메뉴 건너뛰기




Volumn 28, Issue 2, 2014, Pages 302-310

Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011

Author keywords

IKZF1; pediatric acute lymphoblastic leukemia; relapse; single nucleotide polymorphism array analyses; SPRED1

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADD3 GENE; ADOLESCENT; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RISK; CANCER SURVIVAL; CDKN2A GENE; CHILD; CHILDHOOD CANCER; CLINICAL FEATURE; CLONAL EVOLUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; EBF1 GENE; ETV6G GENE; EVENT FREE SURVIVAL; FEMALE; GENE DELETION; GENE REARRANGEMENT; GENOMICS; HAPLOIDY; HUMAN; IKZF1 GENE; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PAN3 GENE; PAX5 GENE; POPULATION BASED CASE CONTROL STUDY; PRE B LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; RAG1 GENE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SPRED1 GENE; TBL1XR1 GENE; UNIPARENTAL DISOMY;

EID: 84893766383     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.206     Document Type: Article
Times cited : (67)

References (51)
  • 3
    • 32944461889 scopus 로고    scopus 로고
    • Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: Results of trial acute lymphoblastic leukemiarelapse study of the Berlin-Frankfurt-Münster Group 87
    • Einsiedel HG, von Stackelberg A, Hartmann R, Fengler R, Schrappe M, Janka-Schaub G et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemiarelapse study of the Berlin-Frankfurt-Münster Group 87. J Clin Oncol 2005; 23: 7942-7950.
    • (2005) J Clin Oncol , vol.23 , pp. 7942-7950
    • Einsiedel, H.G.1    Von Stackelberg, A.2    Hartmann, R.3    Fengler, R.4    Schrappe, M.5    Janka-Schaub, G.6
  • 5
    • 37648999300 scopus 로고    scopus 로고
    • Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952
    • Malempati S, Gaynon PS, Sather H, La MK, Stork LC. Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952. J Clin Oncol 2007; 25: 5800-5807.
    • (2007) J Clin Oncol , vol.25 , pp. 5800-5807
    • Malempati, S.1    Gaynon, P.S.2    Sather, H.3    La, M.K.4    Stork, L.C.5
  • 6
    • 33846892770 scopus 로고    scopus 로고
    • Risk-and response-based classification of childhood B-precursor acute lymphoblastic leukemia: A combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)
    • Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ et al. Risk-and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG). Blood 2007; 109: 926-935.
    • (2007) Blood , vol.109 , pp. 926-935
    • Schultz, K.R.1    Pullen, D.J.2    Sather, H.N.3    Shuster, J.J.4    Devidas, M.5    Borowitz, M.J.6
  • 7
    • 0025322447 scopus 로고
    • Karyotypic changes from initial diagnosis to relapse in childhood acute leukemia
    • Shikano T, Ishikawa Y, Ohkawa M, Hatayama Y, Nakadate H, Hatae Y et al. Karyotypic changes from initial diagnosis to relapse in childhood acute leukemia. Leukemia 1990; 4: 419-422.
    • (1990) Leukemia , vol.4 , pp. 419-422
    • Shikano, T.1    Ishikawa, Y.2    Ohkawa, M.3    Hatayama, Y.4    Nakadate, H.5    Hatae, Y.6
  • 8
    • 0026600953 scopus 로고
    • Cytogenetic analysis in relapse childhood acute lymphoblastic leukemia
    • Heerema NA, Palmer CG, Weetman R, Bertolone S. Cytogenetic analysis in relapse childhood acute lymphoblastic leukemia. Leukemia 1992; 6: 185-192.
    • (1992) Leukemia , vol.6 , pp. 185-192
    • Heerema, N.A.1    Palmer, C.G.2    Weetman, R.3    Bertolone, S.4
  • 9
    • 34547123580 scopus 로고    scopus 로고
    • Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone
    • Choi S, Henderson MJ, Kwan E, Beesley AH, Sutton R, Bahar AY et al. Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone. Blood 2007; 110: 632-639.
    • (2007) Blood , vol.110 , pp. 632-639
    • Choi, S.1    Henderson, M.J.2    Kwan, E.3    Beesley, A.H.4    Sutton, R.5    Bahar, A.Y.6
  • 11
    • 0347357869 scopus 로고    scopus 로고
    • Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development
    • Peham M, Konrad M, Harbott J, Kö nig M, Haas OA, Panzer-Grümayer ER. Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development. Genes Chromosomes Cancer 2004; 39: 156-160.
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 156-160
    • Peham, M.1    Konrad, M.2    Harbott, J.3    König, M.4    Haas, O.A.5    Panzer-Grümayer, E.R.6
  • 12
    • 4143127775 scopus 로고    scopus 로고
    • TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia
    • Zuna J, Ford AM, Peham M, Patel N, Saha V, Eckert C et al. TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. Clin Cancer Res 2004; 10: 5355-5360.
    • (2004) Clin Cancer Res , vol.10 , pp. 5355-5360
    • Zuna, J.1    Ford, A.M.2    Peham, M.3    Patel, N.4    Saha, V.5    Eckert, C.6
  • 13
    • 61549114444 scopus 로고    scopus 로고
    • Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia
    • Yang JJ, Bhojwani D, Yang W, Cai X, Stocco G, Crews K et al. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood 2008; 112: 4178-4183.
    • (2008) Blood , vol.112 , pp. 4178-4183
    • Yang, J.J.1    Bhojwani, D.2    Yang, W.3    Cai, X.4    Stocco, G.5    Crews, K.6
  • 16
    • 77952485949 scopus 로고    scopus 로고
    • Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: Presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations
    • Davidsson J, Paulsson K, Lindgren D, Lilljebjö rn H, Chaplin T, Forestier E et al. Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations. Leukemia 2010; 24: 924-931.
    • (2010) Leukemia , vol.24 , pp. 924-931
    • Davidsson, J.P.1
  • 19
    • 80052922387 scopus 로고    scopus 로고
    • Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
    • Zhang J, Mullighan CG, Harvey RC, Wu G, Chen X, Edmonson M et al. Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood 2011; 118: 3080-3087.
    • (2011) Blood , vol.118 , pp. 3080-3087
    • Zhang, J.1    Mullighan, C.G.2    Harvey, R.C.3    Wu, G.4    Chen, X.5    Edmonson, M.6
  • 20
    • 79751538993 scopus 로고    scopus 로고
    • Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predict 79% of relapses in pediatric acute lymphoblastic leukemia
    • Waanders E, van der Velden VHJ, van der Schoot CE, van Leeuwen FN, van Reijmersdal SV, de Haas V et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predict 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011; 25: 254-258.
    • (2011) Leukemia , vol.25 , pp. 254-258
    • Waanders, E.1    Van Der Velden, V.H.J.2    Van Der Schoot, C.E.3    Van Leeuwen, F.N.4    Van Reijmersdal, S.V.5    De Haas, V.6
  • 22
    • 34548328245 scopus 로고    scopus 로고
    • Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype
    • Brems H, Chmara M, Sahbatou M, Denayer E, Taniguchi K, Kato R et al. Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. Nat Genet 2007; 39: 1120-1126.
    • (2007) Nat Genet , vol.39 , pp. 1120-1126
    • Brems, H.1    Chmara, M.2    Sahbatou, M.3    Denayer, E.4    Taniguchi, K.5    Kato, R.6
  • 24
    • 53049109135 scopus 로고    scopus 로고
    • Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia
    • Case M, Matheson E, Minto L, Hassan R, Harrison CJ, Bown N et al. Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia. Cancer Res 2008; 68: 6803-6809.
    • (2008) Cancer Res , vol.68 , pp. 6803-6809
    • Case, M.1    Matheson, E.2    Minto, L.3    Hassan, R.4    Harrison, C.J.5    Bown, N.6
  • 25
    • 0031790607 scopus 로고    scopus 로고
    • Location and function of linker histones
    • Vignali M, Workman JL. Location and function of linker histones. Nat Struct Biol 1998; 5: 1025-1028.
    • (1998) Nat Struct Biol , vol.5 , pp. 1025-1028
    • Vignali, M.1    Workman, J.L.2
  • 26
    • 80054047151 scopus 로고    scopus 로고
    • Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles
    • Loudin MG, Wang J, Esastwood Leung H-C, Gurusiddappa S, Meyer J, Condos G et al. Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles. Leukemia 2011; 25: 1555-1563.
    • (2011) Leukemia , vol.25 , pp. 1555-1563
    • Loudin, M.G.1    Wang, J.2    Esastwood Leung, H.-C.3    Gurusiddappa, S.4    Meyer, J.5    Condos, G.6
  • 28
    • 84868155769 scopus 로고    scopus 로고
    • Disordered epigenetic regulation in MLL-related leukemia
    • Zhang Y, Chen A, Yan XM, Huang G. Disordered epigenetic regulation in MLL-related leukemia. Int J Hematol 2012; 96: 428-437.
    • (2012) Int J Hematol , vol.96 , pp. 428-437
    • Zhang, Y.1    Chen, A.2    Yan, X.M.3    Huang, G.4
  • 29
    • 77958559111 scopus 로고    scopus 로고
    • HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL
    • Starkova J, Zamostna B, Mejstrikova E, Krejci R, Drabkin HA, Trka J. HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL. Pediatr Blood Cancer 2010; 55: 1072-1082.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 1072-1082
