The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1

Biochemical and Biophysical Research Communications

Volumn 286, Issue 2, 2001, Pages 322-327

  Suzuki, Hirobumi ^a   Seki, Masayuki ^a   Kobayashi, Takayuki ^a   Kawabe, Yoh ichi ^a   Kaneko, Hideo ^b   Kondo, Naomi ^b   Harata, Masahiko ^a   Mizuno, Shigeki ^a   Masuko, Takashi ^a   Enomoto, Takemi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bloom syndrome; DNA helicase; RecQ; SUMO 1; UBC9; Werner syndrome

Indexed keywords

GREEN FLUORESCENT PROTEIN; HELICASE; SUMO 1 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOSOMAL DISORDER; BLOOM SYNDROME; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE; WERNER SYNDROME;

EID: 0034810429     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5387     Document Type: Article

References (21)

1. Bloom syndrome: A Mendelian prototype of somatic mutational disease
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3. Positional cloning of the Werner's syndrome gene
4. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
5. Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1
6. A novel protein interacts with the Werner's syndrome gene product physically and functionally
7. SUMO, ubiquitin's mysterious cousin
8. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
9. A role for PML and the nuclear body in genomic stability
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11. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
12. BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal
13. The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells
14. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
15. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
16. Oligomeric ring structure of the Bloom's syndrome helicase
17. Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes
18. The Bloom's syndrome gene product interacts with topoisomerase III
19. SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
20. SUMO-1 conjugation to human DNA topoisomerase II isozymes
21. Possible association of BLM in decreasing DNA double strand breaks during DNA replication