-
1
-
-
40849083460
-
Non-alcoholic fatty liver disease: The mist gradually clears
-
De Alwis NM, Day CP. (2008) Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatology 48: 104-112.
-
(2008)
J Hepatology
, vol.48
, pp. 104-112
-
-
De Alwis, N.M.1
Day, C.P.2
-
2
-
-
79959466159
-
Current therapeutic strategies in non-alcoholic fatty liver disease
-
PMID: 21449949
-
Dowman JK, Armstrong MJ, Tomlinson JW, Newsome PN. (2011) Current therapeutic strategies in non-alcoholic fatty liver disease. Diabetes Obes Metab 13: 692-702. doi: 10.1111/j.1463-1326.2011.01403.x PMID: 21449949
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 692-702
-
-
Dowman, J.K.1
Armstrong, M.J.2
Tomlinson, J.W.3
Newsome, P.N.4
-
3
-
-
12144259379
-
Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
-
Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, et al. (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288: 462-468.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.288
, pp. 462-468
-
-
Szczepaniak, L.S.1
Nurenberg, P.2
Leonard, D.3
Browning, J.D.4
Reingold, J.S.5
Grundy, S.6
-
4
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
PMID: 21038418
-
Tilg H, Moschen AR. (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52: 1836-1846. doi: 10.1002/hep.24001 PMID: 21038418
-
(2010)
Hepatology
, vol.52
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
5
-
-
0031947715
-
Steatohepatitis: A tale of two "hits"?
-
PMID: 9547102
-
Day CP, James OF. (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology 114: 842-845. PMID: 9547102
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
6
-
-
0037342568
-
Obesity and systemic oxidative stress: Clinical correlates of oxidative stress in the Framingham Study
-
PMID: 12615693
-
Keaney JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, et al. (2003) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 23: 434-439. PMID: 12615693
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 434-439
-
-
Keaney, J.F.1
Larson, M.G.2
Vasan, R.S.3
Wilson, P.W.4
Lipinska, I.5
Corey, D.6
-
7
-
-
33745861300
-
Inflammation and insulin resistance
-
PMID: 16823477
-
Shoelson SE, Lee J, Goldfine AB. (2006) Inflammation and insulin resistance. J. Clin. Invest 116: 1793-1801. PMID: 16823477
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1793-1801
-
-
Shoelson, S.E.1
Lee, J.2
Goldfine, A.B.3
-
8
-
-
62849092266
-
NF-kB in liver diseases: A target for drug therapy
-
PMID: 18937212
-
Muriel P. (2009). NF-kB in liver diseases: a target for drug therapy. J. Appl. Toxicol 29: 91-100. doi: 10.1002/jat.1393 PMID: 18937212
-
(2009)
J. Appl. Toxicol
, vol.29
, pp. 91-100
-
-
Muriel, P.1
-
9
-
-
77955906264
-
The nuclear factor NF-kappaB pathway in inflammation
-
Lawrence T. (2009). The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb. Perspect. Biol 1: 1-18.
-
(2009)
Cold Spring Harb. Perspect. Biol
, vol.1
, pp. 1-18
-
-
Lawrence, T.1
-
10
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF kappaB
-
PMID: 15685173
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF kappaB. Nat. Med 11: 183-190. PMID: 15685173
-
(2005)
Nat. Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
-
11
-
-
0033996762
-
The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
-
PMID: 10723801
-
Karin M., Delhase M. (2000). The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin. Immunol. 12: 85-98. PMID: 10723801
-
(2000)
Semin. Immunol.
