메뉴 건너뛰기




Volumn 5, Issue AUG, 2014, Pages

Tolerance in organ transplantation: From conventional immunosuppression to extracellular vesicles

Author keywords

Exosomes; Extracellular vesicles; Graft rejection; Graft survival; Organ transplantation; Tolerance; Transplantation immunology

Indexed keywords


EID: 84928751378     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00416     Document Type: Article
Times cited : (43)

References (139)
  • 2
    • 10744229153 scopus 로고    scopus 로고
    • Exosomes as Potent Cell-Free Peptide- Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells.
    • André F, Chaput N, Schartz NEC, Flament C, Aubert N, Bernard J, Lemonnier F, Raposo G, Escudier B, Hsu D-H, et al. 2004. Exosomes as Potent Cell-Free Peptide- Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells. J Immunol. 172:2126-2136.
    • (2004) J Immunol. , vol.172 , pp. 2126-2136
    • André, F.1    Chaput, N.2    Schartz, N.E.C.3    Flament, C.4    Aubert, N.5    Bernard, J.6    Lemonnier, F.7    Raposo, G.8    Escudier, B.9    Hsu, D.-H.10
  • 3
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
    • (1998) Nature. , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 4
    • 77449102731 scopus 로고    scopus 로고
    • Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages
    • Barrès CB, Lionel Bette-Bobillo, Pascale André, Sabine Mamoun, Robert Gabius, Hans-Joachim Vidal, Michel. 2009. Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood. 115:696- 705.
    • (2009) Blood. , vol.115 , pp. 696-705
    • Barrès, C.B.1    Bette-Bobillo, L.2    André, P.3    Mamoun, S.4    Gabius, R.5    Vidal, H.-J.6
  • 7
    • 0035412373 scopus 로고    scopus 로고
    • Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers
    • Bittencourt M de CP, Sylvain Contassot, Emmanuel Fresnay, Stéphanie Baron, Marie- Hélène Angonin, Régis Aubin, François Hervé, Patrick Tiberghien, Pierre Saas, Philippe. 2001. Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood. 98:224-230.
    • (2001) Blood. , vol.98 , pp. 224-230
    • de Bittencourt, M.C.P.1    Contassot, S.2    Fresnay, E.3    Baron, S.4    Angonin, M.-H.5    Aubin, R.6    Hervé, F.7    Tiberghien, P.8    Saas, P.9
  • 8
    • 40849083586 scopus 로고    scopus 로고
    • Indirect Allorecognition: Not Simple but Effective.
    • 10.1097/TP.0b013e3181664db3.
    • Bolton EM, Bradley JA, Pettigrew GJ. 2008. Indirect Allorecognition: Not Simple but Effective. Transplantation. 85:667-669 10.1097/TP.0b013e3181664db3.
    • (2008) Transplantation. , vol.85 , pp. 667-669
    • Bolton, E.M.1    Bradley, J.A.2    Pettigrew, G.J.3
  • 9
    • 84890999910 scopus 로고    scopus 로고
    • Transplant Tolerance by Treg Therapy
    • Bradley JA. 2004. Transplant Tolerance by Treg Therapy. Am J Transplant. 14:5-6.
    • (2004) Am J Transplant. , vol.14 , pp. 5-6
    • Bradley, J.A.1
  • 12
    • 84864530691 scopus 로고    scopus 로고
    • Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA dependent reprogramming of resident renal cells
    • Cantaluppi V, Gatti S, Medica D, Figliolini F, Bruno S, Deregibus MC, Sordi A, Biancone L, Tetta C, Camussi G. 2012. Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA dependent reprogramming of resident renal cells. Kidney Int. 82:412-427.
    • (2012) Kidney Int. , vol.82 , pp. 412-427
    • Cantaluppi, V.1    Gatti, S.2    Medica, D.3    Figliolini, F.4    Bruno, S.5    Deregibus, M.C.6    Sordi, A.7    Biancone, L.8    Tetta, C.9    Camussi, G.10
  • 13
    • 84872935957 scopus 로고    scopus 로고
    • Mesenchymal stromal cells to promote solid organ transplantation tolerance
    • Casiraghi F, Perico N, Remuzzi G. 2013. Mesenchymal stromal cells to promote solid organ transplantation tolerance. Curr Opin Organ Transplant. 18:51-58.
    • (2013) Curr Opin Organ Transplant. , vol.18 , pp. 51-58
    • Casiraghi, F.1    Perico, N.2    Remuzzi, G.3
  • 14
    • 70149090341 scopus 로고    scopus 로고
    • Kidney transplantation in the United States.
