21, no. 11, pp. 2121-2128, 2006.
64. S. Chen, R. Yuan, Y. Chai, L. Zhang, N. Wang, and X. Li, "Amperometric third-generation hydrogen peroxide biosensor based on the immobilization of hemoglobin on multiwall carbon nanotubes and gold colloidal nanoparticles, " Biosensors and Bioelectronics, vol. 22, no. 7, pp. 1268-1274, 2007.
65. D. Du, J. Ding, J. Cai, and A. Zhang, "Determination of carbaryl pesticide using amperometric acetylcholinesterase sensor formed by electrochemically deposited chitosan, " Colloids and Surfaces B: Biointerfaces, vol. 58, no. 2, pp. 145-150, 2007.
66. Y. X. Sun, J. T. Zhang, S. W. Huang, and S. F. Wang, "Hydrogen peroxide biosensor based on the bioelectrocatalysis of horseradish peroxidase incorporated in a new hydrogel film, " Sensors and Actuators, B: Chemical, vol. 124, no. 2, pp. 494-500, 2007.
67. J. Li and X. Lin, "Glucose biosensor based on immobilization of glucose oxidase in poly(o-aminophenol) film on polypyrrole-Pt nanocompositemodified glassy carbon electrode, " Biosensors and Bioelectronics, vol. 22, no. 12, pp. 2898-2905, 2007.
68. Q. Liu, X. Lu, J. Li, X. Yao, and J. Li, "Direct electrochemistry of glucose oxidase and electrochemical biosensing of glucose on quantum dots/carbon nanotubes electrodes, " Biosensors and Bioelectronics, vol. 22, no. 12, pp. 3203-3209, 2007.
69. L. Wang and E. Wang, "A novel hydrogen peroxide sensor based on horseradish peroxidase immobilized on colloidal Au modified ITO electrode, " Electrochemistry Communications, vol. 6, no. 2, pp. 225-229, 2004.
70. M. Yang, Y. Yang, G. Shen, and R. Yu, "Bienzymatic amperometric biosensor for choline based on mediator thionine in situ electropolymerized within a carbon paste electrode, " Analytical Biochemistry, vol. 334, no. 1, pp. 127-134, 2004.
71. J. Zhang, M. Feng, and H. Tachikawa, "Layer-by-layer fabrication and direct electrochemistry of glucose oxidase on single wall carbon nanotubes, " Biosensors and Bioelectronics, vol. 22, no. 12, pp. 3036-3041, 2007.
72. Y. Xu, C. Hu, and S. Hu, "A hydrogen peroxide biosensor based on direct electrochemistry of hemoglobin in Hb-Ag sol films, " Sensors and Actuators, B: Chemical, vol. 130, no. 2, pp. 816-822, 2008.
73. R. Chen, L. Zhang, J. Gao, W. Wu, Y. Hu, and X. Jiang, "Chemiluminescent nanomicelles for imaging hydrogen peroxide and self-therapy in photodynamic therapy, " Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 679492, 9 pages, 2011.
74. Q. Chang, L. Zhu, G. Jiang, and H. Tang, "Sensitive fluorescent probes for determination of hydrogen peroxide and glucose based on enzyme-immobilized magnetite/silica nanoparticles, " Analytical and Bioanalytical Chemistry, vol. 395, no. 7, pp. 2377-2385, 2009.
75. G. Kim, Y. K. Lee, H. Xu, M. A. Philbert, and R. Kopelman, "Nanoencapsulation method for high selectivity sensing of hydrogen peroxide inside live cells, " Analytical Chemistry, vol. 82, no. 6, pp. 2165-2169, 2010.
76. Y. C. Shiang, C. C. Huang, and H. T. Chang, "Gold nanodotbased luminescent sensor for the detection of hydrogen peroxide and glucose, " Chemical Communications, no. 23, pp. 3437-3439, 2009.
77. E. Llaudet, S. Hatz, M. Droniou, and N. Dale, "Microelectrode biosensor for real-time measurement of ATP in biological tissue, " Analytical Chemistry, vol. 77, no. 10, pp. 3267-3273, 2005.
78. C. Wang, C. Y. Huang, and W. C. Lin, "Optical ATP biosensor for extracellularATPmeasurement, " Biosensors and Bioelectronics, vol. 43, no. 1, pp. 355-361, 2013.