, vol.12
, pp. 85-98
-
-
Karin, M.1
Delhase, M.2
-
12
-
-
4444376712
-
Signaling to NF-kappaB
-
PMID: 15371334
-
Hayden MS, Ghosh S. (2004). Signaling to NF-kappaB. Genes Dev 18: 2195-2224. PMID: 15371334
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
13
-
-
0023724778
-
I kappa B: A specific inhibitor of the NF-kappa B transcription factor
-
PMID: 3140380
-
Baeuerle PA, Baltimore D. (1988). I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242: 540-546. PMID: 3140380
-
(1988)
Science
, vol.242
, pp. 540-546
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
14
-
-
0025266685
-
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B
-
PMID: 2157987
-
Ghosh S, Baltimore D. (1990). Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature 344: 678-682. PMID: 2157987
-
(1990)
Nature
, vol.344
, pp. 678-682
-
-
Ghosh, S.1
Baltimore, D.2
-
15
-
-
0035040960
-
Mechanisms of action of thiazolidinediones
-
PMID: 11452221
-
Girard J. Mechanisms of action of thiazolidinediones. (2001) Diabetes Metab 27: 271-8. PMID: 11452221
-
(2001)
Diabetes Metab
, vol.27
, pp. 271-278
-
-
Girard, J.1
-
16
-
-
19244365650
-
Thiazolidinediones
-
PMID: 15356308
-
Yki-Jarvinen H. (2004) Thiazolidinediones. N Engl J Med 351:1106-18. PMID: 15356308
-
(2004)
N Engl J Med
, vol.351
, pp. 1106-1118
-
-
Yki-Jarvinen, H.1
-
17
-
-
12844256347
-
Insight into hepatotoxicity: The troglitazone experience
-
PMID: 15657920
-
Watkins PB. Insight into hepatotoxicity: The troglitazone experience. (2005) Hepatology 41:229-30. PMID: 15657920
-
(2005)
Hepatology
, vol.41
, pp. 229-230
-
-
Watkins, P.B.1
-
18
-
-
0035169430
-
Hepatotoxicity with thiazolidinediones: Is it a class effect?
-
PMID: 11735645
-
Scheen AJ. Hepatotoxicity with thiazolidinediones: is it a class effect? (2001) Drug Saf 24: 873-88. PMID: 11735645
-
(2001)
Drug Saf
, vol.24
, pp. 873-888
-
-
Scheen, A.J.1
-
19
-
-
34548306770
-
The effects of discontinuing pioglitazone in pateints with nonalcoholic steatohepatitis
-
PMID: 17559148
-
Lutchman G, Modi A, Kleiner DE, Promrat K, Heller T, Grany M, et al. (2007) The effects of discontinuing pioglitazone in pateints with nonalcoholic steatohepatitis. Hepatology 46:424-9. PMID: 17559148
-
(2007)
Hepatology
, vol.46
, pp. 424-429
-
-
Lutchman, G.1
Modi, A.2
Kleiner, D.E.3
Promrat, K.4
Heller, T.5
Grany, M.6
-
20
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
PMID: 17517853
-
Nissen SE, Wolski K. (2007) Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356: 2457-71. PMID: 17517853
-
(2007)
N Engl J Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
21
-
-
46349088361
-
Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT)
-
PMID: 18503774
-
Ratziu V, Giral P, Jacqueminet S, Charlotte F, Hartemann-Heurtier A, Serfaty L, et al. (2008) Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 135:100-10. doi: 10.1053/j.gastro.2008.03.078 PMID: 18503774
-
(2008)
Trial. Gastroenterology
, vol.135
, pp. 100-110
-
-
Ratziu, V.1
Giral, P.2
Jacqueminet, S.3
Charlotte, F.4
Hartemann-Heurtier, A.5
Serfaty, L.6
-
22
-
-
0030828653
-
The diagnosis of cirrhosis: Clinical relevance and methodology
-
PMID: 9453441
-
Schalm SW. (1997) The diagnosis of cirrhosis: clinical relevance and methodology. J Hepatol. 27(6):1118-9. PMID: 9453441
-
(1997)
J Hepatol.
, vol.27
, Issue.6
, pp. 1118-1119
-
-
Schalm, S.W.1
-
23
-
-
0038455747
-
Cirrhosis: New research provides a basis for rational and targeted treatments
-
Iredale JP. (2003) Cirrhosis: new research provides a basis for rational and targeted treatments. BMJ 19:143-7.
