Altered RECQ helicase expression in sporadic primary colorectal cancers

Translational Oncology

Volumn 6, Issue 4, 2013, Pages 458-469

  Lao, Victoria Valinluck ^a,b,c   Welcsh, Piri ^b   Luo, Yanxin ^a,d   Carter, Kelly T ^a   Dzieciatkowski, Slavomir ^a   Dintzis, Suzanne ^b   Meza, Jane ^c   Sarvetnick, Nora E ^c   Monnat, Raymond J ^b   Loeb, Lawrence A ^b   Grady, William M ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME HELICASE; GENOMIC DNA; MESSENGER RNA; MICROSATELLITE DNA; RECQ HELICASE; WERNER SYNDROME PROTEIN;

ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIMARY TUMOR; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; WESTERN BLOTTING;

EID: 84881072927     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.13238     Document Type: Article

References (52)

1. Siegel R.L, Ward E.M, and Jemal A (2012). Trends in colorectal cancer incidence rates in the United States by tumor location and stage, 1992-2008. Cancer Epidemiol Biomarkers Prev 21, 411-416.
2. Saltz L.B (2010). Adjuvant therapy for colon cancer. Surg Oncol Clin N Am 19, 819-827.
3. Wolpin B.M and Mayer R.J (2008). Systemic treatment of colorectal cancer. Gastroenterology 134, 1296-1310.
4. Hanahan D and Weinberg R.A (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
5. Hanahan D and Weinberg R.A (2000). The hallmarks of cancer. Cell 100, 57-70.
6. Loeb L.A (2010). Mutator phenotype in cancer: origin and consequences. Semin Cancer Biol 20, 279-280.
7. Nyberg K.A, Michelson R.J, Putnam C.W, and Weinert T.A (2002). Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36, 617-656.
8. Postel-Vinay S, Vanhecke E, Olaussen K.A, Lord C.J, Ashworth A, and Soria J.C (2012). The potential of exploiting DNA-repair defects for optimizing lung cancer treatment. Nat Rev Clin Oncol 9, 144-155.
9. Helleday T, Petermann E, Lundin C, Hodgson B, and Sharma RA (2008). DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8, 193-204.
10. Graeser M, McCarthy A, Lord CJ, Savage K, Hills M, Salter J, Orr N, Parton M, Smith I.E, Reis-Filho J.S, et al. (2010). A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer. Clin Cancer Res 16, 6159-6168.
11. Fong P.C, Boss D.S, Yap T.A, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor M.J, et al. (2009). Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361, 123-134.
12. Ribic C.M, Sargent D.J, Moore M.J, Thibodeau S.N, French A.J, Goldberg R.M, Hamilton S.R, Laurent-Puig P, Gryfe R, Shepherd L.E, et al. (2003). Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 349, 247-257.
13. Barratt P.L, Seymour M.T., Stenning S.P, Georgiades I, Walker C, Birbeck K, and Quirke P (2002). DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet 360, 1381-1391.
14. Bertagnolli M.M, Niedzwiecki D, Compton C.C, Hahn H.P, Hall M, Damas B, Jewell S.D, Mayer R.J, Goldberg R.M, Saltz L.B, et al. (2009). Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J Clin Oncol 27, 1814-1821.
15. Sharma S, Doherty K.M, and Brosh R.M Jr (2006). Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J 398, 319-337.
16. Pommier Y, Barcelo J.M, Rao V.A, Sordet O, Jobson A.G, Thibaut L, Miao Z.H, Seiler J.A, Zhang H, Marchand C, et al. (2006). Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol 81, 179-229.
17. Bohr V.A (2008). Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci 33, 609-620.
18. Hu Y, Raynard S, Sehorn M.G, Lu X, Bussen W, Zheng L, Stark J.M, Barnes E.L, Chi P, Janscak P, et al. (2007). RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev 21, 3073-3084.
19. min mice. World J Gastroenterol 16, 1482-1486.
20. Wang X, Lu X, Zhou G, Lou H, and Luo G (2011). RECQL5 is an important determinant for camptothecin tolerance in human colorectal cancer cells. Biosci Rep 31, 363-369.
21. Sidorova J.M (2008). Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) 7, 1776-1786.
22. Sidorova J.M, Li N, Folch A, and Monnat R.J Jr (2008). The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle 7, 796-807.
23. Mao F.J, Sidorova J.M, Lauper J.M, Emond M.J, and Monnat R.J (2010). The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage. Cancer Res 70, 6548-6555.
24. Singh D.K, Popuri V, Kulikowicz T, Shevelev I, Ghosh A.K, Ramamoorthy M, Rossi M.L, Janscak P, Croteau D.L, and Bohr V.A (2012). The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Nucleic Acids Res 40, 6632-6648.
25. Kanagaraj R, Saydam N, Garcia P.L, Zheng L, and Janscak P (2006). Human RECQ5β helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Res 34, 5217-5231.
