The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 74-88

  Thakur, Harish C ^a,e   Singh, Madhurendra ^a   Nagel Steger, Luitgard ^b,c   Kremer, Jana ^a   Prumbaum, Daniel ^d   Fansa, Eyad Kalawy ^a   Ezzahoini, Hakima ^a   Nouri, Kazem ^a   Gremer, Lothar ^b,c   Abts, André ^b   Schmitt, Lutz ^b   Raunser, Stefan ^d   Ahmadian, Mohammad R ^a   Piekorz, Roland P ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL PROLIFERATION; PROTEINS;

ADAPTOR PROTEINS; C-TERMINAL FRAGMENTS; COMPLEX FORMATIONS; CRUCIAL FUNCTIONS; EFFECTOR BINDING; INTRA-DOMAIN INTERACTIONS; MICROTUBULE DYNAMICS; SPINDLE-ASSEMBLY;

ENZYMES;

ADAPTOR PROTEIN; AURORA A KINASE; BINDING PROTEIN; COLONIC AND HEPATIC TUMOR OVEREXPRESSED GENE PROTEIN; TRANSFORMING ACIDIC COILED COIL 3 PROTEIN; UNCLASSIFIED DRUG; AURKA PROTEIN, HUMAN; AURKA PROTEIN, MOUSE; CARRIER PROTEIN; CKAP5 PROTEIN, HUMAN; FETOPROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN BINDING; TACC3 PROTEIN, HUMAN; TACC3 PROTEIN, MOUSE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CENTROSOME; COMPLEX FORMATION; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; ANIMAL; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HUMAN; METABOLISM; MITOSIS; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; AURORA KINASE A; CARRIER PROTEINS; CENTROSOME; FETAL PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84891676441     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.532333     Document Type: Article

References (84)

1. Bornens, M. (2012) The centrosome in cells and organisms. Science 335, 422-426
2. Compton, D. A. (2000) Spindle assembly in animal cells. Annu. Rev. Biochem. 69, 95-114
3. Delgehyr, N., Sillibourne, J., and Bornens, M. (2005) Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. J. Cell Sci. 118, 1565-1575 (Pubitemid 40691885)
4. Mattison, C., and Winey, M. (2006) The Centrosome Cycle/Cell Cycle Regulation (Kaldis, P., ed.) pp. 925-925, Springer, Berlin
5. Nigg, E. A. (2004) Centrosomes in Development and Disease, Wiley-VCH Verlag, Weinheim
6. Anderhub, S. J., Krämer, A., and Maier, B. (2012) Centrosome amplification in tumorigenesis. Cancer Lett. 322, 8-17
7. Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A., and Raff, J. W. (2008) Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032-1042 (Pubitemid 351787756)
8. Bettencourt-Dias, M., Hildebrandt, F., Pellman, D., Woods, G., and Godinho, S. A. (2011) Centrosomes and cilia in human disease. Trends Genet. 27, 307-315
9. Chan, J. Y. (2011) A clinical overview of centrosome amplification in human human cancers. Int. J. Biol. Sci. 7, 1122-1144
10. Mardin, B. R., and Schiebel, E. (2012) Breaking the ties that bind. new advances in centrosome biology. J. Cell Biol. 197, 11-18
11. Schmidt, S., Essmann, F., Cirstea, I. C., Kuck, F., Thakur, H. C., Singh, M., Kletke, A., Jänicke, R. U., Wiek, C., Hanenberg, H., Ahmadian, M. R., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R. P. (2010) The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 9, 4469-4473
12. Zyss, D., and Gergely, F. (2009) Centrosome function in cancer. Guilty or innocent? Trends Cell Biol. 19, 334-346
13. Fielding, A. B., Lim, S., Montgomery, K., Dobreva, I., and Dedhar, S. (2011) A critical role of integrin-linked kinase, ch-TOG, and TACC3 in centrosome clustering in cancer cells. Oncogene 30, 521-534
14. Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Thery, M., and Pellman, D. (2008) Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 22, 2189-2203
15. Marthiens, V., Piel, M., and Basto, R. (2012) Never tear us apart. The importance of centrosome clustering. J. Cell Sci. 125, 3281-3292
