Mechanisms of oleic acid deterioration in insulin secretion: Role in the pathogenesis of type 2 diabetes

Life Sciences

Volumn 77, Issue 17, 2005, Pages 2071-2081

  Zhang, Yali ^a   Xiao, Meifang ^a   Niu, Gang ^b   Tan, Huanran ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Beijing N and N Genetech Company   (China)

Author keywords

Hyperinsulinemia; Insulin resistance; Oleic acid; Pancreatic islets; Type 2 diabetes mellitus

Indexed keywords

CALCIUM ION; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; INSULIN RECEPTOR; OLEIC ACID; PREPROINSULIN; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DESENSITIZATION; GLUCOSE HOMEOSTASIS; HYPERINSULINEMIA; HYPOTHESIS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; INSULIN; ISLETS OF LANGERHANS; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; OLEIC ACID; PROINSULIN; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANS-ACTIVATORS;

EID: 23744447643     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.12.047     Document Type: Article

References (40)

1. M. Ashcroft, P. Proks, P.A. Smith, C. Ammala, K. Bokvist, and P. Rorsman Stimulus-secretion coupling in pancreatic β-cells Journal of Cellular Biochemistry 55 1994 54 65
2. A. Bjorklund, G. Yaney, J.D. McGarry, and G. Weir Fatty acids and beta-cell function Diabetologia 40 Suppl. 3 1997 B21 B26
3. L.C. Bollheimer, R.H. Skelly, M.W. Chester, J.D. McGarry, and C.J. Rhodes Chronic exposure to free fatty acid reduces pancreatic-cell insulin content by increasing basal secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation Journal of Clinical Investigation 101 1998 1094 1101
4. M.A. Charles, E. Eschwege, N. Thibult, J.R. Claude, J.M. Warnet, G.E. Rosselin, J. Girard, and B. Balkau The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris prospective study Diabetologia 40 1997 1101 1106
5. M.N. Elks Chronic perifusion of rat islets with palmitate suppresses glucose stimulated insulin release Endocrinology 133 1993 208 214
6. K.F. Erriksson, and F. Lindgarde Poor physical fitness, and impaired early phase insulin response but late hyperinsulinemia as predictors of NIDDM in middle aged Swedish men Diabetologia 39 1996 573 579
7. E. Ferrannini, A. Natali, P. Bell, P. Cavallo-Perin, N. Lalic, and G. Mingrone On behalf of the European Group for the Study of Insulin Resistance (EGIR): insulin resistance and hypersecretion in obesity Journal of Clinical Investigation 100 1997 1166 1173
8. A. Golay, A.L. Swislocki, Y.D. Chen, and G.M. Reaven Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals Metabolism 36 1987 692 696
9. S.M. Haffner, H. Miettinen, S.P. Gaskill, and M.P. Stern Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican Americans Diabetes 44 1995 1386 1391
10. M.C. Harbeck, D.C. Louie, J. Howland, B.A. Wolf, and P.L. Rothenberg Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells Diabetes 45 1996 711 717
11. H. Hosokawa, B.E. Corkey, and J.L. Leahy Beta-cells hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids Diabetologia 40 1997 392 397
12. M.L. Hribal, L. Perego, S. Lovari, F. Andreozzi, R. Menghini, C. Perego, G. Finzi, L. Usellini, C. Placidi, C. Capella, V. Guzzi, D. Lauro, F. Bertuzzi, A. Davalli, G. Pozza, A. Pontiroli, M. Federici, R. Lauro, A. Brunetti, F. Folli, and G. Sesti Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans FASEB Journal 17 2003 1340 1342
13. C.R. Kahn Insulin action, diabetogenes, and the cause of type 2 diabetes Diabetes 43 1994 1066 1084
14. S.E. Kahn, D.L. Leonetti, R.L. Prigeon, E.J. Boylo, R.W. Bergstrom, and W.Y. Fujimoto Proinsulin levels predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japanese-American men Diabetic Medicine 13 1996 S63 S66
15. W.C. Knowler, D.J. Pettitt, M.F. Saad, and P.H. Bennett Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis Diabetes & Metabolism Reviews 6 1990 1 27
16. K. Koyama, G. Chen, Y. Lee, and R.H. Unger Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia in obesity American Journal of Physiology 273 1997 E708 E713
