Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

Journal of Thrombosis and Haemostasis

Volumn 13, Issue 5, 2015, Pages 827-838

  Dutting S ^a   Heidenreich, J ^a   Cherpokova, D ^a   Amin, E ^b   Zhang, S C ^b,d   Ahmadian, M R ^b   Brakebusch, C ^c   Nieswandt, B ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b Department of Orthopedic Surgery   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Blood platelets; Enzyme inhibitors; Rac1 GTP binding protein; Signal transduction; Thrombosis

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; EHT1864; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; GLYCOPROTEIN IB; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN ALPHA 2 B BETA 3; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 2; PROTEIN INHIBITOR; RAC1 PROTEIN; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; EHT 1864; NEUROPEPTIDE; PYRIMIDINE DERIVATIVE; PYRONE DERIVATIVE; QUINOLINE DERIVATIVE; RAC1 PROTEIN, MOUSE;

AGGREGOMETRY; ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD CLOT RETRACTION; CELL ACTIVATION; CELL SPREADING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SPECIFICITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; IMMUNORECEPTOR TYROSINE BASED ACTIVATION MOTIF; MEASUREMENT; MOUSE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; THROMBOCYTE; THROMBOCYTE ACTIVATION; WILD TYPE MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINOQUINOLINES; ANIMALS; APOPTOSIS; BLOOD PLATELETS; MICE; MICE, KNOCKOUT; NEUROPEPTIDES; PHOSPHORYLATION; PYRIMIDINES; PYRONES; QUINOLINES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84928757883     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12861     Document Type: Article

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