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Volumn 60, Issue , 2015, Pages S135-S143

Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): Characterization, manufacture, mechanisms of action, and quality control of a specific probiotic combination for primary prevention of clostridium difficile infection

Author keywords

Bio K+; Clostridium difficile; Lactobacillus; prevention; probiotic

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; LACTIC ACID; PROBIOTIC AGENT; RNA 16S;

EID: 84928885373     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ179     Document Type: Article
Times cited : (55)

References (64)
  • 1
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • The Human Microbiome Project Consortium
    • The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486: 207-14.
    • (2012) Nature , vol.486 , pp. 207-214
  • 2
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature 2013; 500: 541-6.
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3
  • 3
    • 84870999292 scopus 로고    scopus 로고
    • Intestinal colonization resistance
    • Lawley TD, Walker AW. Intestinal colonization resistance. Immunology 2013; 138: 1-11.
    • (2013) Immunology , vol.138 , pp. 1-11
    • Lawley, T.D.1    Walker, A.W.2
  • 4
    • 84886795788 scopus 로고    scopus 로고
    • Microbiota-mediated colonization resistance against intestinal pathogens
    • Buffie CG, Pamer EG. Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 2013; 13: 790-801.
    • (2013) Nat Rev Immunol , vol.13 , pp. 790-801
    • Buffie, C.G.1    Pamer, E.G.2
  • 5
    • 84898771460 scopus 로고    scopus 로고
    • Role of the intestinal microbiota in resistance to colonization by Clostridium difficile
    • Britton RA, Young VB. Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology 2014; 146: 1547-53.
    • (2014) Gastroenterology , vol.146 , pp. 1547-1553
    • Britton, R.A.1    Young, V.B.2
  • 6
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen L, Huse S, Sogin ML, Relman DA. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008; 6: e280.
    • (2008) PLoS Biol , vol.6 , pp. e280
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3    Relman, D.A.4
  • 7
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 2011; 108(suppl 1): 4554-61.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 8
    • 84896520726 scopus 로고    scopus 로고
    • Effects of beta-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea
    • Knecht H, Neulinger SC, Heinsen FA, et al. Effects of beta-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea. PLoS One 2014; 9: e89417.
    • (2014) PLoS One , vol.9 , pp. e89417
    • Knecht, H.1    Neulinger, S.C.2    Heinsen, F.A.3
  • 9
    • 0031752883 scopus 로고    scopus 로고
    • Risk factors for Clostridium difficile infection
    • Bignardi GE. Risk factors for Clostridium difficile infection. J Hosp Infect 1998; 40: 1-15.
    • (1998) J Hosp Infect , vol.40 , pp. 1-15
    • Bignardi, G.E.1
  • 10
    • 84905868831 scopus 로고    scopus 로고
    • Clostridium difficile: Improving the prevention paradigm in healthcare settings
    • Vassallo A, Tran MC, Goldstein EJ. Clostridium difficile: improving the prevention paradigm in healthcare settings. Expert Rev Anti Infect Ther 2014; 12: 1087-102.
    • (2014) Expert Rev Anti Infect Ther , vol.12 , pp. 1087-1102
    • Vassallo, A.1    Tran, M.C.2    Goldstein, E.J.3
  • 11
    • 42449133334 scopus 로고    scopus 로고
    • Infection control measures to limit the spread of Clostridium difficile
    • Vonberg RP, Kuijper EJ, Wilcox MH, et al. Infection control measures to limit the spread of Clostridium difficile. Clin Microbiol Infect 2008; 14(suppl 5): 2-20.
