메뉴 건너뛰기




Volumn 57, Issue 5-6, 2015, Pages 366-375

Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets

Author keywords

Beta cells; Calcium; Chronic; Cytokines; Diabetes; Endoplasmic reticulum; ER stress; Free fatty acid; Glucotoxicity; High glucose; IL 1beta; IL 6; Insulin; Interleukin; Islets; Linoleate; Low grade inflammation; Oleate; Oxidative stress; Palmitate; Rotenone; Thapsigargin; Unfolded protein response

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CYTOKINE; DIAZOXIDE; FATTY ACID; GLUCOSE; NIFEDIPINE; POTASSIUM CHLORIDE; ROTENONE; THAPSIGARGIN; CALCIUM; INSULIN;

EID: 84928586981     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2015.03.002     Document Type: Article
Times cited : (33)

References (66)
  • 1
    • 64149126546 scopus 로고    scopus 로고
    • Regulation of insulin secretion: a matter of phase control and amplitude modulation
    • Henquin J.C. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia 2009, 52:739-751.
    • (2009) Diabetologia , vol.52 , pp. 739-751
    • Henquin, J.C.1
  • 2
    • 82855161343 scopus 로고    scopus 로고
    • The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes
    • Ramadan J.W., Steiner S.R., O'Neill C.M., Nunemaker C.S. The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium 2011, 50:481-490.
    • (2011) Cell Calcium , vol.50 , pp. 481-490
    • Ramadan, J.W.1    Steiner, S.R.2    O'Neill, C.M.3    Nunemaker, C.S.4
  • 3
    • 77957127882 scopus 로고    scopus 로고
    • Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
    • Dula S.B., Jecmenica M., Wu R., et al. Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium 2010, 48:133-142.
    • (2010) Cell Calcium , vol.48 , pp. 133-142
    • Dula, S.B.1    Jecmenica, M.2    Wu, R.3
  • 4
    • 0031953635 scopus 로고    scopus 로고
    • Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets
    • Straub S.G., James R.F., Dunne M.J., Sharp G.W. Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets. Diabetes 1998, 47:758-763.
    • (1998) Diabetes , vol.47 , pp. 758-763
    • Straub, S.G.1    James, R.F.2    Dunne, M.J.3    Sharp, G.W.4
  • 5
    • 0034938417 scopus 로고    scopus 로고
    • KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic beta-cell
    • Komatsu M., Sato Y., Aizawa T., Hashizume K. KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic beta-cell. Endocr. J. 2001, 48:275-288.
    • (2001) Endocr. J. , vol.48 , pp. 275-288
    • Komatsu, M.1    Sato, Y.2    Aizawa, T.3    Hashizume, K.4
  • 6
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin J.C. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000, 49:1751-1760.
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 8
    • 69949132408 scopus 로고    scopus 로고
    • Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction
    • Li N., Brun T., Cnop M., Cunha D.A., Eizirik D.L., Maechler P. Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction. J. Biol. Chem. 2009, 284:23602-23612.
    • (2009) J. Biol. Chem. , vol.284 , pp. 23602-23612
    • Li, N.1    Brun, T.2    Cnop, M.3    Cunha, D.A.4    Eizirik, D.L.5    Maechler, P.6
  • 10
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik D.L., Cardozo A.K., Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 2008, 29:42-61.
    • (2008) Endocr. Rev. , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 11
    • 72449150103 scopus 로고    scopus 로고
    • The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
    • Kolb H., Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 2010, 53:10-20.
    • (2010) Diabetologia , vol.53 , pp. 10-20
    • Kolb, H.1    Mandrup-Poulsen, T.2
  • 12
    • 84883159268 scopus 로고    scopus 로고
    • Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice
    • O'Neill C.M., Lu C., Corbin K.L., et al. Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology 2013, 154:3077-3088.