16. Krämer, A., Maier, B., and Bartek, J. (2011) Centrosome clustering and chromosomal (in) stability. A matter of life and death. Mol. Oncol. 5, 324-335
17. Raab, M. S., Breitkreutz, I., Anderhub, S., Rønnest, M. H., Leber, B., Larsen, T. O., Weiz, L., Konotop, G., Hayden, P. J., Podar, K., Fruehauf, J., Nissen, F., Mier, W., Haberkorn, U., Ho, A. D., Goldschmidt, H., Anderson, K. C., Clausen, M. H., and Krämer, A. (2012) GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. Cancer Res. 72, 5374-5385
18. Meraldi, P., and Nigg, E. A. (2002) The centrosome cycle. FEBS Lett. 521, 9-13 (Pubitemid 34628448)
19. Nigg, E. A., and Stearns, T. (2011) The centrosome cycle. Centriole biogenesis, duplication, and inherent asymmetries. Nat. Cell Biol. 13, 1154-1160
20. Cunha-Ferreira, I., Bento, I., and Bettencourt-Dias, M. (2009) From zero to many. Control of centriole number in development and disease. Traffic 10, 482-498
21. Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., and Mann, M. (2003) Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426, 570-574 (Pubitemid 37522644)
22. Jakobsen, L., Vanselow, K., Skogs, M., Toyoda, Y., Lundberg, E., Poser, I., Falkenby, L. G., Bennetzen, M., Westendorf, J., Nigg, E. A., Uhlen, M., Hyman, A. A., and Andersen, J. S. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30, 1520-1535
23. Müller, H., Schmidt, D., Steinbrink, S., Mirgorodskaya, E., Lehmann, V., Habermann, K., Dreher, F., Gustavsson, N., Kessler, T., Lehrach, H., Herwig, R., Gobom, J., Ploubidou, A., Boutros, M., and Lange, B. M. (2010) Proteomic and functional analysis of the mitotic Drosophila centrosome. EMBO J. 29, 3344-3357
24. Doxsey, S., McCollum, D., and Theurkauf, W. (2005) Centrosomes in cellular regulation. Annu. Rev. Cell Dev. Biol. 21, 411-434 (Pubitemid 41740641)
25. Hutchins, J. R., Toyoda, Y., Hegemann, B., Poser, I., Hériché, J. K., Sykora, M. M., Augsburg, M., Hudecz, O., Buschhorn, B. A., Bulkescher, J., Conrad, C., Comartin, D., Schleiffer, A., Sarov, M., Pozniakovsky, A., Slabicki, M. M., Schloissnig, S., Steinmacher, I., Leuschner, M., Ssykor, A., Lawo, S., Pelletier, L., Stark, H., Nasmyth, K., Ellenberg, J., Durbin, R., Buchholz, F., Mechtler, K., Hyman, A. A., and Peters, J. M. (2010) Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328, 593-599
26. Neumann, B., Walter, T., Hériché, J. K., Bulkescher, J., Erfle, H., Conrad, C., Rogers, P., Poser, I., Held, M., Liebel, U., Cetin, C., Sieckmann, F., Pau, G., Kabbe, R., Wünsche, A., Satagopam, V., Schmitz, M. H., Chapuis, C., Gerlich, D. W., Schneider, R., Eils, R., Huber, W., Peters, J. M., Hyman, A. A., Durbin, R., Pepperkok, R., and Ellenberg, J. (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464, 721-727
27. Gergely, F., Karlsson, C., Still, I., Cowell, J., Kilmartin, J., and Raff, J. W. (2000) The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc. Natl. Acad. Sci. U. S. A. 97, 14352-14357 (Pubitemid 32016579)
28. Peset, I., and Vernos, I. (2008) The TACC proteins. TACC-ling microtubule dynamics and centrosome function. Trends Cell Biol. 18, 379-388
29. Raff, J. W. (2002) Centrosomes and cancer. Lessons from a TACC. Trends Cell Biol. 12, 222-225
30. Gergely, F. (2002) Centrosomal TACCtics. Bioessays 24, 915-925 (Pubitemid 35180846)
31. Hood, F. E., and Royle, S. J. (2011) Pulling it together. The mitotic function of TACC3. Bioarchitecture 1, 105-109
32. Schneider, L., Essmann, F., Kletke, A., Rio, P., Hanenberg, H., Wetzel, W., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R. P. (2007) The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J. Biol. Chem. 282, 29273-29283 (Pubitemid 350043368)