79. M. J. Leo Bours, P. C. Dagnelie, A. L. Giuliani, A. Wesselius, and F. di Virgilio, "P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation, " Frontiers in Bioscience, vol. 3, no. 4, pp. 1443-1456, 2011.
80. G. Burnstock, "Pathophysiology and therapeutic potential of purinergic signaling, " Pharmacological Reviews, vol. 58, no. 1, pp. 58-86, 2006.
81. R. Corriden and P. A. Insel, "Basal release of ATP: an autocrineparacrinemechanism for cell regulation, " Science Signaling, vol. 3, no. 104, article re1, 2010.
82. M. Wall, R. Eason, and N. Dale, "Biosensor measurement of purine release from cerebellar cultures and slices, " Purinergic Signalling, vol. 6, no. 3, pp. 339-348, 2010.
83. S. W. Schneider, M. E. Egan, B. P. Jena, W. B. Guggino, H. Oberleithner, and J. P. Geibel, "Continuous detection of extracellular ATP on living cells by using atomic force microscopy, " Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 21, pp. 12180-12185, 1999.
84. S. Hayashi, A. Hazama, A. K. Dutta, R. Z. Sabirov, and Y. Okada, "Detecting ATP release by a biosensormethod, " Sciences STKE, vol. 2004, no. 258, article pl14, 2004.
85. L. Xie, X. Yan, and Y. Du, "An aptamer based wall-less LSPR array chip for label-free and high throughput detection of biomolecules, " Biosensors and Bioelectronics, vol. 53, pp. 58-64, 2014.
86. I. Stamenkovic, "Matrix metalloproteinases in tumor invasion and metastasis, " Seminars in Cancer Biology, vol. 10, no. 6, pp. 415-433, 2000.
87. M. Egeblad and Z. Werb, "New functions for the matrix metalloproteinases in cancer progression, " Nature Reviews Cancer, vol. 2, no. 3, pp. 161-174, 2002.
88. C. Cupp-Enyard, "Sigma's non-specific protease activity assay: casein as a substrate, " Journal of Visualized Experiments, no. 19, article no. e899, 2008.
89. J. Hu and S. Liu, "Responsive polymers for detection and sensing applications: current status and future developments, " Macromolecules, vol. 43, no. 20, pp. 8315-8330, 2010.
90. J. Hu, G. Zhang, and S. Liu, "Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels, " Chemical Society Reviews, vol. 41, no. 18, pp. 5933-5949, 2012.
91. Z. Ge and S. Liu, "Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance, " Chemical Society Reviews, vol. 42, no. 17, pp. 7289-7325, 2013.
92. S. B. Lowe, J. A. G. Dick, B. E. Cohen, and M. M. Stevens, "Multiplex sensing of protease and kinase enzyme activity via orthogonal coupling of quantum dot-peptide conjugates, " ACS Nano, vol. 6, no. 1, pp. 851-857, 2012.
93. M. J. Sailor and J. R. Link, ""Smart dust": nanostructured devices in a grain of sand, " Chemical Communications, no. 11, pp. 1375-1383, 2005.
94. M. M. Orosco, C. Pacholski, and M. J. Sailor, "Real-time monitoring of enzyme activity in a mesoporous silicon double layer, " Nature Nanotechnology, vol. 4, no. 4, pp. 255-258, 2009.
95. E. T. W. Bampton, C. G. Goemans, D. Niranjan, N. Mizushima, and A. M. Tolkovsky, "The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes, " Autophagy, vol. 1, no. 1, pp. 23-36, 2005.
96. R. I. Morimoto, "Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging, " Genes and Development, vol. 22, no. 11, pp. 1427-1438, 2008.
97. P. A. Serra, Biosensors for Health, Environment and Biosecurity, InTech, Rijeka, Croatia, 2011.
98. Y. Shevchenko, G. Camci-Unal, D. F. Cuttica, M. R. Dokmeci, J. Albert, and A. Khademhosseini, "Surface plasmon resonance fiber sensor for real-time and label-free monitoring of cellular behavior, " Biosensors and Bioelectronics, vol. 56, pp. 359-367, 2014.
99. Z. Altintas, S. S. Kallempudi, U. Sezerman, and Y. Gurbuz, "A novel magnetic particle-modified electrochemical sensor for immunosensor applications, " Sensors and Actuators, B: Chemical, vol. 174, pp. 187-194, 2012.