    • (2013) Endocrinology , vol.154 , pp. 3077-3088
    • O'Neill, C.M.1    Lu, C.2    Corbin, K.L.3
  • 14
    • 70350330155 scopus 로고    scopus 로고
    • Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes
    • Weir G.C., Marselli L., Marchetti P., Katsuta H., Jung M.H., Bonner-Weir S. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes. Metab. 2009, 11(Suppl 4):82-90.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 82-90
    • Weir, G.C.1    Marselli, L.2    Marchetti, P.3    Katsuta, H.4    Jung, M.H.5    Bonner-Weir, S.6
  • 15
    • 83455176946 scopus 로고    scopus 로고
    • Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments
    • Watt M.J., Hoy A.J., Muoio D.M., Coleman R.A. Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. Am. J. Physiol. Endocrinol. Metab. 2012, 302:E1-E3.
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. E1-E3
    • Watt, M.J.1    Hoy, A.J.2    Muoio, D.M.3    Coleman, R.A.4
  • 16
    • 84891812006 scopus 로고    scopus 로고
    • Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants
    • Sosenko J.M., Skyler J.S., Beam C.A., et al. Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants. Diabetes 2013, 62:4179-4183.
    • (2013) Diabetes , vol.62 , pp. 4179-4183
    • Sosenko, J.M.1    Skyler, J.S.2    Beam, C.A.3
  • 17
    • 0034944773 scopus 로고    scopus 로고
    • The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus
    • Del Prato S., Tiengo A. The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus. Diabetes Metab. Res. Rev. 2001, 17:164-174.
    • (2001) Diabetes Metab. Res. Rev. , vol.17 , pp. 164-174
    • Del Prato, S.1    Tiengo, A.2
  • 18
    • 84881372194 scopus 로고    scopus 로고
    • First phase insulin secretion and type 2 diabetes
    • Cheng K., Andrikopoulos S., Gunton J.E. First phase insulin secretion and type 2 diabetes. Curr. Mol. Med. 2013, 13:126-139.
    • (2013) Curr. Mol. Med. , vol.13 , pp. 126-139
    • Cheng, K.1    Andrikopoulos, S.2    Gunton, J.E.3
  • 20
    • 77952954397 scopus 로고    scopus 로고
    • AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets
    • Crim W.S., Wu R., Carter J.D., et al. AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol. Cell. Endocrinol. 2010, 323:246-255.
    • (2010) Mol. Cell. Endocrinol. , vol.323 , pp. 246-255
    • Crim, W.S.1    Wu, R.2    Carter, J.D.3
  • 21
    • 79951641730 scopus 로고    scopus 로고
    • A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro
    • Corbin K.L., Hall T.E., Haile R., Nunemaker C.S. A novel fluorescence imaging approach for comparative measurements of pancreatic islet function in vitro. Islets 2011, 3:14-20.
    • (2011) Islets , vol.3 , pp. 14-20
    • Corbin, K.L.1    Hall, T.E.2    Haile, R.3    Nunemaker, C.S.4
  • 22
    • 59649088430 scopus 로고    scopus 로고
    • Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets
    • Jahanshahi P., Wu R., Carter J.D., Nunemaker C.S. Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets. Endocrinology 2009, 150:607-615.
    • (2009) Endocrinology , vol.150 , pp. 607-615
    • Jahanshahi, P.1    Wu, R.2    Carter, J.D.3    Nunemaker, C.S.4
  • 23
  • 25
    • 19944432792 scopus 로고    scopus 로고
    • 2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
    • 2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005, 54:452-461.
    • (2005) Diabetes , vol.54 , pp. 452-461
    • Cardozo, A.K.1    Ortis, F.2    Storling, J.3
  • 26
    • 0032705565 scopus 로고    scopus 로고
    • Effects of high extracellular K(+) concentrations, diazoxide and/or Ca(2+) deprivation upon D-glucose metabolism in pancreatic islets
    • Malaisse W.J., Picton S., Malaisse-Lagae F., Sener A. Effects of high extracellular K(+) concentrations, diazoxide and/or Ca(2+) deprivation upon D-glucose metabolism in pancreatic islets. Biochim. Biophys. Acta 1999, 1451:255-262.