-
(2003)
BMJ
, vol.19
, pp. 143-147
-
-
Iredale, J.P.1
-
24
-
-
84870913060
-
Effect of new thiazolidine derivatives LPSF/GQ-02 and LPSF/GQ-16 on atherosclerotic lesions in LDL receptor-deficient mice LDLR(-/-)
-
PMID: 22795892
-
Silva AKS, Torres DOC, Rocha SWS, Gomes FOS, Silva BS, Donato MA, et al. (2013) Effect of new thiazolidine derivatives LPSF/GQ-02 and LPSF/GQ-16 on atherosclerotic lesions in LDL receptor-deficient mice LDLR(-/-). Cardiovasc Pathol 22(1): 81-90. doi: 10.1016/j.carpath.2012.05.006 PMID: 22795892
-
(2013)
Cardiovasc Pathol
, vol.22
, Issue.1
, pp. 81-90
-
-
Silva, A.K.S.1
Torres, D.O.C.2
Rocha, S.W.S.3
Gomes, F.O.S.4
Silva, B.S.5
Donato, M.A.6
-
25
-
-
35148867098
-
Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities
-
PMID: 17448573
-
Leite LFC, Mourão RHV, Lima MC, Galdino SL, Hernandes MZ, Neves FAR, et al. (2007). Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities. Eur J Med Chem. 42: 1263-1271. PMID: 17448573
-
(2007)
Eur J Med Chem
, vol.42
, pp. 1263-1271
-
-
Leite, L.F.C.1
Mourão, R.H.V.2
Lima, M.C.3
Galdino, S.L.4
Hernandes, M.Z.5
Neves, F.A.R.6
-
26
-
-
26844528986
-
Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones
-
PMID: 16040159
-
Mourão RH, Silva TG, Soares AL, Vieira ES, Santos JN, Lima MC, et al. (2005) Synthesis and Biological Activity of Novel Acridinylidene and Benzylidene thiazolidinediones. Eur J Med Chemistry 40: 1129-1133. PMID: 16040159
-
(2005)
Eur J Med Chemistry
, vol.40
, pp. 1129-1133
-
-
Mourão, R.H.1
Silva, T.G.2
Soares, A.L.3
Vieira, E.S.4
Santos, J.N.5
Lima, M.C.6
-
27
-
-
0033864582
-
Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
-
PMID: 10953027
-
Li AC, Brown KK, Silvestre MJ, Willson TM, Palinski W, Glass CK. et al. (2000) Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Investig 106: 523-531. PMID: 10953027
-
(2000)
J Clin Investig
, vol.106
, pp. 523-531
-
-
Li, A.C.1
Brown, K.K.2
Silvestre, M.J.3
Willson, T.M.4
Palinski, W.5
Glass, C.K.6
-
28
-
-
34247103196
-
Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice
-
PMID: 16901490
-
Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, et al. (2007) Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis 192: 85-91. PMID: 16901490
-
(2007)
Atherosclerosis
, vol.192
, pp. 85-91
-
-
Game, B.A.1
He, L.2
Jarido, V.3
Nareika, A.4
Jaffa, A.A.5
Lopes-Virella, M.F.6
-
29
-
-
78649560195
-
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice
-
PMID: 20938947
-
Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, et al. (2010) Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology. 52(6): 2001-11. doi: 10.1002/hep.23941 PMID: 20938947
-
(2010)
Hepatology
, vol.52
, Issue.6
, pp. 2001-2011
-
-
Gupte, A.A.1
Liu, J.Z.2
Ren, Y.3
Minze, L.J.4
Wiles, J.R.5
Collins, A.R.6
-
30
-
-
0000937143
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MA. (1970) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 240-54.
-
(1970)
Anal Biochem
, vol.72
, pp. 240-254
-
-
Bradford, M.A.1
-
32
-
-
0024530685
-
Regulation of the acute phase and immune responses: Interleukin-6
-
Sehgal PB, Grieninger G, Tosato G (eds) (1989) Regulation of the acute phase and immune responses: interleukin-6. Ann New York Acad Sci 557:1-583.
-
(1989)
Ann New York Acad Sci
, vol.557
, pp. 1-583
-
-
Sehgal, P.B.1
Grieninger, G.2
Tosato, G.3
-
33
-
-
84883174052
-
Nonalcoholic fatty liver disease: Dand management
-
PMID: 23939604
-
Wilkins T, Tadkod A, Hepburn I, Schade RR. (2013) Nonalcoholic fatty liver disease: diagnosis and management. Am Fam Physician 88(1):35-42. PMID: 23939604
-
(2013)
Am Fam Physician
, vol.88
, Issue.1
, pp. 35-42
-
-
Wilkins, T.1
Tadkod, A.2
Hepburn, I.3
Schade, R.R.4
-
34
-
-
0035093258
-
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptordeficient mice
-
PMID: 11231915
-
Collins AR. Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G, et al. (2001). Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptordeficient mice. Arterioscler Throm Vasc Biol. 21: 365-371. PMID: 11231915
-
(2001)
Arterioscler Throm Vasc Biol
, vol.21
, pp. 365-371
-
-
Collins, A.R.1
Meehan, W.P.2
Kintscher, U.3
Jackson, S.4
Wakino, S.5
Noh, G.6
-
35
-
-
0037133683
-
Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray
-
PMID: 11901049
-
Napoli C, Nigris F, Welch JS, Calara FB, Stuart RO, Glass CK, et al. (2002) Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation 105: 1360-7. PMID: 11901049
-
(2002)
Circulation
, vol.105
, pp. 1360-1367
-
-
Napoli, C.1
Nigris, F.2
Welch, J.S.3
Calara, F.B.4
Stuart, R.O.5