    • Cecka JM. 2008. Kidney transplantation in the United States. Clin Transpl.1-18.
    • (2008) Clin Transpl. , pp. 1-18
    • Cecka, J.M.1
  • 17
    • 6944253946 scopus 로고    scopus 로고
    • Adhesion and signaling by B cell-derived exosomes: the role of integrins.
    • [Internet]. Available from:. Search of: dendritic cells tolerogenic - List Results - ClinicalTrialsgov [Internet]. [cited 2014 Jul 26]. Available from:
    • Clayton A, Turkes A, Dewitt S, Steadman R, Mason MD, Hallett MB. 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J [Internet]. Available from: http://www.fasebj.org/content/early/2004/06/02/fj.03-1094fje.short Clinicaltrials.gov. Search of: dendritic cells tolerogenic - List Results - ClinicalTrials.gov [Internet]. [cited 2014 Jul 26]. Available from: https://clinicaltrials.gov/ct2/results?term=dendritic+cells+tolerogenic
    • (2004) FASEB J
    • Clayton, A.1    Turkes, A.2    Dewitt, S.3    Steadman, R.4    Mason, M.D.5    Hallett, M.B.6
  • 19
    • 84913605925 scopus 로고    scopus 로고
    • Microvescicles Derived from Mesenchymal Stromal Cells Are Not as Effective as Their Cellular Counterpart in the Ability to Modulate Immune Responses In Vitro.
    • Conforti A, Scarsella M, Starc N, Giorda E, Biagini S, Proia A, Carsetti R, Locatelli F, Bernardo ME. 2014. Microvescicles Derived from Mesenchymal Stromal Cells Are Not as Effective as Their Cellular Counterpart in the Ability to Modulate Immune Responses In Vitro. Stem Cells Dev.
    • (2014) Stem Cells Dev.
    • Conforti, A.1    Scarsella, M.2    Starc, N.3    Giorda, E.4    Biagini, S.5    Proia, A.6    Carsetti, R.7    Locatelli, F.8    Bernardo, M.E.9
  • 20
    • 0034254524 scopus 로고    scopus 로고
    • Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface.
    • Denzer K, van Eijk M, Kleijmeer MJ, Jakobson E, de Groot C, J. Geuze H. 2000. Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface. J Immunol. 165:1259-1265.
    • (2000) J Immunol. , vol.165 , pp. 1259-1265
    • Denzer, K.1    van Eijk, M.2    Kleijmeer, M.J.3    Jakobson, E.4    de Groot, C.J.5    Geuze, H.6
  • 21
    • 77957952606 scopus 로고    scopus 로고
    • Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation
    • Divito SJ, Wang Z, Shufesky WJ, Liu Q, Tkacheva OA, Montecalvo A, Erdos G, Larregina AT, Morelli AE. 2010. Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. 116:2694-2705.
    • (2010) Blood. , vol.116 , pp. 2694-2705
    • Divito, S.J.1    Wang, Z.2    Shufesky, W.J.3    Liu, Q.4    Tkacheva, O.A.5    Montecalvo, A.6    Erdos, G.7    Larregina, A.T.8    Morelli, A.E.9
  • 25
    • 55249099643 scopus 로고    scopus 로고
    • Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.
    • Feng G, Gao W, Strom TB, Oukka M, Francis RS, Wood KJ, Bushell A. 2008. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol. 38:2512-2527.
    • (2008) Eur J Immunol. , vol.38 , pp. 2512-2527
    • Feng, G.1    Gao, W.2    Strom, T.B.3    Oukka, M.4    Francis, R.S.5    Wood, K.J.6    Bushell, A.7
  • 26
    • 52449099834 scopus 로고    scopus 로고
    • Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy
    • Feng G, Wood KJ, Bushell A. 2008. Interferon-gamma conditioning ex vivo generates CD25+CD62L+Foxp3+ regulatory T cells that prevent allograft rejection: potential avenues for cellular therapy. Transplantation. 86:578-589.
    • (2008) Transplantation. , vol.86 , pp. 578-589
    • Feng, G.1    Wood, K.J.2    Bushell, A.3
  • 29
    • 79955571241 scopus 로고    scopus 로고
    • Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury.
    • Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc.
    • Gatti S, Bruno S, Deregibus MC, Sordi A, Cantaluppi V, Tetta C, Camussi G. 2011. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc. 26:1474-1483.