100. J. Ladd, H. Lu, A. D. Taylor, V. Goodell, M. L. Disis, and S. Jiang, "Direct detection of carcinoembryonic antigen autoantibodies in clinical human serum samples using a surface plasmon resonance sensor, " Colloids and Surfaces B: Biointerfaces, vol. 70, no. 1, pp. 1-6, 2009.
101. S. S. Kallempudi, Z. Altintas, J. H. Niazi, and Y. Gurbuz, "A new microfluidics system with a hand-operated, on-chip actuator for immunosensor applications, " Sensors and Actuators, B: Chemical, vol. 163, no. 1, pp. 194-201, 2012.
102. A. Ilyas, W. Asghar, P. B. Allen, H. Duhon, A. D. Ellington, and S. M. Iqbal, "Electrical detection of cancer biomarker using aptamers with nanogap break-junctions, " Nanotechnology, vol. 23, no. 27, Article ID275502, 2012.
103. M. Morris, Fluorescent Biosensors for Cancer Cell Imaging and Diagnostics, Taylor and Francis, 2012.
104. M. C. Morris, "Fluorescent biosensors-probing protein kinase function in cancer and drug discovery, " Biochimica et Biophysica Acta-Proteins and Proteomics, vol. 1834, no. 7, pp. 1387-1395, 2013.
105. V. Ntziachristos, "Fluorescence molecular imaging, " Annual Review of Biomedical Engineering, vol. 8, pp. 1-33, 2006.
106. J. Brognard and T. Hunter, "Protein kinase signaling networks in cancer, " Current Opinion in Genetics and Development, vol. 21, no. 1, pp. 4-11, 2011.
107. S. Lapenna and A. Giordano, "Cell cycle kinases as therapeutic targets for cancer, " Nature Reviews Drug Discovery, vol. 8, no. 7, pp. 547-566, 2009.
108. M. Malumbres, "Physiological relevance of cell cycle kinases, " Physiological Reviews, vol. 91, no. 3, pp. 973-1007, 2011.
109. N. Nakamura, A. Shigematsu, and T. Matsunaga, "Electrochemical detection of viable bacteria in urine and antibiotic selection, " Biosensors and Bioelectronics, vol. 6, no. 7, pp. 575-580, 1991.
110. J. L. Brooks, B. Mirhabibollahi, and R. G. Kroll, "Experimental enzyme-linked amperometric immunosensors for the detection of salmonellas in foods, "The Journal ofApplied Bacteriology, vol. 73, no. 3, pp. 189-196, 1992.
111. M. Plomer, G. G. Guilbault, and B. Hock, "Development of a piezoelectric immunosensor for the detection of enterobacteria, " Enzyme and Microbial Technology, vol. 14, no. 3, pp. 230-235, 1992.
112. W. E. Lee, H. G. Thompson, J. G. Hall, R. E. Fulton, and J. P. Wong, "Rapid immunofiltration assay of Newcastle disease virus using a silicon sensor, " Journal of ImmunologicalMethods, vol. 166, no. 1, pp. 123-131, 1993.
113. T. Y. Yeo, J. S. Choi, B. K. Lee et al., "Electrochemical endotoxin sensors based on TLR4/MD-2 complexes immobilized on gold electrodes, " Biosensors and Bioelectronics, vol. 28, no. 1, pp. 139-145, 2011.
114. A. Leung, P. M. Shankar, and R. Mutharasan, "A review of fiberoptic biosensors, " Sensors and Actuators, B: Chemical, vol. 125, no. 2, pp. 688-703, 2007.
115. G. Priano, D. Pallarola, and F. Battaglini, "Endotoxin detection in a competitive electrochemical assay: synthesis of a suitable endotoxin conjugate, " Analytical Biochemistry, vol. 362, no. 1, pp. 108-116, 2007.
116. X. L. Xiong, S. M. Wang, Y. Zhang, and L. C. Chen, "Detection of endotoxin concentration using piezoelectric based biosensor system, " AppliedMechanics andMaterials, vol. 195-196, pp. 874-878, 2012.
117. L. Yang and R. Bashir, "Electrical/electrochemical impedance for rapid detection of foodborne pathogenic bacteria, " Biotechnology Advances, vol. 26, no. 2, pp. 135-150, 2008.
118. F. Ricci, G. Volpe, L. Micheli, and G. Palleschi, "A review on novel developments and applications of immunosensors in food analysis, " Analytica Chimica Acta, vol. 605, no. 2, pp. 111-129, 2007.