Glass, C.K.6
-
36
-
-
80055016477
-
Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPAR-/LXR-pathway: Findings from in vitro and ex vivo studies
-
PMID: 21862012
-
Ozasa H. Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, et al. (2011) Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPAR-/LXR-pathway: Findings from in vitro and ex vivo studies. Atherosclerosis. 219: 141-150. doi: 10.1016/j.atherosclerosis.2011.07.113 PMID: 21862012
-
(2011)
Atherosclerosis
, vol.219
, pp. 141-150
-
-
Ozasa, H.1
Ayaori, M.2
Iizuka, M.3
Terao, Y.4
Uto-Kondo, H.5
Yakushiji, E.6
-
37
-
-
84928803853
-
The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: Systematic review and meta-analysis of published observational studies
-
PMID: 24400643
-
Varas-Lorenzo C, Margulis AV, Pladevall M, Riera-Guardia N, Calingaert B, Hazell L, et al. (2014) The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: systematic review and meta-analysis of published observational studies. BMC Cardiovasc Disord 14(1): 1-17. doi: 10.1186/1471-2261-14-1 PMID: 24400643
-
(2014)
BMC Cardiovasc Disord
, vol.14
, Issue.1
, pp. 1-17
-
-
Varas-Lorenzo, C.1
Margulis, A.V.2
Pladevall, M.3
Riera-Guardia, N.4
Calingaert, B.5
Hazell, L.6
-
38
-
-
0038206671
-
Thiazolidinediones in diabetes: Current status and future outlook
-
PMID: 12808879
-
Camp HS. (2003) Thiazolidinediones in diabetes: current status and future outlook. Curr Opin Investig Drugs 4:406-11. PMID: 12808879
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 406-411
-
-
Camp, H.S.1
-
39
-
-
0028821066
-
Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: Structural studies
-
PMID: 7706937
-
Yang LY, Kuksis A, Myher JJ, Steiner G. (1995) Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies. Journal of Lipid Research 36: 125-136. PMID: 7706937
-
(1995)
Journal of Lipid Research
, vol.36
, pp. 125-136
-
-
Yang, L.Y.1
Kuksis, A.2
Myher, J.J.3
Steiner, G.4
-
40
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
PMID: 17476695
-
Yamaguchi L, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. (2007). Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45 (6): 1366-1374. PMID: 17476695
-
(2007)
Hepatology
, vol.45
, Issue.6
, pp. 1366-1374
-
-
Yamaguchi, L.1
Yang, L.2
McCall, S.3
Huang, J.4
Yu, X.X.5
Pandey, S.K.6
-
41
-
-
0033708410
-
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
-
PMID: 11086023
-
Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, et al. (2000) Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J. Clin. Invest. 106: 1221-1228. PMID: 11086023
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1221-1228
-
-
Chao, L.1
Marcus-Samuels, B.2
Mason, M.M.3
Moitra, J.4
Vinson, C.5
Arioglu, E.6
-
42
-
-
0033695790
-
Up-regulation of peroxisome proliferatoractivated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
-
PMID: 11089532
-
Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C, et al. (2000). Up-regulation of peroxisome proliferatoractivated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141: 4021-4031. PMID: 11089532
-
(2000)
Endocrinology
, vol.141
, pp. 4021-4031
-
-
Memon, R.A.1
Tecott, L.H.2
Nonogaki, K.3
Beigneux, A.4
Moser, A.H.5
Grunfeld, C.6
-
43
-
-
0034743328
-
Diabetic KKAy mice exhibit increased hepatic PPAR-gamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
-
PMID: 11495036
-
Bedoucha M, Atzpodien E, Boelsterli UA. (2001) Diabetic KKAy mice exhibit increased hepatic PPAR-gamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J. Hepatol 35:17-23. PMID: 11495036
-
(2001)
J. Hepatol
, vol.35
, pp. 17-23
-
-
Bedoucha, M.1
Atzpodien, E.2
Boelsterli, U.A.3
-
44
-
-
80051706346
-
Role for PPARã in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
-
PMID: 21507897
-
Morán-salvador E, López-Parra M, García-Alonso V, Titos E, Martínez-Clemente M, González-Périz A, et al. (2011) Role for PPARã in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J 25: 2538-2550. doi: 10.1096/fj.10-173716 PMID: 21507897
-
(2011)
FASEB J
, vol.25
, pp. 2538-2550
-
-
Morán-salvador, E.1
López-Parra, M.2
García-Alonso, V.3
Titos, E.4
Martínez-Clemente, M.5
González-Périz, A.6
-
45
-
-
84893861975
-
-
Hindawi Publishing Corporation. the Scientific World Journal. Article ID
-
Zhang W, Xu YZ, Liu B, Wu R, Yang YY, Xiao XQ, et al. (2014) Pioglitazone Upregulates Angiotensin Converting Enzyme 2 Expression in Insulin-Sensitive Tissues in Rats with High-Fat Diet-Induced Nonalcoholic Steatohepatitis. Hindawi Publishing Corporation. the Scientific World Journal. Article ID 603409.