26. Botticelli A.R, Casali A.M, Botticelli L, and Zaffe D (1998). Immunohistochemical detection of cell-cycle associated markers on paraffin embedded and formalin fixed needle biopsies of prostate cancer: correlation of p120 protein expression with AgNOR, PCNA/cyclin, Ki-67/MIB1 proliferation-scores and Gleason gradings. Eur J Histochem 42, 41-48.
27. Bolton W.E, Freeman J.W, Mikulka W.R, Healy C.G, Schmittling R.J, and Kenyon N.S (1994). Expression of proliferation-associated antigens (PCNA, p120, p145) during the reentry of G0 cells into the cell cycle. Cytometry 17, 66-74.
28. Turner H.E and Wass J.A (1999). Are markers of proliferation valuable in the histological assessment of pituitary tumours? Pituitary 1, 147-151.
29. Weisenberger D.J, Siegmund K.D, Campan M, Young J, Long T.I, Faasse M.A, Kang G.H, Widschwendter M, Weener D, Buchanan D, et al. (2006). CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38, 787-793.
30. Grady W.M, Myeroff L.L, Swinler S.E, Rajput A, Thiagalingam S, Lutterbaugh J.D, Neumann A, Brattain M.G, Chang J, Kim S.J, et al. (1999). Mutational inactiva-tion of transforming growth factor β receptor type II in microsatellite stable colon cancers. Cancer Res 59, 320-324.
31. Allred D.C, Harvey J.M, Berardo M, and Clark G.M (1998). Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 11, 155-168.
32. Luo Y, Tsuchiya K.D, Il Park D, Fausel R, Kanngurn S, Welcsh P, Dzieciatkowski S, Wang J, and Grady W.M (2012). RET is a potential tumor suppressor gene in colorectal cancer. Oncogene 32, 2037-2047.
33. Monnat R.J Jr (2010). Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin Cancer Biol 20, 329-339.
34. Singh D.K, Ghosh A.K, Croteau D.L, and Bohr V.A (2012). RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res 736, 15-24.
35. Sharma S, Stumpo D.J, Balajee A.S, Bock C.B, Lansdorp P.M, Brosh R.M Jr, and Blackshear P.J (2007). RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol 27, 1784-1794.
36. Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson D.M III, Croteau D.L, and Bohr V.A (2012). Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell 23, 4273-4285.
37. Lu X, Lou H, and Luo G (2011). A Blm-Recql5 partnership in replication stress response. J Mol Cell Biol 3, 31-38.
38. Aygun O and Svejstrup J.Q (2010). RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription. DNA Repair (Amst) 9, 345-353.
39. Wu Y and Brosh R.M Jr (2010). Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) 9, 315-324.
40. Popuri V, Croteau D.L, Brosh R.M Jr, and Bohr V.A (2012). RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle 11, 4252-4265.
41. Sharma S, Phatak P, Stortchevoi A, Jasin M, and Larocque J.R (2012). RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) 11, 537-549.
42. Hu Y, Lu X, Zhou G, Barnes E.L, and Luo G (2009). Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment. MolBiol Cell 20, 114-123.
43. Goss K.H, Risinger M.A, Kordich J.J, Sanz M.M, Straughen J.E, Slovek L.E, Capobianco A.J, German J, Boivin G.P, and Groden J (2002). Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297, 2051-2053.
44. Nakayama H (2002). RecQ family helicases: roles as tumor suppressor proteins. Oncogene 21, 9008-9021.
45. O'Sullivan R.J and Karlseder J (2010). Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 11, 171-181.
46. Opresko P.L (2008). Telomere ResQue and preservation-roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev 129, 79-90.
47. Bhattacharyya S, Sandy A, and Groden J (2010). Unwinding protein complexes in ALTernative telomere maintenance. J Cell Biochem 109, 7-15.
48. Su Y, Meador J.A, Calaf G.M, Proietti De-Santis L, Zhao Y, Bohr V.A, and Balajee A.S (2010). Human RecQL4 helicase plays critical roles in prostate carcinogenesis. Cancer Res 70, 9207-9217.
49. Maire G, Yoshimoto M, Chilton-MacNeill S, Thorner P.S, Zielenska M, and Squire J.A (2009). Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. Neoplasia 11, 260-268, 263 pp. following 268.
50. Ren H, Dou S.X, Zhang X.D, Wang P.Y, Kanagaraj R, Liu J.L, Janscak P, Hu J.S., and Xi X.G (2008). The zinc-binding motif of human RECQ5β suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme. Biochem J 412, 425-433.
51. Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark J.M, Sung P, and Janscak P (2010). Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem 285, 15739-15745.
52. Liu Y, El-Naggar S, Clem B, Chesney J, and Dean D.C (2008). The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression. Biochem J 412, 299-306.