Impaired Akt phosphorylation in insulin-resistant human muscle is accompanied by selective and heterogeneous downstream defects

Diabetologia

Volumn 56, Issue 4, 2013, Pages 875-885

  Tonks, K T ^a,b,c   Ng, Y ^a   Miller, S ^a   Coster, A C F ^a,b   Samocha Bonet, D ^a,b   Iseli, T J ^a   Xu, A ^d   Patrick, E ^e   Yang, J Y H ^e   Junutula, J R ^f   Modrusan, Z ^f   Kolumam, G ^f   Stockli J ^a   Chisholm, D J ^a,b   James, D E ^a   Greenfield, J R ^a,b,c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF SYDNEY   (Australia)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN KINASE B; SERINE; THREONINE; TRANSCRIPTION FACTOR FOXO;

ADULT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MUSCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MUSCLES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84876471343     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2811-y     Document Type: Article

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