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Volumn 31, Issue 7, 2011, Pages 1573-1579

Peroxisome proliferator-activated receptor-α gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice

Author keywords

Atherosclerosis; fatty liver disease; inflammation; murine model; PPAR

Indexed keywords

APOLIPOPROTEIN E2; FENOFIBRATE; INTERCELLULAR ADHESION MOLECULE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

EID: 79959696573     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.220525     Document Type: Article
Times cited : (68)

References (34)
  • 1
    • 50649089597 scopus 로고    scopus 로고
    • Fibrates and future PPARα agonists in the treatment of cardiovascular disease
    • Staels B, Maes M, Zambon A. Fibrates and future PPARα agonists in the treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2008;5:542-553.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 542-553
    • Staels, B.1    Maes, M.2    Zambon, A.3
  • 3
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • DOI 10.1053/jhep.2003.50307
    • Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology. 2003;38:123-132. (Pubitemid 36775803)
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 4
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the Potent PPARα Agonist, Wy-14,643, Reverses Nutritional Fibrosis and Steatohepatitis in Mice
    • DOI 10.1002/hep.20170
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology. 2004;39:1286-1296. (Pubitemid 38569050)
    • (2004) Hepatology , vol.39 , Issue.5 , pp. 1286-1296
    • Ip, E.1    Farrell, G.2    Hall, P.3    Robertson, G.4    Leclercq, I.5
  • 6
    • 77950600111 scopus 로고    scopus 로고
    • Short-term therapy with peroxisome proliferation-activator receptor-α agonist Wy-14,643 protects murine fatty liver against ischemiareperfusion injury
    • Teoh NC, Williams J, Hartley J, Yu J, McCuskey RS, Farrell GC. Short-term therapy with peroxisome proliferation-activator receptor-α agonist Wy-14,643 protects murine fatty liver against ischemiareperfusion injury. Hepatology. 2010;51:996-1006.
    • (2010) Hepatology , vol.51 , pp. 996-1006
    • Teoh, N.C.1    Williams, J.2    Hartley, J.3    Yu, J.4    McCuskey, R.S.5    Farrell, G.C.6
  • 7
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
    • DOI 10.1172/JCI27989
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B. Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. J Clin Invest. 2006;116:571-580. (Pubitemid 43326861)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.-C.3    Staels, B.4
  • 8
  • 10
    • 35848958123 scopus 로고    scopus 로고
    • Absence of peroxisome proliferator-activated receptor-α abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse
    • DOI 10.1161/HYPERTENSIONAHA.107.094268
    • Tordjman KM, Semenkovich CF, Coleman T, Yudovich R, Bak S, Osher E, Vechoropoulos M, Stern N. Absence of peroxisome proliferator-activated receptor-α abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse. Hypertension. 2007;50:945-951. (Pubitemid 350287539)
    • (2007) Hypertension , vol.50 , Issue.5 , pp. 945-951
    • Tordjman, K.M.1    Semenkovich, C.F.2    Coleman, T.3    Yudovich, R.4    Bak, S.5    Osher, E.6    Vechoropoulos, M.7    Stern, N.8
  • 11
    • 34548693923 scopus 로고    scopus 로고
    • Macrophage expression of peroxisome proliferator-activated receptor-α reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    • DOI 10.1161/CIRCULATIONAHA.106.684704
    • Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-α reduces atherosclerosis in lowdensity lipoprotein receptor-deficient mice. Circulation. 2007;116: 1404-1412. (Pubitemid 47417567)
    • (2007) Circulation , vol.116 , Issue.12 , pp. 1404-1412
    • Babaev, V.R.1    Ishiguro, H.2    Ding, L.3    Yancey, P.G.4    Dove, D.E.5    Kovacs, W.J.6    Semenkovich, C.F.7    Fazio, S.8    Linton, M.F.9
  • 12
    • 0042568979 scopus 로고    scopus 로고
    • The peroxisome-proliferator-activated receptor α agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E
    • DOI 10.1042/BJ20030105
    • Fu T, Kashireddy P, Borensztajn J. The peroxisome-proliferator-activated receptor α agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E. Biochem J. 2003;373:941-947. (Pubitemid 36981105)
    • (2003) Biochemical Journal , vol.373 , Issue.3 , pp. 941-947
    • Fu, T.1    Kashireddy, P.2    Borensztajn, J.3
  • 14
    • 33646192257 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice
    • Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL. Peroxisome proliferator-activated receptor-α selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. Mol Cell Biochem. 2006;285:35-50.
    • (2006) Mol Cell Biochem , vol.285 , pp. 35-50