    • (1999) Biochim. Biophys. Acta , vol.1451 , pp. 255-262
    • Malaisse, W.J.1    Picton, S.2    Malaisse-Lagae, F.3    Sener, A.4
  • 27
    • 0030467497 scopus 로고    scopus 로고
    • Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
    • Ling Z., Pipeleers D.G. Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J. Clin. Invest. 1996, 98:2805-2812.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2805-2812
    • Ling, Z.1    Pipeleers, D.G.2
  • 28
    • 0036324151 scopus 로고    scopus 로고
    • Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes
    • Pertusa J.A., Nesher R., Kaiser N., Cerasi E., Henquin J.C., Jonas J.C. Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes. Diabetes 2002, 51:2552-2560.
    • (2002) Diabetes , vol.51 , pp. 2552-2560
    • Pertusa, J.A.1    Nesher, R.2    Kaiser, N.3    Cerasi, E.4    Henquin, J.C.5    Jonas, J.C.6
  • 29
    • 62749103868 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion
    • Leloup C., Tourrel-Cuzin C., Magnan C., et al. Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes 2009, 58:673-681.
    • (2009) Diabetes , vol.58 , pp. 673-681
    • Leloup, C.1    Tourrel-Cuzin, C.2    Magnan, C.3
  • 30
    • 34249682591 scopus 로고    scopus 로고
    • Beta-cell failure in diabetes and preservation by clinical treatment
    • Wajchenberg B.L. Beta-cell failure in diabetes and preservation by clinical treatment. Endocr. Rev. 2007, 28:187-218.
    • (2007) Endocr. Rev. , vol.28 , pp. 187-218
    • Wajchenberg, B.L.1
  • 31
    • 80052730999 scopus 로고    scopus 로고
    • Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets
    • Graciano M.F., Valle M.M., Kowluru A., Curi R., Carpinelli A.R. Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets. Islets 2011, 3:213-223.
    • (2011) Islets , vol.3 , pp. 213-223
    • Graciano, M.F.1    Valle, M.M.2    Kowluru, A.3    Curi, R.4    Carpinelli, A.R.5
  • 32
    • 84861905329 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and type 2 diabetes
    • Back S.H., Kaufman R.J. Endoplasmic reticulum stress and type 2 diabetes. Annu. Rev. Biochem. 2012, 81:767-793.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 767-793
    • Back, S.H.1    Kaufman, R.J.2
  • 33
    • 84903516492 scopus 로고    scopus 로고
    • Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of beta-cell mass in Japanese type 2 diabetic patients
    • Mizukami H., Takahashi K., Inaba W., et al. Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of beta-cell mass in Japanese type 2 diabetic patients. Diabetes Care 2014, 37:1966-1974.
    • (2014) Diabetes Care , vol.37 , pp. 1966-1974
    • Mizukami, H.1    Takahashi, K.2    Inaba, W.3
  • 34
    • 0024385035 scopus 로고
    • Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus
    • discussion 219-34
    • Mandrup-Poulsen T., Helqvist S., Molvig J., Wogensen L.D., Nerup J. Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus. Autoimmunity 1989, 4:191-218. discussion 219-34.
    • (1989) Autoimmunity , vol.4 , pp. 191-218
    • Mandrup-Poulsen, T.1    Helqvist, S.2    Molvig, J.3    Wogensen, L.D.4    Nerup, J.5
  • 35
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11:98-107.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 37
    • 0029900592 scopus 로고    scopus 로고
    • Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP
    • Abdel-Halim S.M., Guenifi A., Khan A., et al. Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP. Diabetes 1996, 45:934-940.
    • (1996) Diabetes , vol.45 , pp. 934-940
    • Abdel-Halim, S.M.1    Guenifi, A.2    Khan, A.3
  • 38
    • 0031964342 scopus 로고    scopus 로고
    • Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats
    • Hughes S.J., Faehling M., Thorneley C.W., Proks P., Ashcroft F.M., Smith P.A. Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats. Diabetes 1998, 47:73-81.