    • (2008) Clin Microbiol Infect , vol.14 , pp. 2-20
    • Vonberg, R.P.1    Kuijper, E.J.2    Wilcox, M.H.3
  • 12
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010; 31: 431-55.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3
  • 13
    • 80051679970 scopus 로고    scopus 로고
    • Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection
    • Talpaert MJ, Gopal Rao G, Cooper BS, Wade P. Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection. J Antimicrob Chemother 2011; 66: 2168-74.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2168-2174
    • Talpaert, M.J.1    Gopal Rao, G.2    Cooper, B.S.3    Wade, P.4
  • 14
    • 84890384818 scopus 로고    scopus 로고
    • Clostridium difficile-associated disease: Adherence with current guidelines at a tertiary medical center
    • Curtin BF, Zarbalian Y, Flasar MH, von Rosenvinge E. Clostridium difficile-associated disease: adherence with current guidelines at a tertiary medical center. World J Gastroenterol 2013; 19: 8647-51.
    • (2013) World J Gastroenterol , vol.19 , pp. 8647-8651
    • Curtin, B.F.1    Zarbalian, Y.2    Flasar, M.H.3    Von Rosenvinge, E.4
  • 15
    • 84905119803 scopus 로고    scopus 로고
    • National European guidelines for the prevention of Clostridium difficile infection: A systematic qualitative review
    • Martin M, ZinggW, Knoll E, Wilson C, Dettenkofer M. National European guidelines for the prevention of Clostridium difficile infection: a systematic qualitative review. J Hosp Infect 2014; 87: 212-9.
    • (2014) J Hosp Infect , vol.87 , pp. 212-219
    • Martin, M.1    Zinggw Knoll, E.2    Wilson, C.3    Dettenkofer, M.4
  • 16
    • 84880691277 scopus 로고    scopus 로고
    • Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011
    • Chitnis AS, Holzbauer SM, Belflower RM, et al. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med 2013; 173: 1359-67.
    • (2013) JAMA Intern Med , vol.173 , pp. 1359-1367
    • Chitnis, A.S.1    Holzbauer, S.M.2    Belflower, R.M.3
  • 18
    • 84905675648 scopus 로고    scopus 로고
    • Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • Hill C, Guarner F, Reid G, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014; 11: 506-14.
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 506-514
    • Hill, C.1    Guarner, F.2    Reid, G.3
  • 19
    • 84910116769 scopus 로고    scopus 로고
    • The yin and yang of bacterial resilience in the human gut microbiota
    • Gibson MK, Pesesky MW, Dantas G. The yin and yang of bacterial resilience in the human gut microbiota. J Mol Biol 2014; 426: 3866-76.
    • (2014) J Mol Biol , vol.426 , pp. 3866-3876
    • Gibson, M.K.1    Pesesky, M.W.2    Dantas, G.3
  • 20
    • 77249101573 scopus 로고    scopus 로고
    • Guidance for substantiating the evidence for beneficial effects of probiotics: Prevention and management of infections by probiotics
    • Wolvers D, Antoine JM, Myllyluoma E, Schrezenmeir J, Szajewska H, Rijkers GT. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. J Nutr 2010; 140: 698S-712.
    • (2010) J Nutr , vol.140 , pp. 698S-712
    • Wolvers, D.1    Antoine, J.M.2    Myllyluoma, E.3    Schrezenmeir, J.4    Szajewska, H.5    Rijkers, G.T.6
  • 21
    • 84891625369 scopus 로고    scopus 로고
    • Probiotics reduce symptoms of antibiotic use in a hospital setting: A randomized dose response study
    • Ouwehand AC, DongLian C, Weijian X, et al. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine 2014; 32: 458-63.
    • (2014) Vaccine , vol.32 , pp. 458-463
    • Ouwehand, A.C.1    Donglian, C.2    Weijian, X.3
  • 22
    • 84860708876 scopus 로고    scopus 로고
    • Probiotics for the prevention and treatment of antibiotic-associated diarrhea: A systematic review and meta-analysis
    • Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA 2012; 307: 1959-69.
    • (2012) JAMA , vol.307 , pp. 1959-1969
    • Hempel, S.1    Newberry, S.J.2    Maher, A.R.3
  • 23
    • 84861201441 scopus 로고    scopus 로고
    • Meta-analysis: Probiotics in antibiotic-associated diarrhoea
    • Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2012; 35: 1355-69.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 1355-1369
    • Videlock, E.J.1    Cremonini, F.2
  • 24
    • 84868195398 scopus 로고    scopus 로고
    • Is primary prevention of Clostridium difficile infection possible with specific probiotics?
