Enzymology of mitomycin C metabolic activation in tumour tissue

Biochemical Pharmacology

Volumn 56, Issue 4, 1998, Pages 405-414

  Cummings, J ^a   Spanswick, V J ^a   Tomasz, M ^a   Smyth, J F ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

DT diaphorase; Enzyme directed bioreductive; Hypoxia; In vivo enzymology; Mitomycin C; Tumour tissue

Indexed keywords

ALKYLATING AGENT; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; MITOMYCIN C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ANTINEOPLASTIC ACTIVITY; DNA MODIFICATION; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; IN VITRO STUDY; METABOLIC ACTIVATION; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SOLID TUMOR;

EID: 0031672124     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00073-2     Document Type: Note

References (102)