-
(2014)
Pioglitazone Upregulates Angiotensin Converting Enzyme 2 Expression in Insulin-Sensitive Tissues in Rats with High-Fat Diet-Induced Nonalcoholic Steatohepatitis
, pp. 603409
-
-
Zhang, W.1
Xu, Y.Z.2
Liu, B.3
Wu, R.4
Yang, Y.Y.5
Xiao, X.Q.6
-
46
-
-
63449137682
-
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease
-
PMID: 19084941
-
Wang HN, Wang YR, Liu GQ, Liu Z, Wu PX, Wei XL, et al. (2008) Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease. World J Gastroenterol 14(47): 7240-7246. PMID: 19084941
-
(2008)
World J Gastroenterol
, vol.14
, Issue.47
, pp. 7240-7246
-
-
Wang, H.N.1
Wang, Y.R.2
Liu, G.Q.3
Liu, Z.4
Wu, P.X.5
Wei, X.L.6
-
47
-
-
84875273697
-
Hepatic angiogenesis and fibrosis are common features in morbidly obese patients
-
PMID: 23519653
-
Ciupińska-Kajor M, Hartleb M, Kajor M, Kukla M, Wyleżoł M, Lange D, et al. (2013) Hepatic angiogenesis and fibrosis are common features in morbidly obese patients. Hepatol Int. v 7 (1): 233-240. PMID: 23519653
-
(2013)
Hepatol Int
, vol.7
, Issue.1
, pp. 233-240
-
-
Ciupińska-Kajor, M.1
Hartleb, M.2
Kajor, M.3
Kukla, M.4
Wylezoł, M.5
Lange, D.6
-
48
-
-
84875344717
-
Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice
-
PMID: 23281771
-
Nasir GA, Mohsin S, Khan M, Shams S, Ali G, Khan SN, et al. (2013) Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice. Journal of Translational Medicine 11: 1-9. doi: 10.1186/1479-5876-11-1 PMID: 23281771
-
(2013)
Journal of Translational Medicine
, vol.11
, pp. 1-9
-
-
Nasir, G.A.1
Mohsin, S.2
Khan, M.3
Shams, S.4
Ali, G.5
Khan, S.N.6
-
49
-
-
0033984744
-
Inflammation, obesity, stress and coronary heart disease: Iinterleukin-6 the link?
-
PMID: 10657556
-
Yudkin JS. Kumari M, Humphries SE, Mohamed-Ali V. (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148: 209-214. PMID: 10657556
-
(2000)
Atherosclerosis
, vol.148
, pp. 209-214
-
-
Yudkin, J.S.1
Kumari, M.2
Humphries, S.E.3
Mohamed-Ali, V.4
-
50
-
-
14644427890
-
Local and systemic insulin resitance resulting from hepatic activation of IKK beta and NF-KappaB
-
PMID: 15685173
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. (2005) Local and systemic insulin resitance resulting from hepatic activation of IKK beta and NF-KappaB. Nat Med 11: 183-190. PMID: 15685173
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
-
51
-
-
0042265627
-
Cytokines and NASH: A pilot study of the effects of lifestyle modifications and vitamin E
-
PMID: 12883485
-
Kugelmas M. Hill DB, Vivian B, Marsano L, McClain CJ. (2003) Cytokines and NASH: a pilot study of the effects of lifestyle modifications and vitamin E. Hepatology 38: 413-419. PMID: 12883485
-
(2003)
Hepatology
, vol.38
, pp. 413-419
-
-
Kugelmas, M.1
Hill, D.B.2
Vivian, B.3
Marsano, L.4
McClain, C.J.5
-
52
-
-
33646161443
-
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
-
PMID: 16618517
-
Haukeland JW. Damås JK, Konopski Z, Løberg EM, Haaland T, Goverud I, et al. (2006) Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol 44: 1167-1174. PMID: 16618517
-
(2006)
J Hepatol
, vol.44
, pp. 1167-1174
-
-
Haukeland, J.W.1
Damås, J.K.2
Konopski, Z.3
Løberg, E.M.4
Haaland, T.5
Goverud, I.6
-
53
-
-
70949094933
-
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis
-
Mas E. Danjoux M, Garcia V, Carpentier S, Ségui B, Levade T, et al. (2009) IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One 4: 7929.