    • Johnson S, Maziade PJ, McFarland LV, et al. Is primary prevention of Clostridium difficile infection possible with specific probiotics? Int J Infect Dis 2012; 16: e786-92.
    • (2012) Int J Infect Dis , vol.16 , pp. e786-e792
    • Johnson, S.1    Maziade, P.J.2    McFarland, L.V.3
  • 25
    • 38649108836 scopus 로고    scopus 로고
    • Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: A randomized, double-blind, placebo-controlled trial
    • Beausoleil M, Fortier N, Guenette S, et al. Effect of a fermented milk combining Lactobacillus acidophilus Cl1285 and Lactobacillus casei in the prevention of antibiotic-associated diarrhea: a randomized, double-blind, placebo-controlled trial. Can J Gastroenterol 2007; 21: 732-6.
    • (2007) Can J Gastroenterol , vol.21 , pp. 732-736
    • Beausoleil, M.1    Fortier, N.2    Guenette, S.3
  • 26
    • 77949370649 scopus 로고    scopus 로고
    • Efficacy of BIO K+ CL1285 in the reduction of antibiotic-associated diarrhea - A placebo controlled double-blind randomized, multi-center study
    • Sampalis J, Psaradellis E, Rampakakis E. Efficacy of BIO K+ CL1285 in the reduction of antibiotic-associated diarrhea-a placebo controlled double-blind randomized, multi-center study. Arch Med Sci 2010; 6: 56-64.
    • (2010) Arch Med Sci , vol.6 , pp. 56-64
    • Sampalis, J.1    Psaradellis, E.2    Rampakakis, E.3
  • 27
    • 77954424086 scopus 로고    scopus 로고
    • Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients
    • Gao XW, Mubasher M, Fang CY, Reifer C, Miller LE. Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol 2010; 105: 1636-41.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1636-1641
    • Gao, X.W.1    Mubasher, M.2    Fang, C.Y.3    Reifer, C.4    Miller, L.E.5
  • 28
    • 84884486438 scopus 로고    scopus 로고
    • Impact of adding prophylactic probiotics to a bundle of standard preventative measures for Clostridium difficile infections: Enhanced and sustained decrease in the incidence and severity of infection at a community hospital
    • Maziade PJ, Andriessen JA, Pereira P, Currie B, Goldstein EJ. Impact of adding prophylactic probiotics to a bundle of standard preventative measures for Clostridium difficile infections: enhanced and sustained decrease in the incidence and severity of infection at a community hospital. Curr Med Res Opin 2013; 29: 1341-7.
    • (2013) Curr Med Res Opin , vol.29 , pp. 1341-1347
    • Maziade, P.J.1    Andriessen, J.A.2    Pereira, P.3    Currie, B.4    Goldstein, E.J.5
  • 29
    • 84928905074 scopus 로고    scopus 로고
    • Natural health product-probiotics
    • Anonymous. Health Canada. Accessed 16 March 2015
    • Anonymous. Natural health product-probiotics. Natural Health Food Directorate. Health Canada, 2014: pp. 1-25. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq.do?atid=probio. Accessed 16 March 2015.
    • (2014) Natural Health Food Directorate , pp. 1-25
  • 30
    • 77954823452 scopus 로고    scopus 로고
    • Anonymous. Food Directorate, Health Products and Food Branch. Health Canada. Accessed 16 March 2015
    • Anonymous. Guidance document-the use of probiotic microorganisms in food. Food Directorate, Health Products and Food Branch. Health Canada, 2009: pp. 1-8. Available at: http://www.hc-sc.gc.ca/fnan/legislation/guide-ld/probiotics-guidance-orientation-probiotiqueseng.php. Accessed 16 March 2015.