33. Still, I. H., Vettaikkorumakankauv, A. K., Di Matteo, A., and Liang, P. (2004) Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. BMC Evol. Biol. 4, 16
34. Thakur, H. C., Singh, M., Nagel-Steger, L., Prumbaum, D., Fansa, E. K., Gremer, L., Ezzahoini, H., Abts, A., Schmitt, L., Raunser, S., Ahmadian, M. R., and Piekorz, R. P. (2013) Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division. Biol. Chem. 394, 1411-1423
35. Hao, Z., Stoler, M. H., Sen, B., Shore, A., Westbrook, A., Flickinger, C. J., Herr, J. C., and Coonrod, S. A. (2002) TACC3 expression and localization in the murine egg and ovary. Mol. Reprod. Dev. 63, 291-299
36. Sadek, C. M., Pelto-Huikko, M., Tujague, M., Steffensen, K. R., Wennerholm, M., and Gustafsson, J. A. (2003) TACC3 expression is tightly regulated during early differentiation. Gene Expr. Patterns 3, 203-211 (Pubitemid 36511307)
37. Schuendeln, M. M., Piekorz, R. P., Wichmann, C., Lee, Y., McKinnon, P. J., Boyd, K., Takahashi, Y., and Ihle, J. N. (2004) The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol. Cell. Biol. 24, 6403-6409 (Pubitemid 38891139)
38. Piekorz, R. P., Hoffmeyer, A., Duntsch, C. D., McKay, C., Nakajima, H., Sexl, V., Snyder, L., Rehg, J., and Ihle, J. N. (2002) The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 21, 653-664 (Pubitemid 34174046)
39. Jeng, J. C., Lin, Y. M., Lin, C. H., and Shih, H. M. (2009) Cdh1 controls the stability of TACC3. Cell Cycle 8, 3529-3536
40. Yao, R., Natsume, Y., and Noda, T. (2007) TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 98, 555-562 (Pubitemid 46562747)
41. Schmidt, S., Schneider, L., Essmann, F., Cirstea, I. C., Kuck, F., Kletke, A., Jänicke, R. U., Wiek, C., Hanenberg, H., Ahmadian, M. R., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R. P. (2010) The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-6192
42. Schneider, L., Essmann, F., Kletke, A., Rio, P., Hanenberg, H., Schulze-Osthoff, K., Nürnberg, B., and Piekorz, R. P. (2008) TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-125
43. Barros, T. P., Kinoshita, K., Hyman, A. A., and Raff, J. W. (2005) Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J. Cell Biol. 170, 1039-1046 (Pubitemid 41362636)
44. Kinoshita, K., Noetzel, T. L., Pelletier, L., Mechtler, K., Drechsel, D. N., Schwager, A., Lee, M., Raff, J. W., and Hyman, A. A. (2005) Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. J. Cell Biol. 170, 1047-1055 (Pubitemid 41362637)
45. Le Roy, P. J., Hunter, J. J., Hoar, K. M., Burke, K. E., Shinde, V., Ruan, J., Bowman, D., Galvin, K., and Ecsedy, J. A. (2007) Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser-558 by Aurora A. A novel pharmacodynamic method for measuring Aurora A activity. Cancer Res. 67, 5362-5370 (Pubitemid 46997276)
46. Peset, I., Seiler, J., Sardon, T., Bejarano, L. A., Rybina, S., and Vernos, I. (2005) Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis. J. Cell Biol. 170, 1057-1066 (Pubitemid 41362638)
47. Fu, W., Chen, H., Wang, G., Luo, J., Deng, Z., Xin, G., Xu, N., Guo, X., Lei, J., Jiang, Q., and Zhang, C. (2013) Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly. Proc. Natl. Acad. Sci. U. S. A. 110, 15295-15300
48. Lioutas, A., and Vernos, I. (2013) Aurora A kinase and its substrate TACC3 are required for central spindle assembly. EMBO Rep. 14, 829-836
49. Fu, W., Jiang, Q., and Zhang, C. (2011) Novel functions of endocytic player clathrin in mitosis. Cell Res. 21, 1655-1661
