메뉴 건너뛰기




Volumn 592, Issue 5, 2014, Pages 915-926

The small GTPase Rac1 is required for smooth muscle contraction

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM; CARBACHOL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHENYLEPHRINE; PHORBOL DIBUTYRATE; POTASSIUM; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN RECEPTOR; PROTEIN KINASE C; RAC1 PROTEIN; THROMBOXANE RECEPTOR;

EID: 84896703875     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.262998     Document Type: Article
Times cited : (36)

References (49)
  • 1
    • 0031662139 scopus 로고    scopus 로고
    • Calcium transients and the effect of a photolytically released calcium chelator during electrically induced contractions in rabbit rectococcygeus smooth muscle
    • Arner A, Malmqvist U & Rigler R (1998). Calcium transients and the effect of a photolytically released calcium chelator during electrically induced contractions in rabbit rectococcygeus smooth muscle. Biophys J 75, 1895-1903.
    • (1998) Biophys J , vol.75 , pp. 1895-1903
    • Arner, A.1    Malmqvist, U.2    Rigler, R.3
  • 2
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take centre stage
    • Burridge K & Wennerberg K (2004). Rho and Rac take centre stage. Cell 116, 167-179.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 3
    • 0033974061 scopus 로고    scopus 로고
    • Regulatory and signalling properties of the Vav family
    • Bustelo XR (2000). Regulatory and signalling properties of the Vav family. Mol Cell Biol 20, 1461-1477.
    • (2000) Mol Cell Biol , vol.20 , pp. 1461-1477
    • Bustelo, X.R.1
  • 4
    • 84874433733 scopus 로고    scopus 로고
    • Regulation of small GTPases by GEFs, GAPs, and GDIs
    • Cherfils J & Zeghouf M (2013). Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev 93, 269-309.
    • (2013) Physiol Rev , vol.93 , pp. 269-309
    • Cherfils, J.1    Zeghouf, M.2
  • 6
    • 84867580539 scopus 로고    scopus 로고
    • AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signalling and inhibits NO-induced relaxation
    • Davis B, Rahman A & Arner A (2012). AMP-activated kinase relaxes agonist induced contractions in the mouse aorta via effects on PKC signalling and inhibits NO-induced relaxation. Eur J Pharmacol 695, 88-95.
    • (2012) Eur J Pharmacol , vol.695 , pp. 88-95
    • Davis, B.1    Rahman, A.2    Arner, A.3
  • 8
    • 0031875033 scopus 로고    scopus 로고
    • A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells
    • Doanes AM, Irani K, Goldschmidt-Clermont PJ & Finkel T (1998). A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells. Biochem Mol Biol Int 45, 279-287.
    • (1998) Biochem Mol Biol Int , vol.45 , pp. 279-287
    • Doanes, A.M.1    Irani, K.2    Goldschmidt-Clermont, P.J.3    Finkel, T.4
  • 9
    • 33644546001 scopus 로고    scopus 로고
    • Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle
    • Ekman M, Andersson KE & Arner A (2006). Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle. Eur J Pharmacol 532, 99-106.
    • (2006) Eur J Pharmacol , vol.532 , pp. 99-106
    • Ekman, M.1    Andersson, K.E.2    Arner, A.3
  • 11
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J & Zheng Y (2004). Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A 101, 7618-7623.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 12
    • 0028927011 scopus 로고
    • Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin
    • Habets GG, van der Kammen RA, Stam JC, Michiels F & Collard JG (1995). Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene 10, 1371-1376.
    • (1995) Oncogene , vol.10 , pp. 1371-1376
    • Habets, G.G.1    van der Kammen, R.A.2    Stam, J.C.3    Michiels, F.4    Collard, J.G.5
  • 13
    • 0035164457 scopus 로고    scopus 로고