-
(2009)
PLoS One
, vol.4
, pp. 7929
-
-
Mas, E.1
Danjoux, M.2
Garcia, V.3
Carpentier, S.4
Ségui, B.5
Levade, T.6
-
54
-
-
84896799696
-
Insulin Sensitizing and Anti-Inflammatory Effects of Thiazolidinediones Are Heightened in Obese Patients
-
PMID: 24141239
-
Esterson YB. Zhang K, Koppaka S, Kehlenbrink S, Kishore P, Raghavan P, et al. (2013) Insulin Sensitizing and Anti-Inflammatory Effects of Thiazolidinediones Are Heightened in Obese Patients. Journal of Investigative Medicine. 61(8): 1152-1160. doi: 10.231/JIM.0000000000000017 PMID: 24141239
-
(2013)
Journal of Investigative Medicine
, vol.61
, Issue.8
, pp. 1152-1160
-
-
Esterson, Y.B.1
Zhang, K.2
Koppaka, S.3
Kehlenbrink, S.4
Kishore, P.5
Raghavan, P.6
-
55
-
-
69749117831
-
Subtherapeutic dose of pioglitazone reduces expression of inflammatory adipokines in db/db mice
-
PMID: 19738399
-
Mohapatra J. Sharma M, Singh S, Chatterjee A, Swain P, Balaraman R, et al. (2009) Subtherapeutic dose of pioglitazone reduces expression of inflammatory adipokines in db/db mice. Pharmacology 84(4):203-10. doi: 10.1159/000235996 PMID: 19738399
-
(2009)
Pharmacology
, vol.84
, Issue.4
, pp. 203-210
-
-
Mohapatra, J.1
Sharma, M.2
Singh, S.3
Chatterjee, A.4
Swain, P.5
Balaraman, R.6
-
56
-
-
73849101167
-
Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease
-
PMID: 19624767
-
Yoneda M. Hotta K, Nozaki Y, Endo H, TomenoW, Watanabe S, et al. (2009) Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease. Hepatol Res 39: 963-971. doi: 10.1111/j.1872-034X.2009.00539.x PMID: 19624767
-
(2009)
Hepatol Res
, vol.39
, pp. 963-971
-
-
Yoneda, M.1
Hotta, K.2
Nozaki, Y.3
Endo, H.4
Tomeno, W.5
Watanabe, S.6
-
57
-
-
84861603829
-
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
-
PMID: 22633099
-
Salamone F, Galvano F, Cappello F, Mangiameli A, Barbagallo I, Li Volti G, et al. (2012) Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. Res transl. 159 (6): 477-86. doi: 10.1016/j.trsl.2011.12.003 PMID: 22633099
-
(2012)
Res Transl
, vol.159
, Issue.6
, pp. 477-486
-
-
Salamone, F.1
Galvano, F.2
Cappello, F.3
Mangiameli, A.4
Barbagallo, I.5
Li Volti, G.6
-
58
-
-
84896747760
-
Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical wnt signaling pathway expression
-
PMID: 24404139
-
Tian F. Zhang YJ, Li Y, Xie Y. (2014) Celecoxib ameliorates non-alcoholic steatohepatitis in type 2 diabetic rats via suppression of the non-canonical wnt signaling pathway expression. Plos one 9(1): e83819. doi: 10.1371/journal.pone.0083819 PMID: 24404139
-
(2014)
Plos One
, vol.9
, Issue.1
, pp. e83819
-
-
Tian, F.1
Zhang, Y.J.2
Li, Y.3
Xie, Y.4
-
59
-
-
33645963118
-
COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator
-
PMID: 16557554
-
Yu J. Ip E, Dela Peña A, Hou JY, Sesha J, Pera N, et al. (2006) COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. Hepatology 43: 826-36. PMID: 16557554
-
(2006)
Hepatology
, vol.43
, pp. 826-836
-
-
Yu, J.1
Ip, E.2
Dela Peña, A.3
Hou, J.Y.4
Sesha, J.5
Pera, N.6
-
60
-
-
75449101395
-
Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxime proliferator activated receptor aplha activity
-
PMID: 20054868
-
Stienstra R. Saudale F, Duval C, Keshtkar S, Groener JE, van Rooijen N, et al. (2010) Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxime proliferator activated receptor aplha activity. Hepatology. 51(2): 511-22. doi: 10.1002/hep.23337 PMID: 20054868
-
(2010)
Hepatology
, vol.51
, Issue.2
, pp. 511-522
-
-
Stienstra, R.1
Saudale, F.2
Duval, C.3
Keshtkar, S.4
Groener, J.E.5
Van Rooijen, N.6
-
61
-
-
0036074141
-
Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation
-
PMID: 12121871
-
