Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: Rare T-cell receptor gene rearrangements are associated with poor outcome

Genes Chromosomes and Cancer

Volumn 48, Issue 9, 2009, Pages 795-805

  Karrman, Kristina ^a   Forestier, Erik ^b   Heyman, Mats ^c   Andersen, Mette K ^d   Autio, Kirsi ^e   Blennow, Elisabeth ^f   Borgström, Georg ^e   Ehrencrona, Hans ^g   Golovleva, Irina ^b   Heim, Sverre ^h,i   Heinonen, Kristiina ^j   Hovland, Randi ^k   Johannsson, Johann H ^l   Kerndrup, Gitte ^m   Nordgren, Ann ^f   Palmqvist, Lars ⁿ   Johansson, Bertil ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d Rigshospitalet   (Denmark)

^e UNIVERSITY OF HELSINKI   (Finland)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UPPSALA UNIVERSITY   (Sweden)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

ⁱ UNIVERSITY OF OSLO   (Norway)

^j ISLAB   (Finland)

^k HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^l LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^m ODENSE UNIVERSITY HOSPITAL   (Denmark)

ⁿ SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; CENTRAL NERVOUS SYSTEM LEUKEMIA; CHILD; CHROMOSOME 10Q; CHROMOSOME 11P; CHROMOSOME 14Q; CHROMOSOME 1P; CHROMOSOME 5Q; CHROMOSOME 7P; CHROMOSOME 7Q; CHROMOSOME 8Q; CHROMOSOME 9P; CHROMOSOME DELETION; CHROMOSOME INSERTION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; CHROMOSOME XP; CHROMOSOME XQ; EVENT FREE SURVIVAL; FEMALE; GENE REARRANGEMENT; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEDIASTINUM MASS; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; SEX RATIO; T CELL LEUKEMIA;

ADOLESCENT; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; COHORT STUDIES; CYTOGENETIC ANALYSIS; FEMALE; GENE REARRANGEMENT, T-LYMPHOCYTE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MULTIVARIATE ANALYSIS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTORS, ANTIGEN, T-CELL;

EID: 68549109745     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20684     Document Type: Article

References (33)