    • Molecular mechanisms of phenotypic plasticity in smooth muscle cells
    • Halayko AJ & Solway J (2001). Molecular mechanisms of phenotypic plasticity in smooth muscle cells. J Appl Physiol 90, 358-368.
    • (2001) J Appl Physiol , vol.90 , pp. 358-368
    • Halayko, A.J.1    Solway, J.2
  • 14
    • 66349113776 scopus 로고    scopus 로고
    • Phospholipase C isozymes as effectors of Ras superfamily GTPases
    • Harden TK, Hicks SN & Sondek J (2009). Phospholipase C isozymes as effectors of Ras superfamily GTPases. J. Lipid Res 50 Suppl, S243-S248.
    • (2009) J. Lipid Res , vol.50 , Issue.Suppl
    • Harden, T.K.1    Hicks, S.N.2    Sondek, J.3
  • 15
    • 84864981988 scopus 로고    scopus 로고
    • Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways
    • Hoover WC, Zhang W, Xue Z, Gao H, Chernoff J, Clapp DW, Gunst SJ & Tepper RS (2012). Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PloS One 7, e42601.
    • (2012) PloS One , vol.7
    • Hoover, W.C.1    Zhang, W.2    Xue, Z.3    Gao, H.4    Chernoff, J.5    Clapp, D.W.6    Gunst, S.J.7    Tepper, R.S.8
  • 17
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • Jaffe AB & Hall A (2005). Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21, 247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 22
    • 33646763902 scopus 로고    scopus 로고
    • Rho kinases in cardiovascular physiology and pathophysiology
    • Loirand G, Guerin P & Pacaud P (2006). Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 98, 322-334.
    • (2006) Circ Res , vol.98 , pp. 322-334
    • Loirand, G.1    Guerin, P.2    Pacaud, P.3
  • 23
    • 78049274198 scopus 로고    scopus 로고
    • The role of Rho protein signalling in hypertension
    • Loirand G & Pacaud P (2010). The role of Rho protein signalling in hypertension. Nat Rev Cardiol 7, 637-647.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 637-647
    • Loirand, G.1    Pacaud, P.2
  • 24
    • 0031963672 scopus 로고    scopus 로고
    • Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins
    • Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K & Pfitzer G (1998). Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J Physiol 506, 83-93.
    • (1998) J Physiol , vol.506 , pp. 83-93
    • Lucius, C.1    Arner, A.2    Steusloff, A.3    Troschka, M.4    Hofmann, F.5    Aktories, K.6    Pfitzer, G.7
  • 25
    • 33746611555 scopus 로고    scopus 로고
    • Modulation of vascular smooth muscle signalling by reactive oxygen species
    • Lyle AN & Griendling KK (2006). Modulation of vascular smooth muscle signalling by reactive oxygen species. Physiology 21, 269-280.
    • (2006) Physiology , vol.21 , pp. 269-280
    • Lyle, A.N.1    Griendling, K.K.2
  • 29
    • 49849092490 scopus 로고    scopus 로고
    • Convergent CaMK and RacGEF signals control dendritic structure and function
    • Penzes P, Cahill ME, Jones KA & Srivastava DP (2008). Convergent CaMK and RacGEF signals control dendritic structure and function. Trends Cell Biol 18, 405-413.
    • (2008) Trends Cell Biol , vol.18 , pp. 405-413
    • Penzes, P.1    Cahill, M.E.2    Jones, K.A.3    Srivastava, D.P.4
  • 30
    • 73949121819 scopus 로고    scopus 로고
    • Regulation of smooth muscle contraction by small GTPases
    • Puetz S, Lubomirov LT & Pfitzer G (2009). Regulation of smooth muscle contraction by small GTPases. Physiology 24, 342-356.
    • (2009) Physiology , vol.24 , pp. 342-356
    • Puetz, S.1    Lubomirov, L.T.2    Pfitzer, G.3
  • 33
    • 34250902907 scopus 로고    scopus 로고
    • Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk
    • Rosenfeldt H, Castellone MD, Randazzo PA & Gutkind JS (2006). Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal 1, 8.
    • (2006) J Mol Signal , vol.1 , pp. 8