Su GL. (2002). Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283: G256-G265. PMID: 12121871
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.283
, pp. G256-G265
-
-
Su, G.L.1
-
62
-
-
34548272744
-
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
-
PMID: 17644211
-
Rivera CA. Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M, et al. (2007) Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol. 47: 571-579. PMID: 17644211
-
(2007)
J Hepatol
, vol.47
, pp. 571-579
-
-
Rivera, C.A.1
Adegboyega, P.2
Van Rooijen, N.3
Tagalicud, A.4
Allman, M.5
Wallace, M.6
-
63
-
-
84856139907
-
Peroxisome proliferator-activated receptor-a agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis
-
PMID: 21929649
-
Larter CZ, Yeh MM, Van Rooyen D, Brooling J, Ghatora K, Farrell GC, et al. (2012). Peroxisome proliferator-activated receptor-a agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis. Journal of Gastroenterology and Hepatology 27 341-350 doi: 10.1111/j.1440-1746.2011.06939.x PMID: 21929649
-
(2012)
Journal of Gastroenterology and Hepatology
, vol.27
, pp. 341-350
-
-
Larter, C.Z.1
Yeh, M.M.2
Van Rooyen, D.3
Brooling, J.4
Ghatora, K.5
Farrell, G.C.6
-
64
-
-
40049088000
-
PPARalpha: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
-
PMID: 18006136
-
Gonzalez FJ, Shah YM. (2008). PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 246: 2-8. PMID: 18006136
-
(2008)
Toxicology
, vol.246
, pp. 2-8
-
-
Gonzalez, F.J.1
Shah, Y.M.2
-
65
-
-
79959696573
-
Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in micePeroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in micePeroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice
-
PMID: 21474829
-
Lalloyer F, Wouters K, Baron M, Caron S, Vallez E, Vanhoutte J, et al. (2011) Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in micePeroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in micePeroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. Arterioscler Thromb Vasc Biol. 31(7): 1573-1579. doi: 10.1161/ATVBAHA.110.220525 PMID: 21474829
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, Issue.7
, pp. 1573-1579
-
-
Lalloyer, F.1
Wouters, K.2
Baron, M.3
Caron, S.4
Vallez, E.5
Vanhoutte, J.6
-
66
-
-
39849099238
-
Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
-
PMID: 18176957
-
Kallwitz ER., MClachlan A, Cotler SJ. (2008). Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J Gastroenterol 14(1): 22-28. PMID: 18176957
-
(2008)
World J Gastroenterol
, vol.14
, Issue.1
, pp. 22-28
-
-
Kallwitz, E.R.1
MClachlan, A.2
Cotler, S.J.3
-
67
-
-
80051706346
-
Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
-
PMID: 21507897
-
Morán-salvador E, López-Parra M, García-Alonso V, Titos E, Martínez-Clemente M, González-Périz A, et al. (2011). Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J, 25: 2538-2550. doi: 10.1096/fj.10-173716 PMID: 21507897
-
(2011)
FASEB J
, vol.25
, pp. 2538-2550
-
-
Morán-salvador, E.1
López-Parra, M.2
García-Alonso, V.3
Titos, E.4
Martínez-Clemente, M.5
González-Périz, A.6
-
68
-
-
0030756303
-
A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription
-
PMID: 9315679
-
Li Z, Nabel GJ. (1997). A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. Mol Cell Biol. 17(10): 6184-90. PMID: 9315679
-
(1997)
Mol Cell Biol
, vol.17
, Issue.10
, pp. 6184-6190
-
-
Li, Z.1
Nabel, G.J.2
-
69
-
-
0034746919
-
NF-kappaB: Um papel chave em doenças inflamatórias
-
PMID: 11134171
-
Tak PP, Firestein GS. (2001) NF-kappaB: um papel chave em doenças inflamatórias. J Clin Invest. 107 (1): 7-11. PMID: 11134171
-
(2001)
J Clin Invest
, vol.107
, Issue.1
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
70
-
-
0033595892
-
The Rel/NF-kB signal transduction pathway: Introduction