    • (2009) Guidance Document - The Use of Probiotic Microorganisms in Food , pp. 1-8
  • 31
    • 5144223899 scopus 로고    scopus 로고
    • Rapid identification of probiotic Lactobacillus species by multiplex PCR using species-specific primers based on the region extending from 16S rRNA through 23S rRNA
    • Kwon HS, Yang EH, Yeon SW, Kang BH, Kim TY. Rapid identification of probiotic Lactobacillus species by multiplex PCR using species-specific primers based on the region extending from 16S rRNA through 23S rRNA. FEMS Microbiol Lett 2004; 239: 267-75.
    • (2004) FEMS Microbiol Lett , vol.239 , pp. 267-275
    • Kwon, H.S.1    Yang, E.H.2    Yeon, S.W.3    Kang, B.H.4    Kim, T.Y.5
  • 32
    • 0032870959 scopus 로고    scopus 로고
    • Differentiation of Lactobacillus casei, Lactobacillus paracasei and Lactobacillus rhamnosus by polymerase chain reaction
    • Ward LJ, Timmins MJ. Differentiation of Lactobacillus casei, Lactobacillus paracasei and Lactobacillus rhamnosus by polymerase chain reaction. Lett Appl Microbiol 1999; 29: 90-2.
    • (1999) Lett Appl Microbiol , vol.29 , pp. 90-92
    • Ward, L.J.1    Timmins, M.J.2
  • 33
    • 84885103912 scopus 로고    scopus 로고
    • Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: Systematic review and meta-analysis
    • Pattani R, Palda VA, Hwang SW, Shah PS. Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis. Open Med 2013; 7: e56-67.
    • (2013) Open Med , vol.7 , pp. e56-67
    • Pattani, R.1    Palda, V.A.2    Hwang, S.W.3    Shah, P.S.4
  • 34
    • 77951210062 scopus 로고    scopus 로고
    • Not all lactic acid bacteria are probiotics, . . . but some are
    • Azais-Braesco V, Bresson JL, Guarner F, Corthier G. Not all lactic acid bacteria are probiotics, . . . but some are. Br J Nutr 2010; 103: 1079-81.
    • (2010) Br J Nutr , vol.103 , pp. 1079-1081
    • Azais-Braesco, V.1    Bresson, J.L.2    Guarner, F.3    Corthier, G.4
  • 35
    • 79955834075 scopus 로고    scopus 로고
    • Manufacturing process influences properties of probiotic bacteria
    • Grzeskowiak L, Isolauri E, Salminen S, Gueimonde M. Manufacturing process influences properties of probiotic bacteria. Br J Nutr 2011; 105: 887-94.
    • (2011) Br J Nutr , vol.105 , pp. 887-894
    • Grzeskowiak, L.1    Isolauri, E.2    Salminen, S.3    Gueimonde, M.4
  • 36
    • 84864030666 scopus 로고    scopus 로고
    • Influence of manufacturing processes on in vitro properties of the probiotic strain Lactobacillus rhamnosus Lcr35
    • Nivoliez A, Camares O, Paquet-GachinatM, Bornes S, Forestier C, Veisseire P. Influence of manufacturing processes on in vitro properties of the probiotic strain Lactobacillus rhamnosus Lcr35. J Biotechnol 2012; 160: 236-41.
    • (2012) J Biotechnol , vol.160 , pp. 236-241
    • Nivoliez, A.1    Camares, O.2    Paquet-Gachinat, M.3    Bornes, S.4    Forestier, C.5    Veisseire, P.6
  • 38
    • 84894437195 scopus 로고    scopus 로고
    • Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics
    • Sanders ME, Klaenhammer TR, Ouwehand AC, et al. Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics. Ann N Y Acad Sci 2014; 1309: 1-18.
    • (2014) Ann N y Acad Sci , vol.1309 , pp. 1-18
    • Sanders, M.E.1    Klaenhammer, T.R.2    Ouwehand, A.C.3
  • 39
    • 84908178307 scopus 로고    scopus 로고
    • Enhancing probiotic stability in industrial processes
    • Gueimonde M, Sanchez B. Enhancing probiotic stability in industrial processes. Microb Ecol Health Dis 2012; 23: 18562.