    • (2011) , vol.26 , pp. 1474-1483
    • Gatti, S.1    Bruno, S.2    Deregibus, M.C.3    Sordi, A.4    Cantaluppi, V.5    Tetta, C.6    Camussi, G.7
  • 30
    • 67650932291 scopus 로고    scopus 로고
    • Infusion of Mesenchymal Stem Cells and Rapamycin Synergize to Attenuate Alloimmune Responses and Promote Cardiac Allograft Tolerance
    • Ge W, Jiang J, Baroja ML, Arp J, Zassoko R, Liu W, Bartholomew A, Garcia B, Wang H. 2009. Infusion of Mesenchymal Stem Cells and Rapamycin Synergize to Attenuate Alloimmune Responses and Promote Cardiac Allograft Tolerance. Am J Transplant. 9:1760-1772.
    • (2009) Am J Transplant. , vol.9 , pp. 1760-1772
    • Ge, W.1    Jiang, J.2    Baroja, M.L.3    Arp, J.4    Zassoko, R.5    Liu, W.6    Bartholomew, A.7    Garcia, B.8    Wang, H.9
  • 31
    • 84880921389 scopus 로고    scopus 로고
    • Cell therapy as a strategy to minimize maintenance immunosuppression in solid organ transplant recipients
    • Geissler EK, Hutchinson JA. 2013. Cell therapy as a strategy to minimize maintenance immunosuppression in solid organ transplant recipients. Curr Opin Organ Transplant. 18:408-415.
    • (2013) Curr Opin Organ Transplant. , vol.18 , pp. 408-415
    • Geissler, E.K.1    Hutchinson, J.A.2
  • 32
    • 50849112029 scopus 로고    scopus 로고
    • The importance of the indirect pathway of allorecognition in clinical transplantation
    • Gökmen MR, Lombardi G, Lechler RI. 2008. The importance of the indirect pathway of allorecognition in clinical transplantation. Curr Opin Immunol. 20:568-574.
    • (2008) Curr Opin Immunol. , vol.20 , pp. 568-574
    • Gökmen, M.R.1    Lombardi, G.2    Lechler, R.I.3
  • 33
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles.
    • Gould SJ, Raposo G. 2013. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles.
    • (2013) J Extracell Vesicles.
    • Gould, S.J.1    Raposo, G.2
  • 36
    • 63549086511 scopus 로고    scopus 로고
    • Alloantigen specific T regulatory cells in transplant tolerance
    • Hall BM, Tran G, Hodgkinson SJ. 2009. Alloantigen specific T regulatory cells in transplant tolerance. Int Immunopharmacol. 9:570-574.
    • (2009) Int Immunopharmacol. , vol.9 , pp. 570-574
    • Hall, B.M.1    Tran, G.2    Hodgkinson, S.J.3
  • 38
    • 30344460536 scopus 로고    scopus 로고
    • Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti inflammatory and Immunosuppressive
    • Hee Kim S, Bianco N, Menon R, Lechman ER, Shufesky WJ, Morelli AE, Robbins PD. 2006. Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti inflammatory and Immunosuppressive. Mol Ther. 13:289-300.
    • (2006) Mol Ther. , vol.13 , pp. 289-300
    • Hee Kim, S.1    Bianco, N.2    Menon, R.3    Lechman, E.R.4    Shufesky, W.J.5    Morelli, A.E.6    Robbins, P.D.7
  • 42
    • 38549139467 scopus 로고    scopus 로고
    • Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression
    • Ikeguchi R, Sacks JM, Unadkat JV, Solari M, Horibe EK, Thomson AW, Lee AWP, Feili-Hariri M. 2008. Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression. Transplantation. 85:237-246.
    • (2008) Transplantation. , vol.85 , pp. 237-246
    • Ikeguchi, R.1    Sacks, J.M.2    Unadkat, J.V.3    Solari, M.4    Horibe, E.K.5    Thomson, A.W.6    Lee, A.W.P.7    Feili-Hariri, M.8
  • 45
    • 33747616431 scopus 로고    scopus 로고
    • Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
    • J. Ratajczak, M. Wysoczynski, F. Hayek, A. Janowska-Wieczorek, M. Z. Ratajczak. 2006. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 20:1487-1495.
    • (2006) Leukemia. , vol.20 , pp. 1487-1495
    • Ratajczak, J.1    Wysoczynski, M.2    Hayek, F.3    Janowska-Wieczorek, A.4    Ratajczak, M.Z.5
  • 47
    • 84899810743 scopus 로고    scopus 로고
    • Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes
    • Kanwar SS, Dunlay CJ, Simeone DM, Nagrath S. 2014. Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip. 14:1891-1900.