    • (1998) Diabetes , vol.47 , pp. 73-81
    • Hughes, S.J.1    Faehling, M.2    Thorneley, C.W.3    Proks, P.4    Ashcroft, F.M.5    Smith, P.A.6
  • 39
    • 0022522943 scopus 로고
    • Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions
    • Leahy J.L., Cooper H.E., Deal D.A., Weir G.C. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J. Clin. Invest. 1986, 77:908-915.
    • (1986) J. Clin. Invest. , vol.77 , pp. 908-915
    • Leahy, J.L.1    Cooper, H.E.2    Deal, D.A.3    Weir, G.C.4
  • 40
    • 0035122490 scopus 로고    scopus 로고
    • Overstimulation and beta-cell function
    • Grill V., Bjorklund A. Overstimulation and beta-cell function. Diabetes 2001, 50(Suppl. 1):S122-S124.
    • (2001) Diabetes , vol.50 , pp. S122-S124
    • Grill, V.1    Bjorklund, A.2
  • 41
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 42
    • 18644376240 scopus 로고    scopus 로고
    • Type 2 diabetes, insulin secretion and beta-cell mass
    • Ahren B. Type 2 diabetes, insulin secretion and beta-cell mass. Curr. Mol. Med. 2005, 5:275-286.
    • (2005) Curr. Mol. Med. , vol.5 , pp. 275-286
    • Ahren, B.1
  • 43
    • 3242718780 scopus 로고    scopus 로고
    • Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose
    • Khaldi M.Z., Guiot Y., Gilon P., Henquin J.C., Jonas J.C. Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E207-E217.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287 , pp. E207-E217
    • Khaldi, M.Z.1    Guiot, Y.2    Gilon, P.3    Henquin, J.C.4    Jonas, J.C.5
  • 45
    • 33751520308 scopus 로고    scopus 로고
    • Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40
    • Schnell S., Schaefer M., Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. Mol. Cell Endocrinol. 2007, 263:173-180.
    • (2007) Mol. Cell Endocrinol. , vol.263 , pp. 173-180
    • Schnell, S.1    Schaefer, M.2    Schofl, C.3
  • 47
    • 0037453056 scopus 로고    scopus 로고
    • Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    • Listenberger L.L., Han X., Lewis S.E., et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:3077-3082.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 3077-3082
    • Listenberger, L.L.1    Han, X.2    Lewis, S.E.3
  • 48
    • 45549102437 scopus 로고    scopus 로고
    • Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells
    • Coll T., Eyre E., Rodriguez-Calvo R., et al. Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J. Biol. Chem. 2008, 283:11107-11116.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11107-11116
    • Coll, T.1    Eyre, E.2    Rodriguez-Calvo, R.3
  • 49
    • 53349099395 scopus 로고    scopus 로고
    • Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway
    • Zhao Y.F., Pei J., Chen C. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J. Endocrinol. 2008, 198:533-540.
    • (2008) J. Endocrinol. , vol.198 , pp. 533-540
    • Zhao, Y.F.1    Pei, J.2    Chen, C.3
  • 50
    • 84928210510 scopus 로고    scopus 로고
    • Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate
    • Tian G., Sol E.R., Xu Y., Shuai H., Tengholm A. Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate. Diabetes 2015, 64:904-915.
    • (2015) Diabetes , vol.64 , pp. 904-915
    • Tian, G.1    Sol, E.R.2    Xu, Y.3    Shuai, H.4    Tengholm, A.5
  • 51
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou Y.P., Grill V.E. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J. Clin. Invest. 1994, 93:870-876.
    • (1994) J. Clin. Invest. , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 52
    • 23744447643 scopus 로고    scopus 로고
    • Mechanisms of oleic acid deterioration in insulin secretion: role in the pathogenesis of type 2 diabetes
    • Zhang Y., Xiao M., Niu G., Tan H. Mechanisms of oleic acid deterioration in insulin secretion: role in the pathogenesis of type 2 diabetes. Life Sci. 2005, 77:2071-2081.
    • (2005) Life Sci. , vol.77 , pp. 2071-2081
    • Zhang, Y.1    Xiao, M.2    Niu, G.3    Tan, H.4
  • 53
    • 0024995157 scopus 로고
    • A 48-h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y., Grill V.E. A 48-h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 1990, 127:1580-1589.