50. Royle, S. J. (2012) The role of clathrin in mitotic spindle organisation. J. Cell Sci. 125, 19-28
51. Booth, D. G., Hood, F. E., Prior, I. A., and Royle, S. J. (2011) A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 30, 906-919
52. Hood, F. E., Williams, S. J., Burgess, S. G., Richards, M. W., Roth, D., Straube, A., Pfuhl, M., Bayliss, R., and Royle, S. J. (2013) Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding. J. Cell Biol. 202, 463-478
53. Gergely, F., Draviam, V. M., and Raff, J. W. (2003) The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells. Genes Dev. 17, 336-341 (Pubitemid 36182191)
54. Yao, R., Kondoh, Y., Natsume, Y., Yamanaka, H., Inoue, M., Toki, H., Takagi, R., Shimizu, T., Yamori, T., Osada, H., and Noda, T. (2013) A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene DOI:10.1038/onc.2013.382
55. Gómez-Baldó, L., Schmidt, S., Maxwell, C. A., Bonifaci, N., Gabaldón, T., Vidalain, P. O., Senapedis, W., Kletke, A., Rosing, M., Barnekow, A., Rottapel, R., Capellá, G., Vidal, M., Astrinidis, A., Piekorz, R. P., and Pujana, M. A. (2010) TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle 9, 1143-1155
56. Lauffart, B., Howell, S. J., Tasch, J. E., Cowell, J. K., and Still, I. H. (2002) Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. Biochem. J. 363, 195-200 (Pubitemid 34280627)
57. Sato, M., Vardy, L., Angel Garcia, M., Koonrugsa, N., and Toda, T. (2004) Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol. Biol. Cell 15, 1609-1622 (Pubitemid 38401812)
58. Albee, A. J., Tao, W., and Wiese, C. (2006) Phosphorylation of maskin by Aurora-A is regulated by RanGTP and importin β. J. Biol. Chem. 281, 38293-38301 (Pubitemid 46041952)
59. Albee, A. J., and Wiese, C. (2008) Xenopus TACC3/maskin is not required for microtubule stability but is required for anchoring microtubules at the centrosome. Mol. Biol. Cell 19, 3347-3356
60. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) ClustalW. Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (Pubitemid 24354800)
61. Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting coiled coils from protein sequences. Science 252, 1162-1164 (Pubitemid 21917026)
62. Thakur, H. C. (2012) Biochemical and biophysical characterization of the centrosomal protein TACC3. Doctoral dissertation, Faculty of Mathematics and Natural Sciences of the Heinrich Heine University, Düsseldorf, Germany
63. Eberth, A., Lundmark, R., Gremer, L., Dvorsky, R., Koessmeier, K. T., McMahon, H. T., and Ahmadian, M. R. (2009) A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Biochem. J. 417, 371-377
64. Risse, S. L., Vaz, B., Burton, M. F., Aspenström, P., Piekorz, R. P., Brunsveld, L., and Ahmadian, M. R. (2013) SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins. Biol. Chem. 394, 421-432
65. Sardon, T., Pache, R. A., Stein, A., Molina, H., Vernos, I., and Aloy, P. (2010) Uncovering new substrates for Aurora A kinase. EMBO Rep. 11, 977-984
66. Partch, C. L., and Gardner, K. H. (2011) Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proc. Natl. Acad. Sci. U. S. A. 108, 7739-7744
67. Cassimeris, L., and Morabito, J. (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15, 1580-1590 (Pubitemid 38401809)
68. Xie, Z., Moy, L. Y., Sanada, K., Zhou, Y., Buchman, J. J., and Tsai, L.-H. (2007) Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron 56, 79-93 (Pubitemid 47487500)
69. Yang, Y. T., Wang, C. L., and Van Aelst, L. (2012) DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat. Neurosci. 15, 1201-1210