    • (2014) Lab Chip. , vol.14 , pp. 1891-1900
    • Kanwar, S.S.1    Dunlay, C.J.2    Simeone, D.M.3    Nagrath, S.4
  • 48
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • Katsuda T, Kosaka N, Takeshita F, Ochiya T. 2013. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. PROTEOMICS. 13:1637-1653.
    • (2013) PROTEOMICS. , vol.13 , pp. 1637-1653
    • Katsuda, T.1    Kosaka, N.2    Takeshita, F.3    Ochiya, T.4
  • 50
    • 84874209081 scopus 로고    scopus 로고
    • Mesenchymal Stem Cell Therapy in the Treatment of Acute and Chronic Graft versus Host Disease.
    • Kebriaei P, Robinson S. 2011. Mesenchymal Stem Cell Therapy in the Treatment of Acute and Chronic Graft versus Host Disease. Front Oncol. 1.
    • (2011) Front Oncol. , vol.1
    • Kebriaei, P.1    Robinson, S.2
  • 52
    • 34848915428 scopus 로고    scopus 로고
    • Effective Treatment of Inflammatory Disease Models with Exosomes Derived from Dendritic Cells Genetically Modified to Express IL-4
    • Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD. 2007. Effective Treatment of Inflammatory Disease Models with Exosomes Derived from Dendritic Cells Genetically Modified to Express IL-4. J Immunol. 179:2242-2249.
    • (2007) J Immunol. , vol.179 , pp. 2242-2249
    • Kim, S.H.1    Bianco, N.R.2    Shufesky, W.J.3    Morelli, A.E.4    Robbins, P.D.5
  • 56
    • 84874831536 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation
    • Lai RC, Yeo RWY, Tan KH, Lim SK. 2013. Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. Regen Med. 8:197- 209.
    • (2013) Regen Med. , vol.8 , pp. 197-209
    • Lai, R.C.1    Yeo, R.W.Y.2    Tan, K.H.3    Lim, S.K.4
  • 57
    • 84874831536 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation
    • Lai RC, Yeo RWY, Tan KH, Lim SK. 2014. Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. Regen Med. 8:197- 209.
    • (2014) Regen Med. , vol.8 , pp. 197-209
    • Lai, R.C.1    Yeo, R.W.Y.2    Tan, K.H.3    Lim, S.K.4
  • 59
    • 0037313473 scopus 로고    scopus 로고
    • The complementary roles of deletion and regulation in transplantation tolerance
    • Lechler RI, Garden OA, Turka LA. 2003. The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol. 3:147-158.
    • (2003) Nat Rev Immunol. , vol.3 , pp. 147-158
    • Lechler, R.I.1    Garden, O.A.2    Turka, L.A.3
  • 60
    • 84891041639 scopus 로고    scopus 로고
    • Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy
    • Lee K, Nguyen V, Lee KM, Kang SM, Tang Q. 2014. Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy. Am J Transplant. 14:27-38.
    • (2014) Am J Transplant. , vol.14 , pp. 27-38
    • Lee, K.1    Nguyen, V.2    Lee, K.M.3    Kang, S.M.4    Tang, Q.5
  • 61
    • 79957602397 scopus 로고    scopus 로고
    • Immunology. Regulatory T cells get their chance to shine.
    • Leslie M. 2011. Immunology. Regulatory T cells get their chance to shine. Science. 332:1020-1021.
    • (2011) Science. , vol.332 , pp. 1020-1021
    • Leslie, M.1
  • 63
  • 64
    • 84899477309 scopus 로고    scopus 로고
    • Acute Rejection, T-Cell-Depleting Antibodies, and Cancer After Transplantation.
    • 10.1097/01.TP.0000442773.38510.32.
    • Lim WH, Turner RM, Chapman JR, Ma MKM, Webster AC, Craig JC, Wong G. 2014. Acute Rejection, T-Cell-Depleting Antibodies, and Cancer After Transplantation. Transplantation. 97:817-825 10.1097/01.TP.0000442773.38510.32.
    • (2014) Transplantation. , vol.97 , pp. 817-825
    • Lim, W.H.1    Turner, R.M.2    Chapman, J.R.3    Ma, M.K.M.4    Webster, A.C.5    Craig, J.C.6    Wong, G.7
  • 66
    • 70350500090 scopus 로고    scopus 로고
    • Immunosuppressive Drugs in Kidney Transplantation
    • Marcén R. 2009. Immunosuppressive Drugs in Kidney Transplantation. Drugs. 69:2227-2243.