    • Srivastava, R.A.1    Jahagirdar, R.2    Azhar, S.3    Sharma, S.4    Bisgaier, C.L.5
  • 15
    • 0028997684 scopus 로고
    • Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995;15:3012-3022.
    • (1995) Mol Cell Biol , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 16
    • 0032128001 scopus 로고    scopus 로고
    • Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human APOE*2
    • Sullivan PM, Mezdour H, Quarfordt SH, Maeda N. Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J Clin Invest. 1998; 102:130-135. (Pubitemid 28323839)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.1 , pp. 130-135
    • Sullivan, P.M.1    Mezdour, H.2    Quarfordt, S.H.3    Maeda, N.4
  • 17
    • 44249124486 scopus 로고    scopus 로고
    • Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-α control of the acute-phase response
    • DOI 10.1210/en.2007-1339
    • Mansouri RM, Bauge E, Staels B, Gervois P. Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-α control of the acute-phase response. Endocrinology. 2008;149:3215-3223. (Pubitemid 351724503)
    • (2008) Endocrinology , vol.149 , Issue.6 , pp. 3215-3223
    • Mansouri, R.M.1    Bauge, E.2    Staels, B.3    Gervois, P.4
  • 18
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • DOI 10.1006/abio.1987.9999
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159. (Pubitemid 17064313)
    • (1987) Analytical Biochemistry , vol.162 , Issue.1 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 19
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010;363:1341-1350.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 20
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
    • DOI 10.1073/pnas.96.13.7473
    • Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA. 1999;96:7473-7478. (Pubitemid 29299686)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.13 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 21
  • 22
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem. 2000;275:28918-28928.
    • (2000) J Biol Chem , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 26
    • 34447114640 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus
    • DOI 10.1007/s00125-007-0698-9
    • Bajaj M, Suraamornkul S, Hardies LJ, Glass L, Musi N, DeFronzo RA. Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus. Diabetologia. 2007;50:1723-1731. (Pubitemid 47036647)
    • (2007) Diabetologia , vol.50 , Issue.8 , pp. 1723-1731
    • Bajaj, M.1    Suraamornkul, S.2    Hardies, L.J.3    Glass, L.4    Musi, N.5    DeFronzo, R.A.6
  • 29
    • 0036013438 scopus 로고    scopus 로고
    • Characterization of the human PPARα promoter: Identification of a functional nuclear receptor response element
    • DOI 10.1210/me.16.5.1013
    • Pineda Torra I, Jamshidi Y, Flavell DM, Fruchart JC, Staels B. Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element. Mol Endocrinol. 2002;16:1013-1028. (Pubitemid 34478538)
    • (2002) Molecular Endocrinology , vol.16 , Issue.5 , pp. 1013-1028
    • Torra, I.P.1    Jamshidi, Y.2    Flavell, D.M.3    Fruchart, J.-C.4    Staels, B.5
  • 31
    • 0028146233 scopus 로고
    • Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
    • Zhang SH, Reddick RL, Burkey B, Maeda N. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest. 1994;94:937-945. (Pubitemid 24286433)
    • (1994) Journal of Clinical Investigation , vol.94 , Issue.3 , pp. 937-945
    • Zhang, S.H.1    Reddick, R.L.2    Burkey, B.3    Maeda, N.4
  • 32
    • 0141918837 scopus 로고    scopus 로고
    • Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis
    • DOI 10.1016/j.tips.2003.08.001
    • Tailleux A, Torpier G, Mezdour H, Fruchart JC, Staels B, Fievet C. Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis. Trends Pharmacol Sci. 2003;24:530-534. (Pubitemid 37244006)
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.10 , pp. 530-534
    • Tailleux, A.1    Torpier, G.2    Mezdour, H.3    Fruchart, J.-C.4    Staels, B.5    Fievet, C.6
  • 33
    • 0034046520 scopus 로고    scopus 로고
    • The human peroxisome proliferator-activated receptor α gene: Identification and functional characterization of two natural allelic variants
    • Sapone A, Peters JM, Sakai S, Tomita S, Papiha SS, Dai R, Friedman FK, Gonzalez FJ. The human peroxisome proliferator-activated receptor α gene: identification and functional characterization of two natural allelic variants. Pharmacogenetics. 2000;10:321-333. (Pubitemid 30345180)
    • (2000) Pharmacogenetics , vol.10 , Issue.4 , pp. 321-333
    • Sapone, A.1    Peters, J.M.2    Sakai, S.3    Tomita, S.4    Papiha, S.S.5    Dai, R.6    Friedman, F.K.7    Gonzalez, F.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.