AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets

Molecular and Cellular Endocrinology

Volumn 323, Issue 2, 2010, Pages 246-255

  Crim, William S ^a   Wu, Runpei ^a   Carter, Jeffrey D ^a   Cole, Banumathi K ^c   Trace, Anthony P ^b   Mirmira, Raghavendra G ^d   Kunsch, Charles ^e   Nadler, Jerry L ^c   Nunemaker, Craig S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e AtheroGenics Inc   (United States)

Author keywords

Anti inflammatory; Antioxidant; Beta cells; Beta cell; Biphasic; Calcium; Cytokines; ER stress; Glucokinase; Glucose sensitivity; Inflammation; Insulin; KATP channel; Oxidative stress; Probucol; Succinobucol

Indexed keywords

2 OXOISOCAPROIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM ION; DIAZOXIDE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; PROBUCOL SUCCINATE; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID METHYL ESTER; UNCLASSIFIED DRUG; ALPHA-KETOISOCAPROIC ACID; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CALCIUM; CYTOKINE; OXOACID; POTASSIUM CHANNEL; PROBUCOL; SUCCINOBUCOL; TOLBUTAMIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION; HUMAN; METABOLISM; PANCREAS ISLET; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CALCIUM; CELL DEATH; CYTOKINES; DIAZOXIDE; GENE EXPRESSION; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; POTASSIUM CHANNELS; PROBUCOL; TOLBUTAMIDE;

EID: 77952954397     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.02.041     Document Type: Article

References (64)

