Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Xie, Chencheng ^a   Lu, Huarui ^a   Nomura, Alice ^a   Hanse, Eric Allan ^a   Forster, Colleen Lynn ^b   Parker, Josh Berken ^b   Linden, Michael Andrew ^a   Karasch, Chris ^a   Hallstrom, Timothy Curtis ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Apoptosis; E2F1; PTEN; RB; Retinoblastoma

Indexed keywords

CALBINDIN; CASPASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN; SHORT HAIRPIN RNA; SYNTAXIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO4; TRANSCRIPTION FACTOR FOXO6; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; PIK3CA PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPORATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RETINA; RETINOBLASTOMA; STEM CELL; TUNEL ASSAY; ANIMAL; BIOLOGICAL MODEL; CELL TRANSFORMATION; CYTOLOGY; DISEASE MODEL; GENE DELETION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PENETRANCE; SIGNAL TRANSDUCTION;

MURINAE; MUS;

ANIMALS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; FORKHEAD BOX PROTEIN O1; FORKHEAD TRANSCRIPTION FACTORS; GENE DELETION; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PENETRANCE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RETINA; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84928545500     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0360-y     Document Type: Article

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