Cooperation between Rb and Arf in suppressing mouse retinoblastoma

Journal of Clinical Investigation

Volumn 122, Issue 5, 2012, Pages 1726-1733

  Conkrite, Karina ^a   Sundby, Maggie ^a   Mu, David ^b   Mukai, Shizuo ^c   MacPherson, David ^a  

^a GEOPHYSICAL LABORATORY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RETINA; RETINOBLASTOMA; TUMOR SUPPRESSOR GENE;

ADP-RIBOSYLATION FACTORS; ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COMPARATIVE GENOMIC HYBRIDIZATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENES, RETINOBLASTOMA; HUMANS; LOSS OF HETEROZYGOSITY; MICE; MICE, KNOCKOUT; RETINAL NEOPLASMS; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860594922     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61403     Document Type: Article

References (34)

1. Macpherson D. Insights from mouse models into human retinoblastoma. Cell Div. 2008;3:9.
2. Corson TW, Gallie BL. One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer. 2007; 46(7):617-634. (Pubitemid 46802329)
3. Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer. 2008;8(9):671-682.
4. Dimaras H, et al. Loss of RB1 induces non-proliferative retinoma; increasing genomic instability correlates with progression to retinoblastoma. Hum Mol Genet. 2008;17(10):1363-1372. (Pubitemid 351627333)
5. Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 2004;5(6):539-551. (Pubitemid 38748916)
6. MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J. 2007;26(3):784-794.
7. Laurie NA, et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006;444(7115):61-66. (Pubitemid 44684754)
8. Xu XL, et al. Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling. Cell. 2009;137(6):1018-1031.
9. Aslanian A, Iaquinta PJ, Verona R, Lees JA. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 2004; 18(12):1413-1422. (Pubitemid 38780628)
10. Bates S, et al. p14ARF links the tumour suppressors RB and p53. Nature. 1998;395(6698):124-125. (Pubitemid 28425642)
11. Brennan RC, et al. Targeting the p53 Pathway in Retinoblastoma with Subconjunctival Nutlin-3a. Cancer Res. 2011;71(12):4205-4213.
12. Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, Gruss P. Pax6 is required for the multipotent state of retinal progenitor cells. Cell. 2001;105(1):43-55. (Pubitemid 32323915)
13. MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 2004; 18(14):1681-1694. (Pubitemid 38938185)
14. Conkrite K, et al. miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev. 2011;25(16):1734-1745.
15. Lowe SW, Sherr CJ. Tumor suppression by Ink4a- Arf: progress and puzzles. Curr Opin Genet Dev. 2003; 13(1):77-83. (Pubitemid 36143931)
16. Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev. 1999; 9(1):22-30. (Pubitemid 29080383)
17. Sangwan M, et al. Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation [published online ahead of print January 30, 2012]. Oncogene. doi:10.1038/ onc.2011.654.
18. McKeller RN, et al. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. Proc Natl Acad Sci U S A. 2002;99(6):3848-3853. (Pubitemid 34252194)
19. Weber JD, et al. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 2000; 14(18):2358-2365.
20. Zhang J, Schweers B, Dyer MA. The first knockout mouse model of retinoblastoma. Cell Cycle. 2004; 3(7):952-959. (Pubitemid 40185382)
21. Gallie BL, Campbell C, Devlin H, Duckett A, Squire JA. Developmental basis of retinal-specific induction of cancer by RB mutation. Cancer Res. 1999; 59(7 suppl):1731s-1735s. (Pubitemid 29165246)
22. Kato MV, et al. Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma. Cancer Lett. 1996;106(1):75-82. (Pubitemid 26306640)
23. Olive KP, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004; 119(6):847-860. (Pubitemid 40017690)
24. de Vries A, et al. Targeted point mutations of p53 lead to dominant-negative inhibition of wildtype p53 function. Proc Natl Acad Sci U S A. 2002; 99(5):2948-2953.
25. Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118.
26. McEvoy J, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011;20(2):260-275.
27. De Clercq S, et al. Widespread overexpression of epitope- tagged Mdm4 does not accelerate tumor formation in vivo. Mol Cell Biol. 2010;30(22):5394- 5405.
28. Choy KW, Pang CP, To KF, Yu CB, Ng JS, Lam DS. Impaired expression and promotor hypermethylation of O6-methylguanine-DNA methyltransferase in retinoblastoma tissues. Invest Ophthalmol Vis Sci. 2002;43(5):1344-1349. (Pubitemid 34462629)
29. Churchman ML, Roig I, Jasin M, Keeney S, Sherr CJ. Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. PLoS Genet. 2011;7(7):e1002157.
30. Sherr CJ. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer. 2006;6(9):663-673. (Pubitemid 44285999)
31. Lakshmi B, et al. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A. 2006; 103(30):11234-11239. (Pubitemid 44156502)
32. Tsai KY, et al. ARF mutation accelerates pituitary tumor development in Rb+/- mice. Proc Natl Acad Sci U S A. 2002;99(26):16865-16870. (Pubitemid 36034064)
33. Liu Y, Bodmer WF. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc Natl Acad Sci U S A. 2006;103(4):976-981. (Pubitemid 43212207)
34. Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc. 2009;4(12):1798-1806.