-
PMID: 10602459
-
Thomas D Gilmore. (1999) The Rel/NF-kB signal transduction pathway: introduction. Oncogene 18: 6842-6844. PMID: 10602459
-
(1999)
Oncogene
, vol.18
, pp. 6842-6844
-
-
Gilmore, T.D.1
-
71
-
-
0036154951
-
The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough
-
PMID: 11826425
-
Groszmann RJ, Wiest R. (2002) The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 35: 478-491. PMID: 11826425
-
(2002)
Hepatology
, vol.35
, pp. 478-491
-
-
Groszmann, R.J.1
Wiest, R.2
-
72
-
-
46249116797
-
Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species
-
PMID: 18459124
-
Langer DA, Das A, Semela D, Kang-Decker N, Hendrickson H, Bronk SF. et al. (2008) Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species. Hepatology 47: 1983-1993. doi: 10.1002/hep.22285 PMID: 18459124
-
(2008)
Hepatology
, vol.47
, pp. 1983-1993
-
-
Langer, D.A.1
Das, A.2
Semela, D.3
Kang-Decker, N.4
Hendrickson, H.5
Bronk, S.F.6
-
73
-
-
0029666293
-
Inhibition of NF-kappaB DNA binding by nitric oxide
-
PMID: 8710491
-
Matthews JR, Botting CH, Panico M, Morris HR, Hay RT, (1996). Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res. 24: 2236-2242. PMID: 8710491
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 2236-2242
-
-
Matthews, J.R.1
Botting, C.H.2
Panico, M.3
Morris, H.R.4
Hay, R.T.5
-
74
-
-
24944536752
-
A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription
-
PMID: 16099468
-
Grumbach IM, Chen W, Mertens SA, Harrison DG. (2005) A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription. J Mol Cell Cardiol. 39: 595-603. PMID: 16099468
-
(2005)
J Mol Cell Cardiol.
, vol.39
, pp. 595-603
-
-
Grumbach, I.M.1
Chen, W.2
Mertens, S.A.3
Harrison, D.G.4
-
75
-
-
77951286204
-
Recent advances in nonalcoholic fatty liver disease
-
PMID: 20168226
-
Cheung O, Sanyal AJ. (2010). Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol. 26: 202-208. doi: 10.1097/MOG.0b013e328337b0c4 PMID: 20168226
-
(2010)
Curr Opin Gastroenterol
, vol.26
, pp. 202-208
-
-
Cheung, O.1
Sanyal, A.J.2
-
76
-
-
77954956697
-
Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance
-
PMID: 20581678
-
Savage DB, Semple RK. (2010) Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance. Curr Opin Lipidol 21: 329-336. doi: 10.1097/MOL.0b013e32833b7782 PMID: 20581678
-
(2010)
Curr Opin Lipidol
, vol.21
, pp. 329-336
-
-
Savage, D.B.1
Semple, R.K.2
-
77
-
-
33845866857
-
Inflammation and metabolic disorders
-
PMID: 17167474
-
Hotamisligil G.S. (2006) Inflammation and metabolic disorders. Nature. v 444: p 860-867. PMID: 17167474
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
78
-
-
84879567781
-
ABCA1 mutation carriers with low-density lipoprotein cholesterol are characterized by a greater atherosclerotic burden
-
PMID: 23136402
-
Bochem AE, van Wijk DF, Holleboom AG, Duivenvoorden R, Motazacker MM, Dallinga-Thie GM, et al. (2013) ABCA1 mutation carriers with low-density lipoprotein cholesterol are characterized by a greater atherosclerotic burden. Eur Heart J. 34 (4): 286 91. doi: 10.1093/eurheartj/ehs376 PMID: 23136402
-
(2013)
Eur Heart J
, vol.34
, Issue.4
, pp. 28691
-
-
Bochem, A.E.1
Van Wijk, D.F.2
Holleboom, A.G.3
Duivenvoorden, R.4
Motazacker, M.M.5
Dallinga-Thie, G.M.6
-
79
-
-
84897604034
-
ApoA-1 and ABCA1 expression alleviates lipid accumulation in hepatocytes
-
PMID: 24219083
-
Liu W, Qin L, Yu H, Lv F, Wang Y. (2014) ApoA-1 and ABCA1 expression alleviates lipid accumulation in hepatocytes. J Gastroenterol Hepatol. 29(3): 614-22. doi: 10.1111/jgh.12430 PMID: 24219083
-
(2014)
J Gastroenterol Hepatol
, vol.29
, Issue.3
, pp. 614-622
-
-
Liu, W.1
Qin, L.2
Yu, H.3
Lv, F.4
Wang, Y.5
|