    • (2012) Microb Ecol Health Dis , vol.23 , pp. 18562
    • Gueimonde, M.1    Sanchez, B.2
  • 40
    • 84655162217 scopus 로고    scopus 로고
    • Probiotics from an industrial perspective
    • Forssten SD, SindelarCW, Ouwehand AC. Probiotics from an industrial perspective. Anaerobe 2011; 17: 410-3.
    • (2011) Anaerobe , vol.17 , pp. 410-413
    • Forssten, S.D.1    Sindelarcw Ouwehand, A.C.2
  • 41
    • 1442280750 scopus 로고    scopus 로고
    • An evaluation of nine probiotics available in South Africa, August 2003
    • Elliot E, Teversham K. An evaluation of nine probiotics available in South Africa, August 2003. S Afr Med J 2004; 94: 121-4.
    • (2004) S Afr Med J , vol.94 , pp. 121-124
    • Elliot, E.1    Teversham, K.2
  • 42
    • 20844438208 scopus 로고    scopus 로고
    • Evaluation of five probiotic products for label claims by DNA extraction and polymerase chain reaction analysis
    • Drisko J, Bischoff B, Giles C, Adelson M, Rao RV, McCallum R. Evaluation of five probiotic products for label claims by DNA extraction and polymerase chain reaction analysis. Dig Dis Sci 2005; 50: 1113-7.
    • (2005) Dig Dis Sci , vol.50 , pp. 1113-1117
    • Drisko, J.1    Bischoff, B.2    Giles, C.3    Adelson, M.4    Rao, R.V.5    McCallum, R.6
  • 43
    • 79952268528 scopus 로고    scopus 로고
    • Assessment of commercial probiotic bacterial contents and label accuracy
    • Weese JS, Martin H. Assessment of commercial probiotic bacterial contents and label accuracy. Can Vet J 2011; 52: 43-6.
    • (2011) Can Vet J , vol.52 , pp. 43-46
    • Weese, J.S.1    Martin, H.2
  • 44
    • 84887568245 scopus 로고    scopus 로고
    • Bacterial counts from five over - The-counter probiotics: Are you getting what you paid for?
    • Goldstein EJ, Citron DM, Claros MC, Tyrrell KL. Bacterial counts from five over-the-counter probiotics: are you getting what you paid for? Anaerobe 2014; 25: 1-4.
    • (2014) Anaerobe , vol.25 , pp. 1-4
    • Goldstein, E.J.1    Citron, D.M.2    Claros, M.C.3    Tyrrell, K.L.4
  • 45
    • 33947160098 scopus 로고    scopus 로고
    • Advancedmolecular tools for the identification of lactic acid bacteria
    • Ben Amor K, Vaughan EE, de VosWM. Advancedmolecular tools for the identification of lactic acid bacteria. J Nutr 2007; 137(3 Suppl 2): 741S-7.
    • (2007) J Nutr , vol.137 , Issue.3 , pp. 741S-7
    • Ben Amor, K.1    Vaughan, E.E.2    De Vos, W.M.3
  • 46
    • 84884845266 scopus 로고    scopus 로고
    • Timely approaches to identify probiotic species of the genus Lactobacillus
    • Herbel SR, Vahjen W, Wieler LH, Guenther S. Timely approaches to identify probiotic species of the genus Lactobacillus. Gut Pathog 2013; 5: 27.
    • (2013) Gut Pathog , vol.5 , pp. 27
    • Herbel, S.R.1    Vahjen, W.2    Wieler, L.H.3    Guenther, S.4
  • 47
    • 0024444791 scopus 로고
    • Isolation and direct complete nucleotide determination of entire genes Characterization of a gene coding for 16S ribosomal RNA
    • Edwards U, Rogall T, Blocker H, Emde M, Bottger EC. Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acids Res 1989; 17: 7843-53.
