Long-term survival of limb allografts induced by pharmacologically conditioned, donor alloantigen-pulsed dendritic cells without maintenance immunosuppression

Transplantation

Volumn 85, Issue 2, 2008, Pages 237-246

  Ikeguchi, Ryosuke ^a   Sacks, Justin M ^a   Unadkat, Jignesh V ^a   Solari, Mario ^a   Horibe, Elaine K ^a   Thomson, Angus W ^a,b   Lee, Andrew W P ^a   Feili Hariri, Maryam ^a,b,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Composite tissue transplantation; Dendritic cells; Rapamycin; Rat; Tolerance

Indexed keywords

ALLOANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYCLOSPORIN A; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 6; LYMPHOCYTE ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAPAMYCIN; TOLL LIKE RECEPTOR;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EX VIVO STUDY; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; LIMB TRANSPLANTATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MAINTENANCE THERAPY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; T LYMPHOCYTE; TRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; DENDRITIC CELLS; GRAFT SURVIVAL; HINDLIMB; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; ISOANTIGENS; MALE; RATS; RATS, INBRED LEW; RATS, INBRED WF; RATS, SPRAGUE-DAWLEY; SIROLIMUS; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS;

EID: 38549139467     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31815e870e     Document Type: Article

References (45)

1. Thaunat O, Badet L, El-Jaafari A, et al. Composite tissue allograft extends a helping hand to transplant immunologists. Am J Transplant 2006; 6: 2238.
2. Gordon CR, Nazzal J, Lozano-Calderan SA, et al. From experimental rat hindlimb to clinical face composite tissue allotransplantation: Historical background and current status. Microsurgery 2006; 26: 566.
3. Kanitakis J, Badet L, Petruzzo P, et al. Clinicopathologic monitoring of the skin and oral mucosa of the first human face allograft: Report on the first eight months. Transplantation 2006; 82: 1610.
4. Lee WPA, Yaremchuk MJ, Pan YC, Randolph MA, Tan CM, Weiland AJ. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg 1991; 87: 401.
5. Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: Report on first 6 months. Lancet 1999; 353: 1315.
6. Jones J-W, Gruber SA, Barker JH, Breidenbach WC. Successful hand transplantation: One-year follow-up. N Engl J Med 2000; 343: 468.
7. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation-how much of the promise has been realized? Nature Med 2005; 6: 605.
8. Cendales L, Hardy MA. Immunological considerations in composite tissue transplantation: Overview. Microsurgery 2000; 20: 412.
9. Morris PJ, Bradley A, Doyal L, et al. Face transplantation: A review of the technical, immunological, psychlogical and clinical issues with recommendations for good practice. Transplantation 2007; 83: 109.
10. Fabre JW, Morris PJ. The effect of donor strain blood pretreatment on renal allograft rejection in rats. Transplantation 1972; 14: 608.
11. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nature Rev Immunol 2003; 3: 199.
12. Mirenda V, Berton I, Read J, et al. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: An efficient way to induce indirect pathway regulation. J Am Soc Nephrol 2004; 15: 987.
13. Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clinc Invest 2003; 112: 795.
14. Siemionow M, Agaoglu G. Role of blood transfusion in transplantation: A review. J Reconstr Microsurg 2005; 21: 555.
15. Chaussabel D, Banchereau J. Dendritic cells, therapeutic vectors of immunity and tolerance. Am J Transplant 2005; 5: 205.
16. Taner T, Hackstein H, Wang Z, et al. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce Ag-specific T cell regulation and prolong graft survival. Am J Transplant 2005; 5: 228.
17. + regulatory T cells including suppressors of alloreactivity. Immunol Rev 2006; 212: 314.
18. Morel PA, Feili-Hariri M, Coates PT, Thomson AW. Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin Exp Immunol 2003; 133: 1.
19. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nature Rev Immunol 2007; 7: 610.
20. Steinman RM, Hawiger D, Nussenzweig M. Tolerogenic dendritic cells. Annu Rev Immunol 2003; 21: 685.
21. Barratt-Boyes SM, Thomson AW. Dendritic cells: Tool and targets for transplant tolerance. Am J Transplant 2005; 12: 2807.
22. Steinbrink K, Wolfl M, Jonuleit H, et al. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159: 4772.
23. Zhu M, Wei M-F, Liu F, et al. Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival. Word J Gastroenterol 2003; 9: 2509.
24. Hackstein H, Thomson AW. Dendritic cells: Emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4: 24.
25. Lu L, Thomson AW. Manipulation of dendritic cells for tolerance induction in transplantation and autoimmune disease. Transplantation 2002; 73: S19.
26. Hackstein H, Taner T, Zahorchak AF, et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003; 101: 4457.
27. Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998; 31: 335.
28. Garrovillo M, Ali A, Depaz HA, et al. Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cells. Am J Transplant 2001; 1: 129.
29. Peche H, Trinite B, Martinet B, Cuturi MC. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005; 5: 255.
30. Sacks JM, Kuo Y-R, Breitenger J, et al. Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression. Plast Reconstr Surg 2008: in press.
31. Taieb A, Breitenger J, Unadkat JV, et al. Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness. Clin Immunol 2007; 123: 176.
32. Feili-Hariri M, Falkner DH, Morel PA. Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. Eur J Immunol 2002; 32: 201.
33. Feili-Hariri M, Falkner DH, Morel PA. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy. J Leuk Biol 2005; 78: 656.
34. Muramatsu K, Kurokawa Y, Ihara K, et al. Donor cell engraftment in recipient lymphoid tissues after rat limb allograft. J Surg Res 2005; 124: 38.
35. McCurry KR, Colvin BL, Zahorchak AF, Thomson AW. Regulatory dendritic cell therapy in organ transplantation. Transpl Int 2006; 19: 525.
36. Nguyen VT, Taieb A, Sacks JM, et al. Allopeptide-pulsed dendritic cells and composite tissue allograft survival. Microsurgery 2007; 27: 105.
37. Buttemeyer R, Jones NF, Min Z, Rao U. Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. Plast Reconstr Surg 1996; 97: 139.
38. Phillips NE, Greiner DL, Mordes JP, Rossini AA. Costimulatory blockade induces hyporesponsiveness in T cells that recognize alloantigen via indirect antigen presentation. Transplantation 2006; 82: 1085.
39. + T cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737.
40. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000; 192: 1213.
41. Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 2002; 195: 695.
42. + T suppressor cells mediate tolerance to allogeneic heart transplants, inducing RIP-B in APC and rendering the graft invulnerable to rejection. Transplant Immunol 2004; 13: 239.
43. + regulatory T cells in immunological tolerance to self and non-self. Nature Immunol 2005; 6: 345.
44. Walsh PT, Strom TB, Turka LA. Routes to transplant tolerance versus rejection: The role of cytokines. Immunity 2004; 20: 121.
45. Groux H, Fournier N, Cottrez F. Role of dendritic cells in the generation of regulatory T cells. Sem Immunol 2004; 16: 99.