119. D. Atias, Y. Liebes, V. Chalifa-Caspi et al., "Chemiluminescent optical fiber immunosensor for the detection of IgM antibody to dengue virus in humans, " Sensors and Actuators B: Chemical, vol. 140, no. 1, pp. 206-215, 2009.
120. R. L. Rich and D. G. Myszka, "Spying onHIVwith SPR, " Trends in Microbiology, vol. 11, no. 3, pp. 124-133, 2003.
121. E. Katz and I. Willner, "Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: Routes to impedimetric immunosensors, DNAsensors, and enzyme biosensors, " Electroanalysis, vol. 15, no. 11, pp. 913-947, 2003.
122. J. Griffin, A. K. Singh, D. Senapati et al., "Sequence-specific HCV RNA quantification using the size-dependent nonlinear optical properties of gold nanoparticles, " Small, vol. 5, no. 7, pp. 839-845, 2009.
123. P. Skladal, C. dos Santos Riccardi, H. Yamanaka, and P. I. da Costa, "Piezoelectric biosensors for real-time monitoring of hybridization and detection of hepatitis C virus, " Journal of Virological Methods, vol. 117, no. 2, pp. 145-151, 2004.
124. M. F. Frasco and N. Chaniotakis, "Semiconductor quantumdots in chemical sensors and biosensors, " Sensors, vol. 9, no. 9, pp. 7266-7286, 2009.
125. I. L. Medintz, K. E. Sapsford, A. R. Clapp et al., "Designer variable repeat length polypeptides as scaffolds for surface immobilization of quantum dots, " Journal of Physical Chemistry B, vol. 110, no. 22, pp. 10683-10690, 2006.
126. D. Cossins, "The cancer-test kid, " Scientist, vol. 27, no. 4, pp. 23-24, 2013.
127. A. Tucker, "Jack Andraka, the teen prodigy of pancreatic cancer, " Smithsonian Magazine, 2012.
128. J. C. Claussen, A. D. Franklin, A. U. Haque, D. Marshall Porterfield, and T. S. Fisher, "Electrochemical biosensor of nanocube-augmented carbon nanotube networks, " ACS Nano, vol. 3, no. 1, pp. 37-44, 2009.
129. J. Wang, J. Dai, and T. Yarlagadda, "Carbon nanotube-conducting-polymer composite nanowires, " Langmuir, vol. 21, no. 1, pp. 9-12, 2005.
130. K. Kim, J. Cheng, Q. Liu, X. Y. Wu, and Y. Sun, "Investigation of mechanical properties of soft hydrogel microcapsules in relation to protein delivery using aMEMS force sensor, " Journal of Biomedical Materials Research A, vol. 92, no. 1, pp. 103-113, 2010.
131. K. Kim, J. Cheng, Q. Liu, X. Y. Wu, and Y. Sun, "MEMS capacitive force sensors for micro-scale compression testing of biomaterials, " in Proceedings of the 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 08), pp. 888-891, Tucson, Ariz, USA, January 2008.
132. S. Mao, K. Yu, J. Chang, D. A. Steeber, L. E. Ocola, and J. Chen, "Direct growth of vertically-oriented graphene for field-effect transistor biosensor, " Scientific Reports, vol. 3, article 1696, 2013.
133. E. Timurdogan, B. E. Alaca, I. H. Kavakli, and H. Urey, "MEMS biosensor for detection of Hepatitis A and C viruses in serum, " Biosensors and Bioelectronics, vol. 28, no. 1, pp. 189-194, 2011.
134. M. Bruchez Jr., M. Moronne, P. Gin, S. Weiss, and A. P. Alivisatos, "Semiconductor nanocrystals as fluorescent biological labels, " Science, vol. 281, no. 5385, pp. 2013-2016, 1998.
135. H. Ceylan Koydemir, H. Kulah, C. Ozgen, A. Alp, and G. Hascelik, "MEMS biosensors for detection of methicillin resistant Staphylococcus aureus, " Biosensors and Bioelectronics, vol. 29, no. 1, pp. 1-12, 2011.
136. C. Ruan, W. Shi, H. Jiang et al., "One-pot preparation of glucose biosensor based on polydopamine-graphene composite film modified enzyme electrode, " Sensors and Actuators B: Chemical, vol. 177, pp. 826-832, 2013.