    • (2009) Drugs. , vol.69 , pp. 2227-2243
    • Marcén, R.1
  • 67
    • 84903908846 scopus 로고    scopus 로고
    • Nomenclature for factors of the HLA system, update March 2014.
    • Marsh SGE. 2014. Nomenclature for factors of the HLA system, update March 2014. Int J Immunogenet. 41:351-360.
    • (2014) Int J Immunogenet. , vol.41 , pp. 351-360
    • Marsh, S.G.E.1
  • 68
    • 1442338509 scopus 로고    scopus 로고
    • Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era
    • Meier-Kriesche H-U, Schold JD, Srinivas TR, Kaplan B. 2004. Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era. Am J Transplant. 4:378-383.
    • (2004) Am J Transplant. , vol.4 , pp. 378-383
    • Meier-Kriesche, H.-U.1    Schold, J.D.2    Srinivas, T.R.3    Kaplan, B.4
  • 72
    • 84902971627 scopus 로고    scopus 로고
    • One Kidney for Life
    • Montgomery RA. 2014. One Kidney for Life. Am J Transplant. 14:1473-1474.
    • (2014) Am J Transplant. , vol.14 , pp. 1473-1474
    • Montgomery, R.A.1
  • 73
    • 84887185886 scopus 로고    scopus 로고
    • Effector Mechanisms of Rejection.
    • Cold Spring Harb Perspect Med [Internet]. 3. Available from:
    • Moreau A, Varey E, Anegon I, Cuturi M-C. 2013. Effector Mechanisms of Rejection. Cold Spring Harb Perspect Med [Internet]. 3. Available from: http://perspectivesinmedicine.cshlp.org/content/3/11/a015461.abstract Moreau A, Varey E, Bériou G, Bouchet-Delbos L, Segovia M, Cuturi MC. 2012.
    • (2013)
    • Moreau, A.1    Varey, E.2    Anegon, I.3    Cuturi, M.-C.4
  • 74
  • 75
    • 77956943707 scopus 로고    scopus 로고
    • Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells
    • Morelli A, Larregina A. 2010. Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells. Apoptosis. 15:1083-1097.
    • (2010) Apoptosis. , vol.15 , pp. 1083-1097
    • Morelli, A.1    Larregina, A.2
  • 77
    • 33644899276 scopus 로고    scopus 로고
    • Use of donor apoptotic cells is a safe and effective means to prolong graft survival through interaction with recipient dendritic cells (Abstract).
    • Morelli AE, Wang Z, Shufesky WJ, Larregina AT, Zahorchak AF, Logar AJ. 2003. Use of donor apoptotic cells is a safe and effective means to prolong graft survival through interaction with recipient dendritic cells (Abstract). Am J Transplant. 3:195.
    • (2003) Am J Transplant. , vol.3 , pp. 195
    • Morelli, A.E.1    Wang, Z.2    Shufesky, W.J.3    Larregina, A.T.4    Zahorchak, A.F.5    Logar, A.J.6
  • 80
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact- dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K, Kitani A, Strober W. 2001. Cell contact- dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 194:629-644.
    • (2001) J Exp Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 82
    • 84874903268 scopus 로고    scopus 로고
    • Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
    • Naslund TI, Gehrmann U, Qazi KR, Karlsson MCI, Gabrielsson S. 2013. Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity. J Immunol. 190:2712-2719.
    • (2013) J Immunol. , vol.190 , pp. 2712-2719
    • Naslund, T.I.1    Gehrmann, U.2    Qazi, K.R.3    Karlsson, M.C.I.4    Gabrielsson, S.5
  • 83
    • 33746514768 scopus 로고    scopus 로고
    • Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    • Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EGA, Willemze R, Fibbe WE. 2006. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood. 108:2114- 2120.
    • (2006) Blood. , vol.108 , pp. 2114-2120
    • Nauta, A.J.1    Westerhuis, G.2    Kruisselbrink, A.B.3    Lurvink, E.G.A.4    Willemze, R.5    Fibbe, W.E.6
  • 84
    • 84864316468 scopus 로고    scopus 로고
    • Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy
    • Patel AN, Genovese J. 2011. Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy. Stem Cells Cloning Adv Appl. 4:61-72.