70. Garriga-Canut, M., and Orkin, S. H. (2004) Transforming acidic coiledcoil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J. Biol. Chem. 279, 23597-23605 (Pubitemid 38685674)
71. Angrisano, T., Lembo, F., Pero, R., Natale, F., Fusco, A., Avvedimento, V. E., Bruni, C. B., and Chiariotti, L. (2006) TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic Acids Res. 34, 364-372 (Pubitemid 43160059)
72. Simpson, R. J., Yi Lee, S. H., Bartle, N., Sum, E. Y., Visvader, J. E., Matthews, J. M., Mackay, J. P., and Crossley, M. (2004) A classic zinc finger from friend of GATAmediates an interaction with the coiled-coil of transforming acidic coiled-coil 3. J. Biol. Chem. 279, 39789-39797 (Pubitemid 39258249)
73. Brouhard, G. J., Stear, J. H., Noetzel, T. L., Al-Bassam, J., Kinoshita, K., Harrison, S. C., Howard, J., and Hyman, A. A. (2008) XMAP215 is a processive microtubule polymerase. Cell 132, 79-88
74. Popov, A. V., Pozniakovsky, A., Arnal, I., Antony, C., Ashford, A. J., Kinoshita, K., Tournebize, R., Hyman, A. A., and Karsenti, E. (2001) XMAP215 regulates microtubule dynamics through two distinct domains. EMBO J. 20, 397-410 (Pubitemid 32126976)
75. Shi, Y., Mowery, R. A., Ashley, J., Hentz, M., Ramirez, A. J., Bilgicer, B., Slunt-Brown, H., Borchelt, D. R., and Shaw, B. F. (2012) Abnormal SDSPAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding. Protein Sci. 21, 1197-1209
76. Yao, R., Natsume, Y., Saiki, Y., Shioya, H., Takeuchi, K., Yamori, T., Toki, H., Aoki, I., Saga, T., and Noda, T. (2012) Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene 31, 135-148
77. Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J. P., Nickerson, E., Auclair, D., Li, L., Place, C., Dicara, D., Ramos, A. H., Lawrence, M. S., Cibulskis, K., Sivachenko, A., Voet, D., Saksena, G., Stransky, N., Onofrio, R. C., Winckler, W., Ardlie, K., Wagle, N., Wargo, J., Chong, K., Morton, D. L., Stemke-Hale, K., Chen, G., Noble, M., Meyerson, M., Ladbury, J. E., Davies, M. A., Gershenwald, J. E., Wagner, S. N., Hoon, D. S., Schadendorf, D., Lander, E. S., Gabriel, S. B., Getz, G., Garraway, L. A., and Chin, L. (2012) Alandscape of driver mutations in melanoma. Cell 150, 251-263
78. Lauffart, B., Vaughan, M. M., Eddy, R., Chervinsky, D., Di Cioccio, R. A., Black, J. D., and Still, I. H. (2005) Aberrations of TACC1 and TACC3 are associated with ovarian cancer. BMC Women's Health 5, 8
79. Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., Guha, A., Aldape, K., Golfinos, J. G., Zagzag, D., Mikkelsen, T., Finocchiaro, G., Lasorella, A., Rabadan, R., and Iavarone, A. (2012) Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235
80. Williams, S. V., Hurst, C. D., and Knowles, M. A. (2013) Oncogenic FGFR3 gene fusions in bladder cancer. Hum. Mol. Genet. 22, 795-803
81. Vitre, B. D., and Cleveland, D. W. (2012) Centrosomes, chromosome instability (CIN) and aneuploidy. Curr. Opin. Cell Biol. 24, 809-815
82. Holland, A. J., and Cleveland, D. W. (2012) Losing balance. The origin and impact of aneuploidy in cancer. EMBO Rep. 13, 501-514
83. Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H., and Gardner, K. H. (2013) Regulating the ARNT/TACC3 axis. Multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem. Biol. 8, 626-635
84. Wurdak, H., Zhu, S., Min, K. H., Aimone, L., Lairson, L. L., Watson, J., Chopiuk, G., Demas, J., Charette, B., Halder, R., Weerapana, E., Cravatt, B. F., Cline, H. T., Peters, E. C., Zhang, J., Walker, J. R., Wu, C., Chang, J., Tuntland, T., Cho, C. Y., and Schultz, P. G. (2010) A small molecule accelerates neuronal differentiation in the adult rat. Proc. Natl. Acad. Sci. U. S. A. 107, 16542-16547