Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities

European Journal of Medicinal Chemistry

Volumn 42, Issue 10, 2007, Pages 1263-1271

  da Costa Leite, Lúcia Fernanda C ^a   Veras Mourão, Rosa Helena ^b   de Lima, Maria do Carmo Alves ^b   Galdino, Suely Lins ^b   Hernandes, Marcelo Zaldini ^b   de Assis Rocha Neves, Francisco ^c   Vidal, Stéphanie ^d   Barbe, Jacques ^d   da Rocha Pitta, Ivan ^b  

^a CATHOLIC UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c UNIVERSITY OF BRASILIA   (Brazil)

^d CNRS   (France)

Author keywords

Arylidene thiazolidinediones; Docking; Hypoglycemic; Hypolipidemic; Molecular modeling

Indexed keywords

3 (4 METHYL BENZYL) 5 (4 METHYL BENZYLIDENE) THIAZOLIDINE 2,4 DIONE; 3 (4 METHYL BENZYL) 5 (4 NITRO BENZYLIDENE) THIAZOLIDINE 2,4 DIONE; 5 (3 BROMO BENZYLIDENE) 3 (4 METHYL BENZYL) THIAZOLIDINE 2,4 DIONE; 5 (3 CHLORO BENZYLIDENE) 3 (4 METHYL BENZYL) THIAZOLIDINE 2,4 DIONE; 5 (4 HYDROXY BENZYLIDENE) 3 (4 METHYL BENZYL) THIAZOLIDINE 2,4 DIONE; ALLOXAN; GLITAZONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DIABETES MELLITUS; DOSE RESPONSE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MOLECULAR MECHANICS; MOUSE; NONHUMAN;

ALLOXAN; ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN BONDING; HYPOGLYCEMIC AGENTS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR ALPHA; PPAR GAMMA; THIAZOLIDINEDIONES; TRIGLYCERIDES;

EID: 35148867098     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.02.015     Document Type: Article

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