    • (1989) Nucleic Acids Res , vol.17 , pp. 7843-7853
    • Edwards, U.1    Rogall, T.2    Blocker, H.3    Emde, M.4    Bottger, E.C.5
  • 48
    • 0027992990 scopus 로고
    • Genomic fingerprinting of bacteria using repetitive sequence-based polymerase chain reaction
    • Versalovic J, Schneider M, de Bruijn FJ, Lupski JR. Genomic fingerprinting of bacteria using repetitive sequence-based polymerase chain reaction. Methods Mol Cell Biol 1994; 5: 25-40.
    • (1994) Methods Mol Cell Biol , vol.5 , pp. 25-40
    • Versalovic, J.1    Schneider, M.2    De Bruijn, F.J.3    Lupski, J.R.4
  • 49
    • 84876301798 scopus 로고    scopus 로고
    • Anonymous. Quality of Natural Health Products Guide. Health Canada. Accessed 16 March 2015
    • Anonymous. Quality of Natural Health Products Guide. Natural Health Products Directorate. Health Canada, 2012: pp. 1-44. Available at: http://www.hc-sc.gc.ca/dhp-mps/prodnatur/legislation/docs/eq-paqeng. php. Accessed 16 March 2015.
    • (2012) Natural Health Products Directorate , pp. 1-44
  • 51
    • 80051470712 scopus 로고    scopus 로고
    • Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract
    • Pitino I, Randazzo CL, Mandalari G, et al. Survival of Lactobacillus rhamnosus strains in the upper gastrointestinal tract. Food Microbiol 2010; 27: 1121-7.
    • (2010) Food Microbiol , vol.27 , pp. 1121-1127
    • Pitino, I.1    Randazzo, C.L.2    Mandalari, G.3
  • 52
    • 0031800841 scopus 로고    scopus 로고
    • Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract
    • Charteris WP, Kelly PM, Morelli L, Collins JK. Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract. J Appl Microbiol 1998; 84: 759-68.
    • (1998) J Appl Microbiol , vol.84 , pp. 759-768
    • Charteris, W.P.1    Kelly, P.M.2    Morelli, L.3    Collins, J.K.4
  • 53
    • 79957822244 scopus 로고    scopus 로고
    • Adhesion of bile-adapted Bifidobacterium strains to the HT29-MTX cell line is modified after sequential gastrointestinal challenge simulated in vitro using human gastric and duodenal juices
    • de los Reyes-Gavilan CG, Suarez A, Fernandez-Garcia M, Margolles A, Gueimonde M, Ruas-Madiedo P. Adhesion of bile-adapted Bifidobacterium strains to the HT29-MTX cell line is modified after sequential gastrointestinal challenge simulated in vitro using human gastric and duodenal juices. Res Microbiol 2011; 162: 514-9.
    • (2011) Res Microbiol , vol.162 , pp. 514-519
    • De Los Reyes-Gavilan, C.G.1    Suarez, A.2    Fernandez-Garcia, M.3    Margolles, A.4    Gueimonde, M.5    Ruas-Madiedo, P.6
  • 54
    • 80051473239 scopus 로고    scopus 로고
    • Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion
    • Lo Curto A, Pitino I, Mandalari G, Dainty JR, Faulks RM, John Wickham MS. Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion. Food Microbiol 2011; 28: 1359-66.
    • (2011) Food Microbiol , vol.28 , pp. 1359-1366
    • Lo Curto, A.1    Pitino, I.2    Mandalari, G.3    Dainty, J.R.4    Faulks, R.M.5    John Wickham, M.S.6
  • 55
    • 16244420758 scopus 로고    scopus 로고
    • A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics
    • Mainville I, Arcand Y, Farnworth ER. A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics. Int J Food Microbiol 2005; 99: 287-96.
    • (2005) Int J Food Microbiol , vol.99 , pp. 287-296
    • Mainville, I.1    Arcand, Y.2    Farnworth, E.R.3
  • 56
    • 48349138946 scopus 로고    scopus 로고
    • Single bioreactor gastrointestinal tract simulator for study of survival of probiotic bacteria
    • Sumeri I, Arike L, Adamberg K, Paalme T. Single bioreactor gastrointestinal tract simulator for study of survival of probiotic bacteria. Appl Microbiol Biotechnol 2008; 80: 317-24.