    • Starkova, J.1    Zamostna, B.2    Mejstrikova, E.3    Krejci, R.4    Drabkin, H.A.5    Trka, J.6
  • 30
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309-315.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Zh, G.3    Pan, C.M.4    Lu, G.5    Shen, Y.6
  • 31
    • 84868157863 scopus 로고    scopus 로고
    • Epigenetic alterations in hematopoietic malignancies
    • Chung YR, Schatoff E, Abdel-Wahab O. Epigenetic alterations in hematopoietic malignancies. Int J Hematol 2012; 96: 413-427.
    • (2012) Int J Hematol , vol.96 , pp. 413-427
    • Chung, Y.R.1    Schatoff, E.2    Abdel-Wahab, O.3
  • 32
    • 57149113918 scopus 로고    scopus 로고
    • The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1
    • Parker H, An Q, Barber K, Case M, Davies T, Konn Z et al. The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1. Genes Chromosomes Cancer 2008; 47: 1118-1125.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 1118-1125
    • Parker, H.1    An, Q.2    Barber, K.3    Case, M.4    Davies, T.5    Konn, Z.6
  • 33
    • 79960691203 scopus 로고    scopus 로고
    • Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia
    • Hauer J, Mullighan CG, Morillon E, Wang G, Bruneau J, Brousse N et al. Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia. Blood 2011; 118: 544-553.
    • (2011) Blood , vol.118 , pp. 544-553
    • Hauer, J.1    Mullighan, C.G.2    Morillon, E.3    Wang, G.4    Bruneau, J.5    Brousse, N.6
  • 34
    • 20444435388 scopus 로고    scopus 로고
    • Expression of adducin genes during erythropoiesis: A novel erythroid promoter for ADD2
    • Yenerel MN, Sundell IB, Weese J, Bulger M, Gilligan DM. Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2. Exp Hematol 2005; 33: 758-766.
    • (2005) Exp Hematol , vol.33 , pp. 758-766
    • Yenerel, M.N.1    Sundell, I.B.2    Weese, J.3    Bulger, M.4    Gilligan, D.M.5
  • 36
    • 0029811599 scopus 로고    scopus 로고
    • PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae
    • Brown CE, Tarun Jr SZ, Boeck R, Sachs AB. PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Mol Cell Biol 1996; 16: 5744-5753.
    • (1996) Mol Cell Biol , vol.16 , pp. 5744-5753
    • Brown, C.E.1    Tarun Jr., S.Z.2    Boeck, R.3    Sachs, A.B.4
  • 37
    • 0038070047 scopus 로고    scopus 로고
    • NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15)
    • Lahortiga I, Vizmanos JL, Agirre X, Vázquez I, Cigudosa JC, Larrayoz MJ et al. NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15). Cancer Res 2003; 63: 3079-3083.
    • (2003) Cancer Res , vol.63 , pp. 3079-3083
    • Lahortiga, I.1    Vizmanos, J.L.2    Agirre, X.3    Vázquez, I.4    Cigudosa, J.C.5    Larrayoz, M.J.6
  • 38
    • 78649742010 scopus 로고    scopus 로고
    • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics and outcome
    • Harvey RC, Mullighan CG, Wang X, Dobbin KK, Davidson GS, Bedrick EJ et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics and outcome. Blood 2010; 116: 4874-4884.
    • (2010) Blood , vol.116 , pp. 4874-4884
    • Harvey, R.C.1    Mullighan, C.G.2    Wang, X.3    Dobbin, K.K.4    Davidson, G.S.5    Bedrick, E.J.6
  • 39
    • 78650745577 scopus 로고    scopus 로고
    • Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
    • Paulsson K, Forestier E, Lilljebjö rn H, Heldrup J, Behrendtz M, Young BD et al. Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010; 107: 21719-21724.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21719-21724
    • Paulsson, K.F.1
  • 40
    • 27544446055 scopus 로고    scopus 로고
    • Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course
    • Irving JA, Minto L, Bailey S, Hall AG. Loss of heterozygosity and somatic mutations of the glucocorticoid receptor gene are rarely found at relapse in pediatric acute lymphoblastic leukemia but may occur in a subpopulation early in the disease course. Cancer Res 2005; 65: 9712-9718.
    • (2005) Cancer Res , vol.65 , pp. 9712-9718
    • Irving, J.A.1    Minto, L.2    Bailey, S.3    Hall, A.G.4
  • 41
    • 0041034370 scopus 로고    scopus 로고
    • The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation
    • Prevot D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP et al. The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. J Biol Chem 2000; 275: 147-153.
    • (2000) J Biol Chem , vol.275 , pp. 147-153