1. Aizawa T., Sato Y., Komatsu M. Diabetes 2002, 51(Suppl 1):S96-S98.
2. Amiel S.A., Dixon T., Mann R., Jameson K. Diabet. Med. 2008, 25:245-254.
3. Bertram R., Smolen P., Sherman A., Mears D., Atwater I., Martin F., Soria B. Biophys. J. 1995, 68:2323-2332.
4. Campbell I.L., Iscaro A., Harrison L.C. J. Immunol. 1988, 141:2325-2329.
5. Cardozo A.K., Ortis F., Storling J., Feng Y.M., Rasschaert J., Tonnesen M., Van Eylen F., Mandrup-Poulsen T., Herchuelz A., Eizirik D.L. Diabetes 2005, 54:452-461.
6. Carter J.D., Dula S.B., Corbin K.L., Wu R., Nunemaker C.S. Biol Proced Online 2009, 11:3-31.
7. Chakrabarti S.K., James J.C., Mirmira R.G. J. Biol. Chem. 2002, 277:13286-13293.
8. Chen M., Yang Z., Wu R., Nadler J.L. Endocrinology 2002, 143:2341-2348.
9. Chen X.L., Dodd G., Sundell C.L., Kunsch C. Diabetes 2008, 57. pp. A359-A359.
10. Drash A.L., Rudert W.A., Borquaye S., Wang R., Lieberman I. Am. J. Cardiol. 1988, 62:27B-30B.
11. Dufer M., Krippeit-Drews P., Buntinas L., Siemen D., Drews G. Biochem. J. 2002, 368:817-825.
12. Eizirik D.L., Cardozo A.K., Cnop M. Endocr. Rev. 2008, 29:42-61.
13. Eizirik D.L., Pipeleers D.G., Ling Z., Welsh N., Hellerstrom C., Andersson A. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:9253-9256.
14. Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M. Endocr. Rev. 2002, 23:599-622.
15. Evans-Molina C., Robbins R.D., Kono T., Tersey S.A., Vestermark G.L., Nunemaker C.S., Garmey J.C., Deering T.G., Keller S.R., Maier B., Mirmira R.G. Mol. Cell. Biol. 2009.
16. Fukuda M., Ikegami H., Kawaguchi Y., Sano T., Ogihara T. Biochem. Biophys. Res. Commun. 1995, 209:953-958.
17. Goebel S., Huang M., Davis W.C., Jennings M., Siahaan T.J., Alexander J.S., Kevil C.G. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G648-G654.
18. Gorogawa S., Kajimoto Y., Umayahara Y., Kaneto H., Watada H., Kuroda A., Kawamori D., Yasuda T., Matsuhisa M., Yamasaki Y., Hori M. Diabetes Res. Clin. Pract. 2002, 57:1-10.
19. Henquin J.C. Diabetes 2000, 49:1751-1760.
20. Henquin J.C., Nenquin M., Stiernet P., Ahren B. Diabetes 2006, 55:441-451.
21. Herchuelz, A., Diaz-Horta, O., van Eylen, F., 2002. Diabetes Metab, 28, 3S54-3S60; discussion 3S108-12.
22. Hotamisligil G.S. Nature 2006, 444:860-867.
23. Jahanshahi P., Wu R., Carter J.D., Nunemaker C.S. Endocrinology 2009, 150:607-615.
24. Kaneto H., Kawamori D., Matsuoka T.A., Kajimoto Y., Yamasaki Y. Am. J. Ther. 2005, 12:529-533.
25. Klug E., Pfeffer M.A., McMurray J.J., Fleming A.G., Long W.A., Small R., Tardif J.C. Diabetes 2008, 57. pp. A132-A132.
26. Kunsch C., Luchoomun J., Grey J.Y., Olliff L.K., Saint L.B., Arrendale R.F., Wasserman M.A., Saxena U., Medford R.M. J. Pharmacol. Exp. Ther. 2004, 308:820-829.
27. Lankin V.Z., Korchin V.I., Konovalova G.G., Lisina M.O., Tikhaze A.K., Akmaev I.G. Bull. Exp. Biol. Med. 2004, 137:20-23.
28. Lee M.S., Chang I., Kim S. Mol. Genet. Metab. 2004, 83:82-92.
29. Luyendyk J.P., Piper J.D., Tencati M., Reddy K.V., Holscher T., Zhang R., Luchoomun J., Chen X., Min W., Kunsch C., Mackman N. Arterioscler. Thromb. Vasc. Biol. 2007, 27:1857-1863.
30. Mandrup-Poulsen T., Bendtzen K., Dinarello C.A., Nerup J. J. Immunol. 1987, 139:4077-4082.
31. Martin F., Soria B. Cell Calcium 1996, 20:409-414.
32. Mears D. J. Membr. Biol. 2004, 200:57-66.
33. Meng C.Q., Somers P.K., Hoong L.K., Zheng X.S., Ye Z., Worsencroft K.J., Simpson J.E., Hotema M.R., Weingarten M.D., Mac D.M.L., Hill R.R., Marino E.M., Suen K.L., Luchoomun J., Kunsch C., Landers L.K., Stefanopoulos D., Howard R.B., Sundell C.L., Saxena U., Wasserman M.A., Sikorski J.A. J. Med. Chem. 2004, 47:6420-6432.
34. Meng C.Q., Somers P.K., Rachita C.L., Holt L.A., Hoong L.K., Zheng X.S., Simpson J.E., Hill R.R., Olliff L.K., Kunsch C., Sundell C.L., Parthasarathy S., Saxena U., Sikorski J.A., Wasserman M.A. Bioorg. Med. Chem. Lett. 2002, 12:2545-2548.