    • (2011) Stem Cells Cloning Adv Appl. , vol.4 , pp. 61-72
    • Patel, A.N.1    Genovese, J.2
  • 85
    • 0345015348 scopus 로고    scopus 로고
    • Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection
    • Pêche H, Heslan M, Usal C, Amigorena S, Cuturi MC. 2003. Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation. 76:1503-1510.
    • (2003) Transplantation. , vol.76 , pp. 1503-1510
    • Pêche, H.1    Heslan, M.2    Usal, C.3    Amigorena, S.4    Cuturi, M.C.5
  • 87
    • 13144253118 scopus 로고    scopus 로고
    • Prolongation of Heart Allograft Survival by Immature Dendritic Cells Generated from Recipient Type Bone Marrow Progenitors
    • Pêche H, Trinité B, Martinet B, Cuturi MC. 2005. Prolongation of Heart Allograft Survival by Immature Dendritic Cells Generated from Recipient Type Bone Marrow Progenitors. Am J Transplant. 5:255-267.
    • (2005) Am J Transplant. , vol.5 , pp. 255-267
    • Pêche, H.1    Trinité, B.2    Martinet, B.3    Cuturi, M.C.4
  • 88
    • 84888286540 scopus 로고    scopus 로고
    • Mesenchymal stromal (stem) cells to improve solid organ transplant outcome: lessons from the initial clinical trials.
    • 10.1097/MOT.0000000000000029.
    • Pileggi A, Xu X, Tan J, Ricordi C. 2013. Mesenchymal stromal (stem) cells to improve solid organ transplant outcome: lessons from the initial clinical trials. Curr Opin Organ Transplant. 18:672-681 10.1097/MOT.0000000000000029.
    • (2013) Curr Opin Organ Transplant. , vol.18 , pp. 672-681
    • Pileggi, A.1    Xu, X.2    Tan, J.3    Ricordi, C.4
  • 89
    • 80051703065 scopus 로고    scopus 로고
    • Present and Future of Immunosuppressive Therapy in Kidney Transplantation
    • Ponticelli C. 2011. Present and Future of Immunosuppressive Therapy in Kidney Transplantation. Transplant Proc. 43:2439-2440.
    • (2011) Transplant Proc. , vol.43 , pp. 2439-2440
    • Ponticelli, C.1
  • 90
    • 77953614768 scopus 로고    scopus 로고
    • Bystander suppression to unrelated allergen sensitization through intranasal administration of tolerogenic exosomes in mouse
    • Prado N, Cañamero M, Villalba M, Rodríguez R, Batanero E. 2010. Bystander suppression to unrelated allergen sensitization through intranasal administration of tolerogenic exosomes in mouse. Mol Immunol. 47:2148-2151.
    • (2010) Mol Immunol. , vol.47 , pp. 2148-2151
    • Prado, N.1    Cañamero, M.2    Villalba, M.3    Rodríguez, R.4    Batanero, E.5
  • 91
    • 34447263249 scopus 로고    scopus 로고
    • Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4+CD25+ regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation
    • Pu L-Y, Wang X-H, Zhang F, Li X-C, Yao A-H, Yu Y, Lv L, Li G-Q. 2007. Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4+CD25+ regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantation. Surgery. 142:67-73.
    • (2007) Surgery. , vol.142 , pp. 67-73
    • Pu, L.-Y.1    Wang, X.-H.2    Zhang, F.3    Li, X.-C.4    Yao, A.-H.5    Yu, Y.6    Lv, L.7    Li, G.-Q.8
  • 93
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.
    • Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, Dvorak P, Ratajczak MZ. 2006. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 20:847-856.
    • (2006) Leukemia. , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3    Zhang, J.4    Reca, R.5    Dvorak, P.6    Ratajczak, M.Z.7
  • 95
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S, Malmström V, Powrie F. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 192:295-302.
    • (2000) J Exp Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmström, V.2    Powrie, F.3
  • 96
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • Robbins PD, Morelli AE. 2014. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 14:195-208.
    • (2014) Nat Rev Immunol. , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 103
    • 38049095528 scopus 로고    scopus 로고
    • Prolongation of Composite Tissue Allograft Survival by Immature Recipient Dendritic Cells Pulsed with Donor Antigen and Transient Low-Dose Immunosuppression.
    • 10.1097/01.prs.0000293754.55706.7f.
    • Sacks JM, Kuo Y-R, Taieb A, Breitinger J, Nguyen VT, Thomson AW, Feili-Hariri M, Lee WPA. 2008. Prolongation of Composite Tissue Allograft Survival by Immature Recipient Dendritic Cells Pulsed with Donor Antigen and Transient Low-Dose Immunosuppression. Plast Reconstr Surg. 121:37-49 10.1097/01.prs.0000293754.55706.7f.
