Marked prolongation of murine cardiac allograft survival using recipient immature dendritic cells loaded with donor-derived apoptotic cells

Scandinavian Journal of Immunology

Volumn 59, Issue 6, 2004, Pages 536-544

  Xu, Dong Liang ^a   Liu, Yong ^a   Tan, Jian Ming ^a   Li, Bo ^a   Zhong, Cui Ping ^b   Zhang, Xin Hua ^b   Wu, Chao Qun ^c   Tang, Xiao Da ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2; OLIGODEOXYRIBONUCLEOTIDE;

ADOPTIVE IMMUNOTHERAPY; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; SPLEEN CELL; TH2 CELL; ULTRAVIOLET B RADIATION;

ANIMALS; APOPTOSIS; DENDRITIC CELLS; GRAFT ENHANCEMENT, IMMUNOLOGIC; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; MALE; MEMBRANE PROTEINS; MICE; NF-KAPPA B; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 2942744597     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2004.01427.x     Document Type: Article

References (50)

1. Lechler R, Ng WF, Steinman RM. Dendritic cells in transplantation - friend or foe? Immunity 2001;14:357-68.
2. Mandelbrot DA, Furukawa Y, McAdam AJ et al. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol 1999;163:3753-7.
3. Lee WC, Zhong C, Qian S et al. Phenotype, function, and in vivo migration and survival of allogenic dendritic cell progenitors genetically engineered to express TGF-beta. Transplantation 1998;66:1810-7.
4. Lee WC, Qiani S, Wan Y et al. Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection. Immunology 2000;101:233-41.
5. Giannoukakis N, Bonham CA, Qian S et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides. Mol Ther 2000;1:430-7.
6. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998;188:2175-80.
7. Bonham CA, Peng L, Liang X et al. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol 2002;169:3382-91.
8. Van Zanten J, Hospers GA, Harmsen MC, The TH, Mulder NH, De Leij LF. Dendritic cells present an intracellular viral antigen derived from apoptotic cells and induce a T-cell response. Scand J Immunol 2002;56:254-9.
9. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-702.
10. Lu L, McCaslin D, Starzl TE, Thomson AW. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 1995;60:1539-45.
11. Fu F, Li Y, Qian S et al. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 1996;62:659-65.
12. Son YI, Mailliard RB, Watkins SC, Lotze MT. Dendritic cells pulsed with apoptotic squamous cell carcinoma have anti-tumor effects when combined with interleukin-2. Laryngoscope 2001;111:1472-8.
13. Wang Y, Rosenstein B, Goldwyn S, Zhang X, Lebwohl M, Wei H. Differential regulation of P53 and Bcl-2 expression by ultraviolet A and B. J Invest Dermatol 1998;111:380-4.
14. Abel EA. Phototherapy. Dermatol Clin 1995;13:841-9.
15. Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 2002;196:1091-7.
16. Chen JF, Gao Y, Sun EW, Wang S. Immunosuppression of allotransplantation induced by transfusion of donor apoptotic cells. Chin J Exp Surg 2003;20:608-10.
17. Rogers NJ, Lechler RI. Allorecognition. Am J Transplant 2001;1:97-102.
18. Game DS, Lechler RI. Pathways of allorecognition: implications for transplantation tolerance. Transpl Immunol 2002;10:101-8.
19. Harris PE, Cortesini R, Suciu-Foca N. Indirect allorecognition in solid organ transplantation. Rev Immunogenet 1999;1:297-308.
20. Sayegh MH, Perico N, Gallon L et al. Mechanisms of acquired thymic unresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation 1994;58:125-32.
21. Zavazava N, Fandrich F, Zhu X, Freese A, Behrens D, Yoo-Ott KA. Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination. J Leukoc Biol 2000;67:793-800.
22. Oluwole SF, Chowdhury NC, Ingram M, Garrovillo M, Jin MX, Agrawal S. Mechanism of acquired thymic tolerance induced by a single major histocompatibility complex class I peptide with the dominant epitope: differential analysis of regulatory cytokines in the lymphoid and intragraft compartments. Transplantation 1999;68:418-29.
23. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-52.
24. Coates PT, Thomson AW. Dendritic cells, tolerance induction and transplant outcome. Am J Transplant 2002;2:299-307.
25. Albert ML, Pearce SF, Francisco LM et al. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998;188:1359-68.
26. Albert ML, Sauter B, Bhatdwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998;392:86-9.
27. Hockenbery D. Defining apoptosis. Am J Pathol 1995;146:16-9.
28. Kurts C, Kosaka H, Carbone FR, Miller JF, Heath WR. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 1997;186:239-45.
29. Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000;191:411-6.
30. Rovere P, Vallinoto C, Bondanza A et al. Bystander apoptosis triggers dendriric cell maturation and antigen-presenting function. J Immunol 1998;161:4467-71.
31. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000;191:423-34.
32. Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway. Int Immunol 2000;12:1539-46.
33. Ouaaz F, Arron J, Zheng Y, Choi Y, Beg AA. Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity 2002;16:257-70.
34. Matsue H, Yang C, Matsue K, Edelbaum D, Mummert M, Takashima A. Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell - T cell interaction during antigen presentation. J Immunol 2002;169:3555-64.
35. Ichim TE, Zhong R, Min WP. Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells. Transpl Immunol 2003;11:295-306.
36. Nadler SG, Eversole AC, Tepper MA, Cleaveland JS. Elucidating the mechanism of action of the immunosuppressant 15-deoxyspergualin. Ther Drug Monit 1995;17:700-3.
37. Hackstein H, Morelli AE, Larregina AT et al. Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells. J Immunol 2001;166:7053-62.
38. Nouri-Shirazi M, Guinet E. Direct and indirect cross-tolerance of alloreactive T cells by dendritic cells retained in the immature stage. Transplantation 2002;74:1035-44.
39. Khanna A, Morelli AE, Zhong C, Takayama T, Lu L, Thomson AW. Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo. J Immunol 2000;164:1346-54.
40. Lutz MB, Suri RM, Niimi M et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 2000;30:1813-22.
41. Lu L, Li W, Zhong C et al. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. Transplantation 1999;68:747-57.
42. Sigal LJ, Crotty S, Andino R, Rock KL. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 1999;398:77-80.
43. Russo V, Zhou D, Sartirana C et al. Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells. Blood 2000;95:3473-7.
44. Bedford P, Garner K, Knight SC. MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions. Int Immunol 1999;11:1739-44.
45. Mahnke K, Schmitt E, Bonifaz L, Enk AH, Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol 2002;80:477-83.
46. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003;21:685-711.
47. Min WP, Zhou D, Ichim TE et al. Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 2003;170:1304-12.
48. Min WP, Zhou D, Ichim TE et al. Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 2003;75:1160-5.
49. Cortesini R. Regulatory T cells and dendritic cells in transplantation medicine. Transpl Immunol 2003;11:231-3.
50. + regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000;30:1538-43.