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 54
    • 70349611130 scopus 로고    scopus 로고
    • Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules
    • Hoppa M.B., Collins S., Ramracheya R., et al. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metab. 2009, 10:455-465.
    • (2009) Cell Metab. , vol.10 , pp. 455-465
    • Hoppa, M.B.1    Collins, S.2    Ramracheya, R.3
  • 55
    • 0028221978 scopus 로고
    • Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells
    • Warnotte C., Gilon P., Nenquin M., Henquin J.C. Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes 1994, 43:703-711.
    • (1994) Diabetes , vol.43 , pp. 703-711
    • Warnotte, C.1    Gilon, P.2    Nenquin, M.3    Henquin, J.C.4
  • 59
    • 63249083149 scopus 로고    scopus 로고
    • 2+ channels in endoplasmic reticulum stress and beta-cell death
    • 2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 2009, 58:422-432.
    • (2009) Diabetes , vol.58 , pp. 422-432
    • Luciani, D.S.1    Gwiazda, K.S.2    Yang, T.L.3
  • 60
    • 0037424245 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    • Li N., Ragheb K., Lawler G., et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 2003, 278:8516-8525.
    • (2003) J. Biol. Chem. , vol.278 , pp. 8516-8525
    • Li, N.1    Ragheb, K.2    Lawler, G.3
  • 61
    • 84855827249 scopus 로고    scopus 로고
    • Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol
    • Saadeh M., Ferrante T.C., Kane A., Shirihai O., Corkey B.E., Deeney J.T. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS ONE 2012, 7:e30200.
    • (2012) PLoS ONE , vol.7 , pp. e30200
    • Saadeh, M.1    Ferrante, T.C.2    Kane, A.3    Shirihai, O.4    Corkey, B.E.5    Deeney, J.T.6
  • 62
    • 33745234081 scopus 로고    scopus 로고
    • Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell
    • Robertson R.P., Harmon J.S. Diabetes, glucose toxicity, and oxidative stress: a case of double jeopardy for the pancreatic islet beta cell. Free Radic. Biol. Med. 2006, 41:177-184.
    • (2006) Free Radic. Biol. Med. , vol.41 , pp. 177-184
    • Robertson, R.P.1    Harmon, J.S.2
  • 63
    • 84655163525 scopus 로고    scopus 로고
    • Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells
    • Sarre A., Gabrielli J., Vial G., Leverve X.M., Assimacopoulos-Jeannet F. Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells. Free Radic. Biol. Med. 2012, 52:142-150.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 142-150
    • Sarre, A.1    Gabrielli, J.2    Vial, G.3    Leverve, X.M.4    Assimacopoulos-Jeannet, F.5
  • 64
    • 84901714175 scopus 로고    scopus 로고
    • Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic beta-cells
    • Takahashi H.K., Santos L.R., Roma L.P., et al. Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic beta-cells. Biochem. J. 2014, 460:411-423.
    • (2014) Biochem. J. , vol.460 , pp. 411-423
    • Takahashi, H.K.1    Santos, L.R.2    Roma, L.P.3
  • 65
    • 20144364947 scopus 로고    scopus 로고
    • Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells
    • Martens G.A., Cai Y., Hinke S., Stange G., Van de Casteele M., Pipeleers D. Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J. Biol. Chem. 2005, 280:20389-20396.
    • (2005) J. Biol. Chem. , vol.280 , pp. 20389-20396
    • Martens, G.A.1    Cai, Y.2    Hinke, S.3    Stange, G.4    Van de Casteele, M.5    Pipeleers, D.6
  • 66
    • 33845667532 scopus 로고    scopus 로고
    • Quantification of basal and stimulated ROS levels as predictors of islet potency and function
    • Armann B., Hanson M.S., Hatch E., Steffen A., Fernandez L.A. Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am. J. Transpl. 2007, 7:38-47.
    • (2007) Am. J. Transpl. , vol.7 , pp. 38-47
    • Armann, B.1    Hanson, M.S.2    Hatch, E.3    Steffen, A.4    Fernandez, L.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.