Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice

Experimental Physiology

Volumn 93, Issue 10, 2008, Pages 1091-1103

  Binker, Marcelo G ^a,b   Binker Cosen, Andres A ^a   Gaisano, Herbert Y ^b   Cosen Binker, Laura I ^a,b  

^a CBRHC Research Center   (Argentina)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CERULETIDE; CHOLECYSTOKININ; DIAMINE; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; MYELOPEROXIDASE; N 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYL 4,6 QUINOLINEDIAMINE; NSC 23766; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRIACYLGLYCEROL LIPASE; TRYPSINOGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; GENE TRANSLOCATION; HISTOPATHOLOGY; LUNG INJURY; MALE; MOUSE; NONHUMAN; PANCREAS NECROSIS; PANCREATITIS; SCORING SYSTEM;

EID: 51749122903     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2008.043141     Document Type: Article

References (46)

1. Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M & Rosenkranz S (2008). Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for α-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem 283, 7864 7876.
2. Bi Y, Page SL & Williams JA (2005). Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol Gastrointest Liver Physiol 289, G561 G570.
3. Bi Y & Williams JA (2005). A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini. Am J Physiol Cell Physiol 289, C22 C32.
4. Böhrer H, Qiu F, Zimmermann T, Zhang Y, Jllmer T, Männel D, Böttiger BW, Stern DM, Waldherr R, Saeger HD, Ziegler R, Bierhaus A, Martin E & Nawroth PP (1997). Role of NFκB in the mortality of sepsis. J Clin Invest 100, 972 985.
5. Chvanov M, Petersen OH & Tepikin A (2005). Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philos Trans R Soc Lond B Biol Sci 360, 2273 2284.
6. Copley L, Van Der Watt P, Wirtz KW, Parker MI & Leaner VD (2008). Photolon™, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis. Int J Biochem Cell Biol 40, 227 235.
7. Cosen-Binker LI, Binker MG, Cosen R, Negri G & Tiscornia O (2006). Influence of nitric oxide-donating nonsteroidal anti-inflammatory drugs on the evolution of acute pancreatitis. Shock 25, 190 203.
8. Cosen-Binker LI & Gaisano HY (2007). Recent insights into the cellular mechanisms of acute pancreatitis. Can J Gastroenterol 21, 19 24.
9. Cosen-Binker LI, Lam PP, Binker MG & Gaisano HY (2007). Alcohol-induced protein kinase Cα phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Gastroenterology 132, 1527 1545.
10. Cuzzocrea S, Genovese T, Mazzon E, Di Paola R, Muià C, Britti D & Salvemini D (2004). Reduction in the development of cerulein-induced acute pancreatitis by treatment with M40401, a new selective superoxide dismutase mimetic. Shock 22, 254 261.
11. De Waele JJ & Hoste E (2006). Current pharmacotherapeutic recommendations for acute pancreatitis. Expert Opin Pharmacother 7, 1017 1025.
12. Etienne-Manneville S & Hall A (2002). Rho GTPases in cell biology. Nature 420, 629 635.
13. Fernández-del Castillo C, Schmide J, Warshaw AL & Rattner DW (1994). Interstitial protease activation is the central event in progression to necrotizing pancreatitis. Surgery 116, 497 504.
14. Gaisano HY, Klueppelberg UG, Pinon D, Pfenning MA, Powers SP & Miller LJ (1989). A novel tool for the study of CCK-stimulated pancreatic enzyme secretion. J Clin Invest 83, 321 325.
15. Gaisano HY, Lutz MP, Leser J, Sheu L, Lynch G, Tang L, Tamori Y, Trimble WS & Salapatek AM (2001). Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane. J Clin Invest 108, 1597 1611.
16. Gao Y, Dickerson JB, Guo F, Zheng J & Zheng Y (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101, 7618 7623.
17. Grady T, Mah'Moud M, Otani T, Rhee S, Lerch MM & Gorelick FS (1998). Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol Gastrointest Liver Physiol 275, G1010 G1017.
18. Granados MP, Salido GM, Pariente JA & González A (2004). Generation of ROS in response to CCK-8 stimulation in mouse pancreatic acinar cells. Mitochondrion 3, 285 296.
19. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440 3450.
20. Gukovskaya AS, Gukovsky I, Jung Y, Mouria M & Pandol SJ (2002). Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J Biol Chem 277, 22595 22604.
21. Han B, Ji B & Logsdon CD (2001). CCK independently activates intracellular trypsinogen and NF-κB in rat pancreatic acinar cells. Am J Physiol Cell Physiol 280, C465 C472.
22. Hartwig W, Jimenez RE, Werner J, Lewandrowski KB, Warshaw AL & Fernández-del Castillo C (1999). Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats. Gastroenterology 117, 717 725.
23. Kawabata S, Miura T, Morita T, Kato H, Fujikawa K, Iwanaga S, Takada K, Kimura T & Sakakibara S (1988). Highly sensitive peptide-4-methylcoumaryl-7- amide substrates for blood-clotting proteases and trypsin. Eur J Biochem 172, 17 25.
24. Klöppel G, Dreyer T, Willemer S, Kern HF & Adler G (1986). Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells. Virchows Arch A Pathol Anat Histopathol 409, 791 803.
25. Kubisch CH & Logsdon CD (2007). Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 292, G1804 G1812.
26. Labarca C & Paigen K (1980). A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102, 344 352.
27. Lampel M & Kern HF (1977). Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A Pathol Anat Histol 373, 97 117.
28. Li C, Wright MM & Jackson RM (2002). Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation. Exp Lung Res 28, 373 389.
29. 2+-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells. J Physiol 550, 431 445.
30. Nakai Y, Zheng Y, MacCollin M & Ratner N (2006). Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. J Neurosci 26, 3390 3395.
31. Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ & Irani K (2000). Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J 14, 418 429.
32. Pandol SJ, Saluja AK, Imrie CW & Banks PA (2007). Acute pancreatitis: bench to the bedside. Gastroenterology 132, 1127 1151.
33. 2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends Pharmacol Sci 27, 113 120.
34. Price LS, Norman JC, Ridley AJ & Koffer A (1995). The small GTPases Rac and Rho as regulators of secretion in mast cells. Curr Biol 5, 68 73.
35. Rakonczay Z Jr., Hegyi P, Takács T, McCarroll J & Saluja AK (2008). The role of NF-κB activation in the pathogenesis of acute pancreatitis. Gut 57, 259 267.
36. Ren XD, Kiosses WB & Schwartz MA (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18, 578 585.
37. Russell ST, Eley H & Tisdale MJ (2007). Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II. Cell Signal 19, 1797 1806.
38. Saluja AK & Bhagat L (2003). Pancreatitis and associated lung injury: when MIF miffs. Gastroenterology 124, 844 847.
39. Saluja AK, Lerch MM, Phillips PA & Dudeja V (2007). Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol 69, 249 269.
40. Scheele G, Adler G & Kern H (1987). Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation. Gastroenterology 92, 345 353.
41. Steer M & Meldolesi J (1987). The cell biology of experimental pancreatitis. N Engl J Med 317, 144 150.
42. Thomas EK, Cancelas JA, Chae HD, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Setchell KD, Zheng Y, Harris CE & Williams DA (2007). Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell 12, 467 478.
43. Van Esch AA, Wilder-Smith OH, Jansen JB, van Goor H & Drenth JP (2006). Pharmacological management of pain in chronic pancreatitis. Dig Liver Dis 38, 518 526.
44. Wang L, Ma Q, Chen X, Sha H & Ma Z (2008). Effects of resveratrol on calcium regulation in rats with severe acute pancreatitis. Eur J Pharmacol 580, 271 276.
45. Willemer S, Bialek R & Adler G 1990). Localization of lysosomal and digestive enzymes in cytoplasmic vacuoles in caerulein-pancreatitis. Histochemistry 94, 161 170.
46. Williams JA (2001). Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. Annu Rev Physiol 63, 77 97.