    • (2008) Appl Microbiol Biotechnol , vol.80 , pp. 317-324
    • Sumeri, I.1    Arike, L.2    Adamberg, K.3    Paalme, T.4
  • 58
    • 84928879655 scopus 로고    scopus 로고
    • Probiotiques et alicaments
    • Luquet F-M, Corrieu G, eds. Paris: Editions Tec & Doc
    • Marteau P, Seksik P. Probiotiques et alicaments. In: Luquet F-M, Corrieu G, eds. Bactéries lactiques et probiotiques. Paris: Editions Tec & Doc, 2005: 255-90.
    • (2005) Bactéries Lactiques et Probiotiques , pp. 255-290
    • Marteau, P.1    Seksik, P.2
  • 59
    • 78049480111 scopus 로고    scopus 로고
    • Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA)
    • Karska-Wysocki B, Bazo M, Smoragiewicz W. Antibacterial activity of Lactobacillus acidophilus and Lactobacillus casei against methicillin-resistant Staphylococcus aureus (MRSA). Microbiol Res 2010; 165: 674-86.
    • (2010) Microbiol Res , vol.165 , pp. 674-686
    • Karska-Wysocki, B.1    Bazo, M.2    Smoragiewicz, W.3
  • 60
    • 33847054764 scopus 로고    scopus 로고
    • In vitro growth control of selected pathogens by Lactobacillus acidophilus-and Lactobacillus casei-fermented milk
    • Millette M, Luquet FM, Lacroix M. In vitro growth control of selected pathogens by Lactobacillus acidophilus-and Lactobacillus casei-fermented milk. Lett Appl Microbiol 2007; 44: 314-9.
    • (2007) Lett Appl Microbiol , vol.44 , pp. 314-319
    • Millette, M.1    Luquet, F.M.2    Lacroix, M.3
  • 61
    • 0024711247 scopus 로고
    • Antibacterial activity of Lactobacillus sake isolated from meat
    • Schillinger U, Lucke FK. Antibacterial activity of Lactobacillus sake isolated from meat. Appl Environ Microbiol 1989; 55: 1901-6.
    • (1989) Appl Environ Microbiol , vol.55 , pp. 1901-1906
    • Schillinger, U.1    Lucke, F.K.2
  • 62
    • 42049101171 scopus 로고    scopus 로고
    • Capacity of human nisin-and pediocin-producing lactic acid bacteria to reduce intestinal colonization by vancomycin-resistant enterococci
    • Millette M, Cornut G, Dupont C, Shareck F, Archambault D, Lacroix M. Capacity of human nisin-and pediocin-producing lactic acid bacteria to reduce intestinal colonization by vancomycin-resistant enterococci. Appl Environ Microbiol 2008; 74: 1997-2003.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 1997-2003
    • Millette, M.1    Cornut, G.2    Dupont, C.3    Shareck, F.4    Archambault, D.5    Lacroix, M.6
  • 63
    • 0032919855 scopus 로고    scopus 로고
    • Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa
    • Castagliuolo I, Riegler MF, Valenick L, LaMont JT, Pothoulakis C. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun 1999; 67: 302-7.
    • (1999) Infect Immun , vol.67 , pp. 302-307
    • Castagliuolo, I.1    Riegler, M.F.2    Valenick, L.3    Lamont, J.T.4    Pothoulakis, C.5
  • 64
    • 0034114105 scopus 로고    scopus 로고
    • PH-induced conformational changes in Clostridium difficile toxin B
    • Qa'Dan M, Spyres LM, Ballard JD. pH-induced conformational changes in Clostridium difficile toxin B. Infect Immun 2000; 68: 2470-4.
    • (2000) Infect Immun , vol.68 , pp. 2470-2474
    • Qa'Dan, M.1    Spyres, L.M.2    Ballard, J.D.3


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