    • (2008) Plast Reconstr Surg. , vol.121 , pp. 37-49
    • Sacks, J.M.1    Kuo, Y.-R.2    Taieb, A.3    Breitinger, J.4    Nguyen, V.T.5    Thomson, A.W.6    Feili-Hariri, M.7    Lee, W.P.A.8
  • 104
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • Saunderson SCD, Amy C. Crocker, Paul R. McLellan, Alexander D. 2013. CD169 mediates the capture of exosomes in spleen and lymph node. Blood. 123:208-216.
    • (2013) Blood. , vol.123 , pp. 208-216
    • Saunderson, S.C.D.1    Crocker, A.C.2    McLellan, P.R.3    Alexander, D.4
  • 105
    • 22344434572 scopus 로고    scopus 로고
    • IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    • Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ. 2005. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med. 201:1925-1935.
    • (2005) J Exp Med. , vol.201 , pp. 1925-1935
    • Sawitzki, B.1    Kingsley, C.I.2    Oliveira, V.3    Karim, M.4    Herber, M.5    Wood, K.J.6
  • 107
    • 84872881139 scopus 로고    scopus 로고
    • Global Observatory on Donation and Transplantation [Internet].
    • [cited 2014 Jul 25]. Available from: Spanish National Transplant Organization (ONT), World Health Organization (WHO).
    • Spanish National Transplant Organization (ONT), World Health Organization (WHO). Global Observatory on Donation and Transplantation [Internet]. [cited 2014 Jul 25]. Available from: http://www.transplant-observatory.org/Pages/home.aspx
  • 109
    • 78649852489 scopus 로고    scopus 로고
    • Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.
    • Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, Hilkens CMU. 2010. Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. Arthritis Rheum. 62:3656-3665.
    • (2010) Arthritis Rheum. , vol.62 , pp. 3656-3665
    • Stoop, J.N.1    Harry, R.A.2    von Delwig, A.3    Isaacs, J.D.4    Robinson, J.H.5    Hilkens, C.M.U.6
  • 111
    • 9944228640 scopus 로고    scopus 로고
    • Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient
    • Sun E, Gao Y, Chen J, Roberts AI, Wang X, Chen Z, Shi Y. 2004. Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient. Cell Death Differ. 11:1258-1264.
    • (2004) Cell Death Differ. , vol.11 , pp. 1258-1264
    • Sun, E.1    Gao, Y.2    Chen, J.3    Roberts, A.I.4    Wang, X.5    Chen, Z.6    Shi, Y.7
  • 113
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S. 2000. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 192:303-310.
    • (2000) J Exp Med. , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6    Mak, T.W.7    Sakaguchi, S.8
  • 114
    • 84876729225 scopus 로고    scopus 로고
    • Visualization and in vivo tracking of the exosomes of murine melanoma B16- BL6 cells in mice after intravenous injection
    • Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T, Takakura Y. 2013. Visualization and in vivo tracking of the exosomes of murine melanoma B16- BL6 cells in mice after intravenous injection. J Biotechnol. 165:77-84.
    • (2013) J Biotechnol. , vol.165 , pp. 77-84
    • Takahashi, Y.1    Nishikawa, M.2    Shinotsuka, H.3    Matsui, Y.4    Ohara, S.5    Imai, T.6    Takakura, Y.7
  • 115
    • 13144256708 scopus 로고    scopus 로고
    • Rapamycin-Treated, Alloantigen-Pulsed Host Dendritic Cells Induce Ag-Specific T Cell Regulation and Prolong Graft Survival
    • Taner T, Hackstein H, Wang Z, Morelli AE, Thomson AW. 2005. Rapamycin-Treated, Alloantigen-Pulsed Host Dendritic Cells Induce Ag-Specific T Cell Regulation and Prolong Graft Survival. Am J Transplant. 5:228-236.
    • (2005) Am J Transplant. , vol.5 , pp. 228-236
    • Taner, T.1    Hackstein, H.2    Wang, Z.3    Morelli, A.E.4    Thomson, A.W.5
  • 116
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. 2002. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 99:3493-3499.
    • (2002) Blood. , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 118
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes
    • Théry C, Duban L, Segura E, Véron P, Lantz O, Amigorena S. 2002. Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol. 3:1156-1162.