1. Aifantis I, Raetz E, Buonamici S. 2008. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 8:380-390.
2. Aricò M, Basso G, Mandelli F, Rizzari C, Colella R, Barisone E, Zanesco L, Rondelli R, Pession A, Masera G. 1995. Good steroid response in vivo predicts a favorable outcome in children with T-cell acute lymphoblastic leukemia. Cancer 75:1684-1693.
3. Ballerini P, Landman-Parker J, Cayuela JM, Asnafi V, Labopin M, Gandemer V, Perel Y, Michel G, Leblanc T, Schmitt C, Fasola S, Hagemejier A, Sigaux F, Auclerc MF, Douay L, Leverger G, Baruchel A. 2008. Impact of genotype on survival of children with T-cell acute lymphoblastic leukemia treated according to the French protocol FRALLE-93: The effect of TLX3/ HOX11L2 gene expression on outcome. Haematologica 93:1658-1665.
4. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, van't Veer MB. 1995. Proposals for the immunological classi-fication of acute leukemias. Leukemia 9:1783-1786.
5. Bergeron J, Clappier E, Radford I, Buzyn A, Millien C, Soler G, Ballerini P, Thomas X, Soulier J, Dombret H, Macintyre EA, Asnafi V. 2007. Prognostic and oncogenic relevance of TLX1/ HOX11 expression level in T-ALLs. Blood 110:2324-2330.
6. Bertin R, Acquaviva C, Mirebeau D, Guidal-Giroux C, Vilmer E, Cave H. 2003. CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 37:44-57.
7. Breit S, Stanulla M, Flohr T, Schrappe M, Ludwig WD, Tolle G, Happich M, Muckenthaler MU, Kulozik AE. 2006. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 108:1151-1157.
8. Cauwelier B, Dastugue N, Cools J, Poppe B, Herens C, De Paepe A, Hagemeijer A, Speleman F. 2006. Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes. Leukemia 20:1238-1244.
9. Cauwelier B, Cavé H, Gervais C, Lessard M, Barin C, Perot C, Van den Akker J, Mugneret F, Charrin C, Pagès MP, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Mozzicconacci MJ, Terré C, Luquet I, Cornillet-Lefebvre P, Laurence B, Plessis G, Lefebvre C, Leroux D, Antoine-Poirel H, Graux C, Mauvieux L, Heimann P, Chalas C, Clappier E, Verhasselt B, Benoit Y, Moerloose BD, Poppe B, Van Roy N, Keersmaecker KD, Cools J, Sigaux F, Soulier J, Hagemeijer A, Paepe AD, Dastugue N, Berger R, Speleman F. 2007. Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: A study of the Groupe Francophone de Cytogénétique Hématologique. Leukemia 21:121-128.
10. Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N. 2004. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: Results of EORTC studies 58881 and 58951. Blood 103:442-450.
11. Erikson J, Finger L, Sun L, ar-Rushdi A, Nishikura K, Minowada J, Finan J, Emanuel BS, Nowell PC, Croce CM. 1986. Deregulation of c-myc by translocation of the a-locus of the T-cell receptor in T-cell leukemias. Science 232:884-886.
12. Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM. 1989. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci USA 86:5039-5043.
13. Garand R, Vannier JP, Béné MC, Faure G, Favre M, Bernard A. 1990. Comparison of outcome, clinical, laboratory, and immunological features in 164 children and adults with T-ALL. Leukemia 4:739-744.
14. Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. 2006. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast. Leukemia 20:1496-1510.
15. Gustafsson G, Schmiegelow K, Forestier E, Clausen N, Glomstein A, Jonmundsson G, Mellander L, Mäkipernaa A, Nygaard R, Saarinen-Pihkala UM. 2000. Improving outcome through two decades in childhood ALL in the Nordic countries: The impact of high-dose methotrexate in the reduction of CNS irradiation. Leukemia 14:2267-2275.
16. Heerema NA, Sather HN, Sensel MG, Kraft P, Nachman JB, Steinherz PG, Lange BJ, Hutchinson RS, Reaman GH, Trigg ME, Arthur DC, Gaynon PS, Uckun FM. 1998. Frequency and clinical significance of cytogenetic abnormalities in pediatric Tlineage acute lymphoblastic leukemia: A report from the Children's Cancer Group. J Clin Oncol 16:1270-1278.
17. Heerema NA, Sather HN, Sensel MG, Lee MK, Hutchinson R, Lange BJ, Bostrom BC, Nachman JB, Steinherz PG, Gaynon PS, Uckun FM. 2000. Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group. Leuk Lymphoma 36:467-478.
18. Huret JL, Brizard A, Slater R, Charrin C, Bertheas MF, Guilhot F, Hählen K, Kroes W, van Leeuwen E, Schoot EV, Beishuizen A, Tanzer J, Hagemeijer A. 1993. Cytogenetic heterogeneity in t(11;19) acute leukemia: Clinical, hematological and cytogenetic analyses of 48 patients-Updated published cases and 16 new observations. Leukemia 7:152-160.
19. Karrman K, Andersson A, Björgvinsdóttir H, Strömbeck B, Lassen C, Olofsson T, Nguyen-Khac F, Berger R, Bernard O, Fioretos T, Johansson B. 2006. Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. Eur J Haematol 77:27-34.
20. Karrman K, Kjeldsen E, Lassen C, Isaksson M, Davidsson J, Andersson A, Hasle H, Fioretos T, Johansson B. 2009. The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. Br J Haematol 144:546-551.
21. Malyukova A, Dohda T, von der Lehr N, Akhoondi S, Corcoran M, Heyman M, Spruck C, Grandér D, Lendahl U, Sangfelt O. 2007. The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res 67:5611-5616.
22. Mitelman F, Johansson B, Mertens F. 2009. Mitelman Database of Chromosome Aberrations in Cancer. http://cgap.nci.nih.gov/ Chromosomes/Mitelman.
23. Pui CH, Behm FG, Singh B, Schell MJ, Williams DL, Rivera GK, Kalwinsky DK, Sandlund JT, Crist WM, Raimondi SC. 1990. Heterogeneity of presenting features and their relation to treatment outcome in 120 children with T-cell acute lymphoblastic leukemia. Blood 75:174-179.
24. Pullen J, Shuster JJ, Link M, Borowitz M, Amylon M, Carroll AJ, Land V, Look AT, McIntyre B, Camitta B. 1999. Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. Leukemia 13:1696-1707.
25. Ramakers-van Woerden NL, Pieters R, Slater RM, Loonen AH, Beverloo HB, van Drunen E, Heyman M, Moreno TC, Rots MG, van Wering ER, Kamps WA, Janka-Schaub GE, Veerman AJ. 2001. In vitro drug resistance and prognostic impact of p16INK4A/P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia. Br J Haematol 112:680-690.
26. Rubnitz JE, Camitta BM, Mahmoud H, Raimondi SC, Carroll AJ, Borowitz MJ, Shuster JJ, Link MP, Pullen DJ, Downing JR, Behm FG, Pui CH. 1999. Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation. J Clin Oncol 17:191-196.
27. Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ, Camitta BM, Katz JA, Amylon MD. 2000. New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: A pediatric oncology group report of 343 cases. Blood 96:2543-2549.
28. Shuster JJ, Falletta JM, Pullen DJ, Crist WM, Humphrey GB, Dowell BL, Wharam MD, Borowitz M. 1990. Prognostic factors in childhood T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood 75:166-173.
29. Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, Van Roy N, Vandesompele J, Graux C, Uyttebroeck A, Boogaerts M, De Moerloose B, Benoit Y, Selleslag D, Billiet J, Robert A, Huguet F, Vandenberghe P, De Paepe A, Marynen P, Hagemeijer A. 2005. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 19:358-366.
30. van Grotel M, Meijerink JP, van Wering ER, Langerak AW, Beverloo HB, Buijs-Gladdines JG, Burger NB, Passier M, van Lieshout EM, Kamps WA, Veerman AJ, van Noesel MM, Pieters R. 2008. Prognostic significance of molecular- cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences. Leukemia 22:124-131.
31. Van Vlierberghe P, van Grotel M, Beverloo HB, Lee C, Helgason T, Buijs-Gladdines J, Passier M, van Wering ER, Veerman AJ, Kamps WA, Meijerink JP, Pieters R. 2006. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood 108:3520-3529.
32. Van Vlierberghe P, Pieters R, Beverloo HB, Meijerink JP. 2008. Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia. Br J Haematol 143:153-168.
33. Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ. 2006. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: Prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res 12:3043-3049.