    • Rosenfeldt, H.1    Castellone, M.D.2    Randazzo, P.A.3    Gutkind, J.S.4
  • 34
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ & Sondek J (2005). GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6, 167-180.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 35
    • 0033615966 scopus 로고    scopus 로고
    • Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour
    • Sander EE, ten Klooster JP, van Delft S, van der Kammen RA & Collard JG (1999). Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviour. J Cell Biol 147, 1009-1022.
    • (1999) J Cell Biol , vol.147 , pp. 1009-1022
    • Sander, E.E.1    ten Klooster, J.P.2    van Delft, S.3    van der Kammen, R.A.4    Collard, J.G.5
  • 37
    • 33947115378 scopus 로고    scopus 로고
    • Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice
    • Sauzeau V, Jerkic M, Lopez-Novoa JM & Bustelo XR (2007). Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice. Mol Biol Cell 18, 943-952.
    • (2007) Mol Biol Cell , vol.18 , pp. 943-952
    • Sauzeau, V.1    Jerkic, M.2    Lopez-Novoa, J.M.3    Bustelo, X.R.4
  • 38
    • 74949139625 scopus 로고    scopus 로고
    • The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells
    • Sauzeau V, Sevilla MA, Montero MJ & Bustelo XR (2010). The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest 120, 315-330.
    • (2010) J Clin Invest , vol.120 , pp. 315-330
    • Sauzeau, V.1    Sevilla, M.A.2    Montero, M.J.3    Bustelo, X.R.4
  • 39
    • 77949760277 scopus 로고    scopus 로고
    • Novel aspects of the roles of Rac1 GTPase in the cardiovascular system
    • Sawada N, Li Y & Liao JK (2010). Novel aspects of the roles of Rac1 GTPase in the cardiovascular system. Curr Opin Pharmacol 10, 116-121.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 116-121
    • Sawada, N.1    Li, Y.2    Liao, J.K.3
  • 40
    • 37249019970 scopus 로고    scopus 로고
    • Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases
    • Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F & Der CJ (2007). Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem 282, 35666-35678.
    • (2007) J Biol Chem , vol.282 , pp. 35666-35678
    • Shutes, A.1    Onesto, C.2    Picard, V.3    Leblond, B.4    Schweighoffer, F.5    Der, C.J.6
  • 43
    • 0141751697 scopus 로고    scopus 로고
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase
    • 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83, 1325-1358.
    • (2003) Physiol Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 44
    • 0036035213 scopus 로고    scopus 로고
    • Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase
    • Takizawa N, Koga Y & Ikebe M (2002). Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase. Biochem Biophys Res Commun 297, 773-778.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 773-778
    • Takizawa, N.1    Koga, Y.2    Ikebe, M.3
  • 47
    • 0038511012 scopus 로고    scopus 로고
    • Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1
    • Wirth A, Schroeter M, Kock-Hauser C, Manser E, Chalovich JM, De Lanerolle P & Pfitzer G (2003). Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1. J Physiol 549, 489-500.
    • (2003) J Physiol , vol.549 , pp. 489-500
    • Wirth, A.1    Schroeter, M.2    Kock-Hauser, C.3    Manser, E.4    Chalovich, J.M.5    De Lanerolle, P.6    Pfitzer, G.7
  • 49
    • 79952231619 scopus 로고    scopus 로고
    • Rho-kinase, a common final path of various contractile bladder and ureter stimuli
    • Zhang X & DiSanto ME (2011). Rho-kinase, a common final path of various contractile bladder and ureter stimuli. Handb Exp Pharmacol 202, 543-568.
    • (2011) Handb Exp Pharmacol , vol.202 , pp. 543-568
    • Zhang, X.1    DiSanto, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.