137. F. Xi, L. Liu, Q. Wu, and X. Lin, "One-step construction of biosensor based on chitosan-ionic liquid-horseradish peroxidase biocomposite formed by electrodeposition, " Biosensors and Bioelectronics, vol. 24, no. 1, pp. 29-34, 2008.
138. K. Yang, J. Wan, S. Zhang, Y. Zhang, S. Lee, and Z. Liu, "In vivo pharmacokinetics, long-termbiodistribution, and toxicology of PEGylated graphene in mice, " ACS Nano, vol. 5, no. 1, pp. 516-522, 2011.
139. T. Kuila, S. Bose, P. Khanra, A. K. Mishra, N. H. Kim, and J. H. Lee, "Recent advances in graphene-based biosensors, " Biosensors and Bioelectronics, vol. 26, no. 12, pp. 4637-4648, 2011.
140. Y. Shao, J. Wang, H. Wu, J. Liu, I. A. Aksay, and Y. Lin, "Graphene based electrochemical sensors and biosensors: a review, " Electroanalysis, vol. 22, no. 10, pp. 1027-1036, 2010.
141. M. Nurunnabi, Z. Khatun, G. R. Reeck, D. Y. Lee, and Y. K. Lee, "Near infra-red photoluminescent graphene nanoparticles greatly expand their use in noninvasive biomedical imaging, " Chemical Communications, vol. 49, no. 44, pp. 5079-5081, 2013.
142. J. Peng, W. Gao, B. K. Gupta et al., "Graphene quantum dots derived fromcarbonfibers, " Nano Letters, vol. 12, no. 2, pp. 844-849, 2012.
143. X. Yan, X. Cui, B. Li, and L. Li, "Large, solution-processable graphene quantum dots as light absorbers for photovoltaics, " Nano Letters, vol. 10, no. 5, pp. 1869-1873, 2010.
144. L. Gao, H. Zhang, and H. Cui, "A general strategy to prepare homogeneous and reagentless GO/lucigenin and enzyme biosensors for detection of small biomolecules, " Biosensors and Bioelectronics, vol. 57, pp. 65-70, 2014.
145. M. Nurunnabi, Z. Khatun, K. M. Huh et al., "In vivo biodistribution and toxicology of carboxylated graphene quantum dots, " ACS Nano, vol. 7, no. 8, pp. 6858-6867, 2013.
146. M. Nurunnabi, Z. Khatun, M. Nafiujjaman, D. Lee, and Y. Lee, "Surface coating of graphene quantum dots using musselinspired polydopamine for biomedical optical imaging, " ACS Applied Materials and Interfaces, vol. 5, no. 16, pp. 8246-8253, 2013.
147. H. Sun, L. Wu, W. Wei, and X. Qu, "Recent advances in graphene quantum dots for sensing, " Materials Today, vol. 16, no. 11, pp. 433-442, 2013.
148. D. Wang, L. Wang, X. Dong, Z. Shi, and J. Jin, "Chemically tailoring graphene oxides into fluorescent nanosheets for Fe3+ ion detection, " Carbon, vol. 50, no. 6, pp. 2147-2154, 2012.
149. Y. Liu, D. Yu, C. Zeng, Z. Miao, and L. Dai, "Biocompatible graphene oxide-based glucose biosensors, " Langmuir, vol. 26, no. 9, pp. 6158-6160, 2010.
150. Z. Wang, X. Zhou, J. Zhang, F. Boey, and H. Zhang, "Direct electrochemical reduction of single-layer graphene oxide and subsequent functionalization with glucose oxidase, " The Journal of Physical Chemistry C, vol. 113, no. 32, pp. 14071-14075, 2009.
151. P. Wu, Q. Shao, Y. Hu et al., "Direct electrochemistry of glucose oxidase assembled on graphene and application to glucose detection, " Electrochimica Acta, vol. 55, no. 28, pp. 8606-8614, 2010.
152. S. Alwarappan, C. Liu, A. Kumar, and C. Li, "Enzyme-doped graphene nanosheets for enhanced glucose biosensing, " Journal of Physical Chemistry C, vol. 114, no. 30, pp. 12920-12924, 2010.
153. B. Liang, L. Fang, G. Yang, Y. Hu, X. Guo, and X. Ye, "Direct electron transfer glucose biosensor based on glucose oxidase selfassembled on electrochemically reduced carboxyl graphene, " Biosensors and Bioelectronics, vol. 43, no. 1, pp. 131-136, 2013.