35. Nunemaker C.S., Bertram R., Sherman A., Tsaneva-Atanasova K., Daniel C.R., Satin L.S. Biophys. J. 2006, 91:2082-2096.
36. Nunemaker C.S., Chen M., Pei H., Kimble S.D., Keller S.R., Carter J.D., Yang Z., Smith K.M., Wu R., Bevard M.H., Garmey J.C., Nadler J.L. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1065-E1075.
37. Nunemaker C.S., Wasserman D.H., McGuinness O.P., Sweet I.R., Teague J.C., Satin L.S. Am. J. Physiol. Endocrinol. Metab. 2006, 290:E523-E529.
38. Nunemaker C.S., Zhang M., Satin L.S. Diabetes 2004, 53:1765-1772.
39. Oprescu A.I., Bikopoulos G., Naassan A., Allister E.M., Tang C., Park E., Uchino H., Lewis G.F., Fantus I.G., Rozakis-Adcock M., Wheeler M.B., Giacca A. Diabetes 2007, 56:2927-2937.
40. Pralong W.F., Bartley C., Wollheim C.B. EMBO J. 1990, 9:53-60.
41. Rabinovitch A. Diabetes Metab. Rev. 1998, 14:129-151.
42. Rabinovitch A., Suarez-Pinzon W.L., Strynadka K., Schulz R., Lakey J.R., Warnock G.L., Rajotte R.V. J. Clin. Endocrinol. Metab. 1994, 79:1058-1062.
43. Robertson R.P., Harmon J., Tran P.O., Poitout V. Diabetes 2004, 53(Suppl 1):S119-S124.
44. Roe M.W., Mertz R.J., Lancaster M.E., Worley J.F., Dukes I.D. Am. J. Physiol. 1994, 266:E852-E862.
45. Roe M.W., Philipson L.H., Frangakis C.J., Kuznetsov A., Mertz R.J., Lancaster M.E., Spencer B., Worley J.F., Dukes I.D. J. Biol. Chem. 1994, 269:18279-18282.
46. Sato Y., Henquin J.C. Diabetes 1998, 47:1713-1721.
47. Scott A.M., Atwater I., Rojas E. Diabetologia 1981, 21:470-475.
48. Shoelson S.E., Lee J., Goldfine A.B. J. Clin. Invest. 2006, 116:1793-1801.
49. Sjoholm A., Berggren P.O., Cooney R.V. Biochem. Biophys. Res. Commun. 2000, 277:334-340.
50. Stocker R. Curr. Opin. Lipidol. 2009, 20:227-235.
51. Straub S.G., James R.F., Dunne M.J., Sharp G.W. Diabetes 1998, 47:758-763.
52. Sundell C.L., Fosgerau K., Chen X.L., Dodd G., Tang-Christensen M., Kunsch C. Diabetes 2008, 57:A167.
53. Sundell C.L., Somers P.K., Meng C.Q., Hoong L.K., Suen K.L., Hill R.R., Landers L.K., Chapman A., Butteiger D., Jones M., Edwards D., Daugherty A., Wasserman M.A., Alexander R.W., Medford R.M., Saxena U. J. Pharmacol. Exp. Ther. 2003, 305:1116-1123.
54. Takatori A., Ohta E., Inenaga T., Horiuchi K., Ishii Y., Itagaki S., Kyuwa S., Yoshikawa Y. Exp. Anim. 2003, 52:317-327.
55. Tardif J.C. Can. J. Cardiol. 2006, 22(Suppl B):61B-65B.
56. Tardif J.C., Cote G., Lesperance J., Bourassa M., Lambert J., Doucet S., Bilodeau L., Nattel S., de Guise P. N. Engl. J. Med. 1997, 337:365-372.
57. Tardif J.C., Gregoire J., L'Allier P.L., Ibrahim R., Anderson T.J., Reeves F., Title L.M., Schampaert E., LeMay M., Lesperance J., Scott R., Guertin M.C., Brennan M.L., Hazen S.L., Bertrand O.F. Atherosclerosis 2008, 197:480-486.
58. Tardif J.C., Gregoire J., Schwartz L., Title L., Laramee L., Reeves F., Lesperance J., Bourassa M.G., L'Allier P.L., Glass M., Lambert J., Guertin M.C. Circulation 2003, 107:552-558.
59. Tardif J.C., McMurray J.J., Klug E., Small R., Schumi J., Choi J., Cooper J., Scott R., Lewis E.F., L'Allier P.L., Pfeffer M.A. Lancet 2008, 371:1761-1768.
60. Terauchi Y., Takamoto I., Kubota N., Matsui J., Suzuki R., Komeda K., Hara A., Toyoda Y., Miwa I., Aizawa S., Tsutsumi S., Tsubamoto Y., Hashimoto S., Eto K., Nakamura A., Noda M., Tobe K., Aburatani H., Nagai R., Kadowaki T. J. Clin. Invest. 2007, 117:246-257.
61. Uehara Y., Shimizu H., Sato N., Shimomura Y., Mori M., Kobayashi I. Diabetes Res. 1991, 17:131-134.
62. Weir G.C., Sharma A., Zangen D.H., Bonner-Weir S. Acta Diabetol. 1997, 34:177-184.
63. Yang Z., Chen M., Ellett J.D., Carter J.D., Brayman K.L., Nadler J.L. Am. J. Transplant. 2005, 5:475-483.
64. Ye J., Laychock S.G. Endocrinology 1998, 139:4155-4163.