17. P.E. Lacy, and M. Kostianovsky Method for the isolation of intact islets of Langerhans from the rat pancreas Diabetes 16 1967 35 39
18. N. Lameloise, P. Muzzin, M. Prentki, and F. Assimacopoulos-Jeannet Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose induced insulin secretion Diabetes 50 2001 803 809
19. i abnormalities in human pancreatic islets: important role of overstimulation Diabetes 49 2000 840 1848
20. B. Leibiger, I.B. Leibiger, T. Moede, S. Kemper, R.N. Kulkarni, C.R. Kahn, L.M. de Vargas, and P.O. Berggren Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells Molecular Cell 7 2001 559 570
21. Y. Liang, C. Buettger, D.K. Berner, and F.M. Matschinsky Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic b-cell line (b HC9) Diabetologia 40 1997 1018 1027
22. Y. Liu, K. Tornheim, and J. Leahy Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets Diabetes 48 1999 1747 1753
23. M.A. Magnuson Glucokinase gene structure. Functional implications of molecular genetic studies Diabetes 39 1990 523 527
24. J.D. McGarry, and R.L. Dobbins Fatty acids, lipotoxicity and insulin secretion Diabetologia 42 1999 128 138
25. C.M. McKinno, and K. Docherty Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function Diabetologia 44 2001 1203 1214
26. P.D.G. Miles, S. Li, M. Hart, O. Romeo, J. Cheng, A. Cohen, K. Raafat, A.R. Moossa, and J.M. Olefsky Mechanisms of insulin resistance in experimental hyperinsulinemic dogs Journal of Clinical Investigation 101 1998 202 211
27. K. Minami, H. Yano, T. Miki, K. Nagashima, C.Z. Wang, H. Tanaka, J. Miyazaki, and S. Seino Insulin secretion gene expression in glucose-responsive and-unresponsive MIN6 sublines American Journal of Physiology: Endocrinology and Metabolism 279 2000 E773 E781
28. 2+ induces a glucose-responsive state in glucose-unresponsive beta-cells Journal of Biological Chemistry 277 2002 25277 25282
29. M. Prentki, and B.E. Corkey Are the b-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45 1996 273 283
30. P.J. Randle, C.N. Hales, Garland, and E.A. Newsholme The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
31. E. Roche, J. Buteau, I. Aniento, J.A. Reig, B. Soria, and M. Prentki Palmitate and oleate induce the immediate early response genes c-fos and nur-77 in the pancreatic-cell line INS-1 Diabetes 48 1999 2007 2014
32. Y. Sako, and V.E. Grill A 48-h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation Endocrinology 127 1990 1580 1589
33. A.L. Swislocki, Y.D. Chen, A. Golay, M.O. Chang, and G.M. Reaven Insulin suppression of plasma-free fatty acid concentration in normal individuals and patients with type 2 (non-insulin-dependent) diabetes Diabetologia 30 1987 622 626
34. J. Takeda, T. Kayano, H. Fukomoto, and G.I. Bell Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene Diabetes 42 1993 773 777
35. J.H. Warram, R.J. Sigal, B.C. Martin, A.S. Krolewski, and J.S. Soeldner Natural history of impaired glucose tolerance: follow-up at Joslin Clinic Diabetic Medicine 13 1996 S40 S45
36. 2+ homeostasis and insulin secretion Journal of Biological Chemistry 274 1999 18067 18074
37. I. Yasuaki, K. Yuji, H. Masataka, K. Makoto, F. Ryo, F. Shoji, O. Kazuhiro, H. Masaki, T. Yasuhiro, U. Hiroshi, T. Hideyuki, M. Minoru, S. Rie, O. Shoichi, K. Hideki, K. Hidetoshi, M. Fumika, N. Yuko, S. Tokuyuki, H. Shuji, F. Yukio, and F. Masahiko Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 Nature 422 2003 173 176
38. Y.P. Zhou, and V.E. Grill Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle Journal of Clinical Investigation 93 1994 870 876
39. Y.P. Zhou, and V. Grill Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans Journal of Clinical Endocrinology and Metabolism 80 1995 1584 1590
40. Y.T. Zhou, M. Shimabukuro, M.Y. Wang, Y. Lee, M. Higa, J.L. Milburn, C.B. Newgard, and R.H. Unger Role of peroxisome proliferator-activated receptor in disease of pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America 95 1998 8898 8903