    • Prevot, D.1    Voeltzel, T.2    Birot, A.M.3    Morel, A.P.4    Rostan, M.C.5    Magaud, J.P.6
  • 42
    • 84859193076 scopus 로고    scopus 로고
    • The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution
    • Waanders E, Scheijen B, van der Meer LT, van Reijmersdal SV, van Emst L, Kroeze Y et al. The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution. PLoS Genet 2012; 8: e1002533.
    • (2012) PLoS Genet , vol.8
    • Waanders, E.1    Scheijen, B.2    Van Der Meer, L.T.3    Van Reijmersdal, S.V.4    Van Emst, L.5    Kroeze, Y.6
  • 43
    • 77954719755 scopus 로고    scopus 로고
    • BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia
    • van Galen JC, Kuiper RP, van Emst L, Levers M, Tijchon E, Scheijen B et al. BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia. Blood 2010; 115: 4810-4819.
    • (2010) Blood , vol.115 , pp. 4810-4819
    • Van Galen, J.C.1    Kuiper, R.P.2    Van Emst, L.3    Levers, M.4    Tijchon, E.5    Scheijen, B.6
  • 44
    • 33746617271 scopus 로고    scopus 로고
    • Glococorticoid-induced glucocorticoid-receptor expression and promoter usage is not linked to glucocorticoid resistance in childhood ALL
    • Tissing WJ, Meijerink JP, Brinkhof B, Broekhuis MJ, Menezes RX, den Boer ML et al. Glococorticoid-induced glucocorticoid-receptor expression and promoter usage is not linked to glucocorticoid resistance in childhood ALL. Blood 2006; 108: 1045-1049.
    • (2006) Blood , vol.108 , pp. 1045-1049
    • Tissing, W.J.1    Meijerink, J.P.2    Brinkhof, B.3    Broekhuis, M.J.4    Menezes, R.X.5    Den Boer, M.L.6
  • 45
    • 55549094418 scopus 로고    scopus 로고
    • Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: The effect of TLX3/HOX11L2 gene expression on outcome
    • Ballerini P, Landman-Parker J, Cayuela JM, Asnafi V, Labopin M, Gandemer V et al. Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: the effect of TLX3/HOX11L2 gene expression on outcome. Haematologica 2008; 93: 1658-1665.
    • (2008) Haematologica , vol.93 , pp. 1658-1665
    • Ballerini, P.1    Landman-Parker, J.2    Cayuela, J.M.3    Asnafi, V.4    Labopin, M.5    Gandemer, V.6
  • 46
    • 2542442633 scopus 로고    scopus 로고
    • Transcriptional control of early B cell development
    • Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol 2004; 22: 55-79.
    • (2004) Annu Rev Immunol , vol.22 , pp. 55-79
    • Busslinger, M.1
  • 47
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79: 143-156.
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3    Molnar, A.4    Wu, P.5    Winandy, S.6
  • 48
    • 70449719091 scopus 로고    scopus 로고
    • IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report
    • Martinelli G, Iacobucci I, Storlazzi CT, Vignetti M, Paoloni F, Cilloni D et al. IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 2009; 27: 5202-5207.
    • (2009) J Clin Oncol , vol.27 , pp. 5202-5207
    • Martinelli, G.1    Iacobucci, I.2    Storlazzi, C.T.3    Vignetti, M.4    Paoloni, F.5    Cilloni, D.6
  • 49
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in B-progenitor-and Down syndrome-associated acute lymphoblastic leukemia
    • Mullighan CG, Collins-Underwood JR, Phillips LAA, Loudin MG, Liu W, Zhang J et al. Rearrangement of CRLF2 in B-progenitor-and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet 2009; 41: 1243-1246.
    • (2009) Nat Genet , vol.41 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Laa, P.3    Loudin, M.G.4    Liu, W.5    Zhang, J.6
  • 50
    • 84859820034 scopus 로고    scopus 로고
    • Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: A Children's Oncology Group study
    • Chen IM, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H et al. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. Blood 2012; 119: 3512-3522.
    • (2012) Blood , vol.119 , pp. 3512-3522
    • Chen, I.M.1    Harvey, R.C.2    Mullighan, C.G.3    Gastier-Foster, J.4    Wharton, W.5    Kang, H.6
  • 51
    • 84883744330 scopus 로고    scopus 로고
    • Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols
    • Ö fverholm I, Tran AN, Heyman M, Zachariadis V, Nordenskjö ld M, Nordgren A et al. Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols. Leukemia 2013; 27: 1936-1939.
    • (2013) Leukemia , vol.27 , pp. 1936-1939
    • Fverholm, O.1    Tran, A.N.2    Heyman, M.3    Zachariadis, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.