Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A

Journal of Hematology and Oncology

Volumn 8, Issue 1, 2015, Pages

  Karrman, Kristina ^a,b   Castor, Anders ^c   Behrendtz, Mikael ^d   Forestier, Erik ^e   Olsson, Linda ^b   Ehinger, Mats ^a   Biloglav, Andrea ^b   Fioretos, Thoas ^a,b   Paulsson, Kajsa ^b   Johansson, Bertil ^a,b  

^a University and Regional Laboratories ^*  (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^e UMEÅ UNIVERSITY   (Sweden)

Author keywords

Genetic characterization; Large scale sequencing; Pediatric; SNP array; T ALL

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; LYMPHOID ENHANCER FACTOR 1; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; NOTCH1 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; CDKN2A GENE; CDKN2B GENE; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; EPIGENETICS; FEMALE; GENE CONTROL; GENE DELETION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENETIC ANALYSIS; GENETIC ASSOCIATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LEF1 GENE; MALE; MOLECULAR CLONING; MOLECULAR PATHOLOGY; MUTATIONAL ANALYSIS; NEWBORN; NOTCH1 GENE; ONCOGENE; PTEN GENE; RBI GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STIL GENE; T CELL ACUTE LYMPHOBLASTIC LEUKEMIA; TRANSCRIPTION REGULATION; UNIPARENTAL DISOMY; GENETICS; INCIDENCE;

CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; INCIDENCE; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1; UNIPARENTAL DISOMY;

EID: 84928536653     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-015-0138-0     Document Type: Article

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