    • (2002) Nat Immunol. , vol.3 , pp. 1156-1162
    • Théry, C.1    Duban, L.2    Segura, E.3    Véron, P.4    Lantz, O.5    Amigorena, S.6
  • 119
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. 2009. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 9:581-593.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 120
  • 121
    • 0033985780 scopus 로고    scopus 로고
    • Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecifi
    • Thornton AM, Shevach EM. 2000. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol Baltim Md 1950. 164:183- 190.
    • (2000) J Immunol Baltim Md 1950. , vol.164 , pp. 183-190
    • Thornton, A.M.1    Shevach, E.M.2
  • 122
    • 4344666767 scopus 로고    scopus 로고
    • ES07.02 The human leucocyte antigen (HLA) system
    • Turner D. 2004. ES07.02 The human leucocyte antigen (HLA) system. Vox Sang. 87:87-90.
    • (2004) Vox Sang. , vol.87 , pp. 87-90
    • Turner, D.1
  • 123
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance.
    • Turnquist HR, Raimondi G, Zahorchak AF, Fischer RT, Wang Z, Thomson AW. 2007. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol Baltim Md 1950. 178:7018-7031.
    • (2007) J Immunol Baltim Md 1950. , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 130
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J. 2012. Regulatory immune cells in transplantation. Nat Rev Immunol. 12:417-430.
    • (2012) Nat Rev Immunol. , vol.12 , pp. 417-430
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 131
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp M. 2013. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab. 33:1711-1715.
    • (2013) J Cereb Blood Flow Metab. , vol.33 , pp. 1711-1715
    • Xin, H.1    Li, Y.2    Cui, Y.3    Yang, J.J.4    Zhang, Z.G.5    Chopp, M.6
  • 132
    • 2942744597 scopus 로고    scopus 로고
    • Marked prolongation of murine cardiac allograft survival using recipient immature dendritic cells loaded with donor-derived apoptotic cells.
    • Xu D-L, Liu Y, Tan J-M, Li B, Zhong C-P, Zhang X-H, Wu C-Q, Tang X-D. 2004. Marked prolongation of murine cardiac allograft survival using recipient immature dendritic cells loaded with donor-derived apoptotic cells. Scand J Immunol. 59:536- 544.
    • (2004) Scand J Immunol. , vol.59 , pp. 536-544
    • Xu, D.-L.1    Liu, Y.2    Tan, J.-M.3    Li, B.4    Zhong, C.-P.5    Zhang, X.-H.6    Wu, C.-Q.7    Tang, X.-D.8
  • 133
    • 0035889926 scopus 로고    scopus 로고
    • Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade.
    • Yamada A, Chandraker A, Laufer TM, Gerth AJ, Sayegh MH, Auchincloss H. 2001. Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockade. J Immunol Baltim Md 1950. 167:5522- 5526.
    • (2001) J Immunol Baltim Md 1950. , vol.167 , pp. 5522-5526
    • Yamada, A.1    Chandraker, A.2    Laufer, T.M.3    Gerth, A.J.4    Sayegh, M.H.5    Auchincloss, H.6
  • 134
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral bloo
    • Yamagiwa S, Gray JD, Hashimoto S, Horwitz DA. 2001. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol Baltim Md 1950. 166:7282-7289.
    • (2001) J Immunol Baltim Md 1950. , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 136
    • 84859712385 scopus 로고    scopus 로고
    • Immunosuppressive Exosomes: A New Approach for Treating Arthritis.
    • Yang C, Robbins PD. 2012. Immunosuppressive Exosomes: A New Approach for Treating Arthritis. Int J Rheumatol. 2012.
    • (2012) Int J Rheumatol. , vol.2012
    • Yang, C.1    Robbins, P.D.2
  • 137
    • 81155151895 scopus 로고    scopus 로고
    • Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats
    • Yang X, Meng S, Jiang H, Zhu C, Wu W. 2011. Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats. J Surg Res. 171:826-832.
    • (2011) J Surg Res. , vol.171 , pp. 826-832
    • Yang, X.1    Meng, S.2    Jiang, H.3    Zhu, C.4    Wu, W.5
  • 139
    • 77952999261 scopus 로고    scopus 로고
    • Epidemiology of CKD in Europe: an uncertain scenario
    • Zoccali C, Kramer A, Jager KJ. 2010. Epidemiology of CKD in Europe: an uncertain scenario. Nephrol Dial Transplant. 25:1731-1733.
    • (2010) Nephrol Dial Transplant. , vol.25 , pp. 1731-1733
    • Zoccali, C.1    Kramer, A.2    Jager, K.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.