154. H. Yin, Y. Zhou, Q. Ma, S. Ai, Q. Chen, and L. Zhu, "Electrocatalytic oxidation behavior of guanosine at graphene, chitosan and Fe3O4 nanoparticles modified glassy carbon electrode and its determination, " Talanta, vol. 82, no. 4, pp. 1193-1199, 2010.
155. V. K. Gupta, N. Atar, M. L. Yola et al., "A novel glucose biosensor platform based on Ag@AuNPs modified graphene oxide nanocomposite and SERS application, " Journal of Colloid and Interface Science, vol. 406, pp. 231-237, 2013.
156. H. Wu, J. Wang, X. Kang et al., "Glucose biosensor based on immobilization of glucose oxidase in platinum nanoparticles/graphene/chitosan nanocomposite film, " Talanta, vol. 80, no. 1, pp. 403-406, 2009.
157. X. Kang, J. Wang, H. Wu, I. A. Aksay, J. Liu, and Y. Lin, "Glucose oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing, " Biosensors and Bioelectronics, vol. 25, no. 4, pp. 901-905, 2009.
158. M. H. Yang, B. G. Choi, H. Park, W. H. Hong, S. Y. Lee, and T. J. Park, "Development of a glucose biosensor using advanced electrodemodified by nanohybrid composing chemically modified graphene and ionic liquid, " Electroanalysis, vol. 22, no. 11, pp. 1223-1228, 2010.
159. J. Singh, P. Khanra, T. Kuila et al., "Preparation of sulfonated poly(ether-ether-ketone) functionalized ternary graphene/AuNPs/chitosan nanocomposite for efficient glucose biosensor, " Process Biochemistry, vol. 48, pp. 1724-1735, 2013.
160. M. B. Gholivand and M. Khodadadian, "Amperometric cholesterol biosensor based on the direct electrochemistry of cholesterol oxidase and catalase on a graphene/ionic liquid-modified glassy carbon electrode, " Biosensors and Bioelectronics, vol. 53, pp. 472-478, 2014.
161. R. S. Dey and C. R. Raj, "Development of an amperometric cholesterol biosensor based on graphene-Pt nanoparticle hybrid material, "The Journal of Physical Chemistry C, vol. 114, no. 49, pp. 21427-21433, 2010.
162. H. Xin, C. Zhang, D. Wang et al., "Tissue-engineered allograft intervertebral disc transplantation for the treatment of degenerative disc disease: experimental study in a beaglemodel, " Tissue Engineering A, vol. 19, no. 1-2, pp. 143-151, 2013.
163. K. Zhou, Y. Zhu, X. Yang, J. Luo, C. Li, and S. Luan, "A novel hydrogen peroxide biosensor based on Au-graphene-HRP-chitosan biocomposites, " Electrochimica Acta, vol. 55, no. 9, pp. 3055-3060, 2010.
164. L. Li, Z. Du, S. Liu et al., "A novel nonenzymatic hydrogen peroxide sensor based on MnO2/graphene oxide nanocomposite, " Talanta, vol. 82, no. 5, pp. 1637-1641, 2010.
165. Y. Wang, Y. Li, L. Tang, J. Lu, and J. Li, "Application of graphenemodified electrode for selective detection of dopamine, " Electrochemistry Communications, vol. 11, no. 4, pp. 889-892, 2009.
166. X. Liu, L. Xie, and H. Li, "Electrochemical biosensor based on reduced graphene oxide and Au nanoparticles entrapped in chitosan/silica sol-gel hybrid membranes for determination of dopamine and uric acid, " Journal of Electroanalytical Chemistry, vol. 682, pp. 158-163, 2012.
167. L. Zhong, S. Gan, X. Fu et al., "Electrochemically controlled growth of silver nanocrystals on graphene thin filmand applications for efficient nonenzymatic H2O2 biosensor, " Electrochimica Acta, vol. 89, pp. 222-228, 2013.
168. S. Hou, M. L. Kasner, S. Su, K. Patel, and R. Cuellari, "Highly sensitive and selective dopamine biosensor fabricated with silanized graphene, " The Journal of Physical Chemistry C, vol. 114, no. 35, pp. 14915-14921, 2010.
169. J. Zhu, X. Chen, and W. Yang, "A high performance electrochemical sensor for NADH based on graphite nanosheet modified electrode, " Sensors and Actuators, B: Chemical, vol. 150, no. 2, pp. 564-568, 2010.
170. M. L. Yola, T. Eren, and N. Atar, "A novel and sensitive electrochemical DNA biosensor based on Fe@Au nanoparticles decorated graphene oxide, " Electrochimica Acta, vol. 125, pp. 38-47, 2014.
171. V. K. Gupta, M. L. Yola, M. S. Qureshi, A. O. Solak, N. Atar, and Z. ?Ustundag, "A novel impedimetric biosensor based on graphene oxide/gold nanoplatform for detection of DNA arrays, " Sensors and Actuators B: Chemical, vol. 188, pp. 1201-1211, 2013.
172. X. Han, X. Fang, A. Shi, J. Wang, and Y. Zhang, "An electrochemical DNA biosensor based on gold nanorods decorated graphene oxide sheets for sensing platform, " Analytical Biochemistry, vol. 443, no. 2, pp. 117-123, 2013.
173. K.-J. Huang, Y.-J. Liu, H.-B. Wang, and Y.-Y. Wang, "A sensitive electrochemical DNA biosensor based on silver nanoparticlespolydopamine@ graphene composite, " Electrochimica Acta, vol. 118, pp. 130-137, 2014.
174. H. Chen and R. E. Nordon, "Application of microfluidics to study stem cell dynamics, " in Emerging Trends in Cell and Gene Therapy, pp. 435-470, 2013.
175. A. Paul, A. Hasan, L. Rodes, M. Sangaralingam, and S. Prakash, "Bioengineered baculoviruses as new class of therapeutics using micro and nanotechnologies: principles, prospects and challenges, " Advanced Drug Delivery Reviews, vol. 71, pp. 115-130, 2014.
176. S. Kumar, S. Kumar, M. A. Ali et al., "Microfluidic-integrated biosensors: prospects for point-of-care diagnostics, " Biotechnology Journal, vol. 8, no. 11, pp. 1267-1279, 2013.
177. C. A. Holland and F. L. Kiechle, "Point-of-care molecular diagnostic systems-past, present and future, " Current Opinion in Microbiology, vol. 8, no. 5, pp. 504-509, 2005.
178. A. Weltin, K. Slotwinski, J. Kieninger et al., "Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem, " Lab on a Chip, vol. 14, no. 1, pp. 138-146, 2014.
179. N. Hu, C. Wu, D. Ha, T. Wang, Q. Liu, and P. Wang, "A novel microphysiometer based on high sensitivity LAPS and microfluidic system for cellular metabolism study and rapid drug screening, " Biosensors and Bioelectronics, vol. 40, no. 1, pp. 167-173, 2013.
180. C.-W. Huang and G.-B. Lee, "A microfluidic system for automatic cell culture, " Journal of Micromechanics and Microengineering, vol. 17, no. 7, article 008, pp. 1266-1274, 2007.
181. S. C. C. Shih, I. Barbulovic-Nad, X. Yang, R. Fobel, and A. R. Wheeler, "Digital microfluidics with impedance sensing for integrated cell culture and analysis, " Biosensors and Bioelectronics, vol. 42, no. 1, pp. 314-320, 2013.
182. K. F. Lei, M. H. Wu, C. W. Hsu, and Y. D. Chen, "Real-time and non-invasive impedimetricmonitoring of cell proliferation and chemosensitivity in a perfusion 3Dcell culture microfluidic chip, " Biosensors and Bioelectronics, vol. 51, pp. 16-21, 2014.
183. T. A. Nguyen, T. I. Yin, D. Reyes, and G. A. Urban, "Microfluidic chip with integrated electrical cell-impedance sensing for monitoring single cancer cell migration in three-dimensional matrixes, " Analytical Chemistry, vol. 85, no. 22, pp. 11068-11076, 2013.
184. S. Choi, M. Goryll, L. Y. M. Sin, P. K. Wong, and J. Chae, "Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins, " Microfluidics and Nanofluidics, vol. 10, no. 2, pp. 231-247, 2011.
185. J. Melin and S. R. Quake, "Microfluidic large-scale integration: the evolution of design rules for biological automation, " Annual Review of Biophysics and Biomolecular Structure, vol. 36, pp. 213-231, 2007.
186. W. Lawi, C. Wiita, S. T. Snyder et al., "A microfluidic cartridge system for multiplexed clinical analysis, " Journal of the Association for Laboratory Automation, vol. 14, no. 6, pp. 407-412, 2009.