Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: A translational approach to improve survival

British Journal of Cancer

Volumn 112, Issue 5, 2015, Pages 851-856

  Kwakman, R ^a   De Cuba, E M V ^a   De Winter, J P ^a   De Hingh, I H J T ^b   Delis Van Diemen, P M ^a   Tijssen, M ^a   Rooimans, M A ^a   Krijgsman, O ^a   Carvalho, B ^a   Peters, G J ^a   Bonjer, H J ^a   Meijer, G A ^a   Te Velde, E A ^a  

^a Amsterdam Gastroenterology Metabolism   (Netherlands)

^b CATHARINA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BIOLOGICAL MARKER; BLOOM SYNDROME HELICASE; FANCONI ANEMIA GROUP D2 PROTEIN; MESSENGER RNA; MITOMYCIN; ANTINEOPLASTIC ANTIBIOTIC; FANCD2 PROTEIN, HUMAN; RECQ HELICASE; TUMOR MARKER;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER SURVIVAL; CHROMOSOME BREAKAGE; COLORECTAL CANCER CELL LINE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; IMMUNOHISTOCHEMISTRY; PATIENT SELECTION; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT RESPONSE; WESTERN BLOTTING; CACO 2 CELL LINE; COLORECTAL NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; HCT116 CELL LINE; HT 29 CELL LINE; HYPERTHERMIC THERAPY; METABOLISM; MORTALITY; PERITONEAL NEOPLASMS; PROCEDURES; SECONDARY; SIGNAL TRANSDUCTION; SURVIVAL; TRANSLATIONAL RESEARCH; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; CACO-2 CELLS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; HYPERTHERMIA, INDUCED; MITOMYCIN; PERITONEAL NEOPLASMS; RECQ HELICASES; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TRANSLATIONAL MEDICAL RESEARCH; TUMOR MARKERS, BIOLOGICAL;

EID: 84928697798     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.18     Document Type: Article

References (50)

1. Auerbach AD (2009) Fanconi anemia and its diagnosis. Mutat Res 668: 4-10.
2. Bijnsdorp IV, Kruyt FA, Fukushima M, Smid K, Gokoel S, Peters GJ (2010) Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines. Cancer Sci 101: 440-447.
3. Bischof O, Kim SH, Irving J, Beresten S, Ellis NA, Campisi J (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153: 367-380.
4. Bretcha-Boix P, Farre-Alegre J, Sureda M, Dussan C, Perez Ruixo JJ, Brugarolas Masllorens A (2010) Cytoreductive surgery and perioperative intraperitoneal chemotherapy in patients with peritoneal carcinomatosis of colonic origin: outcomes after 7 years' experience of a new centre for peritoneal surface malignancies. Clin Transl Oncol 12: 437-442.
5. Cao C, Yan TD, Black D, Morris DL (2009) A systematic review and meta-analysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin. Ann Surg Oncol 16: 2152-2165.
6. Cerretani D, Nencini C, Urso R, Giorgi G, Marrelli D, De Stefano A, Pinto E, Cioppa T, Nastri G, Roviello F (2005) Pharmacokinetics of mitomycin C after resection of peritoneal carcinomatosis and intraperitoneal chemohyperthermic perfusion. J Chemother 17: 668-673.
7. Chen Y, Poon RY (2008) The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Front Biosci 13: 5016-5029.
8. Chua TC, Esquivel J, Pelz JO, Morris DL (2012a) Summary of current therapeutic options for peritoneal metastases from colorectal cancer. J Surg Oncol 107(6): 566-573.
9. Chua TC, Pelz JO, Morris DL (2012b) Surgery for colorectal peritoneal carcinomatosis. Scand J Gastroenterol 47: 277-285.
10. Colavito S, Prakash R, Sung P (2010) Promotion and regulation of homologous recombination by DNA helicases. Methods 51: 329-335.
11. Cummings J, Spanswick VJ, Tomasz M, Smyth JF (1998) Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development. Biochem Pharmacol 56: 405-414.
12. D'Andrea AD, Grompe M (2003) The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 3: 23-34.
13. Davalos AR, Kaminker P, Hansen RK, Campisi J (2004) ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 3: 1579-1586.
14. De Cuba EM, Kwakman R, Knol DL, Bonjer HJ, Meijer GA, Te Velde EA (2013) Cytoreductive surgery and HIPEC for peritoneal metastases combined with curative treatment of colorectal liver metastases: systematic review of all literature and meta-analysis of observational studies. Cancer Treat Rev 39: 321-327.
15. De Cuba EM, Kwakman R, Van Egmond M, Bosch LJ, Bonjer HJ, Meijer GA, Te Velde EA (2012) Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer: future possibilities for personalised treatment by use of biomarkers. Virchows Arch 461(3): 231-243.
16. Elias D, Quenet F, Goere D (2012) Current status and future directions in the treatment of peritoneal dissemination from colorectal carcinoma. Surg Oncol Clin N Am 21: 611-623.
17. Ellis NA, Groden J, Ye TZ, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, German J (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83: 655-666.
18. Ferrer M, De Winter JP, Mastenbroek DC, Curiel DT, Gerritsen WR, Giaccone G, Kruyt FA (2004) Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA. Cancer Gene Ther 11: 539-546.
19. Fitzsimmons SA, Workman P, Grever M, Paull K, Camalier R, Lewis AD (1996) Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. J Natl Cancer Inst 88: 259-269.
20. Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, Barone R, Yonemura Y, Cavaliere F, Quenet F, Gutman M, Tentes AA, Lorimier G, Bernard JL, Bereder JM, Porcheron J, Gomez-Portilla A, Shen P, Deraco M, Rat P (2004) Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol 22: 3284-3292.
21. Gomes IM, Santos CR, Maia CJ (2014) Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms. Genes Cancer 5: 142-151.
22. Karow JK, Chakraverty RK, Hickson ID (1997) The Bloom's syndrome gene product is a 3-5 DNA helicase. J Biol Chem 272: 30611-30614.
23. Kim H, D'Andrea AD (2012) Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 26: 1393-1408.
24. Kitagawa R, Kastan MB (2005) The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol 70: 99-109.
25. Kusamura S, Dominique E, Baratti D, Younan R, Deraco M (2008) Drugs, carrier solutions and temperature in hyperthermic intraperitoneal chemotherapy. J Surg Oncol 98: 247-252.
26. Langland G, Elliott J, Li Y, Creaney J, Dixon K, Groden J (2002) The BLM helicase is necessary for normal DNA double-strand break repair. Cancer Res 62: 2766-2770.
27. Lao VV, Welcsh P, Luo Y, Carter KT, Dzieciatkowski S, Dintzis S, Meza J, Sarvetnick NE, Monnat Jr. RJ, Loeb LA, Grady WM (2013) Altered RECQ helicase expression in sporadic primary colorectal cancers. Transl Oncol 6: 458-469.
28. Liu G, Yang D, Sun Y, Shmulevich I, Xue F, Sood AK, Zhang W (2012) Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer. Pharmacogenomics 13: 1523-1535.
29. Mao FJ, Sidorova JM, Lauper JM, Emond MJ, Monnat RJ (2010) The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage. Cancer Res 70: 6548-6555.
30. Misra V, Klamut HJ, Rauth AM (2002) Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro. Cancer Gene Ther 9: 209-217.
31. Mizumoto A, Canbay E, Hirano M, Takao N, Matsuda T, Ichinose M, Yonemura Y (2012) Morbidity and mortality outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a single institution in Japan. Gastroenterol Res Pract 2012: 836425.
32. Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev 25: 350-362.
33. Oostra AB, Nieuwint AW, Joenje H, De Winter JP (2012) Diagnosis of fanconi anemia: chromosomal breakage analysis. Anemia 2012: 238731.
34. Phillips RM, Burger AM, Loadman PM, Jarrett CM, Swaine DJ, Fiebig HH (2000) Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development. Cancer Res 60: 6384-6390.
35. Pichierri P, Franchitto A, Rosselli F (2004) BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J 23: 3154-3163.
36. Plumb JA, Workman P (1994) Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity. Int J Cancer 56: 134-139.
37. Rouers A, Laurent S, Detroz B, Meurisse M (2006) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: higher complication rate for oxaliplatin compared to mitomycin C. Acta Chir Belg 106: 302-306.
38. Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC (2003) BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J 22: 1210-1222.
39. Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P (2000) Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. Mol Pharmacol 58: 1146-1155.
40. Sitzmann JV, Wiebke EA (2013) Risk-reducing appendectomy and the elimination of BRCA1-associated intraperitoneal cancer. JAMA Surg 148: 285-291, discussion 291.
41. Smyth GK, Michaud J, Scott HS (2005) Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 21: 2067-2075.
42. Suzuki H, Seki M, Kobayashi T, Kawabe Y, Kaneko H, Kondo N, Harata M, Mizuno S, Masuko T, Enomoto T (2001) The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1. Biochem Biophys Res Commun 286: 322-327.
43. Szybalski W, Iyer VN (1964) Crosslinking of DNA by enzymatically or chemically activated mitomycins and porfiromycins, bifunctionally "alkylating" antibiotics. Fed Proc 23: 946-957.
44. Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y (2006) Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem 281: 30814-30823.
45. Van Der Speeten K, Stuart OA, Sugarbaker PH (2009) Pharmacokinetics and pharmacodynamics of perioperative cancer chemotherapy in peritoneal surface malignancy. Cancer J 15: 216-224.
46. Van Ruth S, Verwaal VJ, Zoetmulder FA (2003) Pharmacokinetics of intraperitoneal mitomycin C. Surg Oncol Clin N Am 12: 771-780.
47. Verwaal VJ, Bruin S, Boot H, Van Slooten G, Van Tinteren H (2008) 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol 15: 2426-2432.
48. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (2000) BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 14: 927-939.
49. Whitehead RH, Jones JK, Gabriel A, Lukies RE (1987) A new colon carcinoma cell line (LIM1863) that grows as organoids with spontaneous differentiation into crypt-like structures in vitro. Cancer Res 47: 2683-2689.
50. Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B, Yu X (